A brain-spine interface alleviating gait deficits after spinal cord injury in primates.

abstract：:It has been established that many eukaryotic mRNAs contain poly(adenylic acid) tracts at their 3'-termini. The polyadenylation of mRNA occurs post-transcriptionally in the nucleus as a rapid, initial addition of 100-200 adenylate residues to the pre-mRNA (ref. 1). Subsequently, a slower chain extension (6-8 bases) of ...

journal_title：Nature

authors： Rose KM,Bell LE,Jacob ST

更新日期：1977-05-12 00:00:00

abstract：:The identification of properties that contribute to the persistence and resilience of ecosystems despite climate change constitutes a research priority of global relevance. Here we present a novel, empirical approach to assess the relative sensitivity of ecosystems to climate variability, one property of resilience th...

journal_title：Nature

authors： Seddon AW,Macias-Fauria M,Long PR,Benz D,Willis KJ

更新日期：2016-03-10 00:00:00

abstract：:Five new double-mutant haemoglobins composed of betaS chains and alpha chains with different substitutions, which are located at the surface of the tetramer, have been prepared. Although all the hybrids are more soluble than deoxyhaemoglobin S, the individual differences between these molecules make it possible to eva...

journal_title：Nature

authors： Benesch RE,Yung S,Benesch R,Mack J,Schneider RG

更新日期：1976-03-18 00:00:00

abstract：:C-type (Ca(2+)-dependent) animal lectins such as mannose-binding proteins mediate many cell-surface carbohydrate-recognition events. The crystal structure at 1.7 A resolution of the carbohydrate-recognition domain of rat mannose-binding protein complexed with an oligomannose asparaginyl-oligosaccharide reveals that Ca...

journal_title：Nature

authors： Weis WI,Drickamer K,Hendrickson WA

更新日期：1992-11-12 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, is characterized by elevated glycogen levels and fat deposition. These consistent metabolic alterations are associated with normoxic stabilization of hypoxia-inducible factors (HIFs) secondary to von Hippel-Lindau (VHL) mutations that occu...

journal_title：Nature

authors： Li B,Qiu B,Lee DS,Walton ZE,Ochocki JD,Mathew LK,Mancuso A,Gade TP,Keith B,Nissim I,Simon MC

更新日期：2014-09-11 00:00:00

abstract：:Patterning matter on the nanometre scale is an important objective of current materials chemistry and physics. It is driven by both the need to further miniaturize electronic components and the fact that at the nanometre scale, materials properties are strongly size-dependent and thus can be tuned sensitively. In nano...

journal_title：Nature

authors： Alivisatos AP,Johnsson KP,Peng X,Wilson TE,Loweth CJ,Bruchez MP Jr,Schultz PG

更新日期：1996-08-15 00:00:00

abstract：:DNA lesions interfere with DNA and RNA polymerase activity. Cyclobutane pyrimidine dimers and photoproducts generated by ultraviolet irradiation cause stalling of RNA polymerase II, activation of transcription-coupled repair enzymes, and inhibition of RNA synthesis. During the S phase of the cell cycle, collision of r...

journal_title：Nature

authors： Kruhlak M,Crouch EE,Orlov M,Montaño C,Gorski SA,Nussenzweig A,Misteli T,Phair RD,Casellas R

更新日期：2007-06-07 00:00:00

abstract：:During wild-type development, a protein product of the Caenorhabditis elegans heterochronic gene lin-14 is localized to nuclei of specific somatic cells in embryos and early larvae, but is absent in late larvae and adult soma. Gain-of-function lin-14 mutations cause the level of lin-14 protein to remain high throughou...

journal_title：Nature

authors： Ruvkun G,Giusto J

更新日期：1989-03-23 00:00:00

abstract：:The protein HLA-E is a non-classical major histocompatibility complex (MHC) molecule of limited sequence variability. Its expression on the cell surface is regulated by the binding of peptides derived from the signal sequence of some other MHC class I molecules. Here we report the identification of ligands for HLA-E. ...

journal_title：Nature

authors： Braud VM,Allan DS,O'Callaghan CA,Söderström K,D'Andrea A,Ogg GS,Lazetic S,Young NT,Bell JI,Phillips JH,Lanier LL,McMichael AJ

更新日期：1998-02-19 00:00:00

abstract：:The 30S ribosomal subunit binds messenger RNA and the anticodon stem-loop of transfer RNA during protein synthesis. A crystallographic analysis of the structure of the subunit from the bacterium Thermus thermophilus is presented. At a resolution of 5.5 A, the phosphate backbone of the ribosomal RNA is visible, as are ...

