Regulation of receptor-mediated endocytosis by Rho and Rac.

abstract：:Practice, with feedback, is a fundamental variable that influences the aquisition of motor skills: with it, everyone improves, but some improve more than others. This simple fact has led to frequent debate over the relative importance of genetic and environmental influences on motor learning. In principle these factor...

journal_title：Nature

authors： Fox PW,Hershberger SL,Bouchard TJ Jr

更新日期：1996-11-28 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) sense viral and microbial DNA through endosomal Toll-like receptors to produce type 1 interferons. pDCs do not normally respond to self-DNA, but this restriction seems to break down in human autoimmune disease by an as yet poorly understood mechanism. Here we identify the antimicrob...

journal_title：Nature

authors： Lande R,Gregorio J,Facchinetti V,Chatterjee B,Wang YH,Homey B,Cao W,Wang YH,Su B,Nestle FO,Zal T,Mellman I,Schröder JM,Liu YJ,Gilliet M

更新日期：2007-10-04 00:00:00

abstract：:The quantum-level interplay between geometry, topology and correlation is at the forefront of fundamental physics1-15. Kagome magnets are predicted to support intrinsic Chern quantum phases owing to their unusual lattice geometry and breaking of time-reversal symmetry14,15. However, quantum materials hosting ideal spi...

journal_title：Nature

authors： Yin JX,Ma W,Cochran TA,Xu X,Zhang SS,Tien HJ,Shumiya N,Cheng G,Jiang K,Lian B,Song Z,Chang G,Belopolski I,Multer D,Litskevich M,Cheng ZJ,Yang XP,Swidler B,Zhou H,Lin H,Neupert T,Wang Z,Yao N,Chang TR,Jia S

更新日期：2020-07-01 00:00:00

abstract：:The rare Egyptian vulture (Neophron percnopterus) stands out among the Old World vultures (Family Accipitridae) because of its brightly ornamented head, which is coloured yellow by carotenoid pigments, and its practice of feeding on faeces. Here we show that Egyptian vultures obtain these pigments from the excrement o...

journal_title：Nature

authors： Negro JJ,Grande JM,Tella JL,Garrido J,Hornero D,Donázar JA,Sanchez-Zapata JA,BenItez JR,Barcell M

更新日期：2002-04-25 00:00:00

abstract：:The clinical development of an inhibitor of cellular proteasome function suggests that compounds targeting other components of the ubiquitin-proteasome system might prove useful for the treatment of human malignancies. NEDD8-activating enzyme (NAE) is an essential component of the NEDD8 conjugation pathway that contro...

journal_title：Nature

authors： Soucy TA,Smith PG,Milhollen MA,Berger AJ,Gavin JM,Adhikari S,Brownell JE,Burke KE,Cardin DP,Critchley S,Cullis CA,Doucette A,Garnsey JJ,Gaulin JL,Gershman RE,Lublinsky AR,McDonald A,Mizutani H,Narayanan U,Olhava EJ

更新日期：2009-04-09 00:00:00

abstract：:The repressor of phage 434 binds to six operator sites on the phage chromosome. A comparison of the sequences of these 14-base-pair (bp) operator sites reveals a striking pattern: at five of the six sites, the symmetrically arrayed outer eight base pairs (four in each half-site) are identical and the remaining site di...

journal_title：Nature

authors： Koudelka GB,Harrison SC,Ptashne M

更新日期：1987-04-30 00:00:00

abstract：:Whether or not the Large Hadron Collider reveals the long-awaited Higgs particle, it is likely to lead to discoveries that add to, or challenge, the standard model of particle physics. Data produced will be pored over for any evidence of supersymmetric partners for the existing denizens of the particle 'zoo' and for t...

journal_title：Nature

authors： Ellis J

更新日期：2007-07-19 00:00:00

abstract：:In lung diseases such as asthma, expiratory flow becomes limited, airways can collapse and the vital exchange of gases is compromised. Here we model the inflation of collapsed regions of the lung during inspiration in terms of avalanches propagating through a bifurcating network of airways, and find that the accompany...

journal_title：Nature

authors： Alencar AM,Arold SP,Buldyrev SV,Majumdar A,Stamenović D,Stanley HE,Suki B

更新日期：2002-06-20 00:00:00

abstract：:Exceptional genomic stability is one of the hallmarks of mouse embryonic stem (ES) cells. However, the genes contributing to this stability remain obscure. We previously identified Zscan4 as a specific marker for two-cell embryo and ES cells. Here we show that Zscan4 is involved in telomere maintenance and long-term g...

journal_title：Nature

authors： Zalzman M,Falco G,Sharova LV,Nishiyama A,Thomas M,Lee SL,Stagg CA,Hoang HG,Yang HT,Indig FE,Wersto RP,Ko MS

