An intermediate-mass black hole of over 500 solar masses in the galaxy ESO 243-49.

Abstract:

:Ultraluminous X-ray sources are extragalactic objects located outside the nucleus of the host galaxy with bolometric luminosities exceeding 10(39) erg s(-1). These extreme luminosities-if the emission is isotropic and below the theoretical (Eddington) limit, where the radiation pressure is balanced by the gravitational pressure-imply the presence of an accreting black hole with a mass of approximately 10(2)-10(5) solar masses (M[symbol: see text]). The existence of such intermediate-mass black holes is in dispute, and though many candidates have been proposed, none are widely accepted as definitive. Here we report the detection of a variable X-ray source with a maximum 0.2-10 keV luminosity of up to 1.1 x 10(42) erg s(-1) in the edge-on spiral galaxy ESO 243-49, with an implied conservative lower limit for the mass of the black hole of approximately 500M[symbol: see text].

journal_name

Nature

journal_title

Nature

authors

Farrell SA,Webb NA,Barret D,Godet O,Rodrigues JM

doi

10.1038/nature08083

subject

Has Abstract

pub_date

2009-07-02 00:00:00

pages

73-5

issue

7251

eissn

0028-0836

issn

1476-4687

pii

nature08083

journal_volume

460

pub_type

杂志文章

相关文献

NATURE文献大全
  • A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity.

    abstract::Positive selection allows thymocytes that recognize an individual's own major histocompatibility complex (self-MHC) molecules to survive and differentiate, whereas negative selection removes overtly self-reactive thymocytes. Although both forms of thymic selection are mediated by the alphabeta T-cell receptor (TCR) an...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35019094

    authors: Werlen G,Hausmann B,Palmer E

    更新日期:2000-07-27 00:00:00

  • Sodium channel density in hypomyelinated brain increased by myelin basic protein gene deletion.

    abstract::Trophic control over the expression and membrane distribution of voltage-dependent ion channels is one of the principal organizing events underlying the maturation of excitable cells. The myelin sheath is a major structural determinant of regional ion channel topography in central axons, but the exact molecular signal...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/352431a0

    authors: Noebels JL,Marcom PK,Jalilian-Tehrani MH

    更新日期:1991-08-01 00:00:00

  • An extended upper atmosphere around the extrasolar planet HD209458b.

    abstract::The planet in the system HD209458 is the first one for which repeated transits across the stellar disk have been observed. Together with radial velocity measurements, this has led to a determination of the planet's radius and mass, confirming it to be a gas giant. But despite numerous searches for an atmospheric signa...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature01448

    authors: Vidal-Madjar A,Des Etangs AL,Désert JM,Ballester GE,Ferlet R,Hébrard G,Mayor M

    更新日期:2003-03-13 00:00:00

  • Evolution of the 87A and 87C heat-shock loci in Drosophila.

    abstract::Several species related to Drosophila melanogaster have two loci containing sequences which code for the major heat-shock protein of molecular weight 70,000 (hsp70). These sequences are arranged as two pairs of inverted repeats. The structure of the 87C locus in D. melanogaster seems to have arisen through DNA inserti...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/290677a0

    authors: Leigh Brown AJ,Ish-Horowicz D

    更新日期:1981-04-23 00:00:00

  • Synaptotagmin 7 confers frequency invariance onto specialized depressing synapses.

    abstract::At most synapses in the brain, short-term plasticity dynamically modulates synaptic strength. Rapid frequency-dependent changes in synaptic strength have key roles in sensory adaptation, gain control and many other neural computations. However, some auditory, vestibular and cerebellar synapses maintain constant streng...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature24474

    authors: Turecek J,Jackman SL,Regehr WG

    更新日期:2017-11-23 00:00:00

  • Functional screening identifies miRNAs inducing cardiac regeneration.

    abstract::In mammals, enlargement of the heart during embryonic development is primarily dependent on the increase in cardiomyocyte numbers. Shortly after birth, however, cardiomyocytes stop proliferating and further growth of the myocardium occurs through hypertrophic enlargement of the existing myocytes. As a consequence of t...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11739

    authors: Eulalio A,Mano M,Dal Ferro M,Zentilin L,Sinagra G,Zacchigna S,Giacca M

    更新日期:2012-12-20 00:00:00

  • Tunable long-distance spin transport in a crystalline antiferromagnetic iron oxide.

