Abstract:
:The functional assay of a eukaryotic mRNA, into which additional AUG codons have been introduced by in vitro mutagenesis, shows that a translational initiation site need not necessarily be the nearest AUG codon to the 5' end of a mRNA. Hence, the sequence surrounding the AUG, and not simply its position relative to the 5' end of mRNA, appears to be important in determining initiation efficiency.
journal_name
Naturejournal_title
Natureauthors
Lomedico PT,McAndrew SJdoi
10.1038/299221a0subject
Has Abstractpub_date
1982-09-16 00:00:00pages
221-6issue
5880eissn
0028-0836issn
1476-4687journal_volume
299pub_type
杂志文章相关文献
NATURE文献大全abstract::All of the DNA synthesis genes of budding yeast examined so far are periodically expressed and hence under cell-cycle control (Table 1). Expression occurs near the G1/S phase boundary and the genes seem to be coordinately regulated (reviewed in ref. 4). The upstream promoter sequences of these genes have only a hexame...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/350247a0
更新日期:1991-03-21 00:00:00
abstract::Practice, with feedback, is a fundamental variable that influences the aquisition of motor skills: with it, everyone improves, but some improve more than others. This simple fact has led to frequent debate over the relative importance of genetic and environmental influences on motor learning. In principle these factor...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/384356a0
更新日期:1996-11-28 00:00:00
abstract::Bottom trawling is a non-selective commercial fishing technique whereby heavy nets and gear are pulled along the sea floor. The direct impact of this technique on fish populations and benthic communities has received much attention, but trawling can also modify the physical properties of seafloor sediments, water–sedi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11410
更新日期:2012-09-13 00:00:00
abstract::Nuclear pore complexes reside in the nuclear envelope of eukaryotic cells and mediate the nucleocytoplasmic exchange of macromolecules. Traffic is regulated by mobile transport receptors that target their cargo to the central translocation channel, where phenylalanine-glycine-rich repeats serve as binding sites. The s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06170
更新日期:2007-10-04 00:00:00
abstract::An optimal search theory, the so-called Lévy-flight foraging hypothesis, predicts that predators should adopt search strategies known as Lévy flights where prey is sparse and distributed unpredictably, but that Brownian movement is sufficiently efficient for locating abundant prey. Empirical studies have generated con...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09116
更新日期:2010-06-24 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07678-2
更新日期:2018-12-01 00:00:00
abstract::Activation of the nuclear transcription factor NF-kappaB by inflammatory cytokines requires the successive action of NF-kappaB-inducing kinase (NIK) and an IKB-kinase (IKK) complex composed of IKKalpha and IKKbeta. Here we show that the Akt serine-threonine kinase is involved in the activation of NF-kappaB by tumour n...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/43466
更新日期:1999-09-02 00:00:00
abstract::Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after multiple courses of therapy. In contrast to HER2-amplified primary breast cancer, which is highly sensitive to HER2-targete...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19328
更新日期:2016-09-01 00:00:00
abstract::Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic da...
journal_title:Nature
pub_type: 杂志文章,meta分析
doi:10.1038/nature14618
更新日期:2015-07-23 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-018-07165-8
更新日期:2018-11-01 00:00:00
abstract::Blood production is ensured by rare, self-renewing haematopoietic stem cells (HSCs). How HSCs accommodate the diverse cellular stresses associated with their life-long activity remains elusive. Here we identify autophagy as an essential mechanism protecting HSCs from metabolic stress. We show that mouse HSCs, in contr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11895
更新日期:2013-02-21 00:00:00
abstract::Throughout the latter half of this century, the development and spread of resistance to most front-line antimalarial compounds used in the prevention and treatment of the most severe form of human malaria has given cause for grave clinical concern. Polymorphisms in pfmdr1, the gene encoding the P-glycoprotein homologu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35002615
更新日期:2000-02-24 00:00:00
abstract::Humans differ from other primates in their significantly lengthened growth period. The persistence of a fetal pattern of brain growth after birth is another important feature of human development. Here we present the results of an analysis of the 1.8-million-year-old Mojokerto child (Perning 1, Java), the only well pr...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature02852
更新日期:2004-09-16 00:00:00
abstract::The idea that natural selection on genes might be detected using only a single genome has been put forward by Plotkin and colleagues, who present a method that they claim can detect selection without the need for comparative data and which, if correct, would confer greater power of analysis with less information. Here...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature03221
更新日期:2005-01-20 00:00:00
abstract::Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been proposed as to what the earliest lineage choices are in these primitive haem...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25168
更新日期:2018-01-11 00:00:00
