Abstract:
:The herbal medicine berberine (BBR) has been recently shown to be an AMP-activated protein kinase (AMPK) productive activator with various properties that induce anti-inflammatory responses. We investigated the effects of BBR on the mechanisms of mucosal CD4+T cell activation in vitro and on the inflammatory responses in T cell transfer mouse models of inflammatory bowel disease (IBD). We examined the favorable effects of BBR in vitro, using lamina propria (LP) CD4+ T cells in T cell transfer IBD models in which SCID mice had been injected with CD4+CD45RBhigh T cells. BBR suppressed the frequency of IFN-γ- and Il-17A-producing LP CD4+ T cells. This effect was found to be regulated by AMPK activation possibly induced by oxidative phosphorylation inhibition. We then examined the effects of BBR on the same IBD models in vivo. BBR-fed mice showed AMPK activation in the LPCD4+ T cells and an improvement of colitis. Our study newly showed that the BBR-induced AMPK activation of mucosal CD4+ T cells resulted in an improvement of IBD and underscored the importance of AMPK activity in colonic inflammation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Takahara M,Takaki A,Hiraoka S,Adachi T,Shimomura Y,Matsushita H,Nguyen TTT,Koike K,Ikeda A,Takashima S,Yamasaki Y,Inokuchi T,Kinugasa H,Sugihara Y,Harada K,Eikawa S,Morita H,Udono H,Okada Hdoi
10.1038/s41598-019-48331-wsubject
Has Abstractpub_date
2019-08-15 00:00:00pages
11934issue
1issn
2045-2322pii
10.1038/s41598-019-48331-wjournal_volume
9pub_type
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