Abstract：
:Simulation models in respiratory research are increasingly used for medical product development and testing, especially because in-vivo models are coupled with a high degree of complexity and ethical concerns. This work introduces a respiratory simulation system, which is bridging the gap between the complex, real anatomical environment and the safe, cost-effective simulation methods. The presented electro-mechanical lung simulator, xPULM, combines in-silico, ex-vivo and mechanical respiratory approaches by realistically replicating an actively breathing human lung. The reproducibility of sinusoidal breathing simulations with xPULM was verified for selected breathing frequencies (10-18 bpm) and tidal volumes (400-600 ml) physiologically occurring during human breathing at rest. Human lung anatomy was modelled using latex bags and primed porcine lungs. High reproducibility of flow and pressure characteristics was shown by evaluating breathing cycles (nTotal = 3273) with highest standard deviation |3σ| for both, simplified lung equivalents ([Formula: see text] = 23.98 ± 1.04 l/min, μP = -0.78 ± 0.63 hPa) and primed porcine lungs ([Formula: see text] = 18.87 ± 2.49 l/min, μP = -21.13 ± 1.47 hPa). The adaptability of the breathing simulation parameters, coupled with the use of porcine lungs salvaged from a slaughterhouse process, represents an advancement towards anatomically and physiologically realistic modelling of human respiration.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Pasteka R,Forjan M,Sauermann S,Drauschke Adoi
10.1038/s41598-019-56176-6subject
Has Abstractpub_date
2019-12-24 00:00:00pages
19778issue
1issn
2045-2322pii
10.1038/s41598-019-56176-6journal_volume
9pub_type
杂志文章abstract：:Crops have different strategies to acquire poorly-available soil phosphorus (P) which are dependent on their architectural, morphological, and physiological root traits, but their capacity to enhance P acquisition varies with the type of fertilizer applied. The objective of this study was to examine how P-acquisition ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51204-x
更新日期：2019-10-16 00:00:00
abstract：:The Fabry-Pérot interferometer is used in a variety of high-precision optical interferometry applications, such as gravitational wave detection. It is also used in various types of laser resonators to act as a narrow band filter. In addition, ultra-compact Fabry-Pérot interferometers are used in the optical resonators...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33665-8
更新日期：2018-10-12 00:00:00
abstract：:Three main surveillance systems (laboratory-confirmed, influenza-like illness (ILI) and nationwide Notifiable Infectious Diseases Reporting Information System (NIDRIS)) have been used for influenza surveillance in China. However, it is unclear which surveillance system is more reliable in developing influenza early wa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21059-9
更新日期：2018-02-12 00:00:00
abstract：:Advanced glycation end products (AGEs) are sugar-modified biomolecules that accumulate in the body with advancing age, and are implicated in the development of multiple age-associated structural and functional abnormities and diseases. It has been well documented that AGEs signal via their receptor RAGE to activate se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18822
更新日期：2016-01-05 00:00:00
abstract：:We estimated the prevalence of anemia among school children and investigated factors associated with this problem in Kuwait. A cross-sectional study was conducted on 1415 adolescents randomly selected from middle schools in Kuwait. Hemoglobin, iron, ferritin, folate and vitamin B12, in addition to many other laborator...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60816-7
更新日期：2020-04-03 00:00:00
abstract：:We have experimentally demonstrated a strong correlation between the electrical properties of Zn1-xTex Ovonic threshold switching (OTS) selector device and the material properties analysed by X-ray diffraction (XRD), spectroscopic ellipsometry, and X-ray photoelectron spectroscopy (XPS). The correlation and the key ma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30207-0
更新日期：2018-08-07 00:00:00
abstract：:Although most nanofabrication techniques can control nano/micro particle (NMP) size over a wide range, the majority of NMPs for biomedical applications exhibits a diameter of ~100 nm. Here, the vascular distribution of spherical particles, from 10 to 1,000 nm in diameter, is studied using intravital microscopy and com...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02079
更新日期：2013-01-01 00:00:00
