Modulation of Rab GTPase function by a protein phosphocholine transferase.

abstract：:Mitochondrial genomes (mitochondrial DNA, mtDNA) encode essential oxidative phosphorylation (OXPHOS) components. Because hundreds of mtDNAs exist per cell, a deletion in a single mtDNA has little impact. However, if the deletion genome is enriched, OXPHOS declines, resulting in cellular dysfunction. For example, Kearn...

journal_title：Nature

authors： Lin YF,Schulz AM,Pellegrino MW,Lu Y,Shaham S,Haynes CM

更新日期：2016-05-19 00:00:00

abstract：:There has been much interest in the biochemical and biophysical processes that couple extracellular signals to alterations in gene expression. While many early events associated with the treatment of cells with growth factors have been described (for example, ion flux and protein phosphorylation), it has proved diffic...

journal_title：Nature

authors： Morgan JI,Curran T

更新日期：1986-08-07 00:00:00

abstract：:The structure of water near non-polar molecular fragments or surfaces mediates the hydrophobic interactions that underlie a broad range of interfacial, colloidal and biophysical phenomena. Substantial progress over the past decade has improved our understanding of hydrophobic interactions in simple model systems, but ...

journal_title：Nature

authors： Ma CD,Wang C,Acevedo-Vélez C,Gellman SH,Abbott NL

更新日期：2015-01-15 00:00:00

abstract：:Surface gravity is a basic stellar property, but it is difficult to measure accurately, with typical uncertainties of 25 to 50 per cent if measured spectroscopically and 90 to 150 per cent if measured photometrically. Asteroseismology measures gravity with an uncertainty of about 2 per cent but is restricted to relati...

journal_title：Nature

authors： Bastien FA,Stassun KG,Basri G,Pepper J

更新日期：2013-08-22 00:00:00

abstract：:The import of nuclear proteins proceeds through the nuclear pore complex and requires nuclear localization signals (NLSs), energy and soluble factors, namely importin-alpha (M(r) 60K), importin-beta (90K) and Ran. Importin-alpha is primarily responsible for NLS recognition and is a member of a protein family that incl...

journal_title：Nature

authors： Görlich D,Vogel F,Mills AD,Hartmann E,Laskey RA

更新日期：1995-09-21 00:00:00

abstract：:To ensure cell survival, it is essential that the ubiquitous pro-apoptotic machinery is kept quiescent. As death is irreversible, cells must continually integrate developmental information with regulatory inputs to control the switch between repressing and activating apoptosis. Inappropriate activation or suppression ...

journal_title：Nature

authors： Bloss TA,Witze ES,Rothman JH

更新日期：2003-08-28 00:00:00

abstract：:Digital organisms are computer programs that self-replicate, mutate and adapt by natural selection. They offer an opportunity to test generalizations about living systems that may extend beyond the organic life that biologists usually study. Here we have generated two classes of digital organism: simple programs selec...

journal_title：Nature

authors： Lenski RE,Ofria C,Collier TC,Adami C

更新日期：1999-08-12 00:00:00

abstract：:Modern high-power lasers can generate extreme states of matter that are relevant to astrophysics, equation-of-state studies and fusion energy research. Laser-driven implosions of spherical polymer shells have, for example, achieved an increase in density of 1,000 times relative to the solid state. These densities are ...

journal_title：Nature

authors： Kodama R,Norreys PA,Mima K,Dangor AE,Evans RG,Fujita H,Kitagawa Y,Krushelnick K,Miyakoshi T,Miyanaga N,Norimatsu T,Rose SJ,Shozaki T,Shigemori K,Sunahara A,Tampo M,Tanaka KA,Toyama Y,Yamanaka T,Zepf M

更新日期：2001-08-23 00:00:00

abstract：:Recognition of modified histone species by distinct structural domains within 'reader' proteins plays a critical role in the regulation of gene expression. Readers that simultaneously recognize histones with multiple marks allow transduction of complex chromatin modification patterns into specific biological outcomes....

journal_title：Nature

authors： Tsai WW,Wang Z,Yiu TT,Akdemir KC,Xia W,Winter S,Tsai CY,Shi X,Schwarzer D,Plunkett W,Aronow B,Gozani O,Fischle W,Hung MC,Patel DJ,Barton MC

更新日期：2010-12-16 00:00:00

abstract：:Haematopoiesis is an essential process that evolved in multicellular animals. At the heart of this process are haematopoietic stem cells (HSCs), which are multipotent and self-renewing, and generate the entire repertoire of blood and immune cells throughout an animal's life1. Although there have been comprehensive stu...

