Neural correlates, computation and behavioural impact of decision confidence.

Abstract:

:Humans and other animals must often make decisions on the basis of imperfect evidence. Statisticians use measures such as P values to assign degrees of confidence to propositions, but little is known about how the brain computes confidence estimates about decisions. We explored this issue using behavioural analysis and neural recordings in rats in combination with computational modelling. Subjects were trained to perform an odour categorization task that allowed decision confidence to be manipulated by varying the distance of the test stimulus to the category boundary. To understand how confidence could be computed along with the choice itself, using standard models of decision-making, we defined a simple measure that quantified the quality of the evidence contributing to a particular decision. Here we show that the firing rates of many single neurons in the orbitofrontal cortex match closely to the predictions of confidence models and cannot be readily explained by alternative mechanisms, such as learning stimulus-outcome associations. Moreover, when tested using a delayed reward version of the task, we found that rats' willingness to wait for rewards increased with confidence, as predicted by the theoretical model. These results indicate that confidence estimates, previously suggested to require 'metacognition' and conscious awareness are available even in the rodent brain, can be computed with relatively simple operations, and can drive adaptive behaviour. We suggest that confidence estimation may be a fundamental and ubiquitous component of decision-making.

journal_name

Nature

journal_title

Nature

authors

Kepecs A,Uchida N,Zariwala HA,Mainen ZF

doi

10.1038/nature07200

subject

Has Abstract

pub_date

2008-09-11 00:00:00

pages

227-31

issue

7210

eissn

0028-0836

issn

1476-4687

pii

nature07200

journal_volume

455

pub_type

杂志文章

相关文献

NATURE文献大全
  • Single channel recordings of K+ currents in squid axons.

    abstract::Ionic currents from individual K+ channels in squid axon membrane have been recorded. At hyperpolarizing membrane voltages, unit events occur as widely spaced rectangular pulses with short interruptions. The frequency of occurrence of the units increases strongly when the membrane is depolarized. ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/285140a0

    authors: Conti F,Neher E

    更新日期:1980-05-15 00:00:00

  • The tuatara genome reveals ancient features of amniote evolution.

    abstract::The tuatara (Sphenodon punctatus)-the only living member of the reptilian order Rhynchocephalia (Sphenodontia), once widespread across Gondwana1,2-is an iconic species that is endemic to New Zealand2,3. A key link to the now-extinct stem reptiles (from which dinosaurs, modern reptiles, birds and mammals evolved), the ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-020-2561-9

    authors: Gemmell NJ,Rutherford K,Prost S,Tollis M,Winter D,Macey JR,Adelson DL,Suh A,Bertozzi T,Grau JH,Organ C,Gardner PP,Muffato M,Patricio M,Billis K,Martin FJ,Flicek P,Petersen B,Kang L,Michalak P,Buckley TR,Wilson M

    更新日期:2020-08-01 00:00:00

  • The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs.

    abstract::In contrast to microRNAs and Piwi-associated RNAs, short interfering RNAs (siRNAs) are seemingly dispensable for host-directed gene regulation in Drosophila. This notion is based on the fact that mutants lacking the core siRNA-generating enzyme Dicer-2 or the predominant siRNA effector Argonaute 2 are viable, fertile ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature07015

    authors: Okamura K,Chung WJ,Ruby JG,Guo H,Bartel DP,Lai EC

    更新日期:2008-06-05 00:00:00

  • The crystallography of correlated disorder.

    abstract::Classical crystallography can determine structures as complicated as multi-component ribosomal assemblies with atomic resolution, but is inadequate for disordered systems--even those as simple as water ice--that occupy the complex middle ground between liquid-like randomness and crystalline periodic order. Correlated ...

    journal_title:Nature

    pub_type: 杂志文章,评审

    doi:10.1038/nature14453

    authors: Keen DA,Goodwin AL

    更新日期:2015-05-21 00:00:00

  • Structure and flexibility in cortical representations of odour space.

    abstract::The cortex organizes sensory information to enable discrimination and generalization1-4. As systematic representations of chemical odour space have not yet been described in the olfactory cortex, it remains unclear how odour relationships are encoded to place chemically distinct but similar odours, such as lemon and o...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-020-2451-1

    authors: Pashkovski SL,Iurilli G,Brann D,Chicharro D,Drummey K,Franks KM,Panzeri S,Datta SR