更新日期：2010-04-08 00:00:00

abstract：:The genes torso (tor) and torso-like (tsl) are two of the Drosophila maternal group genes implicated in a receptor tyrosine kinase signalling pathway that specifies terminal cell fate (reviewed in ref. 3). Loss-of-function mutations in these loci cause an identical phenotype in which pattern elements from the anterior...

journal_title：Nature

authors： Martin JR,Raibaud A,Ollo R

更新日期：1994-02-24 00:00:00

abstract：:During the evolution of sea urchins, a transfer RNA gene lost its tRNA function and became part of a protein-coding gene. This functional loss of a tRNA with specificity for one group of leucine codons (CUN, where N is any base) was accompanied by the gain of a new tRNA with that specificity. The new tRNA gene for CUN...

journal_title：Nature

authors： Cantatore P,Gadaleta MN,Roberti M,Saccone C,Wilson AC

更新日期：1987-10-29 00:00:00

abstract：:Transplantation surgery, which is limited by the supply and short-term viability of fresh donor organs, would be revolutionized if these could survive freezing, but early claims of cryopreservation were never realized. Here we describe the successful transplantation in rats of ovaries, fallopian tubes and the upper se...

journal_title：Nature

authors： Wang X,Chen H,Yin H,Kim SS,Lin Tan S,Gosden RG

更新日期：2002-01-24 00:00:00

abstract：:Metastasis is the main cause of death in people with cancer. To colonize distant organs, circulating tumour cells must overcome many obstacles through mechanisms that we are only now starting to understand. These include infiltrating distant tissue, evading immune defences, adapting to supportive niches, surviving as ...

journal_title：Nature

authors： Massagué J,Obenauf AC

更新日期：2016-01-21 00:00:00

abstract：:Activation of a visual pigment molecule to initiate phototransduction requires a minimum energy, Ea, that need not be wholly derived from a photon, but may be supplemented by heat. Theory predicts that absorbance at very long wavelengths declines with the fraction of molecules that have a sufficient complement of ther...

journal_title：Nature

authors： Koskelainen A,Ala-Laurila P,Fyhrquist N,Donner K

更新日期：2000-01-13 00:00:00

abstract：:The current outbreak of coronavirus disease-2019 (COVID-19) poses unprecedented challenges to global health1. The new coronavirus responsible for this outbreak-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-shares high sequence identity to SARS-CoV and a bat coronavirus, RaTG132. Although bats may be the...

journal_title：Nature

authors： Xiao K,Zhai J,Feng Y,Zhou N,Zhang X,Zou JJ,Li N,Guo Y,Li X,Shen X,Zhang Z,Shu F,Huang W,Li Y,Zhang Z,Chen RA,Wu YJ,Peng SM,Huang M,Xie WJ,Cai QH,Hou FH,Chen W,Xiao L,Shen Y

更新日期：2020-07-01 00:00:00

abstract：:Most neurons of the mammalian central nervous system (CNS) lose the ability to regenerate severed axons in vivo after a certain point in development. At least part of this loss in regenerative potential is intrinsic to neurons. Although embryonic retinal ganglion cells (RGCs) can grow axons into tectum of any age, mos...

journal_title：Nature

authors： Chen DF,Schneider GE,Martinou JC,Tonegawa S

更新日期：1997-01-30 00:00:00

abstract：:Large parts of the Antarctic ice sheet lying on bedrock below sea level may be vulnerable to marine-ice-sheet instability (MISI), a self-sustaining retreat of the grounding line triggered by oceanic or atmospheric changes. There is growing evidence that MISI may be underway throughout the Amundsen Sea embayment (ASE),...

journal_title：Nature

authors： Ritz C,Edwards TL,Durand G,Payne AJ,Peyaud V,Hindmarsh RC

更新日期：2015-12-03 00:00:00

abstract：:Excitatory amino acids mediate fast synaptic transmission in the central nervous system through the activation of at least three distinct ionotropic receptors: N-methyl-D-aspartate (NMDA), the alpha-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/quisqualate (QUIS) and the kainate subtypes (for reviews, see ref...

journal_title：Nature

authors： Charpak S,Gähwiler BH,Do KQ,Knöpfel T

更新日期：1990-10-25 00:00:00

abstract：:An unusual feature of the cerebellar cortex is that its output neurons, Purkinje cells, release GABA (γ-aminobutyric acid). Their high intrinsic firing rates (50 Hz) and extensive convergence predict that their target neurons in the cerebellar nuclei would be largely inhibited unless Purkinje cells pause their spiking...

