相关文献
NATURE文献大全abstract::When we see motion, our perception of how one image feature moves depends on the behaviour of other features nearby. In particular, the Gestaltists proposed the law of shared common fate, in which features tend to be perceived as moving together, that is, coherently. Recent psychophysical findings, such as the coopera...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/333071a0
更新日期:1988-05-05 00:00:00
abstract::Lord Rothschild presents his personal views about the terminology used to describe research and development. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/239373a0
更新日期:1972-10-13 00:00:00
abstract::Organocatalysis-catalysis mediated by small chiral organic molecules-is a powerful technology for enantioselective synthesis, and has extensive applications in traditional ionic, two-electron-pair reactivity domains. Recently, organocatalysis has been successfully combined with photochemical reactivity to unlock previ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature25175
更新日期:2018-01-31 00:00:00
abstract::The engrailed gene product of Drosophila specifies the fate of a subset of cells in each segment. Our studies of engrailed regulation suggest that fate determination is an elaborate, multistep process. At the time in embryogenesis when the engrailed-dependent cell fate is probably determined, four modes of control act...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352404a0
更新日期:1991-08-01 00:00:00
abstract::Phase and antigenic variation of pilin expression in Neisseria gonorrhoeae result from recombination events in which variant sequences from one of the silent loci (pilS) are transferred to the expression locus (pilE). Such rearrangements were originally thought to be gene conversions, but findings showing that phase v...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/338651a0
更新日期:1989-04-20 00:00:00
abstract::The human sex chromosomes share a pair of homologous genes which independently encode a cell-surface antigen defined by the monoclonal antibody 12E7 (refs 1, 2; see refs 3, 4 for review). The X-located homologue, MIC2X, escapes X-inactivation and the equivalent Y-located locus, MIC2Y, was one of the first genes shown ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/317739a0
更新日期:1985-10-24 00:00:00
abstract::Pathogenic bacteria such as Escherichia coli assemble surface structures termed pili, or fimbriae, to mediate binding to host-cell receptors1. Type 1 pili are assembled via the conserved chaperone-usher pathway2-5. The outer-membrane usher FimD recruits pilus subunits bound by the chaperone FimC via the periplasmic N-...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0587-z
更新日期:2018-10-01 00:00:00
abstract::The identification of novel metabolites and the characterization of their biological functions are major challenges in biology. X-ray crystallography can reveal unanticipated ligands that persist through purification and crystallization. These adventitious protein-ligand complexes provide insights into new activities,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12180
更新日期:2013-06-06 00:00:00
abstract::Antigen recognition by T lymphocytes is mediated by cell-surface glycoproteins known as T-cell antigen receptors (TCRs). These are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. In contrast to alphabeta TCRs, which recognize antigen only as peptide fragme...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35172
更新日期:1998-01-29 00:00:00
abstract::Whether or not the Large Hadron Collider reveals the long-awaited Higgs particle, it is likely to lead to discoveries that add to, or challenge, the standard model of particle physics. Data produced will be pored over for any evidence of supersymmetric partners for the existing denizens of the particle 'zoo' and for t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06079
更新日期:2007-07-19 00:00:00
abstract::Type III collagen is often found in the same tissues as type I collagen, yet the function and nature of the fibrils formed by the two collagens differ markedly. To understand the evolutionary history of the collagen gene family in more detail, we isolated the gene for type III collagen and compared its structure with ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310333a0
更新日期:1984-07-26 00:00:00
abstract::The hypothesis that certain RNA molecules may be able to catalyse RNA replication is central to current theories of the early evolution of life. In support of this idea, we describe here an RNA that synthesizes RNA using the same reaction as that employed by protein enzymes that catalyse RNA polymerization. In the pre...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/382373a0
更新日期:1996-07-25 00:00:00
abstract::Interleukin-2 (IL-2) has a key role in the antigen-specific clonal growth of T lymphocytes, by virtue of its interaction with a specific cell-surface receptor (IL-2R). The growth signal seems to be delivered by IL-2 bound to the high-affinity, but not the low-affinity, receptor. Genes encoding IL-2 and its receptor (t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/318467a0
更新日期:1985-12-05 00:00:00
abstract::Thermoelectric energy harvesting-the transformation of waste heat into useful electricity-is of great interest for energy sustainability. The main obstacle is the low thermoelectric efficiency of materials for converting heat to electricity, quantified by the thermoelectric figure of merit, ZT. The best available n-ty...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08088
更新日期:2009-06-18 00:00:00
abstract::To mediate its survival and virulence, the malaria parasite Plasmodium falciparum exports hundreds of proteins into the host erythrocyte. To enter the host cell, exported proteins must cross the parasitophorous vacuolar membrane (PVM) within which the parasite resides, but the mechanism remains unclear. A putative Pla...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13574
