Male development of chromosomally female mice transgenic for Sry.

abstract：:Blood vessel growth in the skeletal system and osteogenesis seem to be coupled, suggesting the existence of molecular crosstalk between endothelial and osteoblastic cells. Understanding the nature of the mechanisms linking angiogenesis and bone formation should be of great relevance for improved fracture healing or pr...

journal_title：Nature

authors： Ramasamy SK,Kusumbe AP,Wang L,Adams RH

更新日期：2014-03-20 00:00:00

abstract：:ELLIPTICAL galaxies acting as gravitational lenses occasionally produce spectacular images-Einstein rings-of distant objects. Giant arcs(1) and radio rings(2) have been observed. A wide variety of image morphologies is possible, the generation of which is qualitatively understood in terms of large magnifications at ca...

journal_title：Nature

authors： Langston GI,Conner SR,Lehar J,Burke BF,Weiler KW

更新日期：1990-03-01 00:00:00

abstract：:Seven monoclonal antibodies have been produced against a membrane preparation from adult rat retina. Three antibodies reacted with particular regions of rat photoreceptor cell surfaces: RET-P1 labelled the cell bodies, outer and inner segments (rods but not cones), RET-P2 labelled only outer segments and RET-P3 labell...

journal_title：Nature

authors： Barnstable CJ

更新日期：1980-07-17 00:00:00

abstract：:Morphogens act in developing tissues to control the spatial arrangement of cellular differentiation. The activity of a morphogen has generally been viewed as a concentration-dependent response to a diffusible signal, but the duration of morphogen signalling can also affect cellular responses. One such example is the m...

journal_title：Nature

authors： Dessaud E,Yang LL,Hill K,Cox B,Ulloa F,Ribeiro A,Mynett A,Novitch BG,Briscoe J

更新日期：2007-11-29 00:00:00

abstract：: ...

journal_title：Nature

authors： Bietz A

更新日期：2018-11-01 00:00:00

abstract：:There is a pressing need to develop alternatives to annual influenza vaccines and antiviral agents licensed for mitigating influenza infection. Previous studies reported that acute lung injury caused by chemical or microbial insults is secondary to the generation of host-derived, oxidized phospholipid that potently st...

journal_title：Nature

authors： Shirey KA,Lai W,Scott AJ,Lipsky M,Mistry P,Pletneva LM,Karp CL,McAlees J,Gioannini TL,Weiss J,Chen WH,Ernst RK,Rossignol DP,Gusovsky F,Blanco JC,Vogel SN

更新日期：2013-05-23 00:00:00

abstract：:Contamination of ground waters with water-soluble aromatic hydrocarbons, common components of petroleum pollution, often produces anoxic conditions under which microbial degradation of the aromatics is slow. Oxygen is often added to contaminated ground water to stimulate biodegradation, but this can be technically dif...

journal_title：Nature

authors： Lovley DR,Woodward JC,Chapelle FH

更新日期：1994-07-14 00:00:00

abstract：:MicroRNAs (miRNAs) are approximately 22-nucleotide endogenous RNAs that often repress the expression of complementary messenger RNAs. In animals, miRNAs derive from characteristic hairpins in primary transcripts through two sequential RNase III-mediated cleavages; Drosha cleaves near the base of the stem to liberate a...

journal_title：Nature

authors： Ruby JG,Jan CH,Bartel DP

更新日期：2007-07-05 00:00:00

abstract：:Increasing population and consumption are placing unprecedented demands on agriculture and natural resources. Today, approximately a billion people are chronically malnourished while our agricultural systems are concurrently degrading land, water, biodiversity and climate on a global scale. To meet the world's future ...

journal_title：Nature

authors： Foley JA,Ramankutty N,Brauman KA,Cassidy ES,Gerber JS,Johnston M,Mueller ND,O'Connell C,Ray DK,West PC,Balzer C,Bennett EM,Carpenter SR,Hill J,Monfreda C,Polasky S,Rockström J,Sheehan J,Siebert S,Tilman D,Zaks DP

