Genetic linkage of Werner's syndrome to five markers on chromosome 8.

abstract：:High-harmonic generation by focusing a femtosecond laser onto a gas is a well-known method of producing coherent extreme-ultraviolet (EUV) light. This nonlinear conversion process requires high pulse intensities, greater than 10(13) W cm(-2), which are not directly attainable using only the output power of a femtoseco...

journal_title：Nature

authors： Kim S,Jin J,Kim YJ,Park IY,Kim Y,Kim SW

更新日期：2008-06-05 00:00:00

abstract：:In neuronal cells, opioid peptides and opiates inhibit neurotransmitter release, which is a calcium-dependent process. They also inhibit adenylyl cyclase, presumably via the membrane signal-transducing component, Gi, a guanine nucleotide-binding protein (G-protein). No causal relationship between these two events has ...

journal_title：Nature

authors： Hescheler J,Rosenthal W,Trautwein W,Schultz G

更新日期：1987-01-29 00:00:00

abstract：:Pinocytosis and membrane ruffling are among the earliest and most dramatic cellular responses to stimulation by growth factors or other mitogens. The small Ras-related G proteins Rho and Rac have a regulatory role in membrane ruffling and activated Rho has been shown to stimulate pinocytosis when microinjected into Xe...

journal_title：Nature

authors： Lamaze C,Chuang TH,Terlecky LJ,Bokoch GM,Schmid SL

更新日期：1996-07-11 00:00:00

abstract：:It has been speculated that brain activities might directly control adaptive immune responses in lymphoid organs, although there is little evidence for this. Here we show that splenic denervation in mice specifically compromises the formation of plasma cells during a T cell-dependent but not T cell-independent immune ...

journal_title：Nature

authors： Zhang X,Lei B,Yuan Y,Zhang L,Hu L,Jin S,Kang B,Liao X,Sun W,Xu F,Zhong Y,Hu J,Qi H

更新日期：2020-05-01 00:00:00

abstract：:The initiation of immunoglobulin-E (IgE)-mediated allergic responses requires the binding of IgE antibody to its high-affinity receptor, Fc epsilonRI. Crosslinking of Fc epsilonRI initiates an intracellular signal transduction cascade that triggers the release of mediators of the allergic response. The interaction of ...

journal_title：Nature

authors： Garman SC,Wurzburg BA,Tarchevskaya SS,Kinet JP,Jardetzky TS

更新日期：2000-07-20 00:00:00

abstract：:Nucleation of aerosol particles from trace atmospheric vapours is thought to provide up to half of global cloud condensation nuclei. Aerosols can cause a net cooling of climate by scattering sunlight and by leading to smaller but more numerous cloud droplets, which makes clouds brighter and extends their lifetimes. At...

journal_title：Nature

authors： Almeida J,Schobesberger S,Kürten A,Ortega IK,Kupiainen-Määttä O,Praplan AP,Adamov A,Amorim A,Bianchi F,Breitenlechner M,David A,Dommen J,Donahue NM,Downard A,Dunne E,Duplissy J,Ehrhart S,Flagan RC,Franchin A,Guida R

更新日期：2013-10-17 00:00:00

abstract：:Many galaxies are thought to have supermassive black holes at their centres-more than a million times the mass of the Sun. Measurements of stellar velocities and the discovery of variable X-ray emission have provided strong evidence in favour of such a black hole at the centre of the Milky Way, but have hitherto been ...

journal_title：Nature

authors： Schödel R,Ott T,Genzel R,Hofmann R,Lehnert M,Eckart A,Mouawad N,Alexander T,Reid MJ,Lenzen R,Hartung M,Lacombe F,Rouan D,Gendron E,Rousset G,Lagrange AM,Brandner W,Ageorges N,Lidman C,Moorwood AF,Spyromilio J,Hu

更新日期：2002-10-17 00:00:00

abstract：:There are major impediments to finding improved DEET alternatives because the receptors causing olfactory repellency are unknown, and new chemicals require exorbitant costs to determine safety for human use. Here we identify DEET-sensitive neurons in a pit-like structure in the Drosophila melanogaster antenna called t...

journal_title：Nature

authors： Kain P,Boyle SM,Tharadra SK,Guda T,Pham C,Dahanukar A,Ray A

更新日期：2013-10-24 00:00:00

abstract：:Transport of fermions, particles with half-integer spin, is central to many fields of physics. Electron transport runs modern technology, defining states of matter such as superconductors and insulators, and electron spin is being explored as a new carrier of information. Neutrino transport energizes supernova explosi...

