The role of interfacial lipids in stabilizing membrane protein oligomers.

abstract：:The molecular machinery responsible for the generation of transport carriers moving from the Golgi complex to the plasma membrane relies on a tight interplay between proteins and lipids. Among the lipid-binding proteins of this machinery, we previously identified the four-phosphate adaptor protein FAPP2, the pleckstri...

journal_title：Nature

authors： D'Angelo G,Polishchuk E,Di Tullio G,Santoro M,Di Campli A,Godi A,West G,Bielawski J,Chuang CC,van der Spoel AC,Platt FM,Hannun YA,Polishchuk R,Mattjus P,De Matteis MA

更新日期：2007-09-06 00:00:00

abstract：:Mammalian circadian clocks consist of complex integrated feedback loops that cannot be elucidated without comprehensive measurement of system dynamics and determination of network structures. To dissect such a complicated system, we took a systems-biological approach based on genomic, molecular and cell biological tec...

journal_title：Nature

authors： Ueda HR,Chen W,Adachi A,Wakamatsu H,Hayashi S,Takasugi T,Nagano M,Nakahama K,Suzuki Y,Sugano S,Iino M,Shigeyoshi Y,Hashimoto S

更新日期：2002-08-01 00:00:00

abstract：:For many decades comparative analyses of protein sequences and structures have been used to investigate fundamental principles of molecular evolution. In contrast, relatively little is known about the long-term evolution of species' phenotypic and genetic properties. This represents an important gap in our understandi...

journal_title：Nature

authors： Plata G,Henry CS,Vitkup D

更新日期：2015-01-15 00:00:00

abstract：:Over the last twenty years classical views of how compound eyes work optically have undergone a series of overhauls. Exner's central concept of an optically inhomogeneous lens cylinder has survived, and such devices are now made commercially. He was wrong, however, about some crustacean eyes. They produce images by a ...

journal_title：Nature

authors： Land MF

更新日期：1980-10-23 00:00:00

abstract：:Growth of neurite processes from the cell body is the critical step in neuronal development and involves a large increase in cell membrane surface area. Arachidonic-acid-releasing phospholipases are highly enriched in nerve growth cones and have previously been implicated in neurite outgrowth. Cell membrane expansion ...

journal_title：Nature

authors： Darios F,Davletov B

更新日期：2006-04-06 00:00:00

abstract：:The recent discovery of a pterosaur egg with embryonic skeleton and soft tissues from the Yixian Formation confirmed that the flying pterosaurs were oviparous. Here we describe another pterosaur egg whose exquisite preservation indicates that the shell structure was soft and leathery. ...

journal_title：Nature

authors： Ji Q,Ji SA,Cheng YN,You HL,Lü JC,Liu YQ,Yuan CX

更新日期：2004-12-02 00:00:00

abstract：:Presenilin and signal peptide peptidase (SPP) are intramembrane aspartyl proteases that regulate important biological functions in eukaryotes. Mechanistic understanding of presenilin and SPP has been hampered by lack of relevant structural information. Here we report the crystal structure of a presenilin/SPP homologue...

journal_title：Nature

authors： Li X,Dang S,Yan C,Gong X,Wang J,Shi Y

更新日期：2013-01-03 00:00:00

abstract：:Little is known about metabolic regulation in stem cells and how this modulates tissue regeneration or tumour suppression. We studied the Lkb1 tumour suppressor and its substrate AMP-activated protein kinase (AMPK), kinases that coordinate metabolism with cell growth. Deletion of the Lkb1 (also called Stk11) gene in m...

journal_title：Nature

authors： Nakada D,Saunders TL,Morrison SJ

更新日期：2010-12-02 00:00:00

abstract：:Transfer RNA nucleotidyltransferases (CCA-adding enzymes) are responsible for the maturation or repair of the functional 3' end of tRNAs by means of the addition of the essential nucleotides CCA. However, it is unclear how tRNA nucleotidyltransferases polymerize CCA onto the 3' terminus of immature tRNAs without using...

journal_title：Nature

authors： Xiong Y,Steitz TA

更新日期：2004-08-05 00:00:00

abstract：:There has been an increasing interest in the use of immobilized cells for the production of pharmaceuticals as well as for products such as high fructose syrup or ethanol. Some of these compounds are now produced on an industrial scale whereby the cells are used in a resting or growing state or in a nonviable form as ...

