Greenland supraglacial lake drainages triggered by hydrologically induced basal slip.

abstract：:The Southern Ocean is very important for the potential sequestration of carbon dioxide in the oceans and is expected to be vulnerable to changes in carbon export forced by anthropogenic climate warming. Annual phytoplankton blooms in seasonal ice zones are highly productive and are thought to contribute significantly ...

journal_title：Nature

authors： DiTullio GR,Grebmeier JM,Arrigo KR,Lizotte MP,Robinson DH,Leventer A,Barry JP,VanWoert ML,Dunbar RB

更新日期：2000-04-06 00:00:00

abstract：:An unusual feature of the cerebellar cortex is that its output neurons, Purkinje cells, release GABA (γ-aminobutyric acid). Their high intrinsic firing rates (50 Hz) and extensive convergence predict that their target neurons in the cerebellar nuclei would be largely inhibited unless Purkinje cells pause their spiking...

journal_title：Nature

authors： Person AL,Raman IM

更新日期：2011-12-25 00:00:00

abstract：:Interleukin (IL)-2 is a pleiotropic cytokine that is necessary to prevent chronic inflammation in the gastrointestinal tract1-4. The protective effects of IL-2 involve the generation, maintenance and function of regulatory T (Treg) cells4-8, and the use of low doses of IL-2 has emerged as a potential therapeutic strat...

journal_title：Nature

authors： Zhou L,Chu C,Teng F,Bessman NJ,Goc J,Santosa EK,Putzel GG,Kabata H,Kelsen JR,Baldassano RN,Shah MA,Sockolow RE,Vivier E,Eberl G,Smith KA,Sonnenberg GF

更新日期：2019-04-01 00:00:00

abstract：:Angiosperms developed floral nectaries that reward pollinating insects. Although nectar function and composition have been characterized, the mechanism of nectar secretion has remained unclear. Here we identify SWEET9 as a nectary-specific sugar transporter in three eudicot species: Arabidopsis thaliana, Brassica rapa...

journal_title：Nature

authors： Lin IW,Sosso D,Chen LQ,Gase K,Kim SG,Kessler D,Klinkenberg PM,Gorder MK,Hou BH,Qu XQ,Carter CJ,Baldwin IT,Frommer WB

更新日期：2014-04-24 00:00:00

abstract：:RNAs that contain specific high-affinity binding sites for small molecule ligands immobilized on a solid support are present at a frequency of roughly one in 10(10)-10(11) in pools of random sequence RNA molecules. Here we describe a new in vitro selection procedure designed to ensure the isolation of RNAs that bind t...

journal_title：Nature

authors： Sassanfar M,Szostak JW

更新日期：1993-08-05 00:00:00

abstract：:Our current understanding of immunology was largely defined in laboratory mice, partly because they are inbred and genetically homogeneous, can be genetically manipulated, allow kinetic tissue analyses to be carried out from the onset of disease, and permit the use of tractable disease models. Comparably reductionist ...

journal_title：Nature

authors： Beura LK,Hamilton SE,Bi K,Schenkel JM,Odumade OA,Casey KA,Thompson EA,Fraser KA,Rosato PC,Filali-Mouhim A,Sekaly RP,Jenkins MK,Vezys V,Haining WN,Jameson SC,Masopust D

更新日期：2016-04-28 00:00:00

abstract：:From drug delivery to chemical and biological catalysis and cosmetics, the need for efficient fabrication pathways for particles over a wide range of sizes, from a variety of materials, and in many different structures has been well established. Here we harness the inherent scalability of fibre production and an in-fi...

journal_title：Nature

authors： Kaufman JJ,Tao G,Shabahang S,Banaei EH,Deng DS,Liang X,Johnson SG,Fink Y,Abouraddy AF

更新日期：2012-07-26 00:00:00

abstract：:It has been established that many eukaryotic mRNAs contain poly(adenylic acid) tracts at their 3'-termini. The polyadenylation of mRNA occurs post-transcriptionally in the nucleus as a rapid, initial addition of 100-200 adenylate residues to the pre-mRNA (ref. 1). Subsequently, a slower chain extension (6-8 bases) of ...

journal_title：Nature

authors： Rose KM,Bell LE,Jacob ST

更新日期：1977-05-12 00:00:00

abstract：:Interleukin-5 (IL-5) specifically induces the differentiation of eosinophils, which are important in host defence and the pathogenesis of allergies and asthma. Structurally, IL-5 is a unique member of the short-chain helical-bundle subfamily of cytokines whose canonical motif contains four helices (A-D) arranged in an...

