Corrigendum: Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance.

abstract：:In cardiac muscle, where Ca2+ influx across the sarcolemma is essential for contraction, the dihydropyridine (DHP)-sensitive L-type calcium channel represents the major entry pathway of extracellular Ca2+. We have previously elucidated the primary structure of the rabbit skeletal muscle DHP receptor by cloning and seq...

journal_title：Nature

authors： Mikami A,Imoto K,Tanabe T,Niidome T,Mori Y,Takeshima H,Narumiya S,Numa S

更新日期：1989-07-20 00:00:00

abstract：:Oxygen isotope analyses of Spondylus shells from neolithic sites suggest that the source for the shells used as ornaments in the Balkans and central Europe during the fourth millennium BC was the Aegean and not the Black Sea. The trade in Spondylus may have taken the form of an exchange of gifts. ...

journal_title：Nature

authors： Shackleton N,Renfrew C

更新日期：1970-12-12 00:00:00

abstract：:Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, ...

journal_title：Nature

authors： Hannum CH,Wilcox CJ,Arend WP,Joslin FG,Dripps DJ,Heimdal PL,Armes LG,Sommer A,Eisenberg SP,Thompson RC

更新日期：1990-01-25 00:00:00

abstract：:The conventional treatment of dental caries involves mechanical removal of the affected part and filling of the hole with a resin or metal alloy. But this method is not ideal for tiny early lesions because a disproportionate amount of healthy tooth must be removed to make the alloy or resin stick. Here we describe a d...

journal_title：Nature

authors： Yamagishi K,Onuma K,Suzuki T,Okada F,Tagami J,Otsuki M,Senawangse P

更新日期：2005-02-24 00:00:00

abstract：:To mediate its survival and virulence, the malaria parasite Plasmodium falciparum exports hundreds of proteins into the host erythrocyte. To enter the host cell, exported proteins must cross the parasitophorous vacuolar membrane (PVM) within which the parasite resides, but the mechanism remains unclear. A putative Pla...

journal_title：Nature

authors： Beck JR,Muralidharan V,Oksman A,Goldberg DE

更新日期：2014-07-31 00:00:00

abstract：:The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development that combines dense temporal sampling of prenatal and postnatal periods...

journal_title：Nature

authors： Bakken TE,Miller JA,Ding SL,Sunkin SM,Smith KA,Ng L,Szafer A,Dalley RA,Royall JJ,Lemon T,Shapouri S,Aiona K,Arnold J,Bennett JL,Bertagnolli D,Bickley K,Boe A,Brouner K,Butler S,Byrnes E,Caldejon S,Carey A,Cate

更新日期：2016-07-21 00:00:00

abstract：:Continuous turnover of epithelia is ensured by the extensive self-renewal capacity of tissue-specific stem cells. Similarly, epithelial tumour maintenance relies on cancer stem cells (CSCs), which co-opt stem cell properties. For most tumours, the cellular origin of these CSCs and regulatory pathways essential for sus...

journal_title：Nature

authors： Malanchi I,Peinado H,Kassen D,Hussenet T,Metzger D,Chambon P,Huber M,Hohl D,Cano A,Birchmeier W,Huelsken J

更新日期：2008-04-03 00:00:00

abstract：:Many animals rely on an internal heading representation when navigating in varied environments1-10. How this representation is linked to the sensory cues that define different surroundings is unclear. In the fly brain, heading is represented by 'compass' neurons that innervate a ring-shaped structure known as the elli...

journal_title：Nature

authors： Kim SS,Hermundstad AM,Romani S,Abbott LF,Jayaraman V

更新日期：2019-12-01 00:00:00

abstract：:In the adult brain, new synapses are formed and pre-existing ones are lost, but the function of this structural plasticity has remained unclear. Learning of new skills is correlated with formation of new synapses. These may directly encode new memories, but they may also have more general roles in memory encoding and ...

journal_title：Nature

authors： Ruediger S,Vittori C,Bednarek E,Genoud C,Strata P,Sacchetti B,Caroni P

更新日期：2011-05-26 00:00:00

abstract：:The U6 small nuclear (sn)RNA gene (SNR6) from the yeast Saccharomyces cerevisiae is transcribed by RNA polymerase III in vivo. This gene is unusual in having a TATA box at position -30, and an essential B-block element located downstream of the T-rich termination signal. The B block is one of the two intragenic promot...