    更新日期:2020-07-01 00:00:00

  • Transformation and diversification in early mammal evolution.

    abstract::Evolution of the earliest mammals shows successive episodes of diversification. Lineage-splitting in Mesozoic mammals is coupled with many independent evolutionary experiments and ecological specializations. Classic scenarios of mammalian morphological evolution tend to posit an orderly acquisition of key evolutionary...

    journal_title:Nature

    pub_type: 历史文章,杂志文章,评审

    doi:10.1038/nature06277

    authors: Luo ZX

    更新日期:2007-12-13 00:00:00

  • Infrared emission spectra of candidate interstellar aromatic molecules.

    abstract::Interstellar dust is responsible, through surface reactions, for the creation of molecular hydrogen, the main component of the interstellar clouds in which new stars form. Intermediate between small, gas-phase molecules and dust are the polycyclic aromatic hydrocarbons (PAHs). Such molecules could account for 2-30% of...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/380227a0

    authors: Cook DJ,Schlemmer S,Balucani N,Wagner DR,Steiner B,Saykally RJ

    更新日期:1996-03-21 00:00:00

  • Cooperation and competition in pathogenic bacteria.

    abstract::Explaining altruistic cooperation is one of the greatest challenges for evolutionary biology. One solution to this problem is if costly cooperative behaviours are directed towards relatives. This idea of kin selection has been hugely influential and applied widely from microorganisms to vertebrates. However, a problem...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature02744

    authors: Griffin AS,West SA,Buckling A

    更新日期:2004-08-26 00:00:00

  • Extreme damping in composite materials with negative-stiffness inclusions.

    abstract::When a force deforms an elastic object, practical experience suggests that the resulting displacement will be in the same direction as the force. This property is known as positive stiffness. Less familiar is the concept of negative stiffness, where the deforming force and the resulting displacement are in opposite di...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35069035

    authors: Lakes RS,Lee T,Bersie A,Wang YC

    更新日期:2001-03-29 00:00:00

  • The contribution of bone to whole-organism physiology.

    abstract::The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiolo...

    journal_title:Nature

    pub_type: 杂志文章,评审

    doi:10.1038/nature10763

    authors: Karsenty G,Ferron M

    更新日期:2012-01-18 00:00:00

  • Modulation of brain polyphosphoinositide metabolism by ACTH-sensitive protein phosphorylation.

    abstract::Phosphorylation of membrane components is thought to be an important process in membrane function. Phosphorylated proteins and a special class of phospholipids, the (poly)phosphoinositides (poly PI), are implicated in the regulation of membrane permeability and synaptic transmission in neurones. For many years, protei...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/286623a0

    authors: Jolles J,Zwiers H,van Dongen CJ,Schotman P,Wirtz KW,Gispen WH

    更新日期:1980-08-07 00:00:00

  • Regenerative medicine and human models of human disease.

    abstract::Recent advances in stem-cell technology are now allowing the mechanisms of human disease to be studied in human cells. A new era for regenerative medicine is arising from such disease models, extending beyond early cell-based therapies and towards evaluating genetic variation in humans and identifying the molecular pa...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature07037

    authors: Chien KR

    更新日期:2008-05-15 00:00:00

  • Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.

    abstract::Metastasis is a major cause of death in cancer patients and involves a multistep process including detachment of cancer cells from a primary cancer, invasion of surrounding tissue, spread through circulation, re-invasion and proliferation in distant organs. KiSS-1 is a human metastasis suppressor gene, that suppresses...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35079135

    authors: Ohtaki T,Shintani Y,Honda S,Matsumoto H,Hori A,Kanehashi K,Terao Y,Kumano S,Takatsu Y,Masuda Y,Ishibashi Y,Watanabe T,Asada M,Yamada T,Suenaga M,Kitada C,Usuki S,Kurokawa T,Onda H,Nishimura O,Fujino M

    更新日期:2001-05-31 00:00:00

  • A spectrograph for exoplanet observations calibrated at the centimetre-per-second level.

    abstract::The best spectrographs are limited in stability by their calibration light source. Laser frequency combs are the ideal calibrators for astronomical spectrographs. They emit a spectrum of lines that are equally spaced in frequency and that are as accurate and stable as the atomic clock relative to which the comb is sta...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11092

    authors: Wilken T,Curto GL,Probst RA,Steinmetz T,Manescau A,Pasquini L,González Hernández JI,Rebolo R,Hänsch TW,Udem T,Holzwarth R

