Abstract:
:Serious, and occasionally fatal, anaphylactic-like (anaphylactoid) reactions may occur when a patient is exposed to a drug for the first time. Apart from the penicillins, nothing is known of the nature of antigenic or sensitizing drug determinants and, as yet, there is no evidence for the involvement of IgE antibodies in most drug reactions. Muscle relaxants such as alcuronium have been implicated in many life-threatening anaphylactoid reactions but the mechanisms remain unclear. We have now investigated the possibility that drug-specific IgE antibodies are involved by using an alcuronium-carrier complex in a radioimmunoassay with patients' sera. Alcuronium-reactive antibodies were found in five drug-sensitive subjects and most of the antibodies cross-reacted with other muscle relaxants and with a variety of apparently structurally unrelated drugs. Structure-activity studies designed to explore the molecular basis of the antibody binding established that quaternary and tertiary ammonium ions were the complementary allergenic sites on the reactive drugs. These structures occur widely in many drugs but also in foods, cosmetics, disinfectants and industrial materials. Hence, there would seem to be ample opportunity for sensitive individuals to come into contact with and synthesize IgE antibodies to these unusual, and previously unsuspected, antigenic determinants.
journal_name
Naturejournal_title
Natureauthors
Baldo BA,Fisher MMdoi
10.1038/306262a0subject
Has Abstractpub_date
1983-11-17 00:00:00pages
262-4issue
5940eissn
0028-0836issn
1476-4687journal_volume
306pub_type
杂志文章相关文献
NATURE文献大全abstract::The increasing ability to control light-matter interactions at the nanometre scale has improved the performance of semiconductor lasers in the past decade. The ultimate optimization is realized in semiconductor microcavities, in which strong coupling between quantum-well excitons and cavity photons gives rise to hybri...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06979
更新日期:2008-05-15 00:00:00
abstract::The imaginal discs of Drosophila, which give rise to the adult appendages, are patterned during a period of intense cell proliferation. The specification of differing regions occurs in some cases by subdividing the disc epithelium into lineage compartments. However, in most cases precise boundaries are formed between ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/384072a0
更新日期:1996-11-07 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,信件
doi:10.1038/d41586-019-00232-8
更新日期:2019-01-01 00:00:00
abstract::To understand the complex physics of a system with strong electron-electron interactions, the ideal is to control and monitor its properties while tuning an external electric field applied to the system (the electric-field effect). Indeed, complete electric-field control of many-body states in strongly correlated elec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16175
更新日期:2016-01-14 00:00:00
abstract::Regulated fusion of secretory granules with the plasma membrane in secretory cells requires ATP, Ca2+ and cytosolic as well as membrane proteins. ATP-dependent steps in Ca(2+)-activated secretion from PC12 cells require three cytosolic PEP proteins (priming in exocytosis proteins, PEP1-3), the identity of which will p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/374173a0
更新日期:1995-03-09 00:00:00
abstract::Pairs of asteroids sharing similar heliocentric orbits, but not bound together, were found recently. Backward integrations of their orbits indicated that they separated gently with low relative velocities, but did not provide additional insight into their formation mechanism. A previously hypothesized rotational fissi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09315
更新日期:2010-08-26 00:00:00
abstract::Mitochondrial genomes (mitochondrial DNA, mtDNA) encode essential oxidative phosphorylation (OXPHOS) components. Because hundreds of mtDNAs exist per cell, a deletion in a single mtDNA has little impact. However, if the deletion genome is enriched, OXPHOS declines, resulting in cellular dysfunction. For example, Kearn...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17989
更新日期:2016-05-19 00:00:00
abstract::The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory1,2. Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-se...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1917-5
更新日期:2020-01-01 00:00:00
abstract::Inorganic nanoparticles exhibit size-dependent properties that are of interest for applications ranging from biosensing and catalysis to optics and data storage. They are readily available in a wide variety of discrete compositions and sizes. Shape-selective synthesis strategies now also yield shapes other than nanosp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02020
更新日期:2003-10-02 00:00:00
abstract::Statistical evidence of reduced coronary heart disease in areas of high wine consumption has led to the widespread belief that wine affords a protective effect. Although moderate drinking of any alcohol helps to reduce the incidence of coronary heart disease, there is no clear evidence that red wine confers an additio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/414863a
更新日期:2001-12-20 00:00:00
abstract::China is the world's most populous country and a major emitter of greenhouse gases. Consequently, much research has focused on China's influence on climate change but somewhat less has been written about the impact of climate change on China. China experienced explosive economic growth in recent decades, but with only...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09364
更新日期:2010-09-02 00:00:00
abstract::An inhomogeneous superconducting state, not yet conclusively identified, was predicted by Fulde and Ferrell and Larkin and Ovchinnikov (FFLO) to arise in superconductors with strong Pauli limiting, a consequence of the electrons' Zeeman (spin) energy in a magnetic field. Radovan et al. propose that the observed cascad...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/427802a
更新日期:2004-02-26 00:00:00
abstract::Complex-oxide materials exhibit a vast range of functional properties desirable for next-generation electronic, spintronic, magnetoelectric, neuromorphic, and energy conversion storage devices1-4. Their physical functionalities can be coupled by stacking layers of such materials to create heterostructures and can be f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-1939-z
更新日期:2020-02-01 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-019-00676-y
更新日期:2019-02-01 00:00:00