journal_title：Nature

authors： Sommer A,Ku M,Roati G,Zwierlein MW

更新日期：2011-04-14 00:00:00

abstract：:Five new double-mutant haemoglobins composed of betaS chains and alpha chains with different substitutions, which are located at the surface of the tetramer, have been prepared. Although all the hybrids are more soluble than deoxyhaemoglobin S, the individual differences between these molecules make it possible to eva...

journal_title：Nature

authors： Benesch RE,Yung S,Benesch R,Mack J,Schneider RG

更新日期：1976-03-18 00:00:00

abstract：:The lack of a reliable theory of glass physics has led to the pursuit of correlations between various glass or viscous liquid parameters, one of which is the slope m of the plot of log(viscosity) against Tg/T, extrapolated at the glass-transition temperature, Tg, also termed 'fragility'. Novikov and Sokolov conclude t...

journal_title：Nature

authors： Yannopoulos SN,Johari GP

更新日期：2006-08-03 00:00:00

abstract：:The discovery that atrial extracts have potent diuretic and natriuretic properties revealed a possible endocrine function of the heart in the regulation of extracellular fluid volume. Since that first report intense research activity has been directed towards determining the mechanism of action of the active atrial na...

journal_title：Nature

authors： Harris PJ,Thomas D,Morgan TO

更新日期：1987-04-16 00:00:00

abstract：:Guided by brain-like 'spiking' computational frameworks, neuromorphic computing-brain-inspired computing for machine intelligence-promises to realize artificial intelligence while reducing the energy requirements of computing platforms. This interdisciplinary field began with the implementation of silicon circuits for...

journal_title：Nature

authors： Roy K,Jaiswal A,Panda P

更新日期：2019-11-01 00:00:00

abstract：:Recent studies have shown that initial sensitization to airborne environmental allergens occurs typically in early childhood, but subsequent progression to persistent atopic asthma, which may not manifest for several years, is restricted to only a subset of atopics. The key to establishing the link between atopy and a...

journal_title：Nature

authors： Holt PG,Macaubas C,Stumbles PA,Sly PD

更新日期：1999-11-25 00:00:00

abstract：:The development of photolabile caged neurotransmitters has made possible the study of the split-second kinetics of receptor-ligand interactions. An instrument has now been developed for activating the neurotransmitter and measuring the neuron's response. ...

journal_title：Nature

authors： Marque JJ

更新日期：1989-02-09 00:00:00

abstract：:Ecological and societal disruptions by modern climate change are critically determined by the time frame over which climates shift beyond historical analogues. Here we present a new index of the year when the projected mean climate of a given location moves to a state continuously outside the bounds of historical vari...

journal_title：Nature

authors： Mora C,Frazier AG,Longman RJ,Dacks RS,Walton MM,Tong EJ,Sanchez JJ,Kaiser LR,Stender YO,Anderson JM,Ambrosino CM,Fernandez-Silva I,Giuseffi LM,Giambelluca TW

更新日期：2013-10-10 00:00:00

abstract：:The NLRP3 inflammasome, which has been linked to human inflammatory diseases, is activated by diverse stimuli. How these stimuli activate NLRP3 is unknown. Here we show that different NLRP3 stimuli lead to disassembly of the trans-Golgi network (TGN). NLRP3 is recruited to the dispersed TGN (dTGN) through ionic bondin...

journal_title：Nature

authors： Chen J,Chen ZJ

更新日期：2018-12-01 00:00:00

abstract：:The mineral olivine dominates the composition of the Earth's upper mantle and hence controls its mechanical behaviour and seismic anisotropy. Experiments at high temperature and moderate pressure, and extensive data on naturally deformed mantle rocks, have led to the conclusion that olivine at upper-mantle conditions ...

journal_title：Nature

authors： Mainprice D,Tommasi A,Couvy H,Cordier P,Frost DJ

更新日期：2005-02-17 00:00:00

abstract：:In associative learning, the activated neurones undergo a variety of concomitant functional alterations--increases or decreases of firing activity and modifications of membrane potential or resistance and of synaptic responsiveness. Synaptic transmission which can be strengthened only when there is paired activity in ...

journal_title：Nature

authors： Baranyi A,Fehér O

更新日期：1981-04-02 00:00:00

abstract：:In budding yeast many genes are expressed under cell-cycle control in late G1. These include a large group of DNA synthesis genes, the HO gene involved in mating-type switching, CTS1 (chitinase) and also CLN1 and CLN2 (ref. 4) encoding G1 cyclins. Two factors, encoded by the SWI4 and SWI6 genes, are required for HO (r...