    更新日期:2012-05-30 00:00:00

  • A novel eye in 'eyeless' shrimp from hydrothermal vents of the Mid-Atlantic Ridge.

    abstract::Rimicaris exoculata is a shrimp that swarms over high-temperature (350 degrees C) sulphide chimneys at Mid-Atlantic Ridge hydrothermal fields (3,600 m). This shrimp lacks an externally differentiated eye, having instead a pair of large organs within the cephalothorax immediately beneath the dorsal surface of the trans...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/337458a0

    authors: Van Dover CL,Szuts EZ,Chamberlain SC,Cann JR

    更新日期:1989-02-02 00:00:00

  • Tunable spin-spin interactions and entanglement of ions in separate potential wells.

    abstract::Quantum simulation--the use of one quantum system to simulate a less controllable one--may provide an understanding of the many quantum systems which cannot be modelled using classical computers. Considerable progress in control and manipulation has been achieved for various quantum systems, but one of the remaining c...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature13565

    authors: Wilson AC,Colombe Y,Brown KR,Knill E,Leibfried D,Wineland DJ

    更新日期:2014-08-07 00:00:00

  • East Antarctic rifting triggers uplift of the Gamburtsev Mountains.

    abstract::The Gamburtsev Subglacial Mountains are the least understood tectonic feature on Earth, because they are completely hidden beneath the East Antarctic Ice Sheet. Their high elevation and youthful Alpine topography, combined with their location on the East Antarctic craton, creates a paradox that has puzzled researchers...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature10566

    authors: Ferraccioli F,Finn CA,Jordan TA,Bell RE,Anderson LM,Damaske D

    更新日期:2011-11-16 00:00:00

  • Paths to understanding the genetic basis of autoimmune disease.

    abstract::Some people inherit an unfortunate combination of genetic sequences, such that exposure to an external trigger causes their immune response to turn on their own tissues. Although mutations in a single gene can cause autoimmunity, most autoimmune diseases are associated with several sequence variants. Marked advances i...

    journal_title:Nature

    pub_type: 杂志文章,评审

    doi:10.1038/nature03723

    authors: Rioux JD,Abbas AK

    更新日期:2005-06-02 00:00:00

  • Author Correction: Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.

    abstract::An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature

    pub_type: 已发布勘误

    doi:10.1038/s41586-019-1455-1

    authors: Schwörer S,Becker F,Feller C,Baig AH,Köber U,Henze H,Kraus JM,Xin B,Lechel A,Lipka DB,Varghese CS,Schmidt M,Rohs R,Aebersold R,Medina KL,Kestler HA,Neri F,von Maltzahn J,Tümpel S,Rudolph KL

    更新日期:2019-08-01 00:00:00

  • Modelling vaccination strategies against foot-and-mouth disease.

    abstract::Vaccination has proved a powerful defence against a range of infectious diseases of humans and animals. However, its potential to control major epidemics of foot-and-mouth disease (FMD) in livestock is contentious. Using an individual farm-based model, we consider either national prophylactic vaccination campaigns in ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature01343

    authors: Keeling MJ,Woolhouse ME,May RM,Davies G,Grenfell BT

    更新日期:2003-01-09 00:00:00

  • The life span of the biosphere revisited.

    abstract::A decade ago, Lovelock and Whitfield raised the question of how much longer the biosphere can survive on Earth. They pointed out that, despite the current fossil-fuel induced increase in the atmospheric CO2 concentration, the long-term trend should be in the opposite direction: as increased solar luminosity warms th...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/360721a0

    authors: Caldeira K,Kasting JF

    更新日期:1992-12-24 00:00:00

  • Room-temperature electronic phase transitions in the continuous phase diagrams of perovskite manganites

    abstract::Highly correlated electronic systems--such as transition-metal oxides that are doped Mott insulators--are complex systems which exhibit puzzling phenomena, including high-temperature superconductivity and colossal magnetoresistivity. Recent studies suggest that in such systems collective electronic phenomena are impor...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35021018

    authors: Yoo YK,Duewer F,Yang H,Yi D,Li JW,Xiang XD

    更新日期:2000-08-17 00:00:00

  • Quantitative flux analysis reveals folate-dependent NADPH production.

