The oil palm SHELL gene controls oil yield and encodes a homologue of SEEDSTICK.

abstract：:Glucagon is a 29-amino-acid peptide released from the α-cells of the islet of Langerhans, which has a key role in glucose homeostasis. Glucagon action is transduced by the class B G-protein-coupled glucagon receptor (GCGR), which is located on liver, kidney, intestinal smooth muscle, brain, adipose tissue, heart and p...

journal_title：Nature

authors： Jazayeri A,Doré AS,Lamb D,Krishnamurthy H,Southall SM,Baig AH,Bortolato A,Koglin M,Robertson NJ,Errey JC,Andrews SP,Teobald I,Brown AJ,Cooke RM,Weir M,Marshall FH

更新日期：2016-05-12 00:00:00

abstract：:The accumulation of somatic DNA damage has been implicated as a cause of ageing in metazoa. One possible mechanism by which increased DNA damage could lead to cellular degeneration and death is by stochastic deregulation of gene expression. Here we directly test for increased transcriptional noise in aged tissue by di...

journal_title：Nature

authors： Bahar R,Hartmann CH,Rodriguez KA,Denny AD,Busuttil RA,Dollé ME,Calder RB,Chisholm GB,Pollock BH,Klein CA,Vijg J

更新日期：2006-06-22 00:00:00

abstract：:Biological dinitrogen fixation provides the largest input of nitrogen to the oceans, therefore exerting important control on the ocean's nitrogen inventory and primary productivity. Nitrogen-isotope data from ocean sediments suggest that the marine-nitrogen inventory has been balanced for the past 3,000 years (ref. 4)...

journal_title：Nature

authors： Großkopf T,Mohr W,Baustian T,Schunck H,Gill D,Kuypers MM,Lavik G,Schmitz RA,Wallace DW,LaRoche J

更新日期：2012-08-16 00:00:00

abstract：:Distinctive acute brain damage involving limbic and related brain regions develops in adult rats following sustained limbic seizures induced by systemic administration of kainic acid or dipiperidinoethane (DPE) or by intra-amygdaloid injection of kainic acid or folic acid. This seizure-brain damage (S-BD) syndrome is ...

journal_title：Nature

authors： Olney JW,de Gubareff T,Labruyere J

更新日期：1983-02-10 00:00:00

abstract：:Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated androgen receptor (AR) signalling. Despite the success of recently approved therapies targeting AR signalling, such as abi...

journal_title：Nature

authors： Asangani IA,Dommeti VL,Wang X,Malik R,Cieslik M,Yang R,Escara-Wilke J,Wilder-Romans K,Dhanireddy S,Engelke C,Iyer MK,Jing X,Wu YM,Cao X,Qin ZS,Wang S,Feng FY,Chinnaiyan AM

更新日期：2014-06-12 00:00:00

abstract：:Gross chromosome rearrangements (GCRs), such as translocations, deletion of a chromosome arm, interstitial deletions and inversions, are often observed in cancer cells. Spontaneous GCRs are rare in Saccharomyces cerevisiae; however, the existence of mutator mutants with increased genome instability suggests that GCRs ...

journal_title：Nature

authors： Myung K,Chen C,Kolodner RD

更新日期：2001-06-28 00:00:00

abstract：:A rapid decrease in shear velocity in the suboceanic mantle is used to infer the thickness of the lithosphere. It is proposed that new and highly precise group velocity data constrain the solutions and imply a thickness near 70 km. ...

journal_title：Nature

authors： Kanamori H,Press F

更新日期：1970-04-25 00:00:00

abstract：:The alpha-like and beta-like globin genes have provided a paradigm for the study of molecular evolution and regulation of multigene families in eukaryotes. The human alpha-globin gene cluster, which is on chromosome 16 (ref. 1), consists of six genes arranged in the order 5'-zeta(embryonic)-psi zeta-psi alpha 2-psi al...

journal_title：Nature

authors： Marks J,Shaw JP,Shen CK

更新日期：1986-06-19 00:00:00

abstract：:Recent computational and psychological theories of human texture vision assert that texture discrimination is based on first-order differences in geometric and luminance attributes of texture elements, called 'textons'. Significant differences in the density, orientation, size, or contrast of line segments or other sm...

journal_title：Nature

authors： Voorhees H,Poggio T

更新日期：1988-05-26 00:00:00

abstract：:Activation of RIPK1 controls TNF-mediated apoptosis, necroptosis and inflammatory pathways1. Cleavage of human and mouse RIPK1 after residues D324 and D325, respectively, by caspase-8 separates the RIPK1 kinase domain from the intermediate and death domains. The D325A mutation in mouse RIPK1 leads to embryonic lethali...

