Abstract：
:The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.
journal_name
Naturejournal_title
Natureauthors
Karsenty G,Ferron Mdoi
10.1038/nature10763subject
Has Abstractpub_date
2012-01-18 00:00:00pages
314-20issue
7381eissn
0028-0836issn
1476-4687pii
nature10763journal_volume
481pub_type
杂志文章,评审相关文献
NATURE文献大全abstract：:A three-dimensional image of tubulin protofilaments, reconstructed to 20 A resolution from electron micrographs of negatively stained zinc-induced sheets, has been used to generate an improved model for microtubule substructure. This model has been used to phase a reconstructed image from X-ray amplitudes, which is co...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/279607a0
更新日期：1979-06-14 00:00:00
abstract：:In vertebrates the developing hindbrain is organized in segmental units. These units provide the primary grid for differentiation and axonal outgrowth. In the more anterior regions of the brain, however, the subdivisions remain more controversial. Cellular and molecular studies of the embryonic brain in lower vertebra...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/353267a0
更新日期：1991-09-19 00:00:00
abstract：:The ethics of biological research, and its general impact, are hotly debated in the West. Japanese silence on the issues is counterproductive. Will the Human Genome Project provide the catalyst for change? ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/359770a0
更新日期：1992-10-29 00:00:00
abstract：:The detection of electron spins associated with single defects in solids is a critical operation for a range of quantum information and measurement applications under development. So far, it has been accomplished for only two defect centres in crystalline solids: phosphorus dopants in silicon, for which electrical rea...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12081
更新日期：2013-05-02 00:00:00
abstract：:Throughout the lifespan of a plant, which in some cases can last more than one thousand years, the stem cell niches in the root and shoot apical meristems provide cells for the formation of complete root and shoot systems, respectively. Both niches are superficially different and it has remained unclear whether common...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05703
更新日期：2007-04-12 00:00:00
abstract：:In infected cells, the RNA genomes of RNA tumour viruses are copied into DNA by a virus-encoded reverse transcriptase enzyme. This transfer of information from RNA into DNA was thought to be a unique feature of RNA tumour viruses, but recent results suggest it may be a more general strategy. Hepatitis B virus (HBV) ha...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/305827a0
更新日期：1983-10-27 00:00:00
abstract：:Fresnel lenses allow almost perfect imaging in widely different circumstances, but their focus is perfect only for a single wavelength. Wang et al. have shown how the effective bandpass may be widened for X-ray microscopy by using a compound diffractive/refractive lens near to an absorption edge. A compound lens has a...
journal_title：Nature
pub_type： 评论,杂志文章
doi：10.1038/426245b
更新日期：2003-11-20 00:00:00
abstract：:Population-level analyses often use average quantities to describe heterogeneous systems, particularly when variation does not arise from identifiable groups. A prominent example, central to our current understanding of epidemic spread, is the basic reproductive number, R(0), which is defined as the mean number of inf...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04153
更新日期：2005-11-17 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 评论,新闻
doi：10.1038/d41586-019-00761-2
更新日期：2019-03-01 00:00:00
abstract：:Evolutionary relationships among the eight major lineages of Mollusca have remained unresolved despite their diversity and importance. Previous investigations of molluscan phylogeny, based primarily on nuclear ribosomal gene sequences or morphological data, have been unsuccessful at elucidating these relationships. Re...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10382
更新日期：2011-09-04 00:00:00
abstract：:The assessment of changes in tropical cyclone activity within the context of anthropogenically influenced climate change has been limited by the short temporal resolution of the instrumental tropical cyclone record (less than 50 years). Furthermore, controversy exists regarding the robustness of the observational reco...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature12882
更新日期：2014-01-30 00:00:00
abstract：:The remarkable compositional diversity of volatile ices within comets can plausibly be attributed to several factors, including differences in the chemical, thermal and radiation environments in comet-forming regions, chemical evolution during their long storage in reservoirs far from the Sun, and thermal processing b...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05908
更新日期：2007-07-12 00:00:00
abstract：:In this Letter, in Fig. 3c and f the Saccharomyces cerevisiae and Escherichia coli networks were subject to both weight loss and node deletion, a combination of two types of perturbation, as opposed to weight loss only (as the labelling incorrectly indicated). The collapse in Fig. 3h was also obtained from this combin...