journal_title：Nature

authors： Clemons WM Jr,May JL,Wimberly BT,McCutcheon JP,Capel MS,Ramakrishnan V

更新日期：1999-08-26 00:00:00

abstract：:The Rho-family GTPase, Cdc42, can regulate the actin cytoskeleton through activation of Wiskott-Aldrich syndrome protein (WASP) family members. Activation relieves an autoinhibitory contact between the GTPase-binding domain and the carboxy-terminal region of WASP proteins. Here we report the autoinhibited structure of...

journal_title：Nature

authors： Kim AS,Kakalis LT,Abdul-Manan N,Liu GA,Rosen MK

更新日期：2000-03-09 00:00:00

abstract：:The recently emerged fields of metamaterials and transformation optics promise a family of exciting applications such as invisibility, optical imaging with deeply subwavelength resolution and nanophotonics with the potential for much faster information processing. The possibility of creating optical negative-index met...

journal_title：Nature

authors： Xiao S,Drachev VP,Kildishev AV,Ni X,Chettiar UK,Yuan HK,Shalaev VM

更新日期：2010-08-05 00:00:00

abstract：:Cell competition-the sensing and elimination of less fit 'loser' cells by neighbouring 'winner' cells-was first described in Drosophila. Although cell competition has been proposed as a selection mechanism to optimize tissue and organ development, its evolutionary generality remains unclear. Here, by using live imagin...

journal_title：Nature

authors： Ellis SJ,Gomez NC,Levorse J,Mertz AF,Ge Y,Fuchs E

更新日期：2019-05-01 00:00:00

abstract：:In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome stability and prevents aneuploidy. Kinetochores are large protein complexes that, by assembling onto specialized Cenp-A nucleosomes1,2, function to connect centromeric chromatin to microtubules of the mitotic spindle3,4. Whereas the...

journal_title：Nature

authors： Yan K,Yang J,Zhang Z,McLaughlin SH,Chang L,Fasci D,Ehrenhofer-Murray AE,Heck AJR,Barford D

更新日期：2019-10-01 00:00:00

abstract：:We are in the enviable position of having two distinct drafts of the human genome sequence. Although gaps, errors, redundancy and incomplete annotation mean that individually each falls short of the ideal, many of these problems can be assessed by comparison. Here we present some comparative analyses of these drafts. ...

journal_title：Nature

authors： Aach J,Bulyk ML,Church GM,Comander J,Derti A,Shendure J

更新日期：2001-02-15 00:00:00

abstract：:Many marine invertebrates and fish respond to hydrostatic pressure in order to regulate their depth and synchronize their behaviour to tidal cycles. Here we investigate the effect of hydrostatic pressure on the vestibular hair cells located in the labyrinth of the dogfish Scyliorhinus canicula, and find that it modula...

journal_title：Nature

authors： Fraser PJ,Shelmerdine RL

更新日期：2002-01-31 00:00:00

abstract：:Since the first aeroplane flight more than 100 years ago, aeroplanes have been propelled using moving surfaces such as propellers and turbines. Most have been powered by fossil-fuel combustion. Electroaerodynamics, in which electrical forces accelerate ions in a fluid1,2, has been proposed as an alternative method of ...

journal_title：Nature

authors： Xu H,He Y,Strobel KL,Gilmore CK,Kelley SP,Hennick CC,Sebastian T,Woolston MR,Perreault DJ,Barrett SRH

更新日期：2018-11-01 00:00:00

abstract：:When we see motion, our perception of how one image feature moves depends on the behaviour of other features nearby. In particular, the Gestaltists proposed the law of shared common fate, in which features tend to be perceived as moving together, that is, coherently. Recent psychophysical findings, such as the coopera...

journal_title：Nature

authors： Yuille AL,Grzywacz NM

更新日期：1988-05-05 00:00:00

abstract：:Where continental plates break apart, slip along multiple normal faults provides the required space for the Earth's crust to thin and subside. After initial rifting, however, the displacement on normal faults observed at the sea floor seems not to match the inferred extension. Here we show that crustal thinning can be...

journal_title：Nature

authors： Lavier LL,Manatschal G

更新日期：2006-03-16 00:00:00

abstract：:The tumour necrosis factor (TNF) ligand TALL-1 and its cognate receptors, BCMA, TACI and BAFF-R, were recently identified as members of the TNF superfamily, which are essential factors contributing to B-cell maturation. The functional, soluble fragment of TALL-1 (sTALL-1) forms a virus-like assembly for its proper fun...

journal_title：Nature

authors： Liu Y,Hong X,Kappler J,Jiang L,Zhang R,Xu L,Pan CH,Martin WE,Murphy RC,Shu HB,Dai S,Zhang G