journal_title：Nature

authors： Burnol AF,Margottin F,Huet J,Almouzni G,Prioleau MN,Méchali M,Sentenac A

更新日期：1993-04-01 00:00:00

abstract：:The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair. An imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders. Recently, the first anti-angiogenic agents have been approved for the treatment of cancer and...

journal_title：Nature

authors： Carmeliet P

更新日期：2005-12-15 00:00:00

abstract：:Bird songs frequently contain trilling sounds that demand extremely fast vocalization control. Here we show that doves control their syrinx, a vocal organ that is unique to birds, by using superfast muscles. These muscles, which are similar to those that operate highly specialist acoustic organs such as the rattle of ...

journal_title：Nature

authors： Elemans CP,Spierts IL,Müller UK,Van Leeuwen JL,Goller F

更新日期：2004-09-09 00:00:00

abstract：:A variety of observations indicate that mid-ocean ridges produce less crust at spreading rates below 20 mm yr(-1) (refs 1-3), reflecting changes in fundamental ridge processes with decreasing spreading rate. The nature of these changes, however, remains uncertain, with end-member explanations being decreasing shallow ...

journal_title：Nature

authors： Lizarralde D,Gaherty JB,Collins JA,Hirth G,Kim SD

更新日期：2004-12-09 00:00:00

abstract：:Japan's Ministry of Health will fund a major new heart transplantation project in an effort to resume heart transplants halted by a public outcry against the first such transplant 17 years ago. Opposition to organ donation, which has been attributed variously to Buddhist and Confucian views of the body and to Japanes...

journal_title：Nature

authors： Anderson A

更新日期：1985-01-31 00:00:00

abstract：:The recent discovery of CD4(+) T cells characterized by secretion of interleukin (IL)-17 (T(H)17 cells) and the naturally occurring regulatory FOXP3(+) CD4 T cell (nT(reg)) has had a major impact on our understanding of immune processes not readily explained by the T(H)1/T(H)2 paradigm. T(H)17 and nT(reg) cells have b...

journal_title：Nature

authors： Yang L,Anderson DE,Baecher-Allan C,Hastings WD,Bettelli E,Oukka M,Kuchroo VK,Hafler DA

更新日期：2008-07-17 00:00:00

abstract：:Tectal polarity for retinal connections remains reversible long after the anatomical pattern of neural structures has been determined. Cells in the diencephalon seem to control this polarity. Following certain embryonic operations, the diencephalon developed behind the tectum. In such cases, the polarity of the retino...

journal_title：Nature

authors： Chung SH,Cooke J

更新日期：1975-11-13 00:00:00

abstract：:Reactive oxygen species are involved in many cellular metabolic and signalling processes and are thought to have a role in disease, particularly in carcinogenesis and ageing. We have generated mice with targeted inactivation of Prdx1, a member of the peroxiredoxin family of antioxidant enzymes. Here we show that mice ...

journal_title：Nature

authors： Neumann CA,Krause DS,Carman CV,Das S,Dubey DP,Abraham JL,Bronson RT,Fujiwara Y,Orkin SH,Van Etten RA

更新日期：2003-07-31 00:00:00

abstract：:Climate models with increased levels of carbon dioxide predict that global warming causes heating in the tropics, but investigations of ancient climates based on palaeodata have generally indicated cool tropical temperatures during supposed greenhouse episodes. For example, in the Late Cretaceous and Eocene epochs the...

journal_title：Nature

authors： Pearson PN,Ditchfield PW,Singano J,Harcourt-Brown KG,Nicholas CJ,Olsson RK,Shackleton NJ,Hall MA

更新日期：2001-10-04 00:00:00

abstract：:TATA-binding protein (TBP) binds the minor groove of the TATA element with the DNA bent 80 degrees towards the major groove. A constrained minicircle strategy has been used to test the effect of DNA topology on the affinity of TBP for the TATA element. We report here that TBP bound to DNA which was slightly pre-bent t...

journal_title：Nature

authors： Parvin JD,McCormick RJ,Sharp PA,Fisher DE

更新日期：1995-02-23 00:00:00

abstract：:Repetitive activation of excitatory synapses in the central nervous system results in a long-lasting increase in synaptic transmission called long-term potentiation (LTP). It is generally believed that this synaptic plasticity may underlie certain forms of learning and memory. LTP at most synapses involves the activat...