journal_title：Nature

authors： Person AL,Raman IM

更新日期：2011-12-25 00:00:00

abstract：:Cyclin-dependent kinase 5 (Cdk5) and its neuron-specific regulator p35 are essential for neuronal migration and for the laminar configuration of the cerebral cortex. In addition, p35/Cdk5 kinase concentrates at the leading edges of axonal growth cones and regulates neurite outgrowth in cortical neurons in culture. The...

journal_title：Nature

authors： Nikolic M,Chou MM,Lu W,Mayer BJ,Tsai LH

更新日期：1998-09-10 00:00:00

abstract：:Type II DNA topoisomerases are ubiquitous ATP-dependent enzymes capable of transporting a DNA through a transient double-strand break in a second DNA segment. This enables them to untangle DNA and relax the interwound supercoils (plectonemes) that arise in twisted DNA. In vivo, they are responsible for untangling repl...

journal_title：Nature

authors： Strick TR,Croquette V,Bensimon D

更新日期：2000-04-20 00:00:00

abstract：:The travelling salesman problem is a classical problem in the field of combinatorial optimization, concerned with efficient methods for maximizing or minimizing a function of many independent variables. Given the positions of N cities, which in the simplest case lie in the plane, what is the shortest closed tour in wh...

journal_title：Nature

authors： Durbin R,Willshaw D

更新日期：1987-04-16 00:00:00

abstract：:Brosnan and de Waal report that capuchin monkeys show evidence of a sense of fairness or 'inequity aversion' because they rejected a less preferred reward when they saw a partner monkey receive a preferred reward for the same task. However, this does not show that monkeys are averse to inequity, only that they reject ...

journal_title：Nature

authors： Wynne CD

更新日期：2004-03-11 00:00:00

abstract：:Excitation-contraction coupling in skeletal muscle involves a voltage sensor in the plasma membrane which, in response to depolarization, causes an intracellular calcium-release channel to open. The skeletal isoform of the ryanodine receptor (RyR-1) functions as the Ca2+-release channel and the dihydropyridine recepto...

journal_title：Nature

authors： Nakai J,Dirksen RT,Nguyen HT,Pessah IN,Beam KG,Allen PD

更新日期：1996-03-07 00:00:00

abstract：:The quantum spin properties of nitrogen-vacancy defects in diamond enable diverse applications in quantum computing and communications1. However, fluorescent nanodiamonds also have attractive properties for in vitro biosensing, including brightness2, low cost3 and selective manipulation of their emission4. Nanoparticl...

journal_title：Nature

authors： Miller BS,Bezinge L,Gliddon HD,Huang D,Dold G,Gray ER,Heaney J,Dobson PJ,Nastouli E,Morton JJL,McKendry RA

更新日期：2020-11-01 00:00:00

abstract：:Resistance to infection and clearance of cell debris in mammals depend on the activation of the complement system, which is an important component of innate and adaptive immunity. Central to the complement system is the activated form of C3, called C3b, which attaches covalently to target surfaces to amplify complemen...

journal_title：Nature

authors： Janssen BJ,Christodoulidou A,McCarthy A,Lambris JD,Gros P

更新日期：2006-11-09 00:00:00

abstract：:Design-specific control over excited-state dynamics is necessary for any application seeking to convert light into chemical potential. Such control is especially desirable in iron(II)-based chromophores, which are an Earth-abundant option for a wide range of photo-induced electron-transfer applications including solar...

journal_title：Nature

authors： Paulus BC,Adelman SL,Jamula LL,McCusker JK

更新日期：2020-06-01 00:00:00

abstract：:Alzheimer's disease is a progressive loss of memory and cognition, for which there is no cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at reducing amyloid-have failed to reverse cognitive symptoms. These clinical findings suggest tha...

journal_title：Nature

authors： Canter RG,Penney J,Tsai LH

更新日期：2016-11-10 00:00:00

abstract：:Human lymphocytes have been shown to lyse in vitro a large variety of target cells derived from tumour as well as normal tissues. The effector cells involved in this spontaneous cell-mediated cytotoxicity (SCMC) have generally been characterised as lymphocytes which lack surface membrane immunoglobulin (sIg) and lack ...

journal_title：Nature

authors： de Vries JE,Mendelsohn J,Bont WS

更新日期：1980-02-07 00:00:00

abstract：:The interplay between magnetic fields and interacting particles can lead to exotic phases of matter that exhibit topological order and high degrees of spatial entanglement. Although these phases were discovered in a solid-state setting, recent innovations in systems of ultracold neutral atoms-uncharged atoms that do n...

journal_title：Nature

authors： Tai ME,Lukin A,Rispoli M,Schittko R,Menke T,Dan Borgnia,Preiss PM,Grusdt F,Kaufman AM,Greiner M

更新日期：2017-06-21 00:00:00