更新日期：2011-10-12 00:00:00

abstract：:The inner ear is capable of highly selective frequency discrimination. This is achieved not only by the travelling wave of the basilar membrane in the cochlear partition, but also by the active participation of nonlinear and vulnerable elements that enhance frequency selectivity. It has been shown that isolated mammal...

journal_title：Nature

authors： Brundin L,Flock A,Canlon B

更新日期：1989-12-14 00:00:00

abstract：:The amount of energy used to run a mile is nearly the same whether it is run at top speed or at a leisurely pace (although it is used more rapidly at the higher speed). This puzzling independence of energy cost and speed is found generally among running animals, although, on a per gram basis, cost is much higher for s...

journal_title：Nature

authors： Kram R,Taylor CR

更新日期：1990-07-19 00:00:00

abstract：:A three-dimensional image of tubulin protofilaments, reconstructed to 20 A resolution from electron micrographs of negatively stained zinc-induced sheets, has been used to generate an improved model for microtubule substructure. This model has been used to phase a reconstructed image from X-ray amplitudes, which is co...

journal_title：Nature

authors： Amos LA,Baker TS

更新日期：1979-06-14 00:00:00

abstract：:In mice, the Ter mutation causes primordial germ cell (PGC) loss in all genetic backgrounds. Ter is also a potent modifier of spontaneous testicular germ cell tumour (TGCT) susceptibility in the 129 family of inbred strains, and markedly increases TGCT incidence in 129-Ter/Ter males. In 129-Ter/Ter mice, some of the r...

journal_title：Nature

authors： Youngren KK,Coveney D,Peng X,Bhattacharya C,Schmidt LS,Nickerson ML,Lamb BT,Deng JM,Behringer RR,Capel B,Rubin EM,Nadeau JH,Matin A

更新日期：2005-05-19 00:00:00

abstract：:Marine records of sediment oxygen isotope compositions show that the Earth's climate has gone through a succession of glacial and interglacial periods during the past million years. But the interpretation of the oxygen isotope records is complicated because both isotope storage in ice sheets and deep-water temperature...

journal_title：Nature

authors： Bintanja R,van de Wal RS,Oerlemans J

更新日期：2005-09-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Witze A

更新日期：2019-01-01 00:00:00

abstract：:The plant hormone auxin is central in many aspects of plant development. Previous studies have implicated the ubiquitin-ligase SCF(TIR1) and the AUX/IAA proteins in auxin response. Dominant mutations in several AUX/IAA genes confer pleiotropic auxin-related phenotypes, whereas recessive mutations affecting the functio...

journal_title：Nature

authors： Gray WM,Kepinski S,Rouse D,Leyser O,Estelle M

更新日期：2001-11-15 00:00:00

abstract：:Protein-tyrosine phosphatases (PTPs) are vital for regulating tryosine phosphorylation in many processes, including growth and differentiation. The regulation of receptor-like PTP (RPTP) activity remains poorly understood, but based on the crystal structure of RPTPalpha domain 1 we have proposed that dimerization can ...

journal_title：Nature

authors： Jiang G,den Hertog J,Su J,Noel J,Sap J,Hunter T

更新日期：1999-10-07 00:00:00

abstract：:In the initiation of translation in eukaryotes, binding of the small ribosomal subunit to the messenger RNA results from recognition of the 5' cap structure (m7GpppX) of the mRNA by the cap-binding complex eIF4F. eIF4F is itself a three-subunit complex comprising the cap-binding protein eIF4E, eIF4A, an ATP-dependent ...

journal_title：Nature

authors： Craig AW,Haghighat A,Yu AT,Sonenberg N

更新日期：1998-04-02 00:00:00

abstract：:Important Ca2+ signals in the cytosol and organelles are often extremely localized and hard to measure. To overcome this problem we have constructed new fluorescent indicators for Ca2+ that are genetically encoded without cofactors and are targetable to specific intracellular locations. We have dubbed these fluorescen...