journal_title：Nature

authors： Castillo PE,Janz R,Südhof TC,Tzounopoulos T,Malenka RC,Nicoll RA

更新日期：1997-08-07 00:00:00

abstract：:One of the most debated questions in evolutionary biology is whether female choice of males with exaggerated sexual displays can evolve as a correlated response to selection acting on genes coding for male attractiveness or high overall viability. To date, empirical studies have provided support for parts of this scen...

journal_title：Nature

authors： Qvarnström A,Brommer JE,Gustafsson L

更新日期：2006-05-04 00:00:00

abstract：:Mecsas and colleagues suggest that a deficiency in the chemokine receptor CCR5 in humans is unlikely to confer protection against plague, based on their study of Yersinia pestis infection in Ccr5-deficient mice. They were testing the hypothesis that a mutation in the CCR5 gene, frequently found in Caucasians, may have...

journal_title：Nature

authors： Elvin SJ,Williamson ED,Scott JC,Smith JN,Pérez De Lema G,Chilla S,Clapham P,Pfeffer K,Schlöndorff D,Luckow B

更新日期：2004-07-22 00:00:00

abstract：: ...

journal_title：Nature

authors： Zunger A

更新日期：2019-02-01 00:00:00

abstract：:Activation of many T-cell functions depends on their interaction with antigen-presenting accessory cells which express I region associated (Ia) products. Cells expressing accessory cell function include those of the monocyte/macrophage lineage and dendritic cells. More recently, B cells and a number of tumour cell lin...

journal_title：Nature

authors： Ramila G,Erb P

更新日期：1983-08-04 00:00:00

abstract：:On being heated, ice melts into liquid water. Although in practice this process tends to be heterogeneous, it can occur homogeneously inside bulk ice. The thermally induced homogeneous melting of solids is fairly well understood, and involves the formation and growth of melting nuclei. But in the case of water, resili...

journal_title：Nature

authors： Mochizuki K,Matsumoto M,Ohmine I

更新日期：2013-06-20 00:00:00

abstract：:The rarity and inaccessibility of the earliest primordial germ cells (PGCs) in the mouse embryo thwart efforts to investigate molecular mechanisms of germ-cell specification. stella (also called Dppa3) marks the rare founder population of the germ lineage. Here we differentiate mouse embryonic stem cells carrying a st...

journal_title：Nature

authors： West JA,Viswanathan SR,Yabuuchi A,Cunniff K,Takeuchi A,Park IH,Sero JE,Zhu H,Perez-Atayde A,Frazier AL,Surani MA,Daley GQ

更新日期：2009-08-13 00:00:00

abstract：:Visual working memory provides an essential link between perception and higher cognitive functions, allowing for the active maintenance of information about stimuli no longer in view. Research suggests that sustained activity in higher-order prefrontal, parietal, inferotemporal and lateral occipital areas supports vis...

journal_title：Nature

authors： Harrison SA,Tong F

更新日期：2009-04-02 00:00:00

abstract：:The establishment and maintenance of epigenetic gene silencing is fundamental to cell determination and function. The essential epigenetic systems involved in heritable repression of gene activity are the Polycomb group (PcG) proteins and the DNA methylation systems. Here we show that the corresponding silencing pathw...

journal_title：Nature

authors： Viré E,Brenner C,Deplus R,Blanchon L,Fraga M,Didelot C,Morey L,Van Eynde A,Bernard D,Vanderwinden JM,Bollen M,Esteller M,Di Croce L,de Launoit Y,Fuks F

更新日期：2006-02-16 00:00:00

abstract：:5-hydroxytryptamine type 3 (5-HT3) receptors are members of the Cys-loop receptor superfamily. Neurotransmitter binding in these proteins triggers the opening (gating) of an ion channel by means of an as-yet-uncharacterized conformational change. Here we show that a specific proline (Pro 8*), located at the apex of th...

journal_title：Nature

authors： Lummis SC,Beene DL,Lee LW,Lester HA,Broadhurst RW,Dougherty DA

更新日期：2005-11-10 00:00:00

abstract：:An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Momcilovic M,Jones A,Bailey ST,Waldmann CM,Li R,Lee JT,Abdelhady G,Gomez A,Holloway T,Schmid E,Stout D,Fishbein MC,Stiles L,Dabir DV,Dubinett SM,Christofk H,Shirihai O,Koehler CM,Sadeghi S,Shackelford DB

更新日期：2020-01-01 00:00:00