Timing of archaic hominin occupation of Denisova Cave in southern Siberia.

abstract：:The ATM (ataxia-telangiectasia mutated) protein kinase mediates early cellular responses to DNA double-strand breaks (DSBs) generated during metabolic processes or by DNA-damaging agents. ATM deficiency leads to ataxia-telangiectasia, a disease marked by lymphopenia, genomic instability and an increased predisposition...

journal_title：Nature

authors： Bredemeyer AL,Sharma GG,Huang CY,Helmink BA,Walker LM,Khor KC,Nuskey B,Sullivan KE,Pandita TK,Bassing CH,Sleckman BP

更新日期：2006-07-27 00:00:00

abstract：:Human T-cell leukaemia virus (HTLV), first isolated in the United States from a patient with cutaneous T-cell lymphoma, is a unique horizontally transmitted retrovirus which is highly associated with certain adult T-cell malignancies. Also, HTLV can be transmitted in vitro to cord blood T-lymphocytes. In the accompany...

journal_title：Nature

authors： Clarke MF,Gelmann EP,Reitz MS Jr

更新日期：1983-09-01 00:00:00

abstract：:Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence of an activating adaptor, such as BICD2. Different adaptors link dynein and dynactin to distinct cargoes. Here we use electron microscopy and single-molecule studies to show that adaptors can recruit a second dynein to dynactin...

journal_title：Nature

authors： Urnavicius L,Lau CK,Elshenawy MM,Morales-Rios E,Motz C,Yildiz A,Carter AP

更新日期：2018-02-07 00:00:00

abstract：:The fusion pore is the first crucial intermediate formed during exocytosis, yet little is known about the mechanisms that determine the size and kinetic properties of these transient structures. Here, we reduced the number of available SNAREs (proteins that mediate vesicle fusion) in neurons and observed changes in tr...

journal_title：Nature

authors： Bao H,Das D,Courtney NA,Jiang Y,Briguglio JS,Lou X,Roston D,Cui Q,Chanda B,Chapman ER

更新日期：2018-02-08 00:00:00

abstract：:Cornelia de Lange syndrome (CdLS) is a dominantly inherited congenital malformation disorder, caused by mutations in the cohesin-loading protein NIPBL for nearly 60% of individuals with classical CdLS, and by mutations in the core cohesin components SMC1A (~5%) and SMC3 (<1%) for a smaller fraction of probands. In hum...

journal_title：Nature

authors： Deardorff MA,Bando M,Nakato R,Watrin E,Itoh T,Minamino M,Saitoh K,Komata M,Katou Y,Clark D,Cole KE,De Baere E,Decroos C,Di Donato N,Ernst S,Francey LJ,Gyftodimou Y,Hirashima K,Hullings M,Ishikawa Y,Jaulin C,Kaur

更新日期：2012-09-13 00:00:00

abstract：:Materials showing simultaneous ferroelectric and magnetic ordering are attracting a great deal of interest because of their unusual physics and potential applications. Hemberger et al. have reported relaxor-like dielectric properties and colossal magnetocapacitance (in excess of 500%) for the cubic spinel compound CdC...

journal_title：Nature

authors： Catalan G,Scott JF

更新日期：2007-08-23 00:00:00

abstract：:The process of DNA recognition by the activated form of the restriction endonuclease from E. coli K involves three enzyme-DNA complexes which can be differentiated experimentally. These are: an initial complex formed at a nonspecific site; a recognition complex involving the host specificity site; and a cleavage compl...

journal_title：Nature

authors： Yuan R,Bickle TA,Ebbers W,Brack C

更新日期：1975-08-14 00:00:00

abstract：:Leprosy is a spectral disease in which immune responses to Mycobacterium leprae correlate with the clinical, bacteriological and histopathological manifestations of disease, so study of its pathology provides insights into immunoregulatory mechanisms in man. At the tuberculoid pole, patients have few lesions in the sk...

journal_title：Nature

authors： Modlin RL,Kato H,Mehra V,Nelson EE,Fan XD,Rea TH,Pattengale PK,Bloom BR

更新日期：1986-07-31 00:00:00

abstract：:Observations from Earth-orbiting satellites have been a key component in monitoring climate change for the past two decades. This has become possible with the availability of air temperatures from the Microwave Sounding Unit (MSU) since 1979, sea surface temperatures from the Advanced Very High Resolution Radiometer (...

journal_title：Nature

authors： Wentz FJ,Schabel M

更新日期：2000-01-27 00:00:00

abstract：:The specification of both the germ line and abdomen in Drosophila depends on the localization of oskar messenger RNA to the posterior of the oocyte. This localization requires several trans-acting factors, including Barentsz and the Mago-Y14 heterodimer, which assemble with oskar mRNA into ribonucleoprotein particles ...

