Overcoming evolved resistance to population-suppressing homing-based gene drives.

abstract：:Crosslinking is an effective way to fabricate high-selective CO2 separation membranes because of its unique crosslinking framework. Thus, it is essentially significant to study the influence of crosslinking degree on the permeation selectivities of CO2. Herein, we report a successful and facile synthesis of a series o...

journal_title：Scientific reports

authors： Li J,Chen Z,Umar A,Liu Y,Shang Y,Zhang X,Wang Y

更新日期：2017-01-04 00:00:00

abstract：:The herbal medicine berberine (BBR) has been recently shown to be an AMP-activated protein kinase (AMPK) productive activator with various properties that induce anti-inflammatory responses. We investigated the effects of BBR on the mechanisms of mucosal CD4+T cell activation in vitro and on the inflammatory responses...

journal_title：Scientific reports

authors： Takahara M,Takaki A,Hiraoka S,Adachi T,Shimomura Y,Matsushita H,Nguyen TTT,Koike K,Ikeda A,Takashima S,Yamasaki Y,Inokuchi T,Kinugasa H,Sugihara Y,Harada K,Eikawa S,Morita H,Udono H,Okada H

更新日期：2019-08-15 00:00:00

abstract：:Tumor necrosis factor is a major pro-inflammatory cytokine which triggers various physiological consequences by binding to and trimerizing its receptors, and has been the single most sought-after drug target for intervening autoimmune diseases such as rheumatoid arthritis and psoriasis. However, current TNF-α blockers...

journal_title：Scientific reports

authors： Cui X,Chang L,Li Y,Lv Q,Wang F,Lin Y,Li W,Meade JD,Walden JC,Liang P

更新日期：2018-05-09 00:00:00

abstract：:Heparan sulfate (HS) is a polysaccharide known to modulate many important biological processes, including Wnt signaling. However, the biochemical interaction between HS and Wnt molecules is not well characterized largely due to the lack of suitable methods. To determine the Wnt binding domain in HS, we used a Wnt sign...

journal_title：Scientific reports

authors： Gao W,Xu Y,Liu J,Ho M

更新日期：2016-05-17 00:00:00

abstract：:The annotation of genomic ranges of interest represents a recurring task for bioinformatics analyses. These ranges can originate from various sources, including peaks called for transcription factor binding sites (TFBS) or histone modification ChIP-seq experiments, chromatin structure and accessibility experiments (su...

journal_title：Scientific reports

authors： Kondili M,Fust A,Preussner J,Kuenne C,Braun T,Looso M

更新日期：2017-06-01 00:00:00

abstract：:Emergence of drug-resistant strains of the pathogen Mycobacterium tuberculosis (Mtb) and the ineffectiveness of BCG in curtailing Mtb infection makes vaccine development for tuberculosis an important objective. Identifying immunogenic CD8+ T cell peptide epitopes is necessary for peptide-based vaccine strategies. We p...

journal_title：Scientific reports

authors： Nair SK,Tomaras GD,Sales AP,Boczkowski D,Chan C,Plonk K,Cai Y,Dannull J,Kepler TB,Pruitt SK,Weinhold KJ

更新日期：2014-04-23 00:00:00

abstract：:Observational studies examining the relationship between hypertension and breast cancer risk have reported conflicting findings. We conducted this systematic review and meta-analysis to summarize the evidence regarding the association between hypertension and risk of breast cancer. Eligible studies were identified thr...

journal_title：Scientific reports

authors： Han H,Guo W,Shi W,Yu Y,Zhang Y,Ye X,He J

更新日期：2017-03-20 00:00:00

abstract：:Streptococcus agalactiae (GBS) is the leading cause worldwide of neonatal sepsis. We sought to assess to which extent HIV exposure of neonates is associated with GBS neonatal disease. Furthermore, we assessed to which extent HIV infection in women is associated with maternal rectovaginal GBS carriage, the single most ...

journal_title：Scientific reports

authors： Cools P,van de Wijgert JHHM,Jespers V,Crucitti T,Sanders EJ,Verstraelen H,Vaneechoutte M

更新日期：2017-10-23 00:00:00

abstract：:Epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 epoxygenases from arachidonic acid, and their rapid metabolism is mainly through soluble epoxide hydrolase (sEH). EETs exert vasodilatory, anti-inflammatory, anti-apoptotic, and pro-angiogenic effects. Administration of sEH inhibitors before or at the on...

journal_title：Scientific reports

authors： Tu R,Armstrong J,Lee KSS,Hammock BD,Sapirstein A,Koehler RC

更新日期：2018-03-27 00:00:00

abstract：:The aim of this paper is to investigate the effect that bone marrow mesenchymal stem cells (BMMSCs) - endothelial progenitor cells (EPCs), BMMSCs and EPCs sheets have on repairing maxillary alveolar defects in ovariectomized (OVX) rats. In this study, after identification using multi-lineage differentiation and flow c...

