A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.

abstract：:Combined PD-1 and CTLA-4-targeted immunotherapy with nivolumab and ipilimumab is effective against melanoma, renal cell carcinoma and non-small-cell lung cancer1-3. However, this comes at the cost of frequent, serious immune-related adverse events, necessitating a reduction in the recommended dose of ipilimumab that i...

journal_title：Nature

authors： Perez-Ruiz E,Minute L,Otano I,Alvarez M,Ochoa MC,Belsue V,de Andrea C,Rodriguez-Ruiz ME,Perez-Gracia JL,Marquez-Rodas I,Llacer C,Alvarez M,de Luque V,Molina C,Teijeira A,Berraondo P,Melero I

更新日期：2019-05-01 00:00:00

abstract：:The sensitivity of soil carbon to warming is a major uncertainty in projections of carbon dioxide concentration and climate. Experimental studies overwhelmingly indicate increased soil organic carbon (SOC) decomposition at higher temperatures, resulting in increased carbon dioxide emissions from soils. However, recent...

journal_title：Nature

authors： Knorr W,Prentice IC,House JI,Holland EA

更新日期：2005-01-20 00:00:00

abstract：:Protein modification by the conjugation of ubiquitin moieties--ubiquitination--plays a major part in many biological processes, including cell cycle and apoptosis. The enzymes that mediate ubiquitin-conjugation have been well-studied, but much less is known about the ubiquitin-specific proteases that mediate de-ubiqui...

journal_title：Nature

authors： Brummelkamp TR,Nijman SM,Dirac AM,Bernards R

更新日期：2003-08-14 00:00:00

abstract：:Bone has recently emerged as a pleiotropic endocrine organ that secretes at least two hormones, FGF23 and osteocalcin, which regulate kidney function and glucose homeostasis, respectively. These findings have raised the question of whether other bone-derived hormones exist and what their potential functions are. Here ...

journal_title：Nature

authors： Mosialou I,Shikhel S,Liu JM,Maurizi A,Luo N,He Z,Huang Y,Zong H,Friedman RA,Barasch J,Lanzano P,Deng L,Leibel RL,Rubin M,Nickolas T,Chung W,Zeltser LM,Williams KW,Pessin JE,Kousteni S

更新日期：2017-03-16 00:00:00

abstract：:Mycorrhizae, the symbiotic associations of plant roots and fungal hyphae, are classic examples of mutualisms. In these ecologically important associations, the fungi derive photosynthetic sugars from their plant hosts, which in turn benefit from fungus-mediated uptake of mineral nutrients. Early views on the evolution...

journal_title：Nature

authors： Hibbett DS,Gilbert LB,Donoghue MJ

更新日期：2000-09-28 00:00:00

abstract：:The stable isotope ratios of atmospheric CO(2) ((18)O/(16)O and (13)C/(12)C) have been monitored since 1977 to improve our understanding of the global carbon cycle, because biosphere-atmosphere exchange fluxes affect the different atomic masses in a measurable way. Interpreting the (18)O/(16)O variability has proved d...

journal_title：Nature

authors： Welp LR,Keeling RF,Meijer HA,Bollenbacher AF,Piper SC,Yoshimura K,Francey RJ,Allison CE,Wahlen M

更新日期：2011-09-28 00:00:00

abstract：:Several distinct cell lineages are established during mouse embryogenesis. The trophectoderm and primitive endoderm give rise to extraembryonic structures alone, while the primitive ectoderm becomes the fetus proper. Recent studies suggest that the levels of DNA modification are lower in inactive X chromosomes from ex...

journal_title：Nature

authors： Chapman V,Forrester L,Sanford J,Hastie N,Rossant J

更新日期：1984-01-19 00:00:00

abstract：:Many small proteins seem to fold by a simple process explicable by conventional chemical kinetics and transition-state theory. This assumes an instant equilibrium between reactants and a high-energy activated state. In reality, equilibration occurs on timescales dependent on the molecules involved, below which such an...

journal_title：Nature

authors： Yang WY,Gruebele M

更新日期：2003-05-08 00:00:00

abstract：:Only three elements are ferromagnetic at room temperature: the transition metals iron, cobalt and nickel. The Stoner criterion explains why iron is ferromagnetic but manganese, for example, is not, even though both elements have an unfilled 3d shell and are adjacent in the periodic table: according to this criterion, ...

journal_title：Nature

authors： Ma'Mari FA,Moorsom T,Teobaldi G,Deacon W,Prokscha T,Luetkens H,Lee S,Sterbinsky GE,Arena DA,MacLaren DA,Flokstra M,Ali M,Wheeler MC,Burnell G,Hickey BJ,Cespedes O

