Abstract:
:The prognostic value of current multigene assays for breast cancer is limited to hormone receptor-positive, human epidermal growth factor receptor 2-negative early breast cancer. Despite the prognostic significance of immune response-related genes in breast cancer, immune gene signatures have not been incorporated into most multigene assays. Here, using public gene expression microarray datasets, we classified breast cancer patients into three risk groups according to clinical risk and proliferation risk. We then developed the immune prognostic index based on expression of five immune response-related genes (TRAT1, IL2RB, CTLA4, IGHM and IL21R) and lymph node status to predict the risk of recurrence in the clinical and proliferation high-risk (CPH) group. The 10-year probability of disease-free survival (DFS) or distant metastasis-free survival (DMFS) of patients classified as high risk according to the immune prognostic index was significantly lower than those of patients classified as intermediate or low risk. Multivariate analysis revealed that the index is an independent prognostic factor for DFS or DMFS. Moreover, the C-index revealed that it is superior to clinicopathological variables for predicting prognosis. Its prognostic significance was also validated in independent datasets. The immune prognostic index identified low-risk patients among patients classified as CPH, regardless of the molecular subtype of breast cancer, and may overcome the limitations of current multigene assays.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee H,Kwon MJ,Koo BM,Park HG,Han J,Shin YKdoi
10.1038/s41598-020-80274-5subject
Has Abstractpub_date
2021-01-08 00:00:00pages
128issue
1issn
2045-2322pii
10.1038/s41598-020-80274-5journal_volume
11pub_type
杂志文章abstract::Occlusion of the middle cerebral artery (MCA) by an intraluminal filament is widely used to study focal brain ischemia in male Sprague-Dawley rats. However, permanent occlusion goes along with a high fatality. To overcome this drawback we designed a new filament carrying a bowling pin-shaped tip (BP-tip) and compared ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28401
更新日期:2016-06-22 00:00:00
abstract::In recent years, the topic of noise in the sea and its effects on marine mammals has attracted considerable attention from both the scientific community and the general public. Since marine mammals rely heavily on acoustics as a primary means of communicating, navigating, and foraging in the ocean, any change in their...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00437
更新日期:2012-01-01 00:00:00
abstract::Drugs of abuse represent a growing public health crisis. Accumulating evidence indicates that gabapentin (GBP), a prescription drug, is prone to misuse, abuse, withdrawal, and dependence. Commonly, drugs of abuse modulate the dopaminergic system to induce addiction. In this study, we used the conditioned place prefere...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67318-6
更新日期:2020-06-26 00:00:00
abstract::Referential pointing is a characteristically human behavior, which involves moving a finger through space to direct an addressee towards a desired mental state. Planning this type of action requires an interface between sensorimotor and conceptual abilities. A simple interface could supplement spatially-guided motor r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04442-w
更新日期:2017-06-27 00:00:00
abstract::The interfacial Dzyaloshinskii-Moriya interaction (DMI) is an essential ingredient for stabilizing chiral spin configurations in spintronic applications. Here, via first-principles calculations, we reveal the influence of lattice strain on DMI in Co/Pt interface. We observed a considerable enhancement for a certain la...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69360-w
更新日期:2020-07-23 00:00:00
abstract::Cardiovascular risk rapidly increased following exposure to air pollution. Changes in human autonomic regulation have been implicated based on epidemiological associations between exposure estimates and indirect autonomic nervous system measurements. We conducted a mechanistic study to test the hypothesis that, in hea...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-019-40343-w
更新日期:2019-03-06 00:00:00
abstract::The Csf1r locus encodes the receptor for macrophage colony-stimulating factor, which controls the proliferation, differentiation and survival of macrophages. The 300 bp Fms intronic regulatory element (FIRE), within the second intron of Csf1r, is necessary and sufficient to direct macrophage-specific transcription. We...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15999-x
更新日期:2017-12-07 00:00:00
abstract::The obesity-associated inflammation of white adipose tissue (WAT) is one of the factors leading to the development of related diseases such as insulin resistance and liver steatosis. Recently, microRNAs (miRNAs) were identified as important regulators of WAT functions. Herein, we cultured human Simpson-Golabi-Behmel s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38339
更新日期:2016-12-06 00:00:00
abstract::Radical cystectomy (RC) together with bilateral pelvic lymph node dissection remains the standard treatment for muscle invasive bladder cancer (MIBC). However, radiation-based treatments such as tri-modal therapy (TMT) involving maximally performed transurethral resection of bladder tumor (TURBT), radiotherapy (XRT), ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42864-w
更新日期:2019-04-23 00:00:00
abstract::Greenhouse and field studies were conducted to provide a reference for pre-emergence (PRE) application of isoxaflutole on maize in China. In greenhouse study, the isoxaflutole PRE application at 30 g active ingredient (a.i.) ha-1 could effectively control large numbers of weeds, especially some large-seeded broadleave...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12696-7
更新日期:2017-10-04 00:00:00
abstract::Clobetasol propionate (CLO) is a potent glucocorticoid used to treat inflammation-based skin, scalp, and hair disorders. In such conditions, hair follicles (HF) are not only the target site but can also act as drug reservoirs when certain formulations are topically applied. Recently, we have demonstrated nanostructure...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56760-w
更新日期:2020-01-13 00:00:00
abstract::Dysregulation of iron metabolism, and resultant cytotoxicity, has been implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative processes. Iron accumulation promotes cytotoxicity through various mechanisms including oxidative stress and glutamate toxicity, and occurs in both MS patients an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48087-3
更新日期:2019-08-12 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-28651-z
更新日期:2018-07-05 00:00:00
