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NATURE文献大全abstract::Surgical sectioning of the corpus callosum in epileptic patients has provided a unique opportunity to study separately the competence and processing capacities of the two cerebral hemispheres, each of which is able to perceive, think, memorize and learn independently and essentially outside the realm of awareness of t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/305800a0
更新日期:1983-10-27 00:00:00
abstract::The vasa gene product of Drosophila melanogaster is required only in the female germ line. Progeny of females homozygous for vasa mutations lack posterior structures and pole cells. Isolation and characterization of vasa genomic and complementary DNA clones show that the transcript is abundant in the female germ line ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335611a0
更新日期:1988-10-13 00:00:00
abstract::Octopamine is highly concentrated in neurones of several invertebrate species. Unlike in mammals, octopaminergic neurones in invertebrates are spatially separated from catecholaminergic neurons. In identified nerve cells of Aplysia, however, this amine coexists with other putative neurotransmitters. Octopamine is synt...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/265501a0
更新日期:1977-02-10 00:00:00
abstract::The long-term exchange of volatile species (such as water, carbon, nitrogen and the noble gases) between deep Earth and surface reservoirs controls the habitability of the Earth's surface. The present-day volatile budget of the mantle reflects the integrated history of outgassing and retention of primordial volatiles ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0388-4
更新日期:2018-08-01 00:00:00
abstract::Humans and other animals must often make decisions on the basis of imperfect evidence. Statisticians use measures such as P values to assign degrees of confidence to propositions, but little is known about how the brain computes confidence estimates about decisions. We explored this issue using behavioural analysis an...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07200
更新日期:2008-09-11 00:00:00
abstract::Knowledge of the three-dimensional structures of proteins and other biological macromolecules often aids understanding of how they perform complicated tasks in the cell. Because many such tasks involve the cleavage or formation of chemical bonds, structural characterization at the atomic level is most useful. Developm...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature19948
更新日期:2016-09-15 00:00:00
abstract::Type 1 diabetes (T1D) is a debilitating autoimmune disease that results from T-cell-mediated destruction of insulin-producing beta-cells. Its incidence has increased during the past several decades in developed countries, suggesting that changes in the environment (including the human microbial environment) may influe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07336
更新日期:2008-10-23 00:00:00
abstract::The Gram-negative bacterium Myxococcus xanthus has a complex life cycle during which large amounts of a protein of relative molecular mass (Mr) 19,000, known as protein S, are assembled into a spore surface coat by a process that specifically requires calcium ions. The gene for protein S has been cloned and the DNA se...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/315771a0
更新日期:1985-06-27 00:00:00
abstract::Amyloid beta-protein (AP) is a peptide of relative molecular mass (Mr) 42,000 found in the senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients with Alzheimer's disease and Down's syndrome (trisomy 21). Recent molecular genetic evidence has indicated that AP is encoded as part of a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/329156a0
更新日期:1987-09-10 00:00:00
abstract::Drosophila mutants transformed with a chimaeric gene that expresses the ocellar visual pigment in the major class of photoreceptor cells of the retina were used to investigate the properties of this minor pigment. The photoreceptor cells in which this opsin was misexpressed showed new spectral characteristics and phys...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/333737a0
更新日期:1988-06-23 00:00:00
abstract::Although drugs are intended to be selective, at least some bind to several physiological targets, explaining side effects and efficacy. Because many drug-target combinations exist, it would be useful to explore possible interactions computationally. Here we compared 3,665 US Food and Drug Administration (FDA)-approved...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08506
更新日期:2009-11-12 00:00:00
abstract::TPA (12-O-tetradecanoyl-phorbol-13-acetate) reversibly inhibits the binding of (125)I-labelled epidermal growth factor (EGF) to treated mouse and human cells, but does not affect the binding of various other ligands to their membrane receptors. It alters the affinity of the receptors for EGF without changing the total...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/279387a0
更新日期:1979-05-31 00:00:00
abstract::The recent discoveries of RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. RNA interference has been used as a research tool to control the expression of specific genes in numerous experimental organisms and has potential as a therapeutic strategy to reduce ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature02872
更新日期:2004-09-16 00:00:00
abstract::For cells of the innate immune system to mount a host defence response to infection, they must recognize products of microbial pathogens such as lipopolysaccharide (LPS), the endotoxin secreted by Gram-negative bacteria. These cellular responses require intracellular signalling pathways, such as the four MAP kinase (M...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/386296a0
更新日期:1997-03-20 00:00:00
