The curvature elastic-energy function of the lipid-water cubic mesophase.

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Hsiang S,Allen D,Annan-Phan S,Bell K,Bolliger I,Chong T,Druckenmiller H,Huang LY,Hultgren A,Krasovich E,Lau P,Lee J,Rolf E,Tseng J,Wu T

更新日期：2020-09-01 00:00:00

abstract：:In myelinated nerves, segregation of voltage-dependent sodium channels to nodes of Ranvier is crucial for saltatory conduction along axons. As sodium channels associate and colocalize with ankyrin at nodes of Ranvier, one possibility is that sodium channels are recruited and immobilized at axonal sites which are speci...

journal_title：Nature

authors： Joe EH,Angelides K

更新日期：1992-03-26 00:00:00

abstract：:Escherichia coli RNA polymerase (RNAP) synthesizes RNA with remarkable fidelity in vivo. Its low error rate may be achieved by means of a 'proofreading' mechanism comprised of two sequential events. The first event (backtracking) involves a transcriptionally upstream motion of RNAP through several base pairs, which ca...

journal_title：Nature

authors： Shaevitz JW,Abbondanzieri EA,Landick R,Block SM

更新日期：2003-12-11 00:00:00

abstract：:High pressure is known to influence electronic structure and crystal packing, and can in some cases even induce compound formation between elements that do not bond under ambient conditions. Here we present a computational study showing that high pressure fundamentally alters the reactivity of the light elements lithi...

journal_title：Nature

authors： Feng J,Hennig RG,Ashcroft NW,Hoffmann R

更新日期：2008-01-24 00:00:00

abstract：:Abundant data link hypercholesterolaemia to atherogenesis. However, only recently have we appreciated that inflammatory mechanisms couple dyslipidaemia to atheroma formation. Leukocyte recruitment and expression of pro-inflammatory cytokines characterize early atherogenesis, and malfunction of inflammatory mediators m...

journal_title：Nature

authors： Libby P

更新日期：2002-12-19 00:00:00

abstract：:The electronic properties of heterostructures of atomically thin van der Waals crystals can be modified substantially by moiré superlattice potentials from an interlayer twist between crystals1,2. Moiré tuning of the band structure has led to the recent discovery of superconductivity3,4 and correlated insulating phase...

journal_title：Nature

authors： Kerelsky A,McGilly LJ,Kennes DM,Xian L,Yankowitz M,Chen S,Watanabe K,Taniguchi T,Hone J,Dean C,Rubio A,Pasupathy AN

更新日期：2019-08-01 00:00:00

abstract：:In many cell types, receptor-mediated Ca2+ release from internal stores is followed by Ca2+ influx across the plasma membrane. The sustained entry of Ca2+ is thought to result partly from the depletion of intracellular Ca2+ pools. Most investigations have characterized Ca2+ influx indirectly by measuring Ca(2+)-activa...

journal_title：Nature

authors： Hoth M,Penner R

更新日期：1992-01-23 00:00:00

abstract：:Autosomal recessive juvenile parkinsonism (AR-JP) is an early-onset form of Parkinson's disease characterized by motor disturbances and dopaminergic neurodegeneration. To address its underlying molecular pathogenesis, we generated and characterized loss-of-function mutants of Drosophila PTEN-induced putative kinase 1 ...

journal_title：Nature

authors： Park J,Lee SB,Lee S,Kim Y,Song S,Kim S,Bae E,Kim J,Shong M,Kim JM,Chung J

更新日期：2006-06-29 00:00:00

abstract：:The halo of the Milky Way provides a laboratory to study the properties of the shocked hot gas that is predicted by models of galaxy formation. There is observational evidence of energy injection into the halo from past activity in the nucleus of the Milky Way1-4; however, the origin of this energy (star formation or ...

journal_title：Nature

authors： Predehl P,Sunyaev RA,Becker W,Brunner H,Burenin R,Bykov A,Cherepashchuk A,Chugai N,Churazov E,Doroshenko V,Eismont N,Freyberg M,Gilfanov M,Haberl F,Khabibullin I,Krivonos R,Maitra C,Medvedev P,Merloni A,Nandra K,N

更新日期：2020-12-01 00:00:00

abstract：:T-lymphocyte co-recognition of antigen and major histocompatibility complex (MHC)-encoded molecules (such as murine Ia molecules) is thought to be mediated by a single cell-surface receptor, although the molecular mechanism by which this occurs is controversial (reviewed in ref. 1). One possibility is that the antigen...

