The auroral footprint of Enceladus on Saturn.

abstract：:beta Pictoris (beta Pic) is a main-sequence star with an edge-on dust disk that might represent a state of the early Solar System. The dust does not seem to be a remnant from the original protoplanetary disk, but rather is thought to have been generated from large bodies like planetesimals and/or comets. The history a...

journal_title：Nature

authors： Okamoto YK,Kataza H,Honda M,Yamashita T,Onaka T,Watanabe J,Miyata T,Sako S,Fujiyoshi T,Sakon I

更新日期：2004-10-07 00:00:00

abstract：:Early sensory experience instructs the maturation of neural circuitry in the cortex. This has been studied extensively in the primary visual cortex, in which loss of vision to one eye permanently degrades cortical responsiveness to that eye, a phenomenon known as ocular dominance plasticity (ODP). Cortical inhibition ...

journal_title：Nature

authors： Kuhlman SJ,Olivas ND,Tring E,Ikrar T,Xu X,Trachtenberg JT

更新日期：2013-09-26 00:00:00

abstract：:Maternal immune activation (MIA) contributes to behavioural abnormalities associated with neurodevelopmental disorders in both primate and rodent offspring. In humans, epidemiological studies suggest that exposure of fetuses to maternal inflammation increases the likelihood of developing autism spectrum disorder. In p...

journal_title：Nature

authors： Kim S,Kim H,Yim YS,Ha S,Atarashi K,Tan TG,Longman RS,Honda K,Littman DR,Choi GB,Huh JR

更新日期：2017-09-28 00:00:00

abstract：:Resistance to infection and clearance of cell debris in mammals depend on the activation of the complement system, which is an important component of innate and adaptive immunity. Central to the complement system is the activated form of C3, called C3b, which attaches covalently to target surfaces to amplify complemen...

journal_title：Nature

authors： Janssen BJ,Christodoulidou A,McCarthy A,Lambris JD,Gros P

更新日期：2006-11-09 00:00:00

abstract：:A new system has been developed for measuring the forces produced by a small number (less than 5-150) of myosin molecules interacting with a single actin filament in vitro. The technique can resolve forces of less than a piconewton and has a time resolution in the submillisecond range. It can thus detect fluctuations ...

journal_title：Nature

authors： Ishijima A,Doi T,Sakurada K,Yanagida T

更新日期：1991-07-25 00:00:00

abstract：:Hunger is a hard-wired motivational state essential for survival. Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of the hypothalamus are crucial to the control of hunger. They are activated by caloric deficiency and, when naturally or artificially stimulated, they potently in...

journal_title：Nature

authors： Krashes MJ,Shah BP,Madara JC,Olson DP,Strochlic DE,Garfield AS,Vong L,Pei H,Watabe-Uchida M,Uchida N,Liberles SD,Lowell BB

更新日期：2014-03-13 00:00:00

abstract：:Acyclovir (9-[2-hydroxyethoxymethyl]guanine or ACV) is a nucleoside analogue with considerable potential for the treatment of herpes simplex virus (HSV) infections in man. Two virus-coded enzymes are important in the mechanism of action of this drug: thymidine kinase (TK) which initiates its activation by converting i...

journal_title：Nature

authors： Darby G,Field HJ,Salisbury SA

更新日期：1981-01-01 00:00:00

abstract：:Despite decades of research, the identity of the cells generating the first haematopoietic cells in mammalian embryos is unknown. Indeed, whether blood cells arise from mesodermal cells, mesenchymal progenitors, bipotent endothelial-haematopoietic precursors or haemogenic endothelial cells remains controversial. Proxi...

journal_title：Nature

authors： Eilken HM,Nishikawa S,Schroeder T

更新日期：2009-02-12 00:00:00

abstract：:Glycogen synthase kinase-3beta (GSK-3beta) has integral roles in a variety of biological processes, including development, diabetes, and the progression of Alzheimer's disease. As such, a thorough understanding of GSK-3beta function will have a broad impact on human biology and therapeutics. Because GSK-3beta interact...

journal_title：Nature

authors： Liu KJ,Arron JR,Stankunas K,Crabtree GR,Longaker MT

更新日期：2007-03-01 00:00:00

abstract：:The extent to which an organism is selected to invest in defences against pathogens and parasites depends on the advantages that ensue should infection occur, but also on the costs of maintaining defences in the absence of infection. The presence of heritable variation in resistance suggests that costs exist, but we k...