journal_title：Nature

authors： Tao P,Sun J,Wu Z,Wang S,Wang J,Li W,Pan H,Bai R,Zhang J,Wang Y,Lee PY,Ying W,Zhou Q,Hou J,Wang W,Sun B,Yang M,Liu D,Fang R,Han H,Yang Z,Huang X,Li H,Deuitch N,Zhang Y,Dissanayake D,Haude K,McWalter K

更新日期：2020-01-01 00:00:00

abstract：:Reinforcement learning models postulate that neurons that release dopamine encode information about action and action outcome, and provide a teaching signal to striatal spiny projection neurons in the form of dopamine release1. Dopamine is thought to guide learning via dynamic and differential modulation of protein ki...

journal_title：Nature

authors： Lee SJ,Lodder B,Chen Y,Patriarchi T,Tian L,Sabatini BL

更新日期：2020-12-23 00:00:00

abstract：: ...

journal_title：Nature

authors： Gewin V

更新日期：2019-02-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are zinc endopeptidases that are required for the degradation of extracellular matrix components during normal embryo development, morphogenesis and tissue remodelling. Their proteolytic activities are precisely regulated by endogenous tissue inhibitors of metalloproteinases (TIMPs). D...

journal_title：Nature

authors： Gomis-Rüth FX,Maskos K,Betz M,Bergner A,Huber R,Suzuki K,Yoshida N,Nagase H,Brew K,Bourenkov GP,Bartunik H,Bode W

更新日期：1997-09-04 00:00:00

abstract：:Quantum computation, a paradigm of computing that is completely different from classical methods, benefits from theoretically proved speed-ups for certain problems and can be used to study the properties of quantum systems1. Yet, because of the inherently fragile nature of the physical computing elements (qubits), ach...

journal_title：Nature

authors： Kandala A,Temme K,Córcoles AD,Mezzacapo A,Chow JM,Gambetta JM

更新日期：2019-03-01 00:00:00

abstract：:Intracellular responses recorded in vitro from the cochleas of anaesthetized mammals have shown that the mechanoreceptive inner and outer hair cells are sharply tuned, accounting for many of the properties of the afferent fibres in the auditory nerve. However, in vivo it has not been possible to measure directly the e...

journal_title：Nature

authors： Russell IJ,Richardson GP,Cody AR

更新日期：1986-05-29 00:00:00

abstract：:Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found application in gene-editing techniques1,2. Because previously described cyt...

journal_title：Nature

authors： Mok BY,de Moraes MH,Zeng J,Bosch DE,Kotrys AV,Raguram A,Hsu F,Radey MC,Peterson SB,Mootha VK,Mougous JD,Liu DR

更新日期：2020-07-01 00:00:00

abstract：:Tectal polarity for retinal connections remains reversible long after the anatomical pattern of neural structures has been determined. Cells in the diencephalon seem to control this polarity. Following certain embryonic operations, the diencephalon developed behind the tectum. In such cases, the polarity of the retino...

journal_title：Nature

authors： Chung SH,Cooke J

更新日期：1975-11-13 00:00:00

abstract：:That animals and humans can accomplish the same goal using different effectors and different goals using the same effectors attests to the remarkable flexibility of the central nervous system. This phenomenon has been termed 'motor equivalence', an example being the writing of a name with a pencil held between the toe...

journal_title：Nature

authors： Kelso JA,Fuchs A,Lancaster R,Holroyd T,Cheyne D,Weinberg H

更新日期：1998-04-23 00:00:00

abstract：:Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence of an activating adaptor, such as BICD2. Different adaptors link dynein and dynactin to distinct cargoes. Here we use electron microscopy and single-molecule studies to show that adaptors can recruit a second dynein to dynactin...

journal_title：Nature

authors： Urnavicius L,Lau CK,Elshenawy MM,Morales-Rios E,Motz C,Yildiz A,Carter AP

更新日期：2018-02-07 00:00:00

abstract：:Human leukocyte antigens (HLAs) are highly polymorphic proteins that initiate immunity by presenting pathogen-derived peptides to T cells. HLA polymorphisms mostly map to the antigen-binding cleft, thereby diversifying the repertoire of self-derived and pathogen-derived peptide antigens selected by different HLA allot...