journal_title：Nature

authors： Ashwell JD,Schwartz RH

更新日期：1986-03-13 00:00:00

abstract：:The maternal gene bicoid (bcd) determines pattern in the anterior half of the Drosophila embryo. It is reported here that the injection of bcd mutant embryos with messenger RNAs that encode proteins consisting of heterologous acidic transcriptional activating sequences fused to the DNA-binding portion of the bcd gene ...

journal_title：Nature

authors： Driever W,Ma J,Nüsslein-Volhard C,Ptashne M

更新日期：1989-11-09 00:00:00

abstract：:In developing mammalian muscle, axon branches of several motor neurons co-innervate the same muscle fibre. Competition among them results in the strengthening of one and the withdrawal of the rest. It is not known why one particular axon branch survives or why some competitions resolve sooner than others. Here we show...

journal_title：Nature

authors： Kasthuri N,Lichtman JW

更新日期：2003-07-24 00:00:00

abstract：:The direct involvement of the pituitary-adrenal axis in birth has been well established, at least in sheep, and its removal prolongs pregnancy. As part of the process the fetal sheep adrenal grows rapidly during the 10-15 d prepartum and is associated with a large rise in the plasma corticosteroid concentration. This ...

journal_title：Nature

authors： Roebuck MM,Jones CT,Holland D,Silman R

更新日期：1980-04-17 00:00:00

abstract：:Alzheimer's disease is a progressive loss of memory and cognition, for which there is no cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at reducing amyloid-have failed to reverse cognitive symptoms. These clinical findings suggest tha...

journal_title：Nature

authors： Canter RG,Penney J,Tsai LH

更新日期：2016-11-10 00:00:00

abstract：:Reported widespread declines of wild and managed insect pollinators have serious consequences for global ecosystem services and agricultural production. Bees contribute approximately 80% of insect pollination, so it is important to understand and mitigate the causes of current declines in bee populations . Recent stud...

journal_title：Nature

authors： Gill RJ,Ramos-Rodriguez O,Raine NE

更新日期：2012-11-01 00:00:00

abstract：:Long interspersed nuclear elements-1 (LINE-1 or L1s) are abundant retrotransposons that comprise approximately 20% of mammalian genomes. Active L1 retrotransposons can impact the genome in a variety of ways, creating insertions, deletions, new splice sites or gene expression fine-tuning. We have shown previously that ...

journal_title：Nature

authors： Muotri AR,Marchetto MC,Coufal NG,Oefner R,Yeo G,Nakashima K,Gage FH

更新日期：2010-11-18 00:00:00

abstract：:The dopamine-containing projection from the ventral tegmental area of the midbrain to the nucleus accumbens is critically involved in mediating the reinforcing properties of cocaine. Although neurons in this area respond to rewards on a subsecond timescale, neurochemical studies have only addressed the role of dopamin...

journal_title：Nature

authors： Phillips PE,Stuber GD,Heien ML,Wightman RM,Carelli RM

更新日期：2003-04-10 00:00:00

abstract：:Human-mediated translocation of species to areas beyond their natural distribution (which results in 'alien' populations1) is a key signature of the Anthropocene2, and is a primary global driver of biodiversity loss and environmental change3. Stemming the tide of invasions requires understanding why some species fail ...

journal_title：Nature

authors： Redding DW,Pigot AL,Dyer EE,Şekercioğlu ÇH,Kark S,Blackburn TM

更新日期：2019-07-01 00:00:00

abstract：:The study of bacterial ion channels has provided fundamental insights into the structural basis of neuronal signalling; however, the native role of ion channels in bacteria has remained elusive. Here we show that ion channels conduct long-range electrical signals within bacterial biofilm communities through spatially ...

journal_title：Nature

authors： Prindle A,Liu J,Asally M,Ly S,Garcia-Ojalvo J,Süel GM

更新日期：2015-11-05 00:00:00

abstract：:The additional author support information was erroneously omitted from the Supplementary Information. This has been corrected online. ...

journal_title：Nature

authors： Hilf N,Kuttruff-Coqui S,Frenzel K,Bukur V,Stevanović S,Gouttefangeas C,Platten M,Tabatabai G,Dutoit V,van der Burg SH,Straten PT,Martinez-Ricarte F,Ponsati B,Okada H,Lassen U,Admon A,Ottensmeier CH,Ulges A,Kreiter S,