journal_title：Nature

authors： Kraaijeveld AR,Godfray HC

更新日期：1997-09-18 00:00:00

abstract：:alpha-Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associated with receptor...

journal_title：Nature

authors： Freeman JA

更新日期：1977-09-15 00:00:00

abstract：:The angle between the spin of a star and the orbital planes of its planets traces the history of the planetary system. Exoplanets orbiting close to cool stars are expected to be on circular, aligned orbits because of strong tidal interactions with the stellar convective envelope. Spin-orbit alignment can be measured w...

journal_title：Nature

authors： Bourrier V,Lovis C,Beust H,Ehrenreich D,Henry GW,Astudillo-Defru N,Allart R,Bonfils X,Ségransan D,Delfosse X,Cegla HM,Wyttenbach A,Heng K,Lavie B,Pepe F

更新日期：2018-01-25 00:00:00

abstract：:Recent advances in understanding the molecular basis of human X-linked muscular dystrophies have come from the identification of dystrophin, a cytoskeletal protein associated with the surface membrane. Although there is little or virtually no dystrophin in affected individuals, it is not known how this causes muscle d...

journal_title：Nature

authors： Franco A Jr,Lansman JB

更新日期：1990-04-12 00:00:00

abstract：:Observations from Earth-orbiting satellites have been a key component in monitoring climate change for the past two decades. This has become possible with the availability of air temperatures from the Microwave Sounding Unit (MSU) since 1979, sea surface temperatures from the Advanced Very High Resolution Radiometer (...

journal_title：Nature

authors： Wentz FJ,Schabel M

更新日期：2000-01-27 00:00:00

abstract：:During puberty, the mouse mammary gland develops into a highly branched epithelial network. Owing to the absence of exclusive stem cell markers, the location, multiplicity, dynamics and fate of mammary stem cells (MaSCs), which drive branching morphogenesis, are unknown. Here we show that morphogenesis is driven by pr...

journal_title：Nature

authors： Scheele CL,Hannezo E,Muraro MJ,Zomer A,Langedijk NS,van Oudenaarden A,Simons BD,van Rheenen J

更新日期：2017-02-16 00:00:00

abstract：:Most mitochondrial proteins are synthesized on cytoplasmic ribosomes and imported into mitochondria. The imported proteins are directed to one of four submitochondrial compartments--the outer mitochondrial membrane, the inner mitochondrial membrane, the intramembraneous space, or the matrix--where the protein then fun...

journal_title：Nature

authors： Bose HS,Lingappa VR,Miller WL

更新日期：2002-05-02 00:00:00

abstract：:Ribonucleotide reductase, an essential enzyme for the synthesis of deoxyribonucleotides, is formed by the association of two nonidentical subunits in almost all prokaryotic and eukaryotic cells. The same model probably holds for the herpes simplex virus (HSV)-encoded ribonucleotide reductase; two polypeptides of relat...

journal_title：Nature

authors： Cohen EA,Gaudreau P,Brazeau P,Langelier Y

更新日期：1986-05-22 00:00:00

abstract：:WAVE1--the Wiskott-Aldrich syndrome protein (WASP)--family verprolin homologous protein 1--is a key regulator of actin-dependent morphological processes in mammals, through its ability to activate the actin-related protein (Arp2/3) complex. Here we show that WAVE1 is phosphorylated at multiple sites by cyclin-dependen...

journal_title：Nature

authors： Kim Y,Sung JY,Ceglia I,Lee KW,Ahn JH,Halford JM,Kim AM,Kwak SP,Park JB,Ho Ryu S,Schenck A,Bardoni B,Scott JD,Nairn AC,Greengard P

更新日期：2006-08-17 00:00:00

abstract：:The perception of yellow has played a central role in distinguishing two main theories of colour vision. Hering proposed that yellow results from the activation of a distinct retinal-neural mechanism, whereas according to the Young-Helmholtz-Maxwell view, yellow results from the combined activation of red and green co...