journal_title：Nature

authors： Palacios IM,Gatfield D,St Johnston D,Izaurralde E

更新日期：2004-02-19 00:00:00

abstract：:Cells sense the context in which they grow to adapt their phenotype and allow multicellular patterning by mechanisms of autocrine and paracrine signalling. However, patterns also form in cell populations exposed to the same signalling molecules and substratum, which often correlate with specific features of the popula...

journal_title：Nature

authors： Frechin M,Stoeger T,Daetwyler S,Gehin C,Battich N,Damm EM,Stergiou L,Riezman H,Pelkmans L

更新日期：2015-07-02 00:00:00

abstract：:Endothelial cells adopt tissue-specific characteristics to instruct organ development and regeneration1,2. This adaptability is lost in cultured adult endothelial cells, which do not vascularize tissues in an organotypic manner. Here, we show that transient reactivation of the embryonic-restricted ETS variant transcri...

journal_title：Nature

authors： Palikuqi B,Nguyen DT,Li G,Schreiner R,Pellegata AF,Liu Y,Redmond D,Geng F,Lin Y,Gómez-Salinero JM,Yokoyama M,Zumbo P,Zhang T,Kunar B,Witherspoon M,Han T,Tedeschi AM,Scottoni F,Lipkin SM,Dow L,Elemento O,Xiang JZ

更新日期：2020-09-01 00:00:00

abstract：:Saturn's moon Titan has a nitrogen atmosphere comparable to Earth's, with a surface pressure of 1.4 bar. Numerical models reproduce the tropospheric conditions very well but have trouble explaining the observed middle-atmosphere temperatures, composition and winds. The top of the middle-atmosphere circulation has been...

journal_title：Nature

authors： Teanby NA,Irwin PG,Nixon CA,de Kok R,Vinatier S,Coustenis A,Sefton-Nash E,Calcutt SB,Flasar FM

更新日期：2012-11-29 00:00:00

abstract：:The vomeronasal organ (VNO) is a chemoreceptive organ that is thought to transduce pheromones into electrical responses that regulate sexual, hormonal and reproductive function in mammals. The characteristics of pheromone signal detection by vomeronasal neurons remain unclear. Here we use a mouse VNO slice preparation...

journal_title：Nature

authors： Leinders-Zufall T,Lane AP,Puche AC,Ma W,Novotny MV,Shipley MT,Zufall F

更新日期：2000-06-15 00:00:00

abstract：:Thyroid hormones and retinoic acid function through nuclear receptors that belong to the steroid/thyroid-hormone receptor superfamily. Thyroid hormone receptors (TRs) and retinoic acid receptors (RARs) require auxiliary nuclear proteins for efficient DNA binding. Here we report that retinoid X receptors RXR alpha is o...

journal_title：Nature

authors： Zhang XK,Hoffmann B,Tran PB,Graupner G,Pfahl M

更新日期：1992-01-30 00:00:00

abstract：:Intensive fisheries have reduced fish biodiversity and abundance in aquatic ecosystems worldwide1-3. 'No-take' marine reserves have become a cornerstone of marine ecosystem-based fisheries management4-6, and their benefits for adjacent fisheries are maximized when reserve design fosters synergies among nearby reserves...

journal_title：Nature

authors： Koning AA,Perales KM,Fluet-Chouinard E,McIntyre PB

更新日期：2020-12-01 00:00:00

abstract：:The LamB protein is an integral membrane protein of the outer membrane of Escherichia coli. We have now found that, when synthesized in an E. coli cell-free translation system supplemented with inverted vesicles derived from the E. coli inner membrane, LamB protein is integrated into the vesicle membrane as assayed by...

journal_title：Nature

authors： Watanabe M,Hunt JF,Blobel G

更新日期：1986-09-04 00:00:00

abstract：:A long-standing hypothesis on tumorigenesis is that cell division failure, generating genetically unstable tetraploid cells, facilitates the development of aneuploid malignancies. Here we test this idea by transiently blocking cytokinesis in p53-null (p53-/-) mouse mammary epithelial cells (MMECs), enabling the isolat...

journal_title：Nature

authors： Fujiwara T,Bandi M,Nitta M,Ivanova EV,Bronson RT,Pellman D

更新日期：2005-10-13 00:00:00

abstract：:Exoplanet detections have revolutionized astronomy, offering new insights into solar system architecture and planet demographics. While nearly 1,900 exoplanets have now been discovered and confirmed, none are still in the process of formation. Transition disks, protoplanetary disks with inner clearings best explained ...