abstract：:Balance disorders have been poorly investigated and somewhat neglected in people infected with the human immunodeficiency virus, especially in children, whose have intrinsic and extrinsic risk factors that may compromise the balance. To evaluate the foot plantar pressures and the balance in children with acquired immu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41028-0
更新日期：2019-03-13 00:00:00
abstract：:Plant responses to salinity have been extensively studied over the last decades. Despite the vast accumulated knowledge, the ways Arabidopsis lateral roots (LR) cope with lethal salinity has not been fully resolved. Here we compared the primary root (PR) and the LR responses during events leading to lethal salinity (N...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60163-7
更新日期：2020-02-24 00:00:00
abstract：:Different marine habitats are characterised by different soundscapes. How or which differences may be representative of the habitat characteristics and/or community structure remains however to be explored. A growing project in passive acoustics is to find a way to use soundscapes to have information on the habitat an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33326
更新日期：2016-09-15 00:00:00
abstract：:Lepisosteoids are known for their evolutionary conservatism, and their body plan can be traced at least as far back as the Early Cretaceous, by which point two families had diverged: Lepisosteidae, known since the Late Cretaceous and including all living species and various fossils from all continents, except Antarcti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17984-w
更新日期：2017-12-19 00:00:00
abstract：:The stress distribution around endosseous implants is an important determinant of the surgical success. However, no method developed so far to determine the implant stability is sensitive to the loading conditions of the bone-implant interface (BII). The objective of this study is to investigate whether a quantitative...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50665-4
更新日期：2019-10-02 00:00:00
abstract：:Pectins, the major components of cell walls in plants, are synthesized and secreted to cell walls as highly methyl-esterified polymers and then demethyl-esterified by pectin methylesterases (PMEs). The PMEs are spatially regulated by pectin methylesterase inhibitors (PMEIs). In this study, 43 and 49 putative PME and P...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56254-9
更新日期：2019-12-27 00:00:00
abstract：:On-chip integration of optical detection units into the microfluidic systems for online monitoring is highly desirable for many applications and is also well in line with the spirit of optofluidics technology-fusion of optics and microfluidics for advanced functionalities. This paper reports the construction of a UV-V...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28928
更新日期：2016-06-29 00:00:00
abstract：:Colorectal cancer (CRC) is one of the most prevalent cancers worldwide and Alpha B-crystallin (CRYAB) protein has been identified as a prognostic biomarker for CRC. We evaluated CRYAB C-802G (rs14133)polymorphism in association with CRC risk and survival in Chinese population. We genotyped for CRYAB C-802G (rs14133), ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29589-y
更新日期：2018-08-06 00:00:00
abstract：:FGF10 is a member of fibroblast growth factors (FGFs). We previously showed that FGF10 protects neuron against oxygen-glucose deprivation injury in vitro; however, the effect of FGF10 in ischemic stroke in vivo is unknown. In the present study, we showed that FGF10 was mainly expressed in neurons but not astrocytes, a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19869
更新日期：2016-01-27 00:00:00
abstract：:Next generation sequencing is transforming clinical medicine and genome research, providing a powerful route to establishing molecular diagnoses for genetic conditions; however, challenges remain given the volume and complexity of genetic variation. A number of methods integrate patient phenotype and genotypic data to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13841-y
更新日期：2017-10-18 00:00:00
abstract：:Accumulating evidence suggests that the gut microbiota dysbiosis and their host metabolic phenotype alteration is an important factor in human disease development. A traditional Chinese herbal formula, Chaihu-Shu-Gan-San (CSGS), has been effectively used in the treatment of various gastrointestinal (GI) disorders. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46551
更新日期：2017-04-20 00:00:00
abstract：:Mesoporous silica nanoscale microsphere (MSNM), with a special morphology, high porosity, large pore volume and specific surface area, was successfully prepared and used as the matrix material of lauric acid (LA) to prepare a favorable shape-stabilized phase change material (LA/MSNM). The porous network structure of M...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52553-3