更新日期:2014-07-31 00:00:00
abstract::Do biological motors move with regular steps? To address this question, we constructed instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular scale. We deposited silica beads carrying single molecules of the motor protein kinesin on microtubules using optical tweezers and analysed...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/365721a0
更新日期:1993-10-21 00:00:00
abstract::In Drosophila, as in mammals, epidermal differentiation is controlled by signalling cascades that include Wnt proteins and the ovo/shavenbaby (svb) family of zinc-finger transcription factors. Ovo/svb is a complex gene with two genetic functions corresponding to separate control regions: ovo is required for female ger...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/22330
更新日期:1999-07-15 00:00:00
abstract::Calcium-triggered fusion of synaptic vesicles and neurotransmitter release are fundamental signalling steps in the central nervous system. It is generally assumed that fast transmitter release is triggered by elevations in intracellular calcium concentration ([Ca2+]i) to at least 100 microM near the sites of vesicle f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35022702
更新日期:2000-08-24 00:00:00
abstract::Embryonic stem (ES) cells are pluripotent and characterized by open chromatin and high transcription levels, achieved through auto-regulatory and feed-forward transcription factor loops. ES-cell identity is maintained by a core of factors including Oct4 (also known as Pou5f1), Sox2, Klf4, c-Myc (OSKM) and Nanog, and f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11970
更新日期:2013-03-28 00:00:00
abstract::In contrast to activated CD4+ T cells, resting human CD4+ T cells circulating in blood are highly resistant to infection with human immunodeficiency virus (HIV). Whether the inability of HIV to infect these resting CD4+ T cells is due to the lack of a key factor, or alternatively reflects the presence of an efficient ...
journal_title:Nature
pub_type: 杂志文章,收录出版
doi:10.1038/nature03493
更新日期:2005-05-05 00:00:00
abstract::It has been proposed that the hypothalamus helps to control ageing, but the mechanisms responsible remain unclear. Here we develop several mouse models in which hypothalamic stem/progenitor cells that co-express Sox2 and Bmi1 are ablated, as we observed that ageing in mice started with a substantial loss of these hypo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23282
更新日期:2017-08-03 00:00:00
abstract::The retina in most mammals contains two types of macroglial cells--Müller cells, which span the entire thickness of the retina, and astrocytes, which are mainly confined to the nerve fibre layer. Whereas Müller cells are diffusely distributed in all vertebrate retinae, the presence and distribution of retinal astrocyt...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/332834a0
更新日期:1988-04-28 00:00:00
abstract::The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation and DNA damage response. Perturbations of these processes are hallmarks of cancer and chronic circadian rhythm disruption predisposes individuals to tumour development. This raises the hypothesis that pharmacological modulation o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25170
更新日期:2018-01-18 00:00:00
abstract::A membrane receptor protein for asialoglycoproteins induces voltage-dependent increases in ion conductance across a lipid bilayer, probably reflecting penetration of the protein into the bilayer towards an electrically positive pole. In the presence of specific ligand for the receptor, this penetration leads to a 'tra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/288333a0
更新日期:1980-11-27 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a degenerative disorder of motor neurons in the cortex, brainstem and spinal cord. Its cause is unknown and it is uniformly fatal, typically within five years. About 10% of cases are inherited as an autosomal dominant trait, with high penetrance after the sixth decade. In most in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/362059a0
更新日期:1993-03-04 00:00:00
abstract::The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory1,2. Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-se...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1917-5
更新日期:2020-01-01 00:00:00
abstract::The first event in the initiation of an immune response is the capture and presentation of antigen to T cells. Such presentation involves two distinct steps: (1) display of the antigen, which requires uptake, processing and re-expression of the antigen in association with MHC molecules on the presenting cell surface; ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/334253a0
更新日期:1988-07-21 00:00:00
abstract::The 26S proteasome is the chief site of regulatory protein turnover in eukaryotic cells. It comprises one 20S catalytic complex (composed of four stacked rings of seven members) and two axially positioned 19S regulatory complexes (each containing about 18 subunits) that control substrate access to the catalytic chambe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/416763a
更新日期:2002-04-18 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-018-07209-z
更新日期:2018-11-01 00:00:00
abstract::Zooxanthellae, endosymbiotic algae of reef-building corals, substantially contribute to the high gross primary production of coral reefs, but corals exude up to half of the carbon assimilated by their zooxanthellae as mucus. Here we show that released coral mucus efficiently traps organic matter from the water column ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02344
更新日期:2004-03-04 00:00:00