abstract::In 1928, Dirac published an equation 1 that combined quantum mechanics and special relativity. Negative-energy solutions to this equation, rather than being unphysical as initially thought, represented a class of hitherto unobserved and unimagined particles-antimatter. The existence of particles of antimatter was conf...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0017-2
更新日期:2018-05-01 00:00:00
abstract::Vaccines against a variety of infectious diseases represent one of the great triumphs of medicine. The immune correlates of protection induced by most current vaccines seem to be mediated by long-lived humoral immune responses. By contrast, there are no currently available vaccines that are uniformly effective for dis...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35021239
更新日期:2000-08-17 00:00:00
abstract::The alpha-like and beta-like globin genes have provided a paradigm for the study of molecular evolution and regulation of multigene families in eukaryotes. The human alpha-globin gene cluster, which is on chromosome 16 (ref. 1), consists of six genes arranged in the order 5'-zeta(embryonic)-psi zeta-psi alpha 2-psi al...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/321785a0
更新日期:1986-06-19 00:00:00
abstract::Low-resolution intensity spectra of Earth's atmosphere obtained from space reveal strong signatures of life ('biosignatures'), such as molecular oxygen and methane with abundances far from chemical equilibrium, as well as the presence of a 'red edge' (a sharp increase of albedo for wavelengths longer than 700 nm) caus...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10778
更新日期:2012-02-29 00:00:00
abstract::The brain cholecystokinin-B/gastrin receptor (CCK-B/gastrin) has been implicated in mediating anxiety, panic attacks, satiety, and the perception of pain. The canine and human CCK-B/gastrin receptors share 90% amino-acid identity and have similar agonist affinities. These receptors can be selectively blocked by the no...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/362348a0
更新日期:1993-03-25 00:00:00
abstract::If not properly processed and repaired, DNA double-strand breaks (DSBs) can give rise to deleterious chromosome rearrangements, which could ultimately lead to the tumour phenotype. DSB ends are resected in a 5' to 3' fashion in cells, to yield single-stranded DNA (ssDNA) for the recruitment of factors critical for DNA...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09318
更新日期:2010-09-02 00:00:00
abstract::Carbon exchange between the terrestrial biosphere and the atmosphere is one of the key processes that need to be assessed in the context of the Kyoto Protocol. Several studies suggest that the terrestrial biosphere is gaining carbon, but these estimates are obtained primarily by indirect methods, and the factors that ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35009084
更新日期:2000-04-20 00:00:00
abstract::Nuclear magic numbers correspond to fully occupied energy shells of protons or neutrons inside atomic nuclei. Doubly magic nuclei, with magic numbers for both protons and neutrons, are spherical and extremely rare across the nuclear landscape. Although the sequence of magic numbers is well established for stable nucle...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1155-x
更新日期:2019-05-01 00:00:00
abstract::Bird songs frequently contain trilling sounds that demand extremely fast vocalization control. Here we show that doves control their syrinx, a vocal organ that is unique to birds, by using superfast muscles. These muscles, which are similar to those that operate highly specialist acoustic organs such as the rattle of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/431146a
更新日期:2004-09-09 00:00:00
abstract::The mushroom bodies in the protocerebrum are believed to be the structures of the insect brain most closely associated with higher-order sensory integration and learning. Drosophila melanogaster mutants with olfactory learning deficits have anatomically abnormal mushroom bodies or altered patterns of gene expression i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/364238a0
更新日期:1993-07-15 00:00:00
abstract::Lignin is a complex polymer of phenylpropanoid subunits. It is an essential component of woody tissue, to which it imparts structural rigidity. Lignin is remarkably resistant to degradation by most microbes; nevertheless, a few species of white-rot fungi are able to catalyse its oxidation to CO2. Its biodegradation is...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326520a0
更新日期:1987-04-02 00:00:00
abstract::Muscarinic receptors of cardiac pacemaker and atrial cells are linked to a potassium channel (IK.ACh) by a pertussis toxin-sensitive GTP-binding protein. The dissociation of G-proteins leads to the generation of two potential transducing elements, alpha-GTP and beta gamma. IK.ACh is activated by G-protein alpha- and b...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/337557a0
更新日期:1989-02-09 00:00:00
abstract::Excitatory synaptic transmission in the central nervous system is mediated primarily by the release of glutamate from presynaptic terminals onto postsynaptic channels gated by N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors. The myriad intracellular responses arisi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/39062
更新日期:1997-10-02 00:00:00
abstract::Ultra-compact dwarf galaxies are among the densest stellar systems in the Universe. These systems have masses of up to 2 × 10(8) solar masses, but half-light radii of just 3-50 parsecs. Dynamical mass estimates show that many such dwarfs are more massive than expected from their luminosity. It remains unclear whether ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13762
更新日期:2014-09-18 00:00:00
abstract::The chemical evolution of the Earth and the terrestrial planets is largely controlled by the density of silicate melts. If melt density is higher than that of the surrounding solid, incompatible elements dissolved in the melt will be sequestered in the deep mantle. Previous studies on dry (water-free) melts showed tha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04241
更新日期:2005-11-24 00:00:00
abstract::The T-cell receptor is a cell surface heterodimer consisting of an alpha and a beta chain that binds foreign antigen in the context of a cell surface molecule encoded by the major histocompatibility complex (MHC), thus restricting the T-cell response to the surface of antigen presenting cells. The variable (V) domain ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/324679a0
更新日期:1986-12-18 00:00:00