journal_title：Nature

authors： Nijhawan R

更新日期：1997-03-06 00:00:00

abstract：:Herpesviruses are characterized by their ability to maintain life-long latent infections in their animal hosts. However, the mechanisms that allow establishment and maintenance of the latent state remain poorly understood. Herpes simplex virus 1 (HSV-1) establishes latency in neurons of sensory ganglia, where the only...

journal_title：Nature

authors： Umbach JL,Kramer MF,Jurak I,Karnowski HW,Coen DM,Cullen BR

更新日期：2008-08-07 00:00:00

abstract：:The geometry and dimensions of branched structures such as blood vessels or airways are important factors in determining the efficiency of physiological processes. It has been shown that fractal trees can be space filling and can ensure minimal dissipation. The bronchial tree of most mammalian lungs is a good example ...

journal_title：Nature

authors： Mauroy B,Filoche M,Weibel ER,Sapoval B

更新日期：2004-02-12 00:00:00

abstract：:Xenoturbellida and Acoelomorpha are marine worms with contentious ancestry. Both were originally associated with the flatworms (Platyhelminthes), but molecular data have revised their phylogenetic positions, generally linking Xenoturbellida to the deuterostomes and positioning the Acoelomorpha as the most basally bran...

journal_title：Nature

authors： Philippe H,Brinkmann H,Copley RR,Moroz LL,Nakano H,Poustka AJ,Wallberg A,Peterson KJ,Telford MJ

更新日期：2011-02-10 00:00:00

abstract：:The discovery of a repeating fast radio burst (FRB) source1,2, FRB 121102, eliminated models involving cataclysmic events for this source. No other repeating FRB has hitherto been detected despite many recent discoveries and follow-ups3-5, suggesting that repeaters may be rare in the FRB population. Here we report the...

journal_title：Nature

authors： CHIME\/FRB Collaboration.

更新日期：2019-02-01 00:00:00

abstract：:Although parasite-host co-speciation is a long-held hypothesis, convincing evidence for long-term co-speciation remains elusive, largely because of small numbers of hosts and parasites studied and uncertainty over rates of evolutionary change. Co-speciation is especially rare in RNA viruses, in which cross-species tra...

journal_title：Nature

authors： Switzer WM,Salemi M,Shanmugam V,Gao F,Cong ME,Kuiken C,Bhullar V,Beer BE,Vallet D,Gautier-Hion A,Tooze Z,Villinger F,Holmes EC,Heneine W

更新日期：2005-03-17 00:00:00

abstract：:Cyclin-dependent kinase 5 (Cdk5) and its neuron-specific regulator p35 are essential for neuronal migration and for the laminar configuration of the cerebral cortex. In addition, p35/Cdk5 kinase concentrates at the leading edges of axonal growth cones and regulates neurite outgrowth in cortical neurons in culture. The...

journal_title：Nature

authors： Nikolic M,Chou MM,Lu W,Mayer BJ,Tsai LH

更新日期：1998-09-10 00:00:00

abstract：:It has been suggested that arginine vasopressin (AVP) is involved in the retention of learned responses, in addition to its classical physiological functions of water retention and modulation of blood pressure. AVP administered subcutaneously (s.c.), intraventricularly or intracerebrally can prolong extinction of acti...

journal_title：Nature

authors： Koob GF,Dantzer R,Rodriguez F,Bloom FE,Le Moal M

更新日期：1985-06-27 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Surface melt on the Greenland ice sheet has shown increasing trends in areal extent and duration since the beginning of the satellite era. Records for melt were broken in 2005, 2007, 2010 and 2012. Much of the increased surface melt is occurring in the percolation zone, a region of the accumulation area that is perenn...

journal_title：Nature

authors： Harper J,Humphrey N,Pfeffer WT,Brown J,Fettweis X

更新日期：2012-11-08 00:00:00

abstract：: ...

journal_title：Nature

authors： Bietz A

更新日期：2018-11-01 00:00:00

abstract：:The mechanism by which insulin regulates cellular metabolism remains unknown although indirect evidence suggests that alterations in intracellular calcium are important. More specifically, it has been proposed that insulin triggers an increase in intracellular calcium which is responsible for the subsequent modificati...

journal_title：Nature

authors： Pershadsingh HA,McDonald JM

更新日期：1979-10-11 00:00:00