Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2.

abstract：:Is the big-bang hot, warm or cold? And are galactic masses determined by the interplay of gravitational and strong interactions in the very early universe? ...

journal_title：Nature

authors： Harrison ER

更新日期：1970-10-17 00:00:00

abstract：:In Extended Data Fig. 5d of this Letter, the blots for anti-pS612 and anti-BAK1 were inadvertently duplicated. This figure has been corrected online. ...

journal_title：Nature

authors： Perraki A,DeFalco TA,Derbyshire P,Avila J,Séré D,Sklenar J,Qi X,Stransfeld L,Schwessinger B,Kadota Y,Macho AP,Jiang S,Couto D,Torii KU,Menke FLH,Zipfel C

更新日期：2018-11-01 00:00:00

abstract：:The functional assay of a eukaryotic mRNA, into which additional AUG codons have been introduced by in vitro mutagenesis, shows that a translational initiation site need not necessarily be the nearest AUG codon to the 5' end of a mRNA. Hence, the sequence surrounding the AUG, and not simply its position relative to th...

journal_title：Nature

authors： Lomedico PT,McAndrew SJ

更新日期：1982-09-16 00:00:00

abstract：:Deception is common in nature and humans are no exception. Modern societies have created institutions to control cheating, but many situations remain where only intrinsic honesty keeps people from cheating and violating rules. Psychological, sociological and economic theories suggest causal pathways to explain how the...

journal_title：Nature

authors： Gächter S,Schulz JF

更新日期：2016-03-24 00:00:00

abstract：:The DNA synthetic (S) phase of cell division is about twice as long in human basal cell carcinoma (BCC) as the normal epidermis and several non-malignant skin diseases. A similar increase in S phase duration seems to occur in tumours of the human oesophagus, larynx and recto-colon. At the molecular level, the overall ...

journal_title：Nature

authors： Heenen M,Galand P

更新日期：1980-05-22 00:00:00

abstract：:The rates and routes of lethal systemic spread in breast cancer are poorly understood owing to a lack of molecularly characterized patient cohorts with long-term, detailed follow-up data. Long-term follow-up is especially important for those with oestrogen-receptor (ER)-positive breast cancers, which can recur up to t...

journal_title：Nature

authors： Rueda OM,Sammut SJ,Seoane JA,Chin SF,Caswell-Jin JL,Callari M,Batra R,Pereira B,Bruna A,Ali HR,Provenzano E,Liu B,Parisien M,Gillett C,McKinney S,Green AR,Murphy L,Purushotham A,Ellis IO,Pharoah PD,Rueda C,Apari

更新日期：2019-03-01 00:00:00

abstract：:Somatic sexual differentiation in Drosophila melanogaster is accomplished by a hierarchy of genes of which one, Sex-lethal (Sxl), is required for the functional female-specific splicing of the transcripts of the immediately downstream regulatory gene, transformer (tra). The first exon of the tra primary transcript is ...

journal_title：Nature

authors： Inoue K,Hoshijima K,Sakamoto H,Shimura Y

更新日期：1990-03-29 00:00:00

abstract：:The actions of many peptide growth factors include both stimulation and inhibition of cell proliferation, as well as effects unrelated to the control of cell growth. One peptide can have both stimulatory and inhibitory activity in a single cell, depending on the context of the other signal molecules present. ...

journal_title：Nature

authors： Sporn MB,Roberts AB

更新日期：1988-03-17 00:00:00

abstract：:Deposits of beta-amyloid are one of the main pathological characteristics of Alzheimer's disease. The beta-amyloid peptide constituent (relative molecular mass 4,200) of the deposits is derived from the beta-amyloid precursor protein (beta-APP) which is expressed in several different isoforms. The two most prevalent b...

journal_title：Nature

authors： Quon D,Wang Y,Catalano R,Scardina JM,Murakami K,Cordell B

更新日期：1991-07-18 00:00:00

abstract：:RecBCD is a multi-functional enzyme complex that processes DNA ends resulting from a double-strand break. RecBCD is a bipolar helicase that splits the duplex into its component strands and digests them until encountering a recombinational hotspot (Chi site). The nuclease activity is then attenuated and RecBCD loads Re...

journal_title：Nature

authors： Singleton MR,Dillingham MS,Gaudier M,Kowalczykowski SC,Wigley DB

更新日期：2004-11-11 00:00:00

abstract：:Constructing agents with planning capabilities has long been one of the main challenges in the pursuit of artificial intelligence. Tree-based planning methods have enjoyed huge success in challenging domains, such as chess1 and Go2, where a perfect simulator is available. However, in real-world problems, the dynamics ...