abstract::The biosynthesis of many of the complement proteins by cells of the monocyte-macrophage series has been established. Studies on these cells using radiolabelled amino acids demonstrated synthesis of precursor proteins (pro-complement), and the native complement protein similar in size to that found in the plasma. Howev...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/298389a0
更新日期:1982-07-22 00:00:00
abstract::The immunoglobulin superfamily is a group of proteins, each made of one or several domains sharing key structural features with either the variable (V) or the constant (C) immunoglobulin domains. It includes such functionally important members as the immunoglobulins themselves, major histocompatibility complex (MHC) c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/328267a0
更新日期:1987-07-16 00:00:00
abstract::Visual transduction in vertebrate photoreceptors is thought to involve a diffusible internal transmitter which links photon absorption in disk membranes to the conductance decrease in the plasma membrane of the outer segment. The desensitisation of the photoresponse which occurs during and after illumination may also ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/283085a0
更新日期:1980-01-03 00:00:00
abstract::Hypermethylation is associated with the silencing of tumour susceptibility genes in several forms of cancer; however, the mechanisms responsible for this aberrant methylation are poorly understood. The prototypic DNA methyltransferase, DNMT1, has been widely assumed to be responsible for most of the methylation of the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35010000
更新日期:2000-04-27 00:00:00
abstract::The chemical evolution of the Earth and the terrestrial planets is largely controlled by the density of silicate melts. If melt density is higher than that of the surrounding solid, incompatible elements dissolved in the melt will be sequestered in the deep mantle. Previous studies on dry (water-free) melts showed tha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04241
更新日期:2005-11-24 00:00:00
abstract::Parkinson's disease is the second most common neurodegenerative disorder. Growing evidence indicates a causative role of misfolded forms of the protein α-synuclein in the pathogenesis of Parkinson's disease. Intraneuronal aggregates of α-synuclein occur in Lewy bodies and Lewy neurites, the cytopathological hallmarks ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10324
更新日期:2011-08-14 00:00:00
abstract::In Drosophila and mice, olfactory receptor neurons (ORNs) expressing the same receptors have convergent axonal projections to specific glomerular targets in the antennal lobe/olfactory bulb, creating an odour map in this first olfactory structure of the central nervous system. Projection neurons of the Drosophila ante...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35102574
更新日期:2001-11-08 00:00:00
abstract::We are in the enviable position of having two distinct drafts of the human genome sequence. Although gaps, errors, redundancy and incomplete annotation mean that individually each falls short of the ideal, many of these problems can be assessed by comparison. Here we present some comparative analyses of these drafts. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35057055
更新日期:2001-02-15 00:00:00
abstract::The additional author support information was erroneously omitted from the Supplementary Information. This has been corrected online. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-019-0959-z
更新日期:2019-02-01 00:00:00
abstract::There is still no universally accepted theory of high-temperature superconductivity. Most models assume that doping creates 'holes' in the valence band of an insulating, antiferromagnetic 'parent' compound, and that antiferromagnetism and high-temperature superconductivity are intimately related. If their respective e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01544
更新日期:2003-04-24 00:00:00
abstract::The epiblast (EPI) is the origin of all somatic and germ cells in mammals, and of pluripotent stem cells in vitro. To explore the ontogeny of human and primate pluripotency, here we perform comprehensive single-cell RNA sequencing for pre- and post-implantation EPI development in cynomolgus monkeys (Macaca fasciculari...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19096
更新日期:2016-09-01 00:00:00
abstract::During platelet activation there is a major reorganization in the platelet cytoskeleton that accompanies a rapid change in platelet shape. Many of the events associated with activation are attributed to a rise in calcium concentration within the platelet cytoplasm. One direct consequence of the elevated calcium is the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/317449a0
更新日期:1985-10-03 00:00:00
abstract::DEAD-box RNA helicases are vital for the regulation of various aspects of the RNA life cycle, but the molecular underpinnings of their involvement, particularly in mammalian cells, remain poorly understood. Here we show that the DEAD-box RNA helicase DDX21 can sense the transcriptional status of both RNA polymerase (P...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13923
更新日期:2015-02-12 00:00:00
abstract::Parkinson's disease is characterized by loss of dopamine neurons in the substantia nigra1. Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson's disease. While most treatment strategies aim to prevent neuronal loss or protect vulnerable neuronal circuits, a poten...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2388-4
更新日期:2020-06-01 00:00:00
abstract::Miocene hominoid material is very scarce and has previously only been reported as cranial fragments in the Old World. Here we describe a new specimen of Ouranopithecus macedoniensis, which consists of the right part of the face of an adult male with a portion of the frontal bone, a portion of the left part of the face...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/345712a0
更新日期:1990-06-21 00:00:00