    abstract::Spintronics relies on the transport of spins, the intrinsic angular momentum of electrons, as an alternative to the transport of electron charge as in conventional electronics. The long-term goal of spintronics research is to develop spin-based, low-dissipation computing-technology devices. Recently, long-distance tra...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-018-0490-7

    authors: Lebrun R,Ross A,Bender SA,Qaiumzadeh A,Baldrati L,Cramer J,Brataas A,Duine RA,Kläui M

    更新日期:2018-09-01 00:00:00

  • wingless refines its own expression domain on the Drosophila wing margin.

    abstract::The imaginal discs of Drosophila, which give rise to the adult appendages, are patterned during a period of intense cell proliferation. The specification of differing regions occurs in some cases by subdividing the disc epithelium into lineage compartments. However, in most cases precise boundaries are formed between ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/384072a0

    authors: Rulifson EJ,Micchelli CA,Axelrod JD,Perrimon N,Blair SS

    更新日期:1996-11-07 00:00:00

  • Sensory pollutants alter bird phenology and fitness across a continent.

    abstract::Expansion of anthropogenic noise and night lighting across our planet1,2 is of increasing conservation concern3-6. Despite growing knowledge of physiological and behavioural responses to these stimuli from single-species and local-scale studies, whether these pollutants affect fitness is less clear, as is how and why ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-020-2903-7

    authors: Senzaki M,Barber JR,Phillips JN,Carter NH,Cooper CB,Ditmer MA,Fristrup KM,McClure CJW,Mennitt DJ,Tyrrell LP,Vukomanovic J,Wilson AA,Francis CD

    更新日期:2020-11-01 00:00:00

  • Hox protein mutation and macroevolution of the insect body plan.

    abstract::A fascinating question in biology is how molecular changes in developmental pathways lead to macroevolutionary changes in morphology. Mutations in homeotic (Hox) genes have long been suggested as potential causes of morphological evolution, and there is abundant evidence that some changes in Hox expression patterns co...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature716

    authors: Ronshaugen M,McGinnis N,McGinnis W

    更新日期:2002-02-21 00:00:00

  • Resolving the evolutionary relationships of molluscs with phylogenomic tools.

    abstract::Molluscs (snails, octopuses, clams and their relatives) have a great disparity of body plans and, among the animals, only arthropods surpass them in species number. This diversity has made Mollusca one of the best-studied groups of animals, yet their evolutionary relationships remain poorly resolved. Open questions ha...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature10526

    authors: Smith SA,Wilson NG,Goetz FE,Feehery C,Andrade SC,Rouse GW,Giribet G,Dunn CW

    更新日期:2011-10-26 00:00:00

  • Lower receptor avidity required for thymic clonal deletion than for effector T-cell function.

    abstract::Clonal deletion in the thymus plays a major part in T-cell tolerance to self antigens. But the mechanism of negative selection, its fine specificity and the threshold of affinity and avidity remains unknown. We have now examined these aspects of negative selection with mice expressing a transgenic T-cell receptor with...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/351482a0

    authors: Pircher H,Rohrer UH,Moskophidis D,Zinkernagel RM,Hengartner H

    更新日期:1991-06-06 00:00:00

  • Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.

    abstract::Treatments that target immune checkpoints, such as the one mediated by programmed cell death protein 1 (PD-1) and its ligand PD-L1, have been approved for treating human cancers with durable clinical benefit. However, many patients with cancer fail to respond to compounds that target the PD-1 and PD-L1 interaction, an...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature25015

    authors: Zhang J,Bu X,Wang H,Zhu Y,Geng Y,Nihira NT,Tan Y,Ci Y,Wu F,Dai X,Guo J,Huang YH,Fan C,Ren S,Sun Y,Freeman GJ,Sicinski P,Wei W

    更新日期:2018-01-04 00:00:00

  • T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.