journal_title：Nature

authors： Rosental B,Kowarsky M,Seita J,Corey DM,Ishizuka KJ,Palmeri KJ,Chen SY,Sinha R,Okamoto J,Mantalas G,Manni L,Raveh T,Clarke DN,Tsai JM,Newman AM,Neff NF,Nolan GP,Quake SR,Weissman IL,Voskoboynik A

更新日期：2018-12-01 00:00:00

abstract：:The three-dimensional structures of macromolecules and their complexes are mainly elucidated by X-ray protein crystallography. A major limitation of this method is access to high-quality crystals, which is necessary to ensure X-ray diffraction extends to sufficiently large scattering angles and hence yields informatio...

journal_title：Nature

authors： Ayyer K,Yefanov OM,Oberthür D,Roy-Chowdhury S,Galli L,Mariani V,Basu S,Coe J,Conrad CE,Fromme R,Schaffer A,Dörner K,James D,Kupitz C,Metz M,Nelson G,Xavier PL,Beyerlein KR,Schmidt M,Sarrou I,Spence JC,Weierstall

更新日期：2016-02-11 00:00:00

abstract：:Translation initiation determines both the quantity and identity of the protein that is encoded in an mRNA by establishing the reading frame for protein synthesis. In eukaryotic cells, numerous translation initiation factors prepare ribosomes for polypeptide synthesis; however, the underlying dynamics of this process ...

journal_title：Nature

authors： Wang J,Johnson AG,Lapointe CP,Choi J,Prabhakar A,Chen DH,Petrov AN,Puglisi JD

更新日期：2019-09-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is an early-onset developmental disorder characterized by deficits in communication and social interaction and restrictive or repetitive behaviours1,2. Family studies demonstrate that ASD has a substantial genetic basis with contributions both from inherited and de novo variants3,4. It h...

journal_title：Nature

authors： Mitra I,Huang B,Mousavi N,Ma N,Lamkin M,Yanicky R,Shleizer-Burko S,Lohmueller KE,Gymrek M

更新日期：2021-01-01 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder which affects approximately 1 in 3,300 males, making it the most common of the neuromuscular dystrophies. The biochemical basis of the disease is unknown and as yet no effective treatment is available. A small number of females are also affected with ...

journal_title：Nature

authors： Ray PN,Belfall B,Duff C,Logan C,Kean V,Thompson MW,Sylvester JE,Gorski JL,Schmickel RD,Worton RG

更新日期：1985-12-19 00:00:00

abstract：:The cortex organizes sensory information to enable discrimination and generalization1-4. As systematic representations of chemical odour space have not yet been described in the olfactory cortex, it remains unclear how odour relationships are encoded to place chemically distinct but similar odours, such as lemon and o...

journal_title：Nature

authors： Pashkovski SL,Iurilli G,Brann D,Chicharro D,Drummey K,Franks KM,Panzeri S,Datta SR

更新日期：2020-07-01 00:00:00

abstract：:An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Momcilovic M,Jones A,Bailey ST,Waldmann CM,Li R,Lee JT,Abdelhady G,Gomez A,Holloway T,Schmid E,Stout D,Fishbein MC,Stiles L,Dabir DV,Dubinett SM,Christofk H,Shirihai O,Koehler CM,Sadeghi S,Shackelford DB

更新日期：2020-01-01 00:00:00

abstract：:Chameleons are arboral lizards that spot their prey visually and catch it by highly precise shots with their long sticky tongue. They scan their environment by large-amplitude independent saccadic eye movements; once an insect is detected, the head axis is aligned towards the target ('head tracking', both eyes come fo...

journal_title：Nature

authors： Ott M,Schaeffel F

更新日期：1995-02-23 00:00:00

abstract：:Nuclear pore complexes reside in the nuclear envelope of eukaryotic cells and mediate the nucleocytoplasmic exchange of macromolecules. Traffic is regulated by mobile transport receptors that target their cargo to the central translocation channel, where phenylalanine-glycine-rich repeats serve as binding sites. The s...

journal_title：Nature

authors： Beck M,Lucić V,Förster F,Baumeister W,Medalia O

更新日期：2007-10-04 00:00:00

abstract：:As oligodendrocytes wrap axons of the central nervous system (CNS) with insulating myelin sheaths, sodium channels that are initially continuously distributed along axons become segregated into regularly spaced gaps in the myelin called nodes of Ranvier. It is not known whether the regular spacing of nodes results fro...

journal_title：Nature

authors： Kaplan MR,Meyer-Franke A,Lambert S,Bennett V,Duncan ID,Levinson SR,Barres BA