abstract::Flavonoids, due to their pharmacological attributes, have recently become target molecules for metabolic engineering in commonly consumed food crops. Strategies including expression of single genes and gene pyramiding have provided only limited success, due principally to the highly branched and complex biosynthetic p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05018
更新日期:2014-05-21 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is one of the most common respiratory diseases. Yihuo Huatan Formula (YHF), as a proven Chinese Herbal Medicine (CHM), has been verified to be effective in the treatment of stable COPD through years' of practice. Nevertheless, its working mechanism is still unclear. We soug...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50064-9
更新日期:2019-09-17 00:00:00
abstract::Glucosinolates (GSLs) and their hydrolysis products present in Brassicales play important roles in plants against herbivores and pathogens as well as in the protection of human health. To elucidate the molecular mechanisms underlying the formation of species-specific GSLs and their hydrolysed products in Raphanus sati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16306-4
更新日期:2017-11-22 00:00:00
abstract::In this paper, we investigate the relationship between the quantum speedup, non-Markovianity and formation of a system-environment bound state. Previous results show a monotonic relation between these three such that providing bound states with more negative energy can lead to a higher degree of non-Markovianity, and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51290-x
更新日期:2019-10-18 00:00:00
abstract::When a dot moves horizontally across a set of tilted lines of alternating orientations, the dot appears to be moving up and down along its trajectory. This perceptual phenomenon, known as the slalom illusion, reveals a mismatch between the veridical motion signals and the subjective percept of the motion trajectory, w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64837-0
更新日期:2020-05-08 00:00:00
abstract::Effective population size reflects the history of population growth, contraction, and structuring. When the effect of structuring is negligible, the inferred trajectory of the effective population size can be informative about the key events in the history of a population. We used the IBDNe and DoRIS approaches, which...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/s41598-020-66734-y
更新日期:2020-06-16 00:00:00
abstract::Developing the high-efficient and green synthetic method for chiral amino alcohols is an intriguing target. We have developed the Mg(2+)-doped Cu/ZnO/Al2O3 catalyst for hydrogenation of L-phenylalanine methyl ester to chiral L-phenylalaninol without racemization. The effect of different L-phenylalanine esters on this ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33196
更新日期:2016-09-13 00:00:00
abstract::A new approach for achieving two - dimensional (2D) atom localization microscopy based on the projection of three - dimensional (3D) localization in the plane of the detector is described in the present work. Spatial variation of the position-dependent 2D-localization pattern in the xy-plane is obtained with the shift...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57141-z
更新日期:2020-01-17 00:00:00
abstract::Th17 and regulatory T cells, involved in the pathogenesis of several autoimmune diseases, are new lineages of CD4+ T helper cells. However, the role of their imbalance in human leukocyte antigen B27-associated acute anterior uveitis has not been elucidated. In our study, the percentages of Th17 and Treg cells, their m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40414
更新日期:2017-01-16 00:00:00
abstract::The pathological mechanism of Kashin-Beck disease (KBD), an endemic osteoarthritic disease, remains to be poorly understood. This study was designed to identify signaling pathways and crucial proteins involved in the pathological mechanism of KBD compared with osteoarthritis (OA). The knee cartilage samples were colle...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63932-6
更新日期:2020-04-22 00:00:00
abstract::Peripheral nerve long gap defects are a clinical challenge in the regeneration field. Despite the wide variety of surgical techniques and therapies, autografting is the "gold standard" for peripheral nerve gap reconstruction. The pathological process of Wallerian degeneration from the time of acute injury to efficient...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39828
更新日期:2016-12-23 00:00:00
abstract::Astrocyte reactivation has been discovered to be an important contributor to several neurological diseases. In vitro models involving human astrocytes have the potential to reveal disease-specific mechanisms of these cells and to advance research on neuropathological conditions. Here, we induced a reactive phenotype i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53414-9
更新日期:2019-11-15 00:00:00
abstract::Alcohol and nicotine are the most widely co-abused drugs. Both modify the activity of dopaminergic (DA) neurons of the Ventral Tegmental Area (VTA) and lead to an increase in DA release in the Nucleus Accumbens, thereby affecting the reward system. Evidences support the hypothesis that distinct nicotinic acetylcholine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45116
更新日期:2017-03-23 00:00:00
abstract::A previous randomized, controlled trial had demonstrated that complete intraureteral stent placement (CIU-SP) was superior to conventional stent placement (C-SP) in terms of improvement of stent-related urinary symptoms. However, it is unclear as to which subdomain symptom and cohort could benefit the most from CIU-SP...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-72937-0
更新日期:2020-09-28 00:00:00
abstract::Advanced maternal age is associated with an increased risk of pregnancy complications. It programmes sex-specific cardiovascular dysfunction in rat offspring, however the intrauterine mechanisms involved remain unknown. This study in the rat assessed the impact of advanced maternal age on placental phenotype in relati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53199-x
更新日期:2019-11-28 00:00:00
abstract::We have investigated the paths taken by Budgerigars while flying in a tunnel. The flight trajectories of nine Budgerigars (Melopsittacus undulatus) were reconstructed in 3D from high speed stereo videography of their flights in an obstacle-free tunnel. Individual birds displayed highly idiosyncratic flight trajectorie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59013-3
更新日期:2020-02-13 00:00:00
abstract::Magnetic vortex is one of the simplest topologically non-trivial textures in condensed matter physics. It is the ground state of submicron magnetic elements (dots) of different shapes: cylindrical, square etc. So far, the vast majority of the vortex dynamics studies were focused on thin dots with thickness 5-50 nm and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13881
更新日期:2015-09-10 00:00:00