journal_title：Nature

authors： Sallum S,Follette KB,Eisner JA,Close LM,Hinz P,Kratter K,Males J,Skemer A,Macintosh B,Tuthill P,Bailey V,Defrère D,Morzinski K,Rodigas T,Spalding E,Vaz A,Weinberger AJ

更新日期：2015-11-19 00:00:00

abstract：:The monarch butterfly, Danaus plexippus, is famous for its spectacular annual migration across North America, recent worldwide dispersal, and orange warning colouration. Despite decades of study and broad public interest, we know little about the genetic basis of these hallmark traits. Here we uncover the history of t...

journal_title：Nature

authors： Zhan S,Zhang W,Niitepõld K,Hsu J,Haeger JF,Zalucki MP,Altizer S,de Roode JC,Reppert SM,Kronforst MR

更新日期：2014-10-16 00:00:00

abstract：:Carbon exchange between the terrestrial biosphere and the atmosphere is one of the key processes that need to be assessed in the context of the Kyoto Protocol. Several studies suggest that the terrestrial biosphere is gaining carbon, but these estimates are obtained primarily by indirect methods, and the factors that ...

journal_title：Nature

authors： Valentini R,Matteucci G,Dolman AJ,Schulze ED,Rebmann C,Moors EJ,Granier A,Gross P,Jensen NO,Pilegaard K,Lindroth A,Grelle A,Bernhofer C,Grünwald T,Aubinet M,Ceulemans R,Kowalski AS,Vesala T,Rannik U,Berbigier P,Lo

更新日期：2000-04-20 00:00:00

abstract：:Resistance to infection and clearance of cell debris in mammals depend on the activation of the complement system, which is an important component of innate and adaptive immunity. Central to the complement system is the activated form of C3, called C3b, which attaches covalently to target surfaces to amplify complemen...

journal_title：Nature

authors： Janssen BJ,Christodoulidou A,McCarthy A,Lambris JD,Gros P

更新日期：2006-11-09 00:00:00

abstract：:The T-cell immune response is directed against antigenic peptide fragments generated in intracellular compartments, the cytosol or the endocytic system. Peptides derived from cytosolic proteins, usually of biosynthetic origin, are presented efficiently to T-cell receptors by major histocompatibility complex (MHC) clas...

journal_title：Nature

authors： Deverson EV,Gow IR,Coadwell WJ,Monaco JJ,Butcher GW,Howard JC

更新日期：1990-12-20 00:00:00

abstract：:Is the big-bang hot, warm or cold? And are galactic masses determined by the interplay of gravitational and strong interactions in the very early universe? ...

journal_title：Nature

authors： Harrison ER

更新日期：1970-10-17 00:00:00

abstract：:Tumour necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory and immunomodulatory cytokine implicated in inflammatory conditions such as rheumatoid arthritis, Crohn's disease, multiple sclerosis and the cachexia associated with cancer or human immunodeficiency virus infection. TNF-alpha is initially expressed...

journal_title：Nature

authors： Gearing AJ,Beckett P,Christodoulou M,Churchill M,Clements J,Davidson AH,Drummond AH,Galloway WA,Gilbert R,Gordon JL

更新日期：1994-08-18 00:00:00

abstract：: ...

journal_title：Nature

authors： Clayton EW

更新日期：2018-12-01 00:00:00

abstract：:The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor po...

journal_title：Nature

authors： Derynck R,Jarrett JA,Chen EY,Eaton DH,Bell JR,Assoian RK,Roberts AB,Sporn MB,Goeddel DV

更新日期：1985-08-22 00:00:00

abstract：:The uranyl ion (UO22+; U(VI) oxidation state) is the most common form of uranium found in terrestrial and aquatic environments and is a central component in nuclear fuel processing and waste remediation efforts. Uranyl capture from either seawater or nuclear waste has been well studied and typically relies on extremel...

journal_title：Nature

authors： Keener M,Hunt C,Carroll TG,Kampel V,Dobrovetsky R,Hayton TW,Ménard G

更新日期：2020-01-01 00:00:00

abstract：:More than 50 copies of a phi X174 DNA template can be made in 60 min in an in vitro DNA replication system consisting of seven purfied replication proteins isolated from T4 bacteriophage-infected cells. By transfecting with the DNA products and assaying for the reversion of specific amber mutants, the high degree of b...

journal_title：Nature

authors： Hibner U,Alberts BM

更新日期：1980-05-29 00:00:00

abstract：:Humans differ from other primates in their significantly lengthened growth period. The persistence of a fetal pattern of brain growth after birth is another important feature of human development. Here we present the results of an analysis of the 1.8-million-year-old Mojokerto child (Perning 1, Java), the only well pr...

journal_title：Nature

authors： Coqueugniot H,Hublin JJ,Veillon F,Houët F,Jacob T

更新日期：2004-09-16 00:00:00