Solutions for a cultivated planet.

abstract：:Two principals in the once-raging debate over forensic DNA typing conclude that the scientific issues have all been resolved. ...

journal_title：Nature

authors： Lander ES,Budowle B

更新日期：1994-10-27 00:00:00

abstract：:The biochemical response to food intake must be precisely regulated. Because ingested sugars and fats can feed into many anabolic and catabolic pathways1, how our bodies handle nutrients depends on strategically positioned metabolic sensors that link the intrinsic nutritional value of a meal with intermediary metaboli...

journal_title：Nature

authors： He S,Kahles F,Rattik S,Nairz M,McAlpine CS,Anzai A,Selgrade D,Fenn AM,Chan CT,Mindur JE,Valet C,Poller WC,Halle L,Rotllan N,Iwamoto Y,Wojtkiewicz GR,Weissleder R,Libby P,Fernández-Hernando C,Drucker DJ,Nahrendorf

更新日期：2019-02-01 00:00:00

abstract：:The evolution of self-fertilization in hermaphrodites is opposed by costs that decrease the value of self progeny relative to that of outcross progeny. However, self-fertilization is common in plants; 20% are highly selfing and 33% are intermediate between selfing and outcrossing. Darwin proposed an adaptive benefit o...

journal_title：Nature

authors： Kalisz S,Vogler DW,Hanley KM

更新日期：2004-08-19 00:00:00

abstract：:Techniques to facilitate controlled interactions between single photons and atoms are now being actively explored. These techniques are important for the practical realization of quantum networks, in which multiple memory nodes that utilize atoms for generation, storage and processing of quantum states are connected b...

journal_title：Nature

authors： Eisaman MD,André A,Massou F,Fleischhauer M,Zibrov AS,Lukin MD

更新日期：2005-12-08 00:00:00

abstract：:Most Oryza sativa cultivars die within a week of complete submergence--a major constraint to rice production in south and southeast Asia that causes annual losses of over US 1 billion dollars and affects disproportionately the poorest farmers in the world. A few cultivars, such as the O. sativa ssp. indica cultivar FR...

journal_title：Nature

authors： Xu K,Xu X,Fukao T,Canlas P,Maghirang-Rodriguez R,Heuer S,Ismail AM,Bailey-Serres J,Ronald PC,Mackill DJ

更新日期：2006-08-10 00:00:00

abstract：:Cyclin degradation is the key step governing exit from mitosis and progress into the next cell cycle. When a region in the N terminus of cyclin is fused to a foreign protein, it produces a hybrid protein susceptible to proteolysis at mitosis. During the course of degradation, both cyclin and the hybrid form conjugates...

journal_title：Nature

authors： Glotzer M,Murray AW,Kirschner MW

更新日期：1991-01-10 00:00:00

abstract：:The mir-34/449 family consists of six homologous miRNAs at three genomic loci. Redundancy of miR-34/449 miRNAs and their dominant expression in multiciliated epithelia suggest a functional significance in ciliogenesis. Here we report that mice deficient for all miR-34/449 miRNAs exhibited postnatal mortality, infertil...

journal_title：Nature

authors： Song R,Walentek P,Sponer N,Klimke A,Lee JS,Dixon G,Harland R,Wan Y,Lishko P,Lize M,Kessel M,He L

更新日期：2014-06-05 00:00:00

abstract：: ...

journal_title：Nature

authors： Gewin V

更新日期：2018-10-01 00:00:00

abstract：:RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from D...

journal_title：Nature

authors： McCaffrey AP,Meuse L,Pham TT,Conklin DS,Hannon GJ,Kay MA

更新日期：2002-07-04 00:00:00

abstract：:Helminth parasitic infections are a major global health and social burden. The host defence against helminths such as Nippostrongylus brasiliensis is orchestrated by type 2 cell-mediated immunity. Induction of type 2 cytokines, including interleukins (IL) IL-4 and IL-13, induce goblet cell hyperplasia with mucus produ...

journal_title：Nature

authors： Gerbe F,Sidot E,Smyth DJ,Ohmoto M,Matsumoto I,Dardalhon V,Cesses P,Garnier L,Pouzolles M,Brulin B,Bruschi M,Harcus Y,Zimmermann VS,Taylor N,Maizels RM,Jay P

更新日期：2016-01-14 00:00:00

abstract：:Dehydration embrittlement has been proposed to explain both intermediate- and deep-focus earthquakes in subduction zones. Because such earthquakes primarily occur at shallow depths or within the core of the subducting plate, dehydration at relatively low temperatures has been emphasized. However, recent careful reloca...