abstract::The response of tropical cyclone activity to global warming is widely debated. It is often assumed that warmer sea surface temperatures provide a more favourable environment for the development and intensification of tropical cyclones, but cyclone genesis and intensity are also affected by the vertical thermodynamic p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06423
更新日期:2007-12-13 00:00:00
abstract::Endothelial cells line the inner surface of blood vessels and act as the main barrier to the passage of cells and large molecules from the blood stream to the tissues. Recent interest in the part played by the endothelium in regulating vascular tone has focused on the synthesis and secretion of prostacyclin and an end...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/325811a0
更新日期:1987-02-26 00:00:00
abstract::We often face alternatives that we are free to choose between. Planning movements to select an alternative involves several areas in frontal and parietal cortex that are anatomically connected into long-range circuits. These areas must coordinate their activity to select a common movement goal, but how neural circuits...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06849
更新日期:2008-05-15 00:00:00
abstract::The clinical development of an inhibitor of cellular proteasome function suggests that compounds targeting other components of the ubiquitin-proteasome system might prove useful for the treatment of human malignancies. NEDD8-activating enzyme (NAE) is an essential component of the NEDD8 conjugation pathway that contro...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07884
更新日期:2009-04-09 00:00:00
abstract::Fluorescence polarization (FP) equilibrium binding assays differ from other types of binding studies in one important regard: they require no steps to separate free from bound tracer and are therefore fast, simple and accurate. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/375254a0
更新日期:1995-05-18 00:00:00
abstract::The realization of superfluidity in a dilute gas of fermionic atoms, analogous to superconductivity in metals, represents a long-standing goal of ultracold gas research. In such a fermionic superfluid, it should be possible to adjust the interaction strength and tune the system continuously between two limits: a Barde...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02199
更新日期:2003-12-04 00:00:00
abstract::Primordial germ cells (PGCs) are first identifiable as a population of about eight alkaline phosphatase-positive cells in the 7.0 days postcoitum mouse embryo. During the next 6 days of development they proliferate to give rise to the 25,000 cells that will establish the meiotic population. Steel factor is required fo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/359550a0
更新日期:1992-10-08 00:00:00
abstract::Explaining altruistic cooperation is one of the greatest challenges for evolutionary biology. One solution to this problem is if costly cooperative behaviours are directed towards relatives. This idea of kin selection has been hugely influential and applied widely from microorganisms to vertebrates. However, a problem...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02744
更新日期:2004-08-26 00:00:00
abstract::Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/343336a0
更新日期:1990-01-25 00:00:00
abstract::The visual system analyses information by decomposing complex objects into simple components (visual features) that are widely distributed across the cortex. When several objects are present simultaneously in the visual field, a mechanism is required to group (bind) together visual features that belong to each object ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/28166
更新日期:1998-07-09 00:00:00
abstract::Mesenchymal cells contribute to the 'stroma' of most normal and malignant tissues, with specific mesenchymal cells participating in the regulatory niches of stem cells. By examining how mesenchymal osteolineage cells modulate haematopoiesis, here we show that deletion of Dicer1 specifically in mouse osteoprogenitors, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08851
更新日期:2010-04-08 00:00:00
abstract::Plants encounter a myriad of microorganisms, particularly at the root-soil interface, that can invade with detrimental or beneficial outcomes. Prevalent beneficial associations between plants and microorganisms include those that promote plant growth by facilitating the acquisition of limiting nutrients such as nitrog...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature22009
更新日期:2017-03-15 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,社论
doi:10.1038/d41586-019-00483-5
更新日期:2019-02-01 00:00:00
abstract::Globular star clusters are compact and massive stellar systems old enough to have witnessed the entire history of our Galaxy, the Milky Way. Although recent results suggest that their formation may have been more complex than previously thought, they still are the best approximation to a stellar population formed over...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08581
更新日期:2009-11-26 00:00:00
abstract::Lipoxygenase metabolites of arachidonic acid have recently been shown to modulate the activity of ion channels in nerve and muscle cells. The mechanism of action of these metabolites is, however, unknown. In sensory neurons of Aplysia, the S-K- channel is under the dual modulatory control of 5-hydroxytryptamine (5-HT)...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/342553a0
更新日期:1989-11-30 00:00:00
abstract::Brood parasitism, where a brood of the parasitic species is fostered by the parents of another species, is well known among birds. In most cases, such offspring show a complete reliance upon their host parents for food, protection and warmth until their independence. In other vertebrate groups, however, such total dep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/323058a0
更新日期:1986-09-04 00:00:00