Abstract:
:Human T-cell leukaemias and lymphomas associated with the human T-cell leukaemia viruses (HTLV) are invariably neoplasms of cells with mature T-lymphocyte phenotype. Epstein-Barr virus-transformed B- lymphoycte lines which are productively infected with HTLV may be isolated from patients with HTLV malignancies, but no non-lymphoid tissues seem to be involved. Here, to investigate the basis for this tissue specificity, we introduced type II HTLV (HTLV-II) into a variety of human cells by infection and also by transfection of recombinant genomes. We found no HTLV-II expression in non-lymphoid tissues although expression and correct initiation of transcription was observed in B and T lymphocytes. Our results using recombinant genomes indicate that the restriction of expression is at least partly due to cis-acting functions of the long terminal repeats which lie at each end of the HTLV genome.
journal_name
Naturejournal_title
Natureauthors
Chen IS,McLaughlin J,Golde DWdoi
10.1038/309276a0subject
Has Abstractpub_date
1984-05-17 00:00:00pages
276-9issue
5965eissn
0028-0836issn
1476-4687journal_volume
309pub_type
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