journal_title：Nature

authors： Schrittwieser J,Antonoglou I,Hubert T,Simonyan K,Sifre L,Schmitt S,Guez A,Lockhart E,Hassabis D,Graepel T,Lillicrap T,Silver D

更新日期：2020-12-01 00:00:00

abstract：:A report adopted by the Council of Europe lists eight recommendations on the legal, ethical, and social issues raised by recombinant DNA research. The legislators stressed that the right to a "genetic inheritance free from any form of engineering" should be included in the European Human Rights Convention, and that s...

journal_title：Nature

authors： Becker J

更新日期：1982-02-18 00:00:00

abstract：:Sex is expensive. A population of females that reproduce asexually should prima facie have twice the growth rate of an otherwise equivalent anisogamous sexual population lacking paternal care, or a population with modes of paternal care that can be co-opted by parthenogenetic females. The two leading theories for the ...

journal_title：Nature

authors： Siller S,Department of Zoology, University of Oxford, UK. steven.siller@zoo.ox.ac.uk.

更新日期：2001-06-07 00:00:00

abstract：:Adsorption-based phenomena are important in gas separations, such as the treatment of greenhouse-gas and toxic-gas pollutants, and in water-adsorption-based heat pumps for solar cooling systems. The ability to tune the pore size, shape and functionality of crystalline porous coordination polymers--or metal-organic fra...

journal_title：Nature

authors： Krause S,Bon V,Senkovska I,Stoeck U,Wallacher D,Többens DM,Zander S,Pillai RS,Maurin G,Coudert FX,Kaskel S

更新日期：2016-04-21 00:00:00

abstract：:Pathfinding by growing axons in the developing nervous system is guided by diffusible or bound factors that attract or repel the axonal growth cone. The cytoplasmic signalling mechanisms that trigger the responses of the growth cone to guidance factors are mostly unknown. Previous studies have shown that the level and...

journal_title：Nature

authors： Hong K,Nishiyama M,Henley J,Tessier-Lavigne M,Poo M

更新日期：2000-01-06 00:00:00

abstract：:The kinetics of the thrombin-catalysed release of fibrino-peptides A and B from human fibrinogen have been investigated and a mechanism correlating the release of fibrinopeptides to fibrin formation is presented. The sequential release of fibrinopeptides results in sequential activation of two sets of polymerisation s...

journal_title：Nature

authors： Blombäck B,Hessel B,Hogg D,Therkildsen L

更新日期：1978-10-12 00:00:00

abstract：:The behaviour of electrons in solids is well described by Landau's Fermi-liquid theory, which predicts that although electrons in a metal interact, they can still be treated as well defined fermions, which are called 'quasiparticles'. At low temperatures, the ability of quasiparticles to transport heat is given strict...

journal_title：Nature

authors： Hill RW,Proust C,Taillefer L,Fournier P,Greene RL

更新日期：2001-12-13 00:00:00

abstract：:The neural substrates that the fruitfly Drosophila uses to sense smell, taste and light share marked structural and functional similarities with ours, providing attractive models to dissect sensory stimulus processing. Here we focus on two of the remaining and less understood prime sensory modalities: graviception and...

journal_title：Nature

authors： Kamikouchi A,Inagaki HK,Effertz T,Hendrich O,Fiala A,Göpfert MC,Ito K

更新日期：2009-03-12 00:00:00

abstract：:DNA sequences have been analysed using models, such as an n-step Markov chain, that incorporate the possibility of short-range nucleotide correlations. We propose here a method for studying the stochastic properties of nucleotide sequences by constructing a 1:1 map of the nucleotide sequence onto a walk, which we term...

journal_title：Nature

authors： Peng CK,Buldyrev SV,Goldberger AL,Havlin S,Sciortino F,Simons M,Stanley HE

更新日期：1992-03-12 00:00:00

abstract：:The alpha beta T-cell receptors (TCRs) react with complex ligands composed of peptides bound to major histocompatibility complex (MHC) proteins. In the absence of foreign antigens the peptides bound to MHC molecules come from the proteins of the host itself. Interactions between TCRs and these self-peptide-MHC ligands...

journal_title：Nature

authors： Kozono H,White J,Clements J,Marrack P,Kappler J

更新日期：1994-05-12 00:00:00

abstract：:Vaccines against a variety of infectious diseases represent one of the great triumphs of medicine. The immune correlates of protection induced by most current vaccines seem to be mediated by long-lived humoral immune responses. By contrast, there are no currently available vaccines that are uniformly effective for dis...