更新日期：2015-08-06 00:00:00

abstract：:Seafloor spreading is largely unobserved because 98 per cent of the global mid-ocean-ridge system is below the ocean surface. Our understanding of the dynamic processes that control seafloor spreading is thus inferred largely from geophysical observations of spreading events on land at Afar in East Africa and Iceland....

journal_title：Nature

authors： Tan YJ,Tolstoy M,Waldhauser F,Wilcock WS

更新日期：2016-12-08 00:00:00

abstract：:Systems governed by time reversible equations of motion often give rise to irreversible behaviour. The transition from reversible to irreversible behaviour is fundamental to statistical physics, but has not been observed experimentally in many-body systems. The flow of a newtonian fluid at low Reynolds number can be r...

journal_title：Nature

authors： Pine DJ,Gollub JP,Brady JF,Leshansky AM

更新日期：2005-12-15 00:00:00

abstract：:The mineral olivine dominates the composition of the Earth's upper mantle and hence controls its mechanical behaviour and seismic anisotropy. Experiments at high temperature and moderate pressure, and extensive data on naturally deformed mantle rocks, have led to the conclusion that olivine at upper-mantle conditions ...

journal_title：Nature

authors： Mainprice D,Tommasi A,Couvy H,Cordier P,Frost DJ

更新日期：2005-02-17 00:00:00

abstract：:Scientific theories of how subduction and plate tectonics began on Earth--and what the tectonic structure of Earth was before this--remain enigmatic and contentious. Understanding viable scenarios for the onset of subduction and plate tectonics is hampered by the fact that subduction initiation processes must have bee...

journal_title：Nature

authors： Gerya TV,Stern RJ,Baes M,Sobolev SV,Whattam SA

更新日期：2015-11-12 00:00:00

abstract：:The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has impor...

journal_title：Nature

authors： Acharya R,Fry E,Stuart D,Fox G,Rowlands D,Brown F

更新日期：1989-02-23 00:00:00

abstract：:Analysis of changes in viral load after initiation of treatment with potent antiretroviral agents has provided substantial insight into the dynamics of human immunodeficiency virus type 1 (HIV-1). The concentration of HIV-1 in plasma drops by approximately 99% in the first two weeks of treatment owing to the rapid eli...

journal_title：Nature

authors： Perelson AS,Essunger P,Cao Y,Vesanen M,Hurley A,Saksela K,Markowitz M,Ho DD

更新日期：1997-05-08 00:00:00

abstract：:Transposable elements are viewed as 'selfish genetic elements', yet they contribute to gene regulation and genome evolution in diverse ways. More than half of the human genome consists of transposable elements. Alu elements belong to the short interspersed nuclear element (SINE) family of repetitive elements, and with...

journal_title：Nature

authors： Aktaş T,Avşar Ilık İ,Maticzka D,Bhardwaj V,Pessoa Rodrigues C,Mittler G,Manke T,Backofen R,Akhtar A

更新日期：2017-04-06 00:00:00

abstract：:We have designed a bacterial system that is switched between different states by red light. The system consists of a synthetic sensor kinase that allows a lawn of bacteria to function as a biological film, such that the projection of a pattern of light on to the bacteria produces a high-definition (about 100 megapixel...

journal_title：Nature

authors： Levskaya A,Chevalier AA,Tabor JJ,Simpson ZB,Lavery LA,Levy M,Davidson EA,Scouras A,Ellington AD,Marcotte EM,Voigt CA

更新日期：2005-11-24 00:00:00

abstract：:The specification of both the germ line and abdomen in Drosophila depends on the localization of oskar messenger RNA to the posterior of the oocyte. This localization requires several trans-acting factors, including Barentsz and the Mago-Y14 heterodimer, which assemble with oskar mRNA into ribonucleoprotein particles ...

journal_title：Nature

authors： Palacios IM,Gatfield D,St Johnston D,Izaurralde E

更新日期：2004-02-19 00:00:00

abstract：:Immunization of male and female animals with extracts of whole sperm cells is known to cause infertility. Also, men and women who spontaneously produce antisperm antibodies are infertile but otherwise healthy. Although the critical sperm antigens are unknown, these observations have led to the proposal that sperm prot...

journal_title：Nature

authors： Primakoff P,Lathrop W,Woolman L,Cowan A,Myles D

更新日期：1988-10-06 00:00:00

abstract：:For many decades comparative analyses of protein sequences and structures have been used to investigate fundamental principles of molecular evolution. In contrast, relatively little is known about the long-term evolution of species' phenotypic and genetic properties. This represents an important gap in our understandi...

