Circulating human pituitary pro-gamma-melanotropin enhances the adrenal response to ACTH.

abstract：:Genome instability is central to ageing, cancer and other diseases. It is not only proteins involved in DNA replication or the DNA damage response (DDR) that are important for maintaining genome integrity: from yeast to higher eukaryotes, mutations in genes involved in pre-mRNA splicing and in the biogenesis and expor...

journal_title：Nature

authors： Bhatia V,Barroso SI,García-Rubio ML,Tumini E,Herrera-Moyano E,Aguilera A

更新日期：2014-07-17 00:00:00

abstract：:Neurotransmitters modulate the activity of ion channels through a variety of second messengers, including cyclic AMP, cyclic GMP and the products of phosphatidylinositol breakdown. Little is known about how different transmitters acting through different second-messenger systems interact within a cell to regulate sing...

journal_title：Nature

authors： Belardetti F,Kandel ER,Siegelbaum SA

更新日期：1987-01-08 00:00:00

abstract：:Coordinated cell migration is essential in many fundamental biological processes including embryonic development, organogenesis, wound healing and the immune response. During organogenesis, groups of cells are directed to specific locations within the embryo. Here we show that the zebrafish miles apart (mil) mutation ...

journal_title：Nature

authors： Kupperman E,An S,Osborne N,Waldron S,Stainier DY

更新日期：2000-07-13 00:00:00

abstract：:The evolution of self-fertilization in hermaphrodites is opposed by costs that decrease the value of self progeny relative to that of outcross progeny. However, self-fertilization is common in plants; 20% are highly selfing and 33% are intermediate between selfing and outcrossing. Darwin proposed an adaptive benefit o...

journal_title：Nature

authors： Kalisz S,Vogler DW,Hanley KM

更新日期：2004-08-19 00:00:00

abstract：:The Suzuki-Miyaura cross-coupling of organoboron nucleophiles with aryl halide electrophiles is one of the most widely used carbon-carbon bond-forming reactions in organic and medicinal chemistry1,2. A key challenge associated with these transformations is that they generally require the addition of an exogenous base,...

journal_title：Nature

authors： Malapit CA,Bour JR,Brigham CE,Sanford MS

更新日期：2018-11-01 00:00:00

abstract：:The 5'-->3' exoribonucleases (XRNs) comprise a large family of conserved enzymes in eukaryotes with crucial functions in RNA metabolism and RNA interference. XRN2, or Rat1 in yeast, functions primarily in the nucleus and also has an important role in transcription termination by RNA polymerase II (refs 7-14). Rat1 exo...

journal_title：Nature

authors： Xiang S,Cooper-Morgan A,Jiao X,Kiledjian M,Manley JL,Tong L

更新日期：2009-04-09 00:00:00

abstract：:The midbrain region periaqueductal grey (PAG) is rich in opioid receptors and endogenous opioids and is a major target of analgesic action in the central nervous system. It has been proposed that the analgesic effect of opioids on the PAG works by suppressing the inhibitory influence of the neurotransmitter GABA (gamm...

journal_title：Nature

authors： Vaughan CW,Ingram SL,Connor MA,Christie MJ

更新日期：1997-12-11 00:00:00

abstract：:Susceptibility of rodent cells to infection by ecotropic murine leukaemia viruses (MuLV) is determined by binding of the virus envelope to a membrane receptor that has multiple membrane-spanning domains. Cells infected by ecotropic MuLV synthesize envelope protein, gp70, which binds to this receptor, thereby preventin...

journal_title：Nature

authors： Kim JW,Closs EI,Albritton LM,Cunningham JM

更新日期：1991-08-22 00:00:00

abstract：:5-hydroxytryptamine type 3 (5-HT3) receptors are members of the Cys-loop receptor superfamily. Neurotransmitter binding in these proteins triggers the opening (gating) of an ion channel by means of an as-yet-uncharacterized conformational change. Here we show that a specific proline (Pro 8*), located at the apex of th...

journal_title：Nature

authors： Lummis SC,Beene DL,Lee LW,Lester HA,Broadhurst RW,Dougherty DA

更新日期：2005-11-10 00:00:00

abstract：:The human AIDS viruses human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) represent cross-species (zoonotic) infections. Although the primate reservoir of HIV-2 has been clearly identified as the sooty mangabey (Cercocebus atys), the origin of HIV-1 remains uncertain. Viruses related to HIV-1 have been iso...

journal_title：Nature

authors： Gao F,Bailes E,Robertson DL,Chen Y,Rodenburg CM,Michael SF,Cummins LB,Arthur LO,Peeters M,Shaw GM,Sharp PM,Hahn BH