journal_title：Nature

authors： Lowndes NF,Johnson AL,Breeden L,Johnston LH

更新日期：1992-06-11 00:00:00

abstract：:How diverse cell fates and complex forms emerge and feed back to each other to sculpt functional organs remains unclear. In the developing heart, the myocardium transitions from a simple epithelium to an intricate tissue that consists of distinct layers: the outer compact and inner trabecular layers. Defects in this p...

journal_title：Nature

authors： Priya R,Allanki S,Gentile A,Mansingh S,Uribe V,Maischein HM,Stainier DYR

更新日期：2020-12-01 00:00:00

abstract：:Accurate chromosome segregation requires timely dissolution of chromosome cohesion after chromosomes are properly attached to the mitotic spindle. Separase is absolutely essential for cohesion dissolution in organisms from yeast to man. It cleaves the kleisin subunit of cohesin and opens the cohesin ring to allow chro...

journal_title：Nature

authors： Lin Z,Luo X,Yu H

更新日期：2016-04-07 00:00:00

abstract：:The separation of ON and OFF channels and the development of an antagonistic surround occur at the first synapse in the vertebrate retina. This functional differentiation is mediated by the action of the photoreceptor neurotransmitter on the ON bipolar, OFF bipolar and horizontal cells, respectively. Glutamate mimics ...

journal_title：Nature

authors： Slaughter MM,Miller RF

更新日期：1985-03-07 00:00:00

abstract：:Increasing population and consumption are placing unprecedented demands on agriculture and natural resources. Today, approximately a billion people are chronically malnourished while our agricultural systems are concurrently degrading land, water, biodiversity and climate on a global scale. To meet the world's future ...

journal_title：Nature

authors： Foley JA,Ramankutty N,Brauman KA,Cassidy ES,Gerber JS,Johnston M,Mueller ND,O'Connell C,Ray DK,West PC,Balzer C,Bennett EM,Carpenter SR,Hill J,Monfreda C,Polasky S,Rockström J,Sheehan J,Siebert S,Tilman D,Zaks DP

更新日期：2011-10-12 00:00:00

abstract：:As an approach to the study of the kind of chemical process that might have contributed to the origin of life, attempts have been made to develop purely chemical systems in which oligonucleotides self-replicate. Although performed oligonucleotides have been shown to facilitate the formation of their complements from a...

journal_title：Nature

authors： Zielinski WS,Orgel LE

更新日期：1987-05-28 00:00:00

abstract：:Three subfamilies of grasses, the Ehrhartoideae, Panicoideae and Pooideae, provide the bulk of human nutrition and are poised to become major sources of renewable energy. Here we describe the genome sequence of the wild grass Brachypodium distachyon (Brachypodium), which is, to our knowledge, the first member of the P...

journal_title：Nature

authors： International Brachypodium Initiative.

更新日期：2010-02-11 00:00:00

abstract：:The death of massive stars produces a variety of supernovae, which are linked to the structure of the exploding stars. The detection of several precursor stars of type II supernovae has been reported (see, for example, ref. 3), but we do not yet have direct information on the progenitors of the hydrogen-deficient type...

journal_title：Nature

authors： Pastorello A,Smartt SJ,Mattila S,Eldridge JJ,Young D,Itagaki K,Yamaoka H,Navasardyan H,Valenti S,Patat F,Agnoletto I,Augusteijn T,Benetti S,Cappellaro E,Boles T,Bonnet-Bidaud JM,Botticella MT,Bufano F,Cao C,Deng J,

更新日期：2007-06-14 00:00:00

abstract：:Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic hap...

journal_title：Nature

authors： Liu P,Ji Y,Yuen T,Rendina-Ruedy E,DeMambro VE,Dhawan S,Abu-Amer W,Izadmehr S,Zhou B,Shin AC,Latif R,Thangeswaran P,Gupta A,Li J,Shnayder V,Robinson ST,Yu YE,Zhang X,Yang F,Lu P,Zhou Y,Zhu LL,Oberlin DJ,Davie

更新日期：2017-06-01 00:00:00

abstract：:Living organisms rely on simultaneous reactions catalysed by mutually compatible and selective enzymes to synthesize complex natural products and other metabolites. To combine the advantages of these biological systems with the reactivity of artificial chemical catalysts, chemists have devised sequential, concurrent, ...

journal_title：Nature

authors： Litman ZC,Wang Y,Zhao H,Hartwig JF

更新日期：2018-08-01 00:00:00

abstract：:Observations show that the seismic normal modes of the Earth at frequencies near 10 mHz are excited at a nearly constant level in the absence of large earthquakes. This background level of excitation has been called the 'hum' of the Earth, and is equivalent to the maximum excitation from a magnitude 5.75 earthquake. I...

journal_title：Nature

authors： Webb SC

更新日期：2007-02-15 00:00:00