更新日期：2003-05-01 00:00:00

abstract：:Osmotic pressures are generated by differences in chemical potential of a solution across a membrane. But whether osmosis can have a significant effect on the pressure of fluids in geological environments has been controversial, because the membrane properties of geological media are poorly understood. 'Anomalous' pre...

journal_title：Nature

authors： Neuzil CE

更新日期：2000-01-13 00:00:00

abstract：:Oligonucleotide and complementary DNA microarrays are being used to subclassify histologically similar tumours, monitor disease progress, and individualize treatment regimens. However, extracting new biological insight from high-throughput genomic studies of human diseases is a challenge, limited by difficulties in re...

journal_title：Nature

authors： Calvano SE,Xiao W,Richards DR,Felciano RM,Baker HV,Cho RJ,Chen RO,Brownstein BH,Cobb JP,Tschoeke SK,Miller-Graziano C,Moldawer LL,Mindrinos MN,Davis RW,Tompkins RG,Lowry SF,Inflamm and Host Response to Injury Large Scale

更新日期：2005-10-13 00:00:00

abstract：:Estimates of the effect of increasing atmospheric CO2 concentrations on future global plant production rely on the physiological response of individual plants or plant communities when exposed to high CO2 (refs 1-6). Plant populations may adapt to the changing atmosphere, however, such that the evolved plant communiti...

journal_title：Nature

authors： Collins S,Bell G

更新日期：2004-09-30 00:00:00

abstract：:The dispersal of early humans from Africa by 1.75 Myr ago led to a marked expansion of their range, from the island of Flores in the east to the Iberian peninsula in the west. This range encompassed tropical forest, savannah and Mediterranean habitats, but has hitherto not been demonstrated beyond 45 degrees N. Until ...

journal_title：Nature

authors： Parfitt SA,Ashton NM,Lewis SG,Abel RL,Coope GR,Field MH,Gale R,Hoare PG,Larkin NR,Lewis MD,Karloukovski V,Maher BA,Peglar SM,Preece RC,Whittaker JE,Stringer CB

更新日期：2010-07-08 00:00:00

abstract：:Hen egg-white lysozyme (HEWL) was the first enzyme to have its three-dimensional structure determined by X-ray diffraction techniques. A catalytic mechanism, featuring a long-lived oxocarbenium-ion intermediate, was proposed on the basis of model-building studies. The 'Phillips' mechanism is widely held as the paradig...

journal_title：Nature

authors： Vocadlo DJ,Davies GJ,Laine R,Withers SG

更新日期：2001-08-23 00:00:00

abstract：:For the past couple of centuries the penchant for prediction has been prevalent at century turns. How much have evaluations of scientific discovery and predictions for future advancement changed since those of the science commentators at the end of the last century? ...

journal_title：Nature

authors： Heilbron JL,Bynum WF

更新日期：1999-12-02 00:00:00

abstract：:The 3-dimethylsulphoniopropionate (DMSP) produced by marine algae is the main biogenic precursor of atmospheric dimethylsulphide (DMS). This biogenic DMS, formed by bacterial and algal degradation of DMSP, contributes about 1.5 x 10(13) g of sulphur to the atmosphere annually, and plays a major part in the global sulp...

journal_title：Nature

authors： Gage DA,Rhodes D,Nolte KD,Hicks WA,Leustek T,Cooper AJ,Hanson AD

更新日期：1997-06-26 00:00:00

abstract：:During fertilization, an egg and a sperm fuse to form a new embryo. Eggs develop from oocytes in a process called meiosis. Meiosis in human oocytes is highly error-prone, and defective eggs are the leading cause of pregnancy loss and several genetic disorders such as Down's syndrome. Which genes safeguard accurate pro...

journal_title：Nature

authors： Pfender S,Kuznetsov V,Pasternak M,Tischer T,Santhanam B,Schuh M

更新日期：2015-08-13 00:00:00

abstract：:Double-walled carbon nanotubes are needed in a pure, highly crystalline form before features such as their electronic properties, thermal transport and mechanical behaviour can be investigated. Here we fabricate a paper-like material that consists of hexagonally packed bundles of clean, coaxial carbon nanotubes whose ...

journal_title：Nature

authors： Endo M,Muramatsu H,Hayashi T,Kim YA,Terrones M,Dresselhaus MS

更新日期：2005-02-03 00:00:00

abstract：:Networks of interacting proteins orchestrate the responses of living cells to a variety of external stimuli, but how sensitive is the functioning of these protein networks to variations in their biochemical parameters? One possibility is that to achieve appropriate function, the reaction rate constants and enzyme conc...

journal_title：Nature

authors： Alon U,Surette MG,Barkai N,Leibler S

更新日期：1999-01-14 00:00:00