更新日期：1999-02-04 00:00:00

abstract：:Quasicrystals are unique structures with long-range order but no periodicity. Their properties have intrigued scientists ever since their discovery and initial theoretical analysis. The lack of periodicity excludes the possibility of describing quasicrystal structures with well-established analytical tools, including ...

journal_title：Nature

authors： Freedman B,Bartal G,Segev M,Lifshitz R,Christodoulides DN,Fleischer JW

更新日期：2006-04-27 00:00:00

abstract：:The respiratory organs of terrestrial insects consist of tracheal tubes with external spiracular valves that control gas exchange. Despite their relatively high metabolic rate, many insects have highly discontinuous patterns of gas exchange, including long periods when the spiracles are fully closed. Two explanations ...

journal_title：Nature

authors： Hetz SK,Bradley TJ

更新日期：2005-02-03 00:00:00

abstract：:Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by environmental influences, and functionally implicated in behavioural responses to stress and antidepressants1-4. However, how adult-born neurons regulate dentate gyrus information processing to protect from stress-induced anxiety-like be...

journal_title：Nature

authors： Anacker C,Luna VM,Stevens GS,Millette A,Shores R,Jimenez JC,Chen B,Hen R

更新日期：2018-07-01 00:00:00

abstract：:Recent observations have revealed streams of gas and stars in the halo of the Milky Way that are the debris from interactions between our Galaxy and some of its dwarf companion galaxies; the Sagittarius dwarf galaxy and the Magellanic clouds. Analysis of the material has shown that much of the halo is made up of canni...

journal_title：Nature

authors： Ibata R,Irwin M,Lewis G,Ferguson AM,Tanvir N

更新日期：2001-07-05 00:00:00

abstract：:During development, cells interpret complex and often conflicting signals to make optimal decisions. Plant stomata, the cellular interface between a plant and the atmosphere, develop according to positional cues, which include a family of secreted peptides called epidermal patterning factors (EPFs). How these signalli...

journal_title：Nature

authors： Lee JS,Hnilova M,Maes M,Lin YC,Putarjunan A,Han SK,Avila J,Torii KU

更新日期：2015-06-25 00:00:00

abstract：:Mutations in the Schizosaccharomyces pombe cdc8 gene impair cytokinesis. Here we clone cdc8+ and find that it encodes a novel tropomyosin. Gene disruption results in lethal arrest of the cell cycle, but spore germination, cell growth, DNA replication and mitosis are all unaffected. Haploid cdc8 gene disruptants are re...

journal_title：Nature

authors： Balasubramanian MK,Helfman DM,Hemmingsen SM

更新日期：1992-11-05 00:00:00

abstract：:It has been known for some 50 years that birds use photoreceptors in or near the hypothalamus to mediate the photoperiodic responses that control seasonal breeding. So far, however, attempts to identify the photopigment by determining an action spectrum have failed. The problems stem from the selective filtering of li...

journal_title：Nature

authors： Foster RG,Follett BK,Lythgoe JN

更新日期：1985-01-03 00:00:00

abstract：:Granular superconductivity occurs when microscopic superconducting grains are separated by non-superconducting regions; Josephson tunnelling between the grains establishes the macroscopic superconducting state. Although crystals of the copper oxide high-transition-temperature (high-Tc) superconductors are not granular...

journal_title：Nature

authors： Lang KM,Madhavan V,Hoffman JE,Hudson EW,Eisaki H,Uchida S,Davis JC

更新日期：2002-01-24 00:00:00

abstract：:Very large collisions in the asteroid belt could lead temporarily to a substantial increase in the rate of impacts of meteorites on Earth. Orbital simulations predict that fragments from such events may arrive considerably faster than the typical transit times of meteorites falling today, because in some large impacts...

journal_title：Nature

authors： Heck PR,Schmitz B,Baur H,Halliday AN,Wieler R

更新日期：2004-07-15 00:00:00

abstract：:Red colobus are one of a small number of primate species in which females have been reported to transfer between breeding groups more commonly than males. Several authors have hypothesised that in such species transference may serve to reduce the risk to females of producing offspring of lower fitness through inbreedi...

journal_title：Nature

authors： Marsh CW

更新日期：1979-10-18 00:00:00

abstract：:Fireflies communicate with each other by emitting yellow-green to yellow-orange brilliant light. The bioluminescence reaction, which uses luciferin, Mg-ATP and molecular oxygen to yield an electronically excited oxyluciferin species, is carried out by the enzyme luciferase. Visible light is emitted during relaxation o...

