Abstract:
:The Encyclopedia of DNA Elements (ENCODE) project has established a genomic resource for mammalian development, profiling a diverse panel of mouse tissues at 8 developmental stages from 10.5 days after conception until birth, including transcriptomes, methylomes and chromatin states. Here we systematically examined the state and accessibility of chromatin in the developing mouse fetus. In total we performed 1,128 chromatin immunoprecipitation with sequencing (ChIP-seq) assays for histone modifications and 132 assay for transposase-accessible chromatin using sequencing (ATAC-seq) assays for chromatin accessibility across 72 distinct tissue-stages. We used integrative analysis to develop a unified set of chromatin state annotations, infer the identities of dynamic enhancers and key transcriptional regulators, and characterize the relationship between chromatin state and accessibility during developmental gene regulation. We also leveraged these data to link enhancers to putative target genes and demonstrate tissue-specific enrichments of sequence variants associated with disease in humans. The mouse ENCODE data sets provide a compendium of resources for biomedical researchers and achieve, to our knowledge, the most comprehensive view of chromatin dynamics during mammalian fetal development to date.
journal_name
Naturejournal_title
Natureauthors
Gorkin DU,Barozzi I,Zhao Y,Zhang Y,Huang H,Lee AY,Li B,Chiou J,Wildberg A,Ding B,Zhang B,Wang M,Strattan JS,Davidson JM,Qiu Y,Afzal V,Akiyama JA,Plajzer-Frick I,Novak CS,Kato M,Garvin TH,Pham QT,Harrington ANdoi
10.1038/s41586-020-2093-3subject
Has Abstractpub_date
2020-07-01 00:00:00pages
744-751issue
7818eissn
0028-0836issn
1476-4687pii
10.1038/s41586-020-2093-3journal_volume
583pub_type
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