    abstract::ATP is the dominant energy source in animals for mechanical and electrical work (for example, muscle contraction or neuronal firing). For chemical work, there is an equally important role for NADPH, which powers redox defence and reductive biosynthesis. The most direct route to produce NADPH from glucose is the oxidat...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature13236

    authors: Fan J,Ye J,Kamphorst JJ,Shlomi T,Thompson CB,Rabinowitz JD

    更新日期:2014-06-12 00:00:00

  • Structural and functional conservation of key domains in InsP3 and ryanodine receptors.

    abstract::Inositol-1,4,5-trisphosphate receptors (InsP(3)Rs) and ryanodine receptors (RyRs) are tetrameric intracellular Ca(2+) channels. In each of these receptor families, the pore, which is formed by carboxy-terminal transmembrane domains, is regulated by signals that are detected by large cytosolic structures. InsP(3)R gati...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature10751

    authors: Seo MD,Velamakanni S,Ishiyama N,Stathopulos PB,Rossi AM,Khan SA,Dale P,Li C,Ames JB,Ikura M,Taylor CW

    更新日期:2012-01-29 00:00:00

  • Identification of a distinct synaptic glutamate receptor on horizontal cells in mudpuppy retina.

    abstract::The separation of ON and OFF channels and the development of an antagonistic surround occur at the first synapse in the vertebrate retina. This functional differentiation is mediated by the action of the photoreceptor neurotransmitter on the ON bipolar, OFF bipolar and horizontal cells, respectively. Glutamate mimics ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/314096a0

    authors: Slaughter MM,Miller RF

    更新日期:1985-03-07 00:00:00

  • The diurnal cycle of water ice on comet 67P/Churyumov-Gerasimenko.

    abstract::Observations of cometary nuclei have revealed a very limited amount of surface water ice, which is insufficient to explain the observed water outgassing. This was clearly demonstrated on comet 9P/Tempel 1, where the dust jets (driven by volatiles) were only partially correlated with the exposed ice regions. The observ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature14869

    authors: De Sanctis MC,Capaccioni F,Ciarniello M,Filacchione G,Formisano M,Mottola S,Raponi A,Tosi F,Bockelée-Morvan D,Erard S,Leyrat C,Schmitt B,Ammannito E,Arnold G,Barucci MA,Combi M,Capria MT,Cerroni P,Ip WH,Kuehrt E,M

    更新日期:2015-09-24 00:00:00

  • Mapping human visual cortex with positron emission tomography.

    abstract::Positron-emission tomography (PET) can localize functions of the human brain by imaging regional cerebral blood flow (CBF) during voluntary behaviour. Functional brain mapping with PET, however, has been hindered by PET's poor spatial resolution (typically greater than 1 cm). We have developed an image-analysis strate...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/323806a0

    authors: Fox PT,Mintun MA,Raichle ME,Miezin FM,Allman JM,Van Essen DC

    更新日期:1986-10-30 00:00:00

  • Evidence for male allocation in pipefish?

    abstract::Sexual differences in the extent and type of parental care lie at the heart of sexual selection theory, and evolution resulting from parental conflict has produced some striking behavioural and morphological adaptations. In a study of male pregnancy in Gulf pipefish, Paczolt and Jones showed that more eggs were transf...

    journal_title:Nature

    pub_type: 评论,杂志文章

    doi:10.1038/nature09275

    authors: Gwynne DT,Judge KA,Kelly CD

    更新日期:2010-08-26 00:00:00

  • Helical self-assembled polymers from cooperative stacking of hydrogen-bonded pairs.

    abstract::The double helix of DNA epitomizes this molecule's ability to self-assemble in aqueous solutions into a complex chiral structure using hydrogen bonding and hydrophobic interactions. Non-covalently interacting molecules in organic solvents are used to design systems that similarly form controlled architectures. Periphe...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35025027

    authors: Hirschberg JH,Brunsveld L,Ramzi A,Vekemans JA,Sijbesma RP,Meijer EW

    更新日期:2000-09-14 00:00:00

  • A concise synthesis of (+)-batzelladine B from simple pyrrole-based starting materials.

    abstract::Alkaloids, secondary metabolites that contain basic nitrogen atoms, are some of the most well-known biologically active natural products in chemistry and medicine. Although efficient laboratory synthesis of alkaloids would enable the study and optimization of their biological properties, their preparation is often com...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature14902

    authors: Parr BT,Economou C,Herzon SB

    更新日期:2015-09-24 00:00:00