journal_title：Nature

authors： Nakatsu T,Ichiyama S,Hiratake J,Saldanha A,Kobashi N,Sakata K,Kato H

更新日期：2006-03-16 00:00:00

abstract：:Framework cavities are the largest but least explored coral reef habitat. Previous dive studies of caverns, spaces below plate corals, rubble and artificial cavities suggest that cavity-dwelling (coelobite) filter-feeders are important in the trophodynamics of reefs. Quantitative community data are lacking, however, a...

journal_title：Nature

authors： Richter C,Wunsch M,Rasheed M,Kötter I,Badran MI

更新日期：2001-10-18 00:00:00

abstract：:An increasing body of evidence points to mitochondrial dysfunction as a contributor to the molecular pathogenesis of neurodegenerative diseases such as Parkinson's disease. Recent studies of the Parkinson's disease associated genes PINK1 (ref. 2) and parkin (PARK2, ref. 3) indicate that they may act in a quality contr...

journal_title：Nature

authors： Hasson SA,Kane LA,Yamano K,Huang CH,Sliter DA,Buehler E,Wang C,Heman-Ackah SM,Hessa T,Guha R,Martin SE,Youle RJ

更新日期：2013-12-12 00:00:00

abstract：:Generalization is a cognitive ability that allows similar stimuli along a given dimension to be treated as equivalents. Insects exhibit high levels of visual generalization. Honeybees trained to recognize complex visual stimuli on the basis of a single feature generalize their choice to novel stimuli sharing that comm...

journal_title：Nature

authors： Stach S,Benard J,Giurfa M

更新日期：2004-06-17 00:00:00

abstract：:The unusual helium-rich (type Ib) supernova SN 2005E is distinguished from all supernovae hitherto observed by its faint and rapidly fading light curve, prominent calcium lines in late-phase spectra and lack of any mark of recent star formation near the supernova location. These properties are claimed to be explained ...

journal_title：Nature

authors： Kawabata KS,Maeda K,Nomoto K,Taubenberger S,Tanaka M,Deng J,Pian E,Hattori T,Itagaki K

更新日期：2010-05-20 00:00:00

abstract：:As the fraction of electricity generation from intermittent renewable sources--such as solar or wind--grows, the ability to store large amounts of electrical energy is of increasing importance. Solid-electrode batteries maintain discharge at peak power for far too short a time to fully regulate wind or solar power out...

journal_title：Nature

authors： Huskinson B,Marshak MP,Suh C,Er S,Gerhardt MR,Galvin CJ,Chen X,Aspuru-Guzik A,Gordon RG,Aziz MJ

更新日期：2014-01-09 00:00:00

abstract：:The type I interferon (IFN) response protects cells from viral infection by inducing hundreds of interferon-stimulated genes (ISGs), some of which encode direct antiviral effectors. Recent screening studies have begun to catalogue ISGs with antiviral activity against several RNA and DNA viruses. However, antiviral ISG...

journal_title：Nature

authors： Schoggins JW,MacDuff DA,Imanaka N,Gainey MD,Shrestha B,Eitson JL,Mar KB,Richardson RB,Ratushny AV,Litvak V,Dabelic R,Manicassamy B,Aitchison JD,Aderem A,Elliott RM,García-Sastre A,Racaniello V,Snijder EJ,Yokoyama WM,

更新日期：2014-01-30 00:00:00

abstract：:In the initiation of translation in eukaryotes, binding of the small ribosomal subunit to the messenger RNA results from recognition of the 5' cap structure (m7GpppX) of the mRNA by the cap-binding complex eIF4F. eIF4F is itself a three-subunit complex comprising the cap-binding protein eIF4E, eIF4A, an ATP-dependent ...

journal_title：Nature

authors： Craig AW,Haghighat A,Yu AT,Sonenberg N

更新日期：1998-04-02 00:00:00

abstract：:There has been much interest in the biochemical and biophysical processes that couple extracellular signals to alterations in gene expression. While many early events associated with the treatment of cells with growth factors have been described (for example, ion flux and protein phosphorylation), it has proved diffic...

journal_title：Nature

authors： Morgan JI,Curran T

更新日期：1986-08-07 00:00:00

abstract：:Seventeen hominoid fossils recovered from Pliocene strata at Aramis, Middle Awash, Ethiopia make up a series comprising dental, cranial and postcranial specimens dated to around 4.4 million years ago. When compared with Australopithecus afarensis and with modern and fossil apes the Aramis fossil hominids are recognize...

journal_title：Nature

authors： White TD,Suwa G,Asfaw B

更新日期：1994-09-22 00:00:00