journal_title：Nature

authors： Plata G,Henry CS,Vitkup D

更新日期：2015-01-15 00:00:00

abstract：:Transcriptional activator proteins (activators) function, at least in part, by increasing preinitiation complex assembly (for reviews see refs 1-4). Previous studies have shown that an acidic activator forms a contact with the general transcription factor TFIIB (refs 5-7) and recruits it into the preinitiation complex...

journal_title：Nature

authors： Roberts SG,Green MR

更新日期：1994-10-20 00:00:00

abstract：:NADH oxidation in the respiratory chain is coupled to ion translocation across the membrane to build up an electrochemical gradient. The sodium-translocating NADH:quinone oxidoreductase (Na(+)-NQR), a membrane protein complex widespread among pathogenic bacteria, consists of six subunits, NqrA, B, C, D, E and F. To ou...

journal_title：Nature

authors： Steuber J,Vohl G,Casutt MS,Vorburger T,Diederichs K,Fritz G

更新日期：2014-12-04 00:00:00

abstract：:The human B cell-specific alloantigen which is closely linked genetically to HLA contains two non-covalently associated, sialogycoprotein subunits of molecular weight (MW) 29,000 (p29), and 34,000 (p34). Although p29 and p34 have different amino-terminal sequences, their tyrosine peptide maps indicate considerable sim...

journal_title：Nature

authors： Springer TA,Kaufman JF,Terhorst C,Strominger JL

更新日期：1977-07-21 00:00:00

abstract：:We have postulated that an excitatory postsynaptic potential (e.p.s.p.) may open voltage-sensitive K+ ('M') channels, in an appropriate depolarizing range, and that this could alter the e.p.s.p. waveform. Consequently, the fast e.p.s.p. in neurones of sympathetic ganglia, elicited by a nicotinic action of acetylcholin...

journal_title：Nature

authors： Tosaka T,Tasaka J,Miyazaki T,Libet B

更新日期：1983-09-08 00:00:00

abstract：:Repetitive activation of excitatory synapses in the central nervous system results in a long-lasting increase in synaptic transmission called long-term potentiation (LTP). It is generally believed that this synaptic plasticity may underlie certain forms of learning and memory. LTP at most synapses involves the activat...

journal_title：Nature

authors： Castillo PE,Janz R,Südhof TC,Tzounopoulos T,Malenka RC,Nicoll RA

更新日期：1997-08-07 00:00:00

abstract：:Cells sense the context in which they grow to adapt their phenotype and allow multicellular patterning by mechanisms of autocrine and paracrine signalling. However, patterns also form in cell populations exposed to the same signalling molecules and substratum, which often correlate with specific features of the popula...

journal_title：Nature

authors： Frechin M,Stoeger T,Daetwyler S,Gehin C,Battich N,Damm EM,Stergiou L,Riezman H,Pelkmans L

更新日期：2015-07-02 00:00:00

abstract：:The kinetics of the thrombin-catalysed release of fibrino-peptides A and B from human fibrinogen have been investigated and a mechanism correlating the release of fibrinopeptides to fibrin formation is presented. The sequential release of fibrinopeptides results in sequential activation of two sets of polymerisation s...

journal_title：Nature

authors： Blombäck B,Hessel B,Hogg D,Therkildsen L

更新日期：1978-10-12 00:00:00

abstract：:Dysfunction in prosocial interactions is a core symptom of autism spectrum disorder. However, the neural mechanisms that underlie sociability are poorly understood, limiting the rational development of therapies to treat social deficits. Here we show in mice that bidirectional modulation of the release of serotonin (5...

journal_title：Nature

authors： Walsh JJ,Christoffel DJ,Heifets BD,Ben-Dor GA,Selimbeyoglu A,Hung LW,Deisseroth K,Malenka RC

更新日期：2018-08-01 00:00:00

abstract：:In associative learning, the activated neurones undergo a variety of concomitant functional alterations--increases or decreases of firing activity and modifications of membrane potential or resistance and of synaptic responsiveness. Synaptic transmission which can be strengthened only when there is paired activity in ...

journal_title：Nature

authors： Baranyi A,Fehér O

更新日期：1981-04-02 00:00:00

abstract：:Microcrystals of the lipoprotein-phosphoprotein complex which are found in the oocytes of Xenopus laevis were examined using electron microscopy. Analysis of Fourier transforms of the images of the (010) and (001) projections showed the space group to be P2(1)22(1). Ten projections were combined to produce a map of th...

journal_title：Nature

authors： Ohlendorf DH,Wrenn RF,Banaszak LJ

更新日期：1978-03-02 00:00:00