journal_title：Nature

authors： Mosbach K,Birnbaum S,Hardy K,Davies J,Bülow L

更新日期：1983-04-07 00:00:00

abstract：:Metastasis is the main cause of death in people with cancer. To colonize distant organs, circulating tumour cells must overcome many obstacles through mechanisms that we are only now starting to understand. These include infiltrating distant tissue, evading immune defences, adapting to supportive niches, surviving as ...

journal_title：Nature

authors： Massagué J,Obenauf AC

更新日期：2016-01-21 00:00:00

abstract：:The nucleosome subunit of chromatin consists of DNA folded around a histone core as a 1.8-turn left-handed solenoid. The crystal structure of the nucleosome core particle revealed that it has a dyad symmetry axis and that the minor helix groove faces outwards from the protein core. Richmond et al. noticed that the pat...

journal_title：Nature

authors： Hogan ME,Rooney TF,Austin RH

更新日期：1987-08-06 00:00:00

abstract：:Surface melt on the Greenland ice sheet has shown increasing trends in areal extent and duration since the beginning of the satellite era. Records for melt were broken in 2005, 2007, 2010 and 2012. Much of the increased surface melt is occurring in the percolation zone, a region of the accumulation area that is perenn...

journal_title：Nature

authors： Harper J,Humphrey N,Pfeffer WT,Brown J,Fettweis X

更新日期：2012-11-08 00:00:00

abstract：:The selection and design of modern high-performance structural engineering materials is driven by optimizing combinations of mechanical properties such as strength, ductility, toughness, elasticity and requirements for predictable and graceful (non-catastrophic) failure in service. Highly processable bulk metallic gla...

journal_title：Nature

authors： Hofmann DC,Suh JY,Wiest A,Duan G,Lind ML,Demetriou MD,Johnson WL

更新日期：2008-02-28 00:00:00

abstract：:DNA sequences have been analysed using models, such as an n-step Markov chain, that incorporate the possibility of short-range nucleotide correlations. We propose here a method for studying the stochastic properties of nucleotide sequences by constructing a 1:1 map of the nucleotide sequence onto a walk, which we term...

journal_title：Nature

authors： Peng CK,Buldyrev SV,Goldberger AL,Havlin S,Sciortino F,Simons M,Stanley HE

更新日期：1992-03-12 00:00:00

abstract：:Autosomal recessive juvenile parkinsonism (AR-JP) is an early-onset form of Parkinson's disease characterized by motor disturbances and dopaminergic neurodegeneration. To address its underlying molecular pathogenesis, we generated and characterized loss-of-function mutants of Drosophila PTEN-induced putative kinase 1 ...

journal_title：Nature

authors： Park J,Lee SB,Lee S,Kim Y,Song S,Kim S,Bae E,Kim J,Shong M,Kim JM,Chung J

更新日期：2006-06-29 00:00:00

abstract：:A non-discriminatory base analogue, or universal base, would be an invaluable component of oligonucleotide probes and primers for solving the design problems that arise as a result of the degeneracy of the genetic code, or when only fragmentary peptide sequence data are available. We have designed an alternative to pr...

journal_title：Nature

authors： Nichols R,Andrews PC,Zhang P,Bergstrom DE

更新日期：1994-06-09 00:00:00

abstract：:Human B cell stimulatory factor 2 (BSF-2) was originally characterized and isolated as a T cell-derived factor that caused the terminal maturation of activated B cells to immunoglobulin-producing cells. Molecular cloning of the complementary DNA predicts that BSF-2 is a protein of relative molecular mass (Mr) 26,000 s...

journal_title：Nature

authors： Kawano M,Hirano T,Matsuda T,Taga T,Horii Y,Iwato K,Asaoku H,Tang B,Tanabe O,Tanaka H

更新日期：1988-03-03 00:00:00

abstract：:Haematopoietic stem cells (HSCs) must achieve a balance between quiescence and activation that fulfils immediate demands for haematopoiesis without compromising long-term stem cell maintenance, yet little is known about the molecular events governing this balance. Phosphatase and tensin homologue (PTEN) functions as a...

journal_title：Nature

authors： Zhang J,Grindley JC,Yin T,Jayasinghe S,He XC,Ross JT,Haug JS,Rupp D,Porter-Westpfahl KS,Wiedemann LM,Wu H,Li L

更新日期：2006-05-25 00:00:00

abstract：:Retinoid X receptor (RXR) plays a central role in the regulation of many intracellular receptor signalling pathways and can mediate ligand-dependent transcription, acting as a homodimer or as a heterodimer. Here we identify an antagonist towards RXR homodimers which also functions as an agonist when RXR is paired as a...