journal_title：Nature

authors： Zhang J,Green HW,Bozhilov K,Jin Z

更新日期：2004-04-08 00:00:00

abstract：:Tuberculosis is the leading cause of death in the world resulting from a single bacterial infection. Despite its enormous burden on world health, little is known about the molecular mechanisms of pathogenesis of Mycobacterium tuberculosis. Bacterial multiplication and concomitant tissue damage within an infected host,...

journal_title：Nature

authors： Cox JS,Chen B,McNeil M,Jacobs WR Jr

更新日期：1999-11-04 00:00:00

abstract：:Peptidoglycan is the major structural constituent of the bacterial cell wall, forming a meshwork outside the cytoplasmic membrane that maintains cell shape and prevents lysis. In Gram-negative bacteria, peptidoglycan is located in the periplasm, where it is protected from exogenous lytic enzymes by the outer membrane....

journal_title：Nature

authors： Russell AB,Hood RD,Bui NK,LeRoux M,Vollmer W,Mougous JD

更新日期：2011-07-20 00:00:00

abstract：:In cardiac muscle, where Ca2+ influx across the sarcolemma is essential for contraction, the dihydropyridine (DHP)-sensitive L-type calcium channel represents the major entry pathway of extracellular Ca2+. We have previously elucidated the primary structure of the rabbit skeletal muscle DHP receptor by cloning and seq...

journal_title：Nature

authors： Mikami A,Imoto K,Tanabe T,Niidome T,Mori Y,Takeshima H,Narumiya S,Numa S

更新日期：1989-07-20 00:00:00

abstract：:The nature of ultrahigh-energy cosmic rays (UHECRs) at energies >10(20) eV remains a mystery. They are likely to be of extragalactic origin, but should be absorbed within approximately 50 Mpc through interactions with the cosmic microwave background. As there are no sufficiently powerful accelerators within this dista...

journal_title：Nature

authors： Falcke H,Apel WD,Badea AF,Bähren L,Bekk K,Bercuci A,Bertaina M,Biermann PL,Blümer J,Bozdog H,Brancus IM,Buitink S,Brüggemann M,Buchholz P,Butcher H,Chiavassa A,Daumiller K,de Bruyn AG,de Vos CM,Di Pierro F,Doll P

更新日期：2005-05-19 00:00:00

abstract：:The Colorado plateau is a large, tectonically intact, physiographic province in the southwestern North American Cordillera that stands at ∼1,800-2,000 m elevation and has long been thought to be in isostatic equilibrium. The origin of these high elevations is unclear because unlike the surrounding provinces, which hav...

journal_title：Nature

authors： Levander A,Schmandt B,Miller MS,Liu K,Karlstrom KE,Crow RS,Lee CT,Humphreys ED

更新日期：2011-04-28 00:00:00

abstract：: ...

journal_title：Nature

authors： Kelly S,Carrington M

更新日期：2018-11-01 00:00:00

abstract：:Behavioural studies and field observations demonstrate that echolocating bats simultaneously perceive range, direction and shape of multiple objects in the environment as acoustic images derived from echoes. Cortical echo delay-tuned neurons contribute to the perception of object range, because focal inactivation of t...

journal_title：Nature

authors： Dear SP,Simmons JA,Fritz J

更新日期：1993-08-12 00:00:00

abstract：:Chemotaxis in Caenorhabditis elegans, like chemotaxis in bacteria, involves a random walk biased by the time derivative of attractant concentration, but how the derivative is computed is unknown. Laser ablations have shown that the strongest deficits in chemotaxis to salts are obtained when the ASE chemosensory neuron...

journal_title：Nature

authors： Suzuki H,Thiele TR,Faumont S,Ezcurra M,Lockery SR,Schafer WR

更新日期：2008-07-03 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, is characterized by elevated glycogen levels and fat deposition. These consistent metabolic alterations are associated with normoxic stabilization of hypoxia-inducible factors (HIFs) secondary to von Hippel-Lindau (VHL) mutations that occu...

journal_title：Nature

authors： Li B,Qiu B,Lee DS,Walton ZE,Ochocki JD,Mathew LK,Mancuso A,Gade TP,Keith B,Nissim I,Simon MC

更新日期：2014-09-11 00:00:00

abstract：:Evolutionary relationships among the eight major lineages of Mollusca have remained unresolved despite their diversity and importance. Previous investigations of molluscan phylogeny, based primarily on nuclear ribosomal gene sequences or morphological data, have been unsuccessful at elucidating these relationships. Re...