journal_title：Nature

authors： Miyawaki A,Llopis J,Heim R,McCaffery JM,Adams JA,Ikura M,Tsien RY

更新日期：1997-08-28 00:00:00

abstract：:The nature and length scales of charge screening in complex oxides are fundamental to a wide range of systems, spanning ceramic voltage-dependent resistors (varistors), oxide tunnel junctions and charge ordering in mixed-valence compounds. There are wide variations in the degree of charge disproportionation, length sc...

journal_title：Nature

authors： Ohtomo A,Muller DA,Grazul JL,Hwang HY

更新日期：2002-09-26 00:00:00

abstract：:For parallel computers to simulate our brains, we must face the fact that human beings have a better claim on the title Homo seriatim than Homo sapiens--we're more consistently serial than wise. ...

journal_title：Nature

authors： Calvin WH

更新日期：1987-11-05 00:00:00

abstract：:Kinetoplastid RNA editing alters mitochondrial RNA transcripts by addition and deletion of uridine residues, producing open reading frames that may be twice as long as the original RNA. Although the COIII gene encoding cytochrome c oxidase subunit III in Trypanosoma brucei is edited along its entire length, the presum...

journal_title：Nature

authors： Landweber LF,Gilbert W

更新日期：1993-05-13 00:00:00

abstract：:T cells bearing the alpha beta receptor can specifically react with target cells coated with staphylococcal enterotoxin and expressing major histocompatibility complex class II molecules; these responses depend on which variable region (V) of the receptor's beta-subunit is used. We have now examined whether a similar ...

journal_title：Nature

authors： Rust CJ,Verreck F,Vietor H,Koning F

更新日期：1990-08-09 00:00:00

abstract：:In Fig. 6a of this Article, the two dots corresponding to Cidea and S100b were erroneously moved to the top left of the volcano plot; this figure has been corrected online.An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Zeng X,Ye M,Resch JM,Jedrychowski MP,Hu B,Lowell BB,Ginty DD,Spiegelman BM

更新日期：2019-06-01 00:00:00

abstract：:Mating and egg laying are tightly cooordinated events in the reproductive life of all oviparous females. Oviposition is typically rare in virgin females but is initiated after copulation. Here we identify the neural circuitry that links egg laying to mating status in Drosophila melanogaster. Activation of female-speci...

journal_title：Nature

authors： Wang F,Wang K,Forknall N,Patrick C,Yang T,Parekh R,Bock D,Dickson BJ

更新日期：2020-03-01 00:00:00

abstract：:Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis. To date, no robustly replicated genetic loci have been identified, despite analysis of more than 9,000 cases. Here, using low-coverag...

journal_title：Nature

authors： CONVERGE consortium.

更新日期：2015-07-30 00:00:00

abstract：:Measuring the completeness of the fossil record is essential to understanding evolution over long timescales, particularly when comparing evolutionary patterns among biological groups with different preservational properties. Completeness measures have been presented for various groups based on gaps in the stratigraph...

journal_title：Nature

authors： Foote M,Sepkoski JJ Jr

更新日期：1999-04-01 00:00:00

abstract：:Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellula...

journal_title：Nature

authors： Dustin ML,Springer TA

更新日期：1989-10-19 00:00:00

abstract：:The lack of a reliable theory of glass physics has led to the pursuit of correlations between various glass or viscous liquid parameters, one of which is the slope m of the plot of log(viscosity) against Tg/T, extrapolated at the glass-transition temperature, Tg, also termed 'fragility'. Novikov and Sokolov conclude t...

journal_title：Nature

authors： Yannopoulos SN,Johari GP

更新日期：2006-08-03 00:00:00

abstract：:Fungi are the principal degraders of biomass in terrestrial ecosystems and establish important interactions with plants and animals. However, our current understanding of fungal evolutionary diversity is incomplete and is based upon species amenable to growth in culture. These culturable fungi are typically yeast or f...

journal_title：Nature

authors： Jones MD,Forn I,Gadelha C,Egan MJ,Bass D,Massana R,Richards TA

更新日期：2011-05-11 00:00:00