Abstract:
:In Drosophila and mice, olfactory receptor neurons (ORNs) expressing the same receptors have convergent axonal projections to specific glomerular targets in the antennal lobe/olfactory bulb, creating an odour map in this first olfactory structure of the central nervous system. Projection neurons of the Drosophila antennal lobe send dendrites into glomeruli and axons to higher brain centres, thereby transferring this odour map further into the brain. Here we use the MARCM method to perform a systematic clonal analysis of projection neurons, allowing us to correlate lineage and birth time of projection neurons with their glomerular choice. We demonstrate that projection neurons are prespecified by lineage and birth order to form synapses with specific incoming ORN axons, and therefore to carry specific olfactory information. This prespecification could be used to hardwire the fly's olfactory system, enabling stereotyped behavioural responses to odorants. Developmental studies lead us to hypothesize that recognition molecules ensure reciprocally specific connections of ORNs and projection neurons. These studies also imply a previously unanticipated role for precise dendritic targeting by postsynaptic neurons in determining connection specificity.
journal_name
Naturejournal_title
Natureauthors
Jefferis GS,Marin EC,Stocker RF,Luo Ldoi
10.1038/35102574keywords:
subject
Has Abstractpub_date
2001-11-08 00:00:00pages
204-8issue
6860eissn
0028-0836issn
1476-4687journal_volume
414pub_type
杂志文章相关文献
NATURE文献大全abstract::The formation of precise connections between retina and lateral geniculate nucleus (LGN) involves the activity-dependent elimination of some synapses, with strengthening and retention of others. Here we show that the major histocompatibility complex (MHC) class I molecule H2-D(b) is necessary and sufficient for synaps...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13154
更新日期:2014-05-08 00:00:00
abstract::The coupling of ATP hydrolysis to electron transfer by the enzyme nitrogenase during biological nitrogen fixation is an important example of a nucleotide-dependent transduction mechanism. The crystal structure has been determined for the complex between the Fe-protein and MoFe-protein components of nitrogenase stabili...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/387370a0
更新日期:1997-05-22 00:00:00
abstract::It is not yet clear whether humans are able to learn while they are sleeping. Here we show that full-term human newborns can be taught to discriminate between similar vowel sounds when they are fast asleep. It is possible that such sleep training soon after birth could find application in clinical or educational situa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415599b
更新日期:2002-02-07 00:00:00
abstract::The effect of ions on the light-sensitive current of retinal rods was studied by sucking the inner segment into a tightly fitting capillary with the outer segment projecting into a flowing solution. This new method showed that the light-sensitive pathway, in which Na+ is the normal carrier of current, has an ionic sel...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/292502a0
更新日期:1981-08-06 00:00:00
abstract::Marine records of sediment oxygen isotope compositions show that the Earth's climate has gone through a succession of glacial and interglacial periods during the past million years. But the interpretation of the oxygen isotope records is complicated because both isotope storage in ice sheets and deep-water temperature...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature03975
更新日期:2005-09-01 00:00:00
abstract::We describe an integrated physical, genetic and cytogenetic map of human chromosome 16 comprising both a low-resolution megaYAC map and a high-resolution cosmid contig/miniYAC map, which provides nearly complete coverage of the euchromatic arms of the chromosome. The physical map is anchored to a high-resolution cytog...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/377335a0
更新日期:1995-09-28 00:00:00
abstract::The generation and selection of somatic antibody mutants are key elements of acquired immunity, essential for the affinity maturation of antibody responses dependent on T cells. The mutants are generated through a mechanism that introduces point mutations at high rate into rearranged variable (V) region genes in the c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/354389a0
更新日期:1991-12-05 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 社论
doi:10.1038/d41586-018-06975-0
更新日期:2018-10-01 00:00:00
abstract::If not properly processed and repaired, DNA double-strand breaks (DSBs) can give rise to deleterious chromosome rearrangements, which could ultimately lead to the tumour phenotype. DSB ends are resected in a 5' to 3' fashion in cells, to yield single-stranded DNA (ssDNA) for the recruitment of factors critical for DNA...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09318
更新日期:2010-09-02 00:00:00
abstract::The factors shaping cometary nuclei are still largely unknown, but could be the result of concurrent effects of evolutionary and primordial processes. The peculiar bilobed shape of comet 67P/Churyumov-Gerasimenko may be the result of the fusion of two objects that were once separate or the result of a localized excava...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature15511
更新日期:2015-10-15 00:00:00
abstract::Humoral immune responses to immunization and infection and susceptibilities to antibody-mediated autoimmunity are generally lower in males1-3. However, the mechanisms underlying such sexual dimorphism are not well understood. Here we show that there are intrinsic differences between the B cells that produce germinal c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1873-0
更新日期:2020-01-01 00:00:00
abstract::There are major impediments to finding improved DEET alternatives because the receptors causing olfactory repellency are unknown, and new chemicals require exorbitant costs to determine safety for human use. Here we identify DEET-sensitive neurons in a pit-like structure in the Drosophila melanogaster antenna called t...