journal_title：Nature

authors： Seder RA,Hill AV

更新日期：2000-08-17 00:00:00

abstract：:The pseudogap is a partial gap in the electronic density of states that opens in the normal (non-superconducting) state of cuprate superconductors and whose origin is a long-standing puzzle. Its connection to the Mott insulator phase at low doping (hole concentration, p) remains ambiguous and its relation to the charg...

journal_title：Nature

authors： Badoux S,Tabis W,Laliberté F,Grissonnanche G,Vignolle B,Vignolles D,Béard J,Bonn DA,Hardy WN,Liang R,Doiron-Leyraud N,Taillefer L,Proust C

更新日期：2016-03-10 00:00:00

abstract：:Elucidation of the nature of the gene interactions that underly the sterility of interspecific hybrids is important in evolutionary biology. The interactions between the heterospecific X and Y (or Z and W) chromosomes are often used as an explanation for two reasons. First, the fertility of the hybrids of the heteroga...

journal_title：Nature

authors： Johnson NA,Perez DE,Cabot EL,Hollocher H,Wu CI

更新日期：1992-08-27 00:00:00

abstract：:Theory predicts that sexual behaviour in animals can evolve rapidly, accelerating the rate of species formation. Here we estimate the rate of speciation in Laupala, a group of forest-dwelling Hawaiian crickets that is characterized primarily through differences in male courtship song. We find that Laupala has the high...

journal_title：Nature

authors： Mendelson TC,Shaw KL

更新日期：2005-01-27 00:00:00

abstract：:Tumour necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory and immunomodulatory cytokine implicated in inflammatory conditions such as rheumatoid arthritis, Crohn's disease, multiple sclerosis and the cachexia associated with cancer or human immunodeficiency virus infection. TNF-alpha is initially expressed...

journal_title：Nature

authors： Gearing AJ,Beckett P,Christodoulou M,Churchill M,Clements J,Davidson AH,Drummond AH,Galloway WA,Gilbert R,Gordon JL

更新日期：1994-08-18 00:00:00

abstract：:Every cancer originates from a single cell. During expansion of the neoplastic cell population, individual cells acquire genetic and phenotypic differences from each other. Here, to investigate the nature and extent of intra-tumour diversification, we characterized organoids derived from multiple single cells from thr...

journal_title：Nature

authors： Roerink SF,Sasaki N,Lee-Six H,Young MD,Alexandrov LB,Behjati S,Mitchell TJ,Grossmann S,Lightfoot H,Egan DA,Pronk A,Smakman N,van Gorp J,Anderson E,Gamble SJ,Alder C,van de Wetering M,Campbell PJ,Stratton MR,Clevers

更新日期：2018-04-01 00:00:00

abstract：:The bithorax gene complex in Drosophila contains a minimum of eight genes that seem to code for substances controlling levels of thoracic and abdominal development. The state of repression of at least four of these genes is controlled by cis-regulatory elements and a separate locus (Polycomb) seems to code for a repre...

journal_title：Nature

authors： Lewis EB

更新日期：1978-12-07 00:00:00

abstract：:Recent studies have demonstrated that monkeys and humans can use signals from the brain to guide computer cursors. Brain-computer interfaces (BCIs) may one day assist patients suffering from neurological injury or disease, but relatively low system performance remains a major obstacle. In fact, the speed and accuracy ...

journal_title：Nature

authors： Santhanam G,Ryu SI,Yu BM,Afshar A,Shenoy KV

更新日期：2006-07-13 00:00:00

abstract：:Landscapes modified by glacial erosion show a distinct distribution of surface area with elevation (hypsometry). In particular, the height of these regions is influenced by climatic gradients controlling the altitude where glacial and periglacial processes are the most active, and as a result, surface area is focused ...

journal_title：Nature

authors： Pedersen VK,Egholm DL

更新日期：2013-01-10 00:00:00

abstract：:We have designed a bacterial system that is switched between different states by red light. The system consists of a synthetic sensor kinase that allows a lawn of bacteria to function as a biological film, such that the projection of a pattern of light on to the bacteria produces a high-definition (about 100 megapixel...

journal_title：Nature

authors： Levskaya A,Chevalier AA,Tabor JJ,Simpson ZB,Lavery LA,Levy M,Davidson EA,Scouras A,Ellington AD,Marcotte EM,Voigt CA

更新日期：2005-11-24 00:00:00