journal_title：Scientific reports

authors： Wen Y,Yang H,Liu Y,Liu Q,Wang A,Ding Y,Jin Z

更新日期：2017-11-29 00:00:00

abstract：:Because of the critical role of transportation in modern times, one of the most successful application areas of statistical physics of complex networks is the study of traffic dynamics. However, the vast majority of works treat transportation networks as an isolated system, which is inconsistent with the fact that man...

journal_title：Scientific reports

authors： Du WB,Zhou XL,Jusup M,Wang Z

更新日期：2016-01-21 00:00:00

abstract：:Maize (corn) is the dominant grain grown in the world. Total maize production in 2018 equaled 1.12 billion tons. Maize is used primarily as an animal feed in the production of eggs, dairy, pork and chicken. The US produces 32% of the world's maize followed by China at 22% and Brazil at 9% ( https://apps.fas.usda.gov/p...

journal_title：Scientific reports

authors： Jiang Z,Liu C,Ganapathysubramanian B,Hayes DJ,Sarkar S

更新日期：2020-09-11 00:00:00

abstract：:The potency of cellular immune responses strongly depends on T cell avidity to antigen. Yet, functional avidity measurements are rarely performed in patients, mainly due to the technical challenges of characterizing heterogeneous T cells. The mean functional T cell avidity can be determined by the IFN-γ Elispot assay,...

journal_title：Scientific reports

authors： Ioannidou K,Baumgaertner P,Gannon PO,Speiser MF,Allard M,Hebeisen M,Rufer N,Speiser DE

更新日期：2017-03-13 00:00:00

abstract：:Plants traditionally used by farmers to manage livestock ailments could reduce reliance on synthetic antibiotics and anthelmintics but in many cases their chemical composition is unknown. As a case study, we analyzed the metabolite profiles of 17 plant species and 45 biomass samples from agricultural grasslands in Eng...

journal_title：Scientific reports

authors： French KE,Harvey J,McCullagh JSO

更新日期：2018-01-26 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the most deadly of the gynecological cancers. New approaches and better tools for monitoring treatment efficacy and disease progression of EOC are required. In this study, metabolomics using rapid resolution liquid chromatography mass spectrometry was applied to a systematic investig...

journal_title：Scientific reports

authors： Ke C,Li A,Hou Y,Sun M,Yang K,Cheng J,Wang J,Ge T,Zhang F,Li Q,Li J,Wu Y,Lou G,Li K

更新日期：2016-03-21 00:00:00

abstract：:The time evolution of the distribution and shareability of quantum coherence of a tripartite system in a non-Markovian environment is examined. The total coherence can be decomposed into various contributions, ranging from local, global bipartite and global tripartite, which characterize the type of state. We identify...

journal_title：Scientific reports

authors： Radhakrishnan C,Chen PW,Jambulingam S,Byrnes T,Ali MM

更新日期：2019-02-20 00:00:00

abstract：:Accumulating evidences have suggested the potential association between Int7G24A (rs334354) polymorphism and cancer risk. However, results from epidemiological studies are controversial. We thus conducted this meta-analysis to clarify the association. Relevant studies were identified on electronic databases according ...

journal_title：Scientific reports

authors： Wu W,Tong Y,Wei X,Zhao Q,Pan X,Yu G,Lu Q

更新日期：2015-06-15 00:00:00

abstract：:The number of magnetoelectric multiferroic materials reported to date is scarce, as magnetic structures that break inversion symmetry and induce an improper ferroelectric polarization typically arise through subtle competition between different magnetic interactions. The (NH4)2[FeCl5(H2O)] compound is a rare case wher...

journal_title：Scientific reports

authors： Alberto Rodríguez-Velamazán J,Fabelo Ó,Millán Á,Campo J,Johnson RD,Chapon L

更新日期：2015-09-29 00:00:00

abstract：:Colorectal cancer (CRC) is a common complex disease caused by the combination of genetic variants and environmental factors. Genome-wide association studies (GWAS) have been performed and reported some novel CRC susceptibility variants. However, the potential genetic mechanisms for newly identified CRC susceptibility ...

journal_title：Scientific reports

authors： Lu X,Cao M,Han S,Yang Y,Zhou J

更新日期：2016-05-05 00:00:00

abstract：:The major components of vitelline membrane (VM) are ovomucin, VM outer (VMO) I and VMO II. At present, the distribution pattern of maternal cells on the VM has not been described in detail. In this study, the existence and distribution characteristics of maternal cells on VM were observed. There were more than 3.2 × 1...

journal_title：Scientific reports

authors： Li Q,Li W,Li X,Liu L,Zhang Y,Guo Y,Chen X,Xu G,Zheng J

更新日期：2017-07-26 00:00:00

abstract：:Computed Tomography derived Fractional Flow Reserve (CTFFR) is an emerging non-invasive imaging modality to assess functional significance of coronary stenosis. We performed a meta-analysis to compare the diagnostic performance of CTFFR to invasive Fractional Flow reserve (FFR). Electronic search was performed to iden...