journal_title：Nature

authors： Kocot KM,Cannon JT,Todt C,Citarella MR,Kohn AB,Meyer A,Santos SR,Schander C,Moroz LL,Lieb B,Halanych KM

更新日期：2011-09-04 00:00:00

abstract：:The assembly of ribosomes in bacterial cells is a complex process that remains poorly characterized. The in vitro assembly of active ribosomal subunits from purified RNA and protein components indicates that all of the information for proper assembly resides in the primary sequences of these macromolecules. On the oth...

journal_title：Nature

authors： Nishi K,Morel-Deville F,Hershey JW,Leighton T,Schnier J

更新日期：1988-12-01 00:00:00

abstract：:A hemispheric dichotomy on Mars is marked by the sharp contrast between the sparsely cratered northern lowland plains and the heavily cratered southern highlands. Mechanisms proposed to remove ancient crust or form younger lowland crust include one or more giant impacts, subcrustal transport by mantle convection, the ...

journal_title：Nature

authors： Watters TR,Leuschen CJ,Plaut JJ,Picardi G,Safaeinili A,Clifford SM,Farrell WM,Ivanov AB,Phillips RJ,Stofan ER

更新日期：2006-12-14 00:00:00

abstract：:The atmosphere and ionosphere of Venus have been studied in the past by spacecraft with remote sensing or in situ techniques. These early missions, however, have left us with questions about, for example, the atmospheric structure in the transition region from the upper troposphere to the lower mesosphere (50-90 km) a...

journal_title：Nature

authors： Pätzold M,Häusler B,Bird MK,Tellmann S,Mattei R,Asmar SW,Dehant V,Eidel W,Imamura T,Simpson RA,Tyler GL

更新日期：2007-11-29 00:00:00

abstract：:Information--be it classical or quantum--is measured by the amount of communication needed to convey it. In the classical case, if the receiver has some prior information about the messages being conveyed, less communication is needed. Here we explore the concept of prior quantum information: given an unknown quantum ...

journal_title：Nature

authors： Horodecki M,Oppenheim J,Winter A

更新日期：2005-08-04 00:00:00

abstract：:Although the link between long gamma-ray bursts (GRBs) and supernovae has been established, hitherto there have been no observations of the beginning of a supernova explosion and its intimate link to a GRB. In particular, we do not know how the jet that defines a gamma-ray burst emerges from the star's surface, nor ho...

journal_title：Nature

authors： Campana S,Mangano V,Blustin AJ,Brown P,Burrows DN,Chincarini G,Cummings JR,Cusumano G,Della Valle M,Malesani D,Mészáros P,Nousek JA,Page M,Sakamoto T,Waxman E,Zhang B,Dai ZG,Gehrels N,Immler S,Marshall FE,Mason KO

更新日期：2006-08-31 00:00:00

abstract：:The mitotic recombination behaviour of a duplication of the his4 region on chromosome III in the yeast Saccharomyces cerevisiae was studied. The major recombination event between the duplicated segments is gene conversion unassociated with reciprocal recombination. The rad52-1 mutation preferentially decreases mitotic...

journal_title：Nature

authors： Jackson JA,Fink GR

更新日期：1981-07-23 00:00:00

abstract：:The neuronal structure and connectivity underlying receptive field organisation of cells in the cat visual cortex have been investigated. Intracellular recordings were made using a micropipette filled with a histochemical marker, which was injected into the cells after their receptive fields had been characterised. Th...

journal_title：Nature

authors： Gilbert CD,Wiesel TN

更新日期：1979-07-12 00:00:00

abstract：:DNA replication in eukaryotes is strictly regulated by several mechanisms. A central step in this replication is the assembly of the heterohexameric minichromosome maintenance (MCM2-7) helicase complex at replication origins during G1 phase as an inactive double hexamer. Here, using cryo-electron microscopy, we report...

journal_title：Nature

authors： Li N,Zhai Y,Zhang Y,Li W,Yang M,Lei J,Tye BK,Gao N

更新日期：2015-08-13 00:00:00

abstract：:Ultra-compact dwarf galaxies are among the densest stellar systems in the Universe. These systems have masses of up to 2 × 10(8) solar masses, but half-light radii of just 3-50 parsecs. Dynamical mass estimates show that many such dwarfs are more massive than expected from their luminosity. It remains unclear whether ...

journal_title：Nature

authors： Seth AC,van den Bosch R,Mieske S,Baumgardt H,den Brok M,Strader J,Neumayer N,Chilingarian I,Hilker M,McDermid R,Spitler L,Brodie J,Frank MJ,Walsh JL

更新日期：2014-09-18 00:00:00