更新日期：2019-11-05 00:00:00
abstract：:Real-time in-situ temperature detection is essential in many applications. In this paper, a simple and robust optode, which uses Ruthenium (II) complex as a temperature indicator, has been developed for rapid and sensitive temperature detection in small volume samples (<5 μL). Transmission of excitation light and coll...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05009
更新日期：2014-05-30 00:00:00
abstract：:The prognostic value of current multigene assays for breast cancer is limited to hormone receptor-positive, human epidermal growth factor receptor 2-negative early breast cancer. Despite the prognostic significance of immune response-related genes in breast cancer, immune gene signatures have not been incorporated int...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80274-5
更新日期：2021-01-08 00:00:00
abstract：:Bimetallic Pd1-x Pt x solid-solution nanoparticles (NPs) display charging/discharging of hydrogen gas, which has relevance for fuel cell technologies; however, the constituent elements are immiscible in the bulk phase. We examined these material systems using high-energy synchrotron X-ray diffraction, X-ray absorption...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14494-7
更新日期：2017-11-06 00:00:00
abstract：:A marine isolate, Nesiotobacter exalbescens COD22, isolated from deep sea sediment (2100 m depth) was capable of degrading aromatic hydrocarbons. The Nesiotobacter sp. grew well in the presence of toluene at 0.1 MPa and 10 MPa at a rate of 0.24 h-1 and 0.12 h-1, respectively, in custom designed high pressure reactors....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55115-9
更新日期：2019-12-10 00:00:00
abstract：:Although carbon nanotubes (CNTs) have shown great potential for enhancing the performance of polymer matrices, their reinforcement role still needs to be further improved. Here we implement a structural modification of multi-walled CNTs (MWCNTs) to fully utilize their fascinating mechanical and electrical properties v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17365-3
更新日期：2017-12-07 00:00:00
abstract：:Inbreeding can depress individuals' fitness traits and reduce population viability. However, studies that directly translate inbreeding depression on fitness traits into consequences for population viability, and further, into consequences for management choices, are lacking. Here, we estimated impacts of inbreeding d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79979-4
更新日期：2021-01-12 00:00:00
abstract：:Inositol Requiring Enzyme-1 (IRE1) is the most conserved transducer of the Unfolded Protein Response (UPR), a surveillance mechanism that ensures homeostasis of the endoplasmic reticulum (ER) in eukaryotes. IRE1 activation orchestrates adaptive responses, including lipid anabolism, metabolic reprogramming, increases i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16662-1
更新日期：2017-11-28 00:00:00
abstract：:Streptococcus mutans is known to be a major causative agent of dental caries, and strains expressing the cell surface collagen-binding Cnm protein contribute to the development of several systemic diseases. A relationship between tonsillar immunity and glomerulonephritis has been recognized in IgA nephropathy (IgAN), ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56679-2
更新日期：2019-12-27 00:00:00
abstract：:The physiological importance of CD151 tetraspanin is known from somatic cells and its outside-in signalling through integrins was described. In male germ cells, two tetraspanins, CD9 and CD81, are involved in sperm-egg membrane fusion, and similarly to integrins, they occupy characteristic regions. We report here on a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61334-2
更新日期：2020-03-09 00:00:00
abstract：:Wnt/β-catenin signalling plays a prominent role in maintaining self-renewal and pluripotency of mouse embryonic stem cells (mESCs). microRNAs (miRNAs) have critical roles in maintaining pluripotency and directing reprogramming. To investigate the effect of GSK3 inhibitors on miRNA expression, we analysed the miRNA exp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08666
更新日期：2015-03-02 00:00:00
abstract：:Birds have a highly specialized and efficient digestive system, but when this system originated remains uncertain. Here we report six gastric pellets attributable to the recently discovered 160-million-year-old troodontid dinosaur Anchiornis, which is among the key taxa for understanding the transition to birds. The g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32202-x
更新日期：2018-09-21 00:00:00