journal_title：Nature

authors： Lala DS,Mukherjee R,Schulman IG,Koch SS,Dardashti LJ,Nadzan AM,Croston GE,Evans RM,Heyman RA

更新日期：1996-10-03 00:00:00

abstract：:The sensitivity of soil carbon to warming is a major uncertainty in projections of carbon dioxide concentration and climate. Experimental studies overwhelmingly indicate increased soil organic carbon (SOC) decomposition at higher temperatures, resulting in increased carbon dioxide emissions from soils. However, recent...

journal_title：Nature

authors： Knorr W,Prentice IC,House JI,Holland EA

更新日期：2005-01-20 00:00:00

abstract：:Traditionally, entanglement was considered to be a quirk of microscopic objects that defied a common-sense explanation. Now, however, entanglement is recognized to be ubiquitous and robust. With the realization that entanglement can occur in macroscopic systems - and with the development of experiments aimed at exploi...

journal_title：Nature

authors： Vedral V

更新日期：2008-06-19 00:00:00

abstract：:The exceptionally broad species diversity of vascular plant genera in east Asian temperate forests, compared with their sister taxa in North America, has been attributed to the greater climatic diversity of east Asia, combined with opportunities for allopatric speciation afforded by repeated fragmentation and coalesce...

journal_title：Nature

authors： Harrison SP,Yu G,Takahara H,Prentice IC

更新日期：2001-09-13 00:00:00

abstract：:The silicate Earth is strongly depleted in moderately volatile elements (such as lead, zinc, indium and alkali elements) relative to CI chondrites, the meteorites that compositionally most closely resemble the Sun. This depletion may be explained qualitatively by accretion of 10 to 20 per cent of a volatile-rich body ...

journal_title：Nature

authors： Norris CA,Wood BJ

更新日期：2017-09-27 00:00:00

abstract：:With the world's focus on reducing our dependency on fossil-fuel energy, the scientific community can investigate new plastic materials that are much less dependent on petroleum than are conventional plastics. Given increasing environmental issues, the idea of replacing plastics with water-based gels, so-called hydrog...

journal_title：Nature

authors： Wang Q,Mynar JL,Yoshida M,Lee E,Lee M,Okuro K,Kinbara K,Aida T

更新日期：2010-01-21 00:00:00

abstract：:Monoclonal antibodies were raised against antibodies to distinct carboxy-terminal KDEL sequences of two soluble, resident endoplasmic reticulum proteins. These anti-idiotype reagents recognize an intrinsic membrane protein with characteristics expected of a receptor responsible for the recognition and return of reside...

journal_title：Nature

authors： Vaux D,Tooze J,Fuller S

更新日期：1990-06-07 00:00:00

abstract：:The European Commission has made good progress in gathering support for its new programme of basic and applied research. Now Europe's industries and heads of state need to fulfill promises made two years ago. ...

journal_title：Nature

authors：

更新日期：2002-01-31 00:00:00

abstract：:Although the sex-determining gene Sry has been identified in mammals, no comparable genes have been found in non-mammalian vertebrates. Here, we used recombinant breakpoint analysis to restrict the sex-determining region in medaka fish (Oryzias latipes) to a 530-kilobase (kb) stretch of the Y chromosome. Deletion anal...

journal_title：Nature

authors： Matsuda M,Nagahama Y,Shinomiya A,Sato T,Matsuda C,Kobayashi T,Morrey CE,Shibata N,Asakawa S,Shimizu N,Hori H,Hamaguchi S,Sakaizumi M

更新日期：2002-05-30 00:00:00

abstract：:Cancer cells hijack and remodel existing metabolic pathways for their benefit. Argininosuccinate synthase (ASS1) is a urea cycle enzyme that is essential in the conversion of nitrogen from ammonia and aspartate to urea. A decrease in nitrogen flux through ASS1 in the liver causes the urea cycle disorder citrullinaemia...

journal_title：Nature

authors： Rabinovich S,Adler L,Yizhak K,Sarver A,Silberman A,Agron S,Stettner N,Sun Q,Brandis A,Helbling D,Korman S,Itzkovitz S,Dimmock D,Ulitsky I,Nagamani SC,Ruppin E,Erez A

更新日期：2015-11-19 00:00:00

abstract：:Many chemical and physical systems can occur in two forms distinguished solely by being mirror images of each other. This phenomenon, known as chirality, is important in biochemistry, where reactions involving chiral molecules often require the participation of one specific enantiomer (mirror image) of the two possibl...

journal_title：Nature

authors： Rikken GL,Raupach E

更新日期：2000-06-22 00:00:00