    abstract::The clinical course of autoimmune and infectious disease varies greatly, even between individuals with the same condition. An understanding of the molecular basis for this heterogeneity could lead to significant improvements in both monitoring and treatment. During chronic infection the process of T-cell exhaustion in...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature14468

    authors: McKinney EF,Lee JC,Jayne DR,Lyons PA,Smith KG

    更新日期:2015-07-30 00:00:00

  • Nitrogen fixation gene (nifL) involved in oxygen regulation of nitrogenase synthesis in K. pneumoniae.

    abstract::The enzyme complex nitrogenase, which reduces N2 to NH+4, involves two redox proteins, both irreversibly damaged by O2 (ref. 1). Enzyme activity therefore requires anaerobic conditions, a source of reductant and a large amount of ATP (approximately 16 ATPs per N2). In both aerobic and facultative anaerobic N2-fixing b...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/290424a0

    authors: Hill S,Kennedy C,Kavanagh E,Goldberg RB,Hanau R

    更新日期:1981-04-02 00:00:00

  • NLRX1 is a regulator of mitochondrial antiviral immunity.

    abstract::The RIG-like helicase (RLH) family of intracellular receptors detect viral nucleic acid and signal through the mitochondrial antiviral signalling adaptor MAVS (also known as Cardif, VISA and IPS-1) during a viral infection. MAVS activation leads to the rapid production of antiviral cytokines, including type 1 interfer...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature06501

    authors: Moore CB,Bergstralh DT,Duncan JA,Lei Y,Morrison TE,Zimmermann AG,Accavitti-Loper MA,Madden VJ,Sun L,Ye Z,Lich JD,Heise MT,Chen Z,Ting JP

    更新日期:2008-01-31 00:00:00

  • Structural basis for transcription elongation by bacterial RNA polymerase.

    abstract::The RNA polymerase elongation complex (EC) is both highly stable and processive, rapidly extending RNA chains for thousands of nucleotides. Understanding the mechanisms of elongation and its regulation requires detailed information about the structural organization of the EC. Here we report the 2.5-A resolution struct...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature05932

    authors: Vassylyev DG,Vassylyeva MN,Perederina A,Tahirov TH,Artsimovitch I

    更新日期:2007-07-12 00:00:00

  • Division and differentiation of isolated CNS blast cells in microculture.

    abstract::The mechanism of transformation of the overtly similar cells of the neural plate into the numerous and diverse cell types of the mature vertebrate central nervous system (CNS) can better be understood by studying the clonal development of isolated CNS precursor cells. Here I describe a culture system in which blast ce...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/340471a0

    authors: Temple S

    更新日期:1989-08-10 00:00:00

  • Sex in flies: the splice of life.

    abstract::The discovery that the primary transcripts of many genes are processed to produce more than one kind of messenger RNA focuses attention on the control of RNA processing as a developmental regulatory mechanism. In the fruit-fly Drosophila melanogaster, differential splicing of a hierarchy of regulatory genes determines...

    journal_title:Nature

    pub_type: 杂志文章,评审

    doi:10.1038/340521a0

    authors: Baker BS

    更新日期:1989-08-17 00:00:00

  • Continuum of overlapping clones spanning the entire human chromosome 21q.

    abstract::A continuous array of overlapping clones covering the entire human chromosome 21q was constructed from human yeast artificial chromosome libraries using sequence-tagged sites as landmarks specifically detected by polymerase chain reaction. The yeast artificial chromosome contiguous unit starts with pericentromeric and...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/359380a0

    authors: Chumakov I,Rigault P,Guillou S,Ougen P,Billaut A,Guasconi G,Gervy P,LeGall I,Soularue P,Grinas L

    更新日期:1992-10-01 00:00:00

  • Signatures of granular microstructure in dense shear flows

    abstract::Granular materials and ordinary fluids react differently to shear stresses. Rather than deforming uniformly, materials such as dry sand or cohesionless powders develop shear bands--narrow zones of large relative particle motion, with essentially rigid adjacent regions. Because shear bands mark areas of flow, material ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35019032

    authors: Mueth DM,Debregeas GF,Karczmar GS,Eng PJ,Nagel SR,Jaeger HM

    更新日期:2000-07-27 00:00:00

  • v-Src and EJ Ras alleviate repression of c-Jun by a cell-specific inhibitor.