journal_title：Scientific reports

authors： Agasthi P,Kanmanthareddy A,Khalil C,Egbuche O,Yarlagadda V,Sachdeva R,Arsanjani R

更新日期：2018-08-01 00:00:00

abstract：:Spin Hall effect (SHE) has been discussed in the context of Kubo formulation, geometric physics, spin orbit force, and numerous semi-classical treatments. It can be confusing if the different pictures have partial or overlapping claims of contribution to the SHE. In this article, we present a gauge-theoretic, time-mom...

journal_title：Scientific reports

authors： Tan SG,Jalil MB,Ho CS,Siu Z,Murakami S

更新日期：2015-12-22 00:00:00

abstract：:Mobility of people and goods during the Upper Paleolithic has proven difficult to reconstruct given the relative rareness of remains. Nevertheless, archaeological contexts like the Late Pleistocene horizon of Borsuka Cave (Southern Poland) represent a unique opportunity to explore patterns of objects' transportation a...

journal_title：Scientific reports

authors： Kowalik N,Anczkiewicz R,Wilczyński J,Wojtal P,Müller W,Bondioli L,Nava A,Gasparik M

更新日期：2020-06-25 00:00:00

abstract：:Knowledge of the structure-property-function relationship of humic substances (HSs) is key for understanding their role in soil. Despite progress, studies on this topic are still under discussion. We analyzed 37 humic fractions with respect to their isotopic composition, structural characteristics, and properties resp...

journal_title：Scientific reports

authors： García AC,de Souza LG,Pereira MG,Castro RN,García-Mina JM,Zonta E,Lisboa FJ,Berbara RL

更新日期：2016-02-10 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) affects over 30% of adults in the United States. Bone morphogenetic protein (BMP) signaling is known to contribute to hepatic fibrosis, but the role of BMP signaling in the development of NAFLD is unclear. In this study, treatment with either of two BMP inhibitors reduced hepa...

journal_title：Scientific reports

authors： Thayer TE,Lino Cardenas CL,Martyn T,Nicholson CJ,Traeger L,Wunderer F,Slocum C,Sigurslid H,Shakartzi HR,O'Rourke C,Shelton G,Buswell MD,Barnes H,Neitzel LR,Ledsky CD,Li JP,Burke MF,Farber-Eger E,Perrien DS,Kumar R,

更新日期：2020-06-19 00:00:00

abstract：:The pathogenesis of glioblastoma (GBM) is characterized by highly invasive behavior allowing dissemination and progression. A conclusive image of the invasive process is not available. The aim of this work was to study invasion dynamics in GBM using an innovative in vivo imaging approach. Primary brain tumor initiatin...

journal_title：Scientific reports

authors： Alieva M,Leidgens V,Riemenschneider MJ,Klein CA,Hau P,van Rheenen J

更新日期：2019-02-14 00:00:00

abstract：:It is critical to understand how variations in chemical composition in surface seawater (SSW) affect the chemistry of marine atmospheric aerosols. We investigated the sea-to-air transfer of dissolved organic carbon (DOC) via cruise measurements of both ambient aerosols and SSW in the Oyashio and its coastal regions, t...

journal_title：Scientific reports

authors： Miyazaki Y,Yamashita Y,Kawana K,Tachibana E,Kagami S,Mochida M,Suzuki K,Nishioka J

更新日期：2018-10-05 00:00:00

abstract：:Ethidium bromide (EB) and acridine orange (AO) bind to nucleic acids and are thus considered as potential mutagens. In this study, the effects of EB and AO on the germination behaviours of white, yellow, red, and purple maize seeds were investigated. The results indicate that low concentrations of EB (50 μg mL-1) and ...

journal_title：Scientific reports

authors： Zhang Y,Shi H,Deng B

更新日期：2018-09-19 00:00:00

abstract：:Pancreatic cancer induces a substantial global burden. We examined its global incidence/mortality rates and their correlation with socioeconomic development (Human Development Index [HDI] and Gross Domestic Product [GDP] in 2000 as proxy measures). Data on age-standardized incidence/mortality rates in 2012 were retrie...

journal_title：Scientific reports

authors： Wong MCS,Jiang JY,Liang M,Fang Y,Yeung MS,Sung JJY

更新日期：2017-06-09 00:00:00

abstract：:Epidermal electronic systems (EESs) are skin-like electronic systems, which can be used to measure several physiological parameters from the skin. This paper presents materials and a simple, straightforward fabrication process for skin-conformable inkjet-printed temperature sensors. Epidermal temperature sensors are a...

journal_title：Scientific reports

authors： Vuorinen T,Niittynen J,Kankkunen T,Kraft TM,Mäntysalo M

更新日期：2016-10-18 00:00:00