journal_title：Nature
pub_type： 已发布勘误
doi：10.1038/s41586-019-1091-9
更新日期：2019-04-01 00:00:00
abstract：:The amplitude and frequency of laser light can be routinely measured and controlled on a femtosecond (10(-15) s) timescale. However, in pulses comprising just a few wave cycles, the amplitude envelope and carrier frequency are not sufficient to characterize and control laser radiation, because evolution of the light f...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01414
更新日期：2003-02-06 00:00:00
abstract：:Knowledge of the composition of the Earth's core is important for understanding its melting point and therefore the temperature at the inner-core boundary and the temperature profile of the core and mantle. In addition, the partitioning of light elements between solid and liquid, as the outer core freezes at the inner...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35012056
更新日期：2000-05-11 00:00:00
abstract：:The innate immune system is critical for the early detection of invading pathogens and for initiating cellular host defence countermeasures, which include the production of type I interferon (IFN). However, little is known about how the innate immune system is galvanized to respond to DNA-based microbes. Here we show ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08476
更新日期：2009-10-08 00:00:00
abstract：:Magnetars are neutron stars with X-ray and soft γ-ray outbursts thought to be powered by intense internal magnetic fields. Like conventional neutron stars in the form of radio pulsars, magnetars exhibit 'glitches' during which angular momentum is believed to be transferred between the solid outer crust and the superfl...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12159
更新日期：2013-05-30 00:00:00
abstract：:In this Letter, the received date should have been 23 March 2017 instead of 13 April 2018. Authors R.M.K. and O.D.K. were incorrectly denoted as 'equally contributing' authors. The labels for 'control' and 'IFNγ' in Extended Data Fig. 4g were reversed. These have been corrected online. ...
journal_title：Nature
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41586-018-0370-1
更新日期：2018-10-01 00:00:00
abstract：:Naturally occurring peptides with biological actions have in most cases been detected by observing their biological activities in crude extracts and their isolation has been followed using bioassays. As a complement to the classical biological detection systems, we have proposed a chemical detection system based on fr...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/285417a0
更新日期：1980-06-05 00:00:00
abstract：:Developing neurons transiently express somatostatin and its receptors, but little is known about their function at these early stages. As we thought that endogenous somatostatin might control the migratory behaviour of immature neurons, we have examined the effects of somatostatin in cerebellar granule cells of early ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/415077a
更新日期：2002-01-03 00:00:00
abstract：:Many intracellular targets of protein-tyrosine kinases possess Src homology 2 (SH2) domains that directly recognize phosphotyrosine-containing sites on autophosphorylated growth factor receptors and cytoplasmic proteins, and thereby mediate the activation of biochemical signalling pathways. SH2 domains possess relativ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/369502a0
更新日期：1994-06-09 00:00:00
abstract：:Many collective human activities, including violence, have been shown to exhibit universal patterns. The size distributions of casualties both in whole wars from 1816 to 1980 and terrorist attacks have separately been shown to follow approximate power-law distributions. However, the possibility of universal patterns r...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08631
更新日期：2009-12-17 00:00:00
abstract：:Although freeze-fracture electron microscopy is normally analysed with the presumption that particles represent proteins embedded within the membrane, particles which appeared to represent inverted lipid micelles within membranes have been reported. I have now confirmed the occurrence of particles in protein-free lipo...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/287166a0
更新日期：1980-09-11 00:00:00
abstract：:The crystal structure of human H-Ras complexed with the Ras guanine-nucleotide-exchange-factor region of the Son of sevenless (Sos) protein has been determined at 2.8 A resolution. The normally tight interaction of nucleotides with Ras is disrupted by Sos in two ways. First, the insertion into Ras of an alpha-helix fr...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/28548
更新日期：1998-07-23 00:00:00
abstract：:In the Caenorhabditis elegans hermaphrodite germ line, sperm and then oocytes are made from a common pool of germ-cell precursors. The decision to differentiate as a sperm or an oocyte is regulated by the sex-determining gene, fem-3. Expression of fem-3 in the hermaphrodite germ line directs spermatogenesis and must b...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/349346a0
更新日期：1991-01-24 00:00:00
abstract：:A decision is a commitment to a proposition or plan of action based on evidence and the expected costs and benefits associated with the outcome. Progress in a variety of fields has led to a quantitative understanding of the mechanisms that evaluate evidence and reach a decision. Several formalisms propose that a repre...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08275
更新日期：2009-09-10 00:00:00
abstract：:Jupiter's atmosphere is rotating differentially, with zones and belts rotating at speeds that differ by up to 100 metres per second. Whether this is also true of the gas giant's interior has been unknown, limiting our ability to probe the structure and composition of the planet. The discovery by the Juno spacecraft th...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature25775
更新日期：2018-03-07 00:00:00
abstract：:In this Review, the middle initial of author Kim M. Cobb was omitted. The original Review has been corrected online. ...
journal_title：Nature
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41586-019-0994-9
更新日期：2019-03-01 00:00:00
abstract：:We report here the identification of human cell-surface glycoprotein with unusual and interesting properties. We initially detected this glycoprotein on the surface of cultured human haematopoietic cell lines by means of a monoclonal antibody. Although it is expressed on all cultured human haematopoietic cell lines te...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/286888a0
更新日期：1980-08-28 00:00:00
abstract：:Defects in the architecture or integrity of the nuclear envelope are associated with a variety of human diseases1. Micronuclei, one common nuclear aberration, are an origin for chromothripsis2, a catastrophic mutational process that is commonly observed in cancer3-5. Chromothripsis occurs after micronuclei spontaneous...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-018-0534-z
更新日期：2018-09-01 00:00:00