journal_title：Nature

authors： Dickason RR,Huston DP

更新日期：1996-02-15 00:00:00

abstract：:Water has many kinetic and thermodynamic properties that exhibit an anomalous dependence on temperature, in particular in the supercooled phase. These anomalies have long been interpreted in terms of underlying structural causes, and their experimental characterization points to the existence of a singularity at a tem...

journal_title：Nature

authors： Torre R,Bartolini P,Righini R

更新日期：2004-03-18 00:00:00

abstract：:Since the early 1980s, most electronics have relied on the use of complementary metal-oxide-semiconductor (CMOS) transistors. However, the principles of CMOS operation, involving a switchable semiconductor conductance controlled by an insulating gate, have remained largely unchanged, even as transistors are miniaturiz...

journal_title：Nature

authors： Manipatruni S,Nikonov DE,Lin CC,Gosavi TA,Liu H,Prasad B,Huang YL,Bonturim E,Ramesh R,Young IA

更新日期：2019-01-01 00:00:00

abstract：:Q beta replicase, in the absence of added template, will synthesize RNA autocatalytically. A variety of small RNa species, termed '6S RNAs' are generated. As this reaction purportedly occurs in the absence of template, it has been termed 'de novo' RNA synthesis. The question of whether Q beta replicase can polymerize ...

journal_title：Nature

authors： Hill D,Blumenthal T

更新日期：1983-01-27 00:00:00

abstract：:The formation and guidance of specialized endothelial tip cells is essential for both developmental and pathological angiogenesis. Notch-1 signalling regulates the generation of tip cells, which respond to gradients of vascular endothelial growth factor (VEGF-A). The molecular cues and signalling pathways that control...

journal_title：Nature

authors： Sawamiphak S,Seidel S,Essmann CL,Wilkinson GA,Pitulescu ME,Acker T,Acker-Palmer A

更新日期：2010-05-27 00:00:00

abstract：:(Na+ + K+)ATPase contains two different subunits, a catalytic subunit (alpha) and a subunit with uncertain function (beta). The enzyme binds ATP, ouabain and vanadate, and can be phosphorylated by ATP as well as by inorganic phosphate. From the previously reported maximal binding and phosphorylation capacities of 3.5-...

journal_title：Nature

authors： Peters WH,Swarts HG,de Pont JJ,Schuurmans Stekhoven FM,Bonting SL

更新日期：1981-03-26 00:00:00

abstract：:The theory of quantum electrodynamics (QED) predicts that beta decay of the neutron into a proton, electron and antineutrino should be accompanied by a continuous spectrum of soft photons. While this inner bremsstrahlung branch has been previously measured in nuclear beta and electron capture decay, it has never been ...

journal_title：Nature

authors： Nico JS,Dewey MS,Gentile TR,Mumm HP,Thompson AK,Fisher BM,Kremsky I,Wietfeldt FE,Chupp TE,Cooper RL,Beise EJ,Kiriluk KG,Byrne J,Coakley KJ

更新日期：2006-12-21 00:00:00

abstract：:It is possible to infer aspects of an organism's lifestyle from its gene content. Can the reverse also be done? Here we consider this issue by modelling evolution of the reduced genomes of endosymbiotic bacteria. The diversity of gene content in these bacteria may reflect both variation in selective forces and conting...

journal_title：Nature

authors： Pál C,Papp B,Lercher MJ,Csermely P,Oliver SG,Hurst LD

更新日期：2006-03-30 00:00:00

abstract：:Numerous studies have suggested that biodiversity reduces variability in ecosystem productivity through compensatory effects; that is, a species increases in its abundance in response to the reduction of another in a fluctuating environment. But this view has been challenged on several grounds. Because most studies ha...

journal_title：Nature

authors： Bai Y,Han X,Wu J,Chen Z,Li L

更新日期：2004-09-09 00:00:00

abstract：:The heterotrimeric G proteins mediate a variety of cellular processes by coupling transmembrane receptors to different effector molecules, including adenylyl cyclases and inositol-phospholipid-specific phospholipase C (PLC)1-3. Activation of adenylyl cyclases results in the production of cyclic AMP and activation of c...

journal_title：Nature

authors： Liu M,Simon MI

更新日期：1996-07-04 00:00:00

abstract：:The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear translocation and TCF/LEF-dependent gene transactivation. Mutations in ...