    abstract::The AP-1 family of transcription factors, which includes the proto-oncogene products c-Jun and c-Fos, controls the stimulation of cellular genes by growth factors and the expression of oncogenes, including src and ras. Transcriptional activation by c-Jun is regulated by a cell-type-specific inhibitor that represses th...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/352165a0

    authors: Baichwal VR,Park A,Tjian R

    更新日期:1991-07-11 00:00:00

  • Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

    abstract::Considerable evidence points to a role for G1 cyclin-dependent kinase (CDK) in allowing the accumulation of E2F transcription factor activity and induction of the S phase of the cell cycle. Numerous experiments have also demonstrated a critical role for both Myc and Ras activities in allowing cell-cycle progression. H...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/387422a0

    authors: Leone G,DeGregori J,Sears R,Jakoi L,Nevins JR

    更新日期:1997-05-22 00:00:00

  • An alternative approach to establishing trade-offs among greenhouse gases.

    abstract::The Kyoto Protocol permits countries to meet part of their emission reduction obligations by cutting back on gases other than CO2 (ref. 1). This approach requires a definition of trade-offs among the radiatively active gases. The Intergovernmental Panel on Climate Change has suggested global warming potentials for thi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35070541

    authors: Manne AS,Richels RG

    更新日期:2001-04-05 00:00:00

  • The chemical structure of the Hawaiian mantle plume.

    abstract::The Hawaiian-Emperor volcanic island and seamount chain is usually attributed to a hot mantle plume, located beneath the Pacific lithosphere, that delivers material sourced from deep in the mantle to the surface. The shield volcanoes of the Hawaiian islands are distributed in two curvilinear, parallel trends (termed '...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature03907

    authors: Ren ZY,Ingle S,Takahashi E,Hirano N,Hirata T

    更新日期:2005-08-11 00:00:00

  • Salmon-hurling scientists enrich an ecosystem.

    abstract:: ...

    journal_title:Nature

    pub_type: 新闻

    doi:10.1038/d41586-018-07142-1

    authors:

    更新日期:2018-11-01 00:00:00

  • A record of planet migration in the main asteroid belt.

    abstract::The main asteroid belt lies between the orbits of Mars and Jupiter, but the region is not uniformly filled with asteroids. There are gaps, known as the Kirkwood gaps, in distinct locations that are associated with orbital resonances with the giant planets; asteroids placed in these locations will follow chaotic orbits...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature07778

    authors: Minton DA,Malhotra R

    更新日期:2009-02-26 00:00:00

  • Author Correction: Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.

    abstract::An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature

    pub_type: 已发布勘误

    doi:10.1038/s41586-019-1455-1

    authors: Schwörer S,Becker F,Feller C,Baig AH,Köber U,Henze H,Kraus JM,Xin B,Lechel A,Lipka DB,Varghese CS,Schmidt M,Rohs R,Aebersold R,Medina KL,Kestler HA,Neri F,von Maltzahn J,Tümpel S,Rudolph KL

    更新日期:2019-08-01 00:00:00

  • Microconversion between murine H-2 genes integrated into yeast.

    abstract::Patchwork homology observed between divergent members of polymorphic multigene families is thought to reflect evolution by short-tract gene conversion (nonreciprocal recombination), although this mechanism cannot usually be confirmed in higher organisms. In contrast to meiotic conversions observed in laboratory yeast ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/347192a0

    authors: Wheeler CJ,Maloney D,Fogel S,Goodenow RS

    更新日期:1990-09-13 00:00:00

  • Structure and function of endoglucanase V.

    abstract::Cellulose is the major polysaccharide component of plant cell walls and is the most abundant organic compound on the planet. A number of bacterial and fungal organisms can use cellulose as a food source, possessing cellulases (cellobiohydrolases and endoglucanases) that can catalyse the hydrolysis of the beta-(1,4) gl...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/365362a0

    authors: Davies GJ,Dodson GG,Hubbard RE,Tolley SP,Dauter Z,Wilson KS,Hjort C,Mikkelsen JM,Rasmussen G,Schülein M

    更新日期:1993-09-23 00:00:00