更新日期：2019-02-01 00:00:00

abstract：:Inhibitory neurotransmission mediated by GABA(A) receptors can be modulated by the endogenous neurosteroids, allopregnanolone and tetrahydro-deoxycorticosterone. Neurosteroids are synthesized de novo in the brain during stress, pregnancyand after ethanol consumption, and disrupted steroid regulation of GABAergic trans...

journal_title：Nature

authors： Hosie AM,Wilkins ME,da Silva HM,Smart TG

更新日期：2006-11-23 00:00:00

abstract：:The properties of synapses between retinal neurons make an essential contribution to early visual processing. Light produces a graded hyperpolarization in photoreceptors, up to 25 mV in amplitude, and it is conventionally assumed that all of this response range is available for coding visual information. We report her...

journal_title：Nature

authors： Attwell D,Borges S,Wu SM,Wilson M

更新日期：1987-08-06 00:00:00

abstract：:Type 2 diabetes (T2D) is a result of complex gene-environment interactions, and several risk factors have been identified, including age, family history, diet, sedentary lifestyle and obesity. Statistical models that combine known risk factors for T2D can partly identify individuals at high risk of developing the dise...

journal_title：Nature

authors： Karlsson FH,Tremaroli V,Nookaew I,Bergström G,Behre CJ,Fagerberg B,Nielsen J,Bäckhed F

更新日期：2013-06-06 00:00:00

abstract：:Oscillations in cyclin-dependent kinase (CDK) activity drive the somatic cell cycle. After entry into mitosis, CDKs activate the anaphase-promoting complex (APC), which then promotes cyclin degradation and mitotic exit. The re-accumulation of cyclin A causes the inactivation of APC and entry into S phase, but how cycl...

journal_title：Nature

authors： Rape M,Kirschner MW

更新日期：2004-12-02 00:00:00

abstract：:Diminishing fossil fuel reserves and growing concerns about global warming indicate that sustainable sources of energy are needed in the near future. For fuels to be useful in the transportation sector, they must have specific physical properties that allow for efficient distribution, storage and combustion; these pro...

journal_title：Nature

authors： Román-Leshkov Y,Barrett CJ,Liu ZY,Dumesic JA

更新日期：2007-06-21 00:00:00

abstract：:'Long' gamma-ray bursts (GRBs) are commonly accepted to originate in the explosion of particularly massive stars, which give rise to highly relativistic jets. Inhomogeneities in the expanding flow result in internal shock waves that are believed to produce the gamma-rays we see. As the jet travels further outward into...

journal_title：Nature

authors： Tagliaferri G,Goad M,Chincarini G,Moretti A,Campana S,Burrows DN,Perri M,Barthelmy SD,Gehrels N,Krimm H,Sakamoto T,Kumar P,Mészáros PI,Kobayashi S,Zhang B,Angelini L,Banat P,Beardmore AP,Capalbi M,Covino S,Cusuman

更新日期：2005-08-18 00:00:00

abstract：:Over the past decade, ice loss from the Greenland Ice Sheet increased as a result of both increased surface melting and ice discharge to the ocean. The latter is controlled by the acceleration of ice flow and subsequent thinning of fast-flowing marine-terminating outlet glaciers. Quantifying the future dynamic contrib...

journal_title：Nature

authors： Nick FM,Vieli A,Andersen ML,Joughin I,Payne A,Edwards TL,Pattyn F,van de Wal RS

更新日期：2013-05-09 00:00:00

abstract：:Anomalies in temperature and precipitation in northern Russia over the past few years have been viewed as manifestations of anthropogenic climate change, prompting suggestions that this may also account for exceptional forest fires in the region. Here we examine the number of forest-fire events across the boreal Russi...

journal_title：Nature

authors： Mollicone D,Eva HD,Achard F

更新日期：2006-03-23 00:00:00

abstract：:Temperature is a key factor in controlling the distribution of marine organisms and is particularly important at hydrothermal vents, where steep thermal gradients are present over a scale of centimetres. The thermophilic worm Alvinella pompejana, which is found at the vents of the East Pacific Rise (2,500-m depth), ha...

journal_title：Nature

authors： Pradillon F,Shillito B,Young CM,Gaill F

更新日期：2001-10-18 00:00:00

abstract：:The complexity of ecosystems can cause subtle and chaotic responses to changes in external forcing. Although ecosystems may not normally behave chaotically, sensitivity to external influences associated with nonlinearity can lead to amplification of climatic signals. Strong correlations between an El Niño index and ra...

journal_title：Nature

authors： Taylor AH,Allen JI,Clark PA

更新日期：2002-04-11 00:00:00