journal_title：Nature

authors： Illing PT,Vivian JP,Dudek NL,Kostenko L,Chen Z,Bharadwaj M,Miles JJ,Kjer-Nielsen L,Gras S,Williamson NA,Burrows SR,Purcell AW,Rossjohn J,McCluskey J

更新日期：2012-06-28 00:00:00

abstract：:ELLIPTICAL galaxies acting as gravitational lenses occasionally produce spectacular images-Einstein rings-of distant objects. Giant arcs(1) and radio rings(2) have been observed. A wide variety of image morphologies is possible, the generation of which is qualitatively understood in terms of large magnifications at ca...

journal_title：Nature

authors： Langston GI,Conner SR,Lehar J,Burke BF,Weiler KW

更新日期：1990-03-01 00:00:00

abstract：:A quantum internet that connects remote quantum processors1,2 should enable a number of revolutionary applications such as distributed quantum computing. Its realization will rely on entanglement of remote quantum memories over long distances. Despite enormous progress3-12, at present the maximal physical separation a...

journal_title：Nature

authors： Yu Y,Ma F,Luo XY,Jing B,Sun PF,Fang RZ,Yang CW,Liu H,Zheng MY,Xie XP,Zhang WJ,You LX,Wang Z,Chen TY,Zhang Q,Bao XH,Pan JW

更新日期：2020-02-01 00:00:00

abstract：:The type I interferon response protects cells against invading viral pathogens. The cellular factors that mediate this defence are the products of interferon-stimulated genes (ISGs). Although hundreds of ISGs have been identified since their discovery more than 25 years ago, only a few have been characterized with res...

journal_title：Nature

authors： Schoggins JW,Wilson SJ,Panis M,Murphy MY,Jones CT,Bieniasz P,Rice CM

更新日期：2011-04-28 00:00:00

abstract：:Protein engineering is being developed for mapping the energetics and pathway of protein folding. From kinetic studies on wild-type and mutant proteins, the sequence and energetics of formation of tertiary interactions of side chains can be mapped and the formation of secondary structure inferred. Here we cross-check ...

journal_title：Nature

authors： Bycroft M,Matouschek A,Kellis JT Jr,Serrano L,Fersht AR

更新日期：1990-08-02 00:00:00

abstract：:The nuclear bulge is a region with a radius of about 200 parsecs around the centre of the Milky Way. It contains stars with ages ranging from a few million years to over a billion years, yet its star-formation history and the triggering process for star formation remain to be resolved. Recently, episodic star formatio...

journal_title：Nature

authors： Matsunaga N,Kawadu T,Nishiyama S,Nagayama T,Kobayashi N,Tamura M,Bono G,Feast MW,Nagata T

更新日期：2011-08-24 00:00:00

abstract：: ...

journal_title：Nature

authors： Narayan A

更新日期：2019-03-01 00:00:00

abstract：:For many pathogens the availability of genome sequence, permitting genome-dependent methods of research, can partially substitute for powerful forward genetic methods (genome-independent) that have advanced model organism research for decades. In 2002 the genome sequence of Plasmodium falciparum, the parasite causing ...

journal_title：Nature

authors： Winzeler EA

更新日期：2008-10-09 00:00:00

abstract：:Deep chlorophyll maxima (DCMs) are widespread in large parts of the world's oceans. These deep layers of high chlorophyll concentration reflect a compromise of phytoplankton growth exposed to two opposing resource gradients: light supplied from above and nutrients supplied from below. It is often argued that DCMs are ...

journal_title：Nature

authors： Huisman J,Pham Thi NN,Karl DM,Sommeijer B

更新日期：2006-01-19 00:00:00

abstract：:Homeostatic mechanisms in mammals respond to hormones and nutrients to maintain blood glucose levels within a narrow range. Caloric restriction causes many changes in glucose metabolism and extends lifespan; however, how this metabolism is connected to the ageing process is largely unknown. We show here that the Sir2 ...

journal_title：Nature

authors： Rodgers JT,Lerin C,Haas W,Gygi SP,Spiegelman BM,Puigserver P

更新日期：2005-03-03 00:00:00

abstract：:Cocaine is believed to work by blocking the dopamine transporter (DAT) and thereby increasing the availability of free dopamine within the brain. Although this concept is central to current cocaine research and to treatment development, a direct relationship between DAT blockade and the subjective effects of cocaine h...

journal_title：Nature

authors： Volkow ND,Wang GJ,Fischman MW,Foltin RW,Fowler JS,Abumrad NN,Vitkun S,Logan J,Gatley SJ,Pappas N,Hitzemann R,Shea CE

更新日期：1997-04-24 00:00:00