更新日期：1997-04-17 00:00:00

abstract：:The discovery of the basis of genetic variation has opened inroads to understanding our history as a species. It has revealed the remarkable genetic similarity we share with other individuals as well as with our closest primate relatives. To understand what make us unique, both as individuals and as a species, we need...

journal_title：Nature

authors： Pääbo S

更新日期：2003-01-23 00:00:00

abstract：:Exceptional genomic stability is one of the hallmarks of mouse embryonic stem (ES) cells. However, the genes contributing to this stability remain obscure. We previously identified Zscan4 as a specific marker for two-cell embryo and ES cells. Here we show that Zscan4 is involved in telomere maintenance and long-term g...

journal_title：Nature

authors： Zalzman M,Falco G,Sharova LV,Nishiyama A,Thomas M,Lee SL,Stagg CA,Hoang HG,Yang HT,Indig FE,Wersto RP,Ko MS

更新日期：2010-04-08 00:00:00

abstract：:Electronic devices have advanced from their heavy, bulky origins to become smart, mobile appliances. Nevertheless, they remain rigid, which precludes their intimate integration into everyday life. Flexible, textile and stretchable electronics are emerging research areas and may yield mainstream technologies. Rollable ...

journal_title：Nature

authors： Kaltenbrunner M,Sekitani T,Reeder J,Yokota T,Kuribara K,Tokuhara T,Drack M,Schwödiauer R,Graz I,Bauer-Gogonea S,Bauer S,Someya T

更新日期：2013-07-25 00:00:00

abstract：:An evolutionary view of ageing suggests that mortality may be due to an energy-saving strategy of reduced error regulation in somatic cells. This supports Orgel's 'error catastrophe' hypothesis and offers a new basis for the study of normal and abnormal ageing syndromes and of apparently immortal transformed cell line...

journal_title：Nature

authors： Kirkwood TB

更新日期：1977-11-24 00:00:00

abstract：:Eukaryotic transfer RNA genes have two internal discontinuous control regions, the A and B blocks, which correspond approximately to the D-stem and the pseudo-U arm of tRNA. In reconstituted transcription systems at least two components are required to direct accurate initiation by RNA polymerase (refs 4,5). However, ...

journal_title：Nature

authors： Smagowicz W,Ruet A,Camier S,Sentenac A,Fromageot P,Sternbach H

更新日期：1983-08-25 00:00:00

abstract：:Deep chlorophyll maxima (DCMs) are widespread in large parts of the world's oceans. These deep layers of high chlorophyll concentration reflect a compromise of phytoplankton growth exposed to two opposing resource gradients: light supplied from above and nutrients supplied from below. It is often argued that DCMs are ...

journal_title：Nature

authors： Huisman J,Pham Thi NN,Karl DM,Sommeijer B

更新日期：2006-01-19 00:00:00

abstract：:Marine records of sediment oxygen isotope compositions show that the Earth's climate has gone through a succession of glacial and interglacial periods during the past million years. But the interpretation of the oxygen isotope records is complicated because both isotope storage in ice sheets and deep-water temperature...

journal_title：Nature

authors： Bintanja R,van de Wal RS,Oerlemans J

更新日期：2005-09-01 00:00:00

abstract：:Cosmological models in which dark matter consists of cold elementary particles predict that the dark halo population should extend to masses many orders of magnitude below those at which galaxies can form1-3. Here we report a cosmological simulation of the formation of present-day haloes over the full range of observe...

journal_title：Nature

authors： Wang J,Bose S,Frenk CS,Gao L,Jenkins A,Springel V,White SDM

更新日期：2020-09-01 00:00:00

abstract：:Polycomb and trithorax group (PcG and trxG) proteins maintain silent and active transcriptional states, respectively, throughout development. In Drosophila, PcG and trxG proteins associate with DNA regions named Polycomb and trithorax response elements (PRE and TRE), but the mechanisms of recruitment are unknown. We p...

journal_title：Nature

authors： Déjardin J,Rappailles A,Cuvier O,Grimaud C,Decoville M,Locker D,Cavalli G

更新日期：2005-03-24 00:00:00

abstract：:Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellula...

journal_title：Nature

authors： Dustin ML,Springer TA

更新日期：1989-10-19 00:00:00

abstract：:Variations in atmospheric radiocarbon (14C) concentrations can be attributed either to changes in the carbon cycle--through the rate of radiocarbon removal from the atmosphere--or to variations in the production rate of 14C due to changes in solar activity or the Earth's magnetic field. The production rates of 10Be an...

journal_title：Nature

authors： Muscheler R,Beer J,Wagner G,Finkel RC

更新日期：2000-11-30 00:00:00