journal_title：Nature

authors： Yan KS,Janda CY,Chang J,Zheng GXY,Larkin KA,Luca VC,Chia LA,Mah AT,Han A,Terry JM,Ootani A,Roelf K,Lee M,Yuan J,Li X,Bolen CR,Wilhelmy J,Davies PS,Ueno H,von Furstenberg RJ,Belgrader P,Ziraldo SB,Ordonez H,H

更新日期：2017-05-11 00:00:00

abstract：:The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiolo...

journal_title：Nature

authors： Karsenty G,Ferron M

更新日期：2012-01-18 00:00:00

abstract：:The study of language origin and divergence is important for understanding the history of human populations and their cultures. The Sino-Tibetan language family is the second largest in the world after Indo-European, and there is a long-running debate about its phylogeny and the time depth of its original divergence1....

journal_title：Nature

authors： Zhang M,Yan S,Pan W,Jin L

更新日期：2019-05-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Gewin V

更新日期：2018-10-01 00:00:00

abstract：:The four R-spondin secreted ligands (RSPO1-RSPO4) act via their cognate LGR4, LGR5 and LGR6 receptors to amplify WNT signalling1-3. Here we report an allelic series of recessive RSPO2 mutations in humans that cause tetra-amelia syndrome, which is characterized by lung aplasia and a total absence of the four limbs. Fun...

journal_title：Nature

authors： Szenker-Ravi E,Altunoglu U,Leushacke M,Bosso-Lefèvre C,Khatoo M,Thi Tran H,Naert T,Noelanders R,Hajamohideen A,Beneteau C,de Sousa SB,Karaman B,Latypova X,Başaran S,Yücel EB,Tan TT,Vlaminck L,Nayak SS,Shukla A,Giris

更新日期：2018-05-01 00:00:00

abstract：:The cyanobacterium Prochlorococcus is the dominant oxygenic phototroph in the tropical and subtropical regions of the world's oceans. It can grow at a range of depths over which light intensities can vary by up to 4 orders of magnitude. This broad depth distribution has been hypothesized to stem from the coexistence o...

journal_title：Nature

authors： Moore LR,Rocap G,Chisholm SW

更新日期：1998-06-04 00:00:00

abstract：:Protoplanetary disks are known to possess a variety of substructures in the distribution of their millimetre-sized grains, predominantly seen as rings and gaps1, which are frequently interpreted as arising from the shepherding of large grains by either hidden, still-forming planets within the disk2 or (magneto-)hydrod...

journal_title：Nature

authors： Teague R,Bae J,Bergin EA

更新日期：2019-10-01 00:00:00

abstract：:Breast cancer patients with the same stage of disease can have markedly different treatment responses and overall outcome. The strongest predictors for metastases (for example, lymph node status and histological grade) fail to classify accurately breast tumours according to their clinical behaviour. Chemotherapy or ho...

journal_title：Nature

authors： van 't Veer LJ,Dai H,van de Vijver MJ,He YD,Hart AA,Mao M,Peterse HL,van der Kooy K,Marton MJ,Witteveen AT,Schreiber GJ,Kerkhoven RM,Roberts C,Linsley PS,Bernards R,Friend SH

更新日期：2002-01-31 00:00:00

abstract：:Three environmental groups have filed suit against the National Institutes of Health in an attempt to block an experiment approved in April by the NIH Recombinant DNA Advisory Committee. The experiment, designed by researchers at the University of California, Berkeley, to enhance the frost resistance of crops, would ...

journal_title：Nature

authors： David P

更新日期：1983-09-22 00:00:00

abstract：:Materials showing simultaneous ferroelectric and magnetic ordering are attracting a great deal of interest because of their unusual physics and potential applications. Hemberger et al. have reported relaxor-like dielectric properties and colossal magnetocapacitance (in excess of 500%) for the cubic spinel compound CdC...

journal_title：Nature

authors： Catalan G,Scott JF

更新日期：2007-08-23 00:00:00

abstract：:The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating reg...

journal_title：Nature

authors： Ptashne M,Gann A

更新日期：1997-04-10 00:00:00

abstract：:Spontaneous type 1 diabetes occurs when the autoimmune destruction of pancreatic beta-islet cells prevents production of the hormone insulin. This causes an inability to regulate glucose metabolism, which results in dangerously raised blood glucose concentrations. It is generally accepted that thymus-derived lymphocyt...

journal_title：Nature

authors： Wilson DB

更新日期：2005-11-24 00:00:00