journal_title:Nature
pub_type: 杂志文章,收录出版
doi:10.1038/nature12594
更新日期:2013-10-24 00:00:00
abstract::Calcium-dependent protease (calcium protease) is apparently involved in a variety of cellular processes. Here we have attempted to clarify the role and regulatory mechanism of calcium protease by analysing its structure. The complete primary structure of calcium protease (relative molecular mass (Mr) 80,000 (80K), 705...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/312566a0
更新日期:1984-12-06 00:00:00
abstract::A first step towards somatic hybridization in plants has been achieved. Protoplasts have been isolated and seen to fuse. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/2251016a0
更新日期:1970-03-14 00:00:00
abstract::Early sensory experience instructs the maturation of neural circuitry in the cortex. This has been studied extensively in the primary visual cortex, in which loss of vision to one eye permanently degrades cortical responsiveness to that eye, a phenomenon known as ocular dominance plasticity (ODP). Cortical inhibition ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12485
更新日期:2013-09-26 00:00:00
abstract::Lyman-alpha emitters are thought to be young, low-mass galaxies with ages of approximately 10(8) yr (refs 1, 2). An overdensity of them in one region of the sky (the SSA 22 field) traces out a filamentary structure in the early Universe at a redshift of z approximately 3.1 (equivalent to 15 per cent of the age of the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07947
更新日期:2009-05-07 00:00:00
abstract::When present in single-stranded DNA, palindromic or quasi-palindromic sequences have the potential to form complex secondary structures, including hairpins, which may facilitate interstrand misalignment of direct repeats and be responsible for diverse types of replication-based mutations, including deletions, addition...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352544a0
更新日期:1991-08-08 00:00:00
abstract::Defects in the architecture or integrity of the nuclear envelope are associated with a variety of human diseases1. Micronuclei, one common nuclear aberration, are an origin for chromothripsis2, a catastrophic mutational process that is commonly observed in cancer3-5. Chromothripsis occurs after micronuclei spontaneous...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0534-z
更新日期:2018-09-01 00:00:00
abstract::The presence of papillomaviruses in epithelial-derived cancers from several animal species has led to the speculation that these viruses may also have a pathogenic role in the development of certain human carcinomas, particularly those associated with the anogenital tract. Recently, human papillomavirus (HPV) DNA has ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/300771a0
更新日期:1982-12-23 00:00:00
abstract::Heterotrimeric G-proteins bind to cell-surface receptors and are integral in transmission of signals from outside the cell. Upon activation of the Galpha subunit by binding of GTP, the Galpha and Gbetagamma subunits dissociate and interact with effector proteins for signal transduction. Regulatory proteins with the 19...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/416878a
更新日期:2002-04-25 00:00:00
abstract::Type 2 diabetes (T2D) is a result of complex gene-environment interactions, and several risk factors have been identified, including age, family history, diet, sedentary lifestyle and obesity. Statistical models that combine known risk factors for T2D can partly identify individuals at high risk of developing the dise...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12198
更新日期:2013-06-06 00:00:00
abstract::The fundamental properties of neutron stars provide a direct test of the equation of state of cold nuclear matter, a relationship between pressure and density that is determined by the physics of the strong interactions between the particles that constitute the star. The most straightforward method of determining thes...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01159
更新日期:2002-11-07 00:00:00
abstract::A kinase distinct from the MEK activator Raf, termed MEK kinase-1 (MEKK), was originally identified by virtue of its homology to kinases involved in yeast mating signal cascades. Like Raf, MEKK is capable of activating MEK in vitro. High-level expression of MEKK in COS-7 cells or using vaccinia virus vectors also acti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/372798a0
更新日期:1994-12-22 00:00:00
abstract::Although the influence of electrical activity on neural development has been studied extensively, experiments have only recently focused on the role of activity in the development of the mammalian central nervous system (CNS). Using tetrodotoxin (TTX) to abolish sodium-mediated action potentials, studies on the visual...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/323156a0
更新日期:1986-09-11 00:00:00
abstract::Novel capsomeric complexes, pentamers and hexamers were detected as chemical entities in phage Q beta. Both were composed of identical protein subunits and stabilized by intermolecular disulphide bonds. Their numbers per particle were about 12 for pentamers and about 20 for hexamers--consistent with theoretical expect...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/298819a0
更新日期:1982-08-26 00:00:00
abstract::Molecular processes that govern pathogenic features of erythrocyte invasion and cytoadherence in malaria are reliant on Plasmodium-specific Duffy-binding-like domains (DBLs). These cysteine-rich modules recognize diverse host cell-surface receptors during pathogenesis. DBLs of parasite erythrocyte-binding proteins med...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04443
更新日期:2006-02-09 00:00:00
abstract::Dopamine (DA) has largely been ignored in considering possible mechanisms underlying the therapeutic effects of tricyclic anti-depressants (TCA). Most previous work done has focused on the ability of some TCAs to block the in vitro re-uptake of DA--an effect which unfortunately requires very high doses. Recently, howe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/287451a0
更新日期:1980-10-02 00:00:00
abstract::The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitt's lymphoma uncouple proliferation from apoptosis and, as a result, are more effec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03845
更新日期:2005-08-11 00:00:00
abstract::Photoinduced electron transfer (PET) is a phenomenon whereby the absorption of light by a chemical species provides an energetic driving force for an electron-transfer reaction1-4. This mechanism is relevant in many areas of chemistry, including the study of natural and artificial photosynthesis, photovoltaics and pho...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2131-1
更新日期:2020-04-01 00:00:00
abstract::The separation of ON and OFF channels and the development of an antagonistic surround occur at the first synapse in the vertebrate retina. This functional differentiation is mediated by the action of the photoreceptor neurotransmitter on the ON bipolar, OFF bipolar and horizontal cells, respectively. Glutamate mimics ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/314096a0
更新日期:1985-03-07 00:00:00