Abstract：
:The Csf1r locus encodes the receptor for macrophage colony-stimulating factor, which controls the proliferation, differentiation and survival of macrophages. The 300 bp Fms intronic regulatory element (FIRE), within the second intron of Csf1r, is necessary and sufficient to direct macrophage-specific transcription. We have analysed the conservation and divergence of the FIRE DNA sequence in vertebrates. FIRE is present in the same location in the Csf1r locus in reptile, avian and mammalian genomes. Nearest neighbor analysis based upon this element alone largely recapitulates phylogenies inferred from much larger genomic sequence datasets. One core element, containing binding sites for AP1 family and the macrophage-specific transcription factor, PU.1, is conserved from lizards to humans. Around this element, the FIRE sequence is conserved within clades with the most conserved elements containing motifs for known myeloid-expressed transcription factors. Conversely, there is little alignment between clades outside the AP1/PU.1 element. The analysis favours a hybrid between "enhanceosome" and "smorgasbord" models of enhancer function, in which elements cooperate to bind components of the available transcription factor milieu.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hume DA,Wollscheid-Lengeling E,Rojo R,Pridans Cdoi
10.1038/s41598-017-15999-xsubject
Has Abstractpub_date
2017-12-07 00:00:00pages
17115issue
1issn
2045-2322pii
10.1038/s41598-017-15999-xjournal_volume
7pub_type
杂志文章abstract：:Peptides derived from the N-terminal heptad repeat (NHR) of HIV-1 gp41 can be potent inhibitors against viral entry when presented in a nonaggregating trimeric coiled-coil conformation via the introduction of exogenous trimerization motifs and intermolecular disulfide bonds. We recently discovered that crosslinking is...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32161
更新日期：2016-08-26 00:00:00
abstract：:Spherical radioactive caesium (Cs)-bearing microparticles (CsMPs) were emitted during the Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident in March, 2011. The emission source (timing) and formation process of these particles remain unclear. In this study, the isotopic ratios of uranium (235U and 238U) and caesi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59933-0
更新日期：2020-02-24 00:00:00
abstract：:Biomarkers are measurable changes associated with the disease. Urine can reflect the changes of the body while blood is under control of the homeostatic mechanisms; thus, urine is considered an important source for early and sensitive disease biomarker discovery. A comprehensive profile of the urinary proteome will pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03226-6
更新日期：2017-06-08 00:00:00
abstract：:El Niño-Southern Oscillation (ENSO), which is one of the main drivers of Earth's inter-annual climate variability, often causes a wide range of climate anomalies, and the advance prediction of ENSO is always an important and challenging scientific issue. Since a unified and complete ENSO theory has yet to be establish...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65070-5
更新日期：2020-05-15 00:00:00
abstract：:Evolutions of Asian and Australian monsoons have important significance for understanding the past global change but are still a controversial subject. Here, we explore systematically the effects of plate movement and plateau uplift on the formation and evolution of the Asian and Australian monsoons by numerical simul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40344
更新日期：2017-01-13 00:00:00
abstract：:Autism is a common and often severe neurodevelopmental disorder for which diverse pathophysiological processes have been proposed. Recent gene expression data comparing autistic and control brains suggest that the normal differential gene expression between frontal and temporal cortex is attenuated in autistic brains....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01831
更新日期：2013-01-01 00:00:00
abstract：:Phagocytosis is a required mechanism for the defense against pathogens. Staphylococcus aureus, an important bacterial pathogen, can promptly escape from phagosomes and proliferate within the cytoplasm of host. However, the mechanism of phagocytosis against S. aureus has not been intensively investigated. In this study...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14854
更新日期：2015-10-07 00:00:00
abstract：:Until now, the only kind of practical quantum private query (QPQ), quantum-key-distribution (QKD)-based QPQ, focuses on the retrieval of a single bit. In fact, meaningful message is generally composed of multiple adjacent bits (i.e., a multi-bit block). To obtain a message a1a2···al from database, the user Alice has t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07537
更新日期：2014-12-18 00:00:00
abstract：:The recent reported trapped "rainbow" storage of light using metamaterials and plasmonic graded surface gratings has generated considerable interest for on-chip slow light. The potential for controlling the velocity of broadband light in guided photonic structures opens up tremendous opportunities to manipulate light ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01249
更新日期：2013-01-01 00:00:00
abstract：:We have investigated the use of fluorescent molecular rotors as probes for detection of p53 binding to DNA. These are a class of fluorophores that undergo twisted intramolecular charge transfer (TICT). They are non-fluorescent in a freely rotating conformation and experience a fluorescence increase when restricted in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31197-9
更新日期：2018-08-28 00:00:00
abstract：:Platelet-derived growth factor receptor beta (PDGFRβ) affects in numerous human cancers and has been recognized as a promising molecular target for cancer therapies. The overexpression of PDGFRβ could be a biomarker for cancer diagnosis. Radiolabeled ligands having high affinity for the molecular target could be usefu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28529-0
更新日期：2018-07-10 00:00:00
abstract：:Hirsutella sinensis mycelium (HSM), the anamorph of Cordyceps sinensis, is a traditional Chinese medicine that has been shown to possess various pharmacological properties. We previously reported that this fungus suppresses interleukin-1β and IL-18 secretion by inhibiting both canonical and non-canonical inflammasomes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15282
更新日期：2015-10-26 00:00:00
abstract：:The study utilizes autofluorescence spectroscopy (AFS) along with multivariate spectral analysis for differentiating various stages of hepatic fibrosis. AFS has recently emerged as an efficient tool for evaluating the variations in different endogenous flurophores. In this study, the potential of AFS for differentiati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29370-1
更新日期：2018-07-20 00:00:00
abstract：:Grafting of commercial tomato varieties and hybrids on the tomato ecotype Manduria resulted in high levels of tolerance to the infection of Sw5 resistance-breaking strains of tomato spotted wilt virus and of severe cucumber mosaic virus strains supporting hypervirulent satellite RNAs that co-determine stunting and nec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59421-5
更新日期：2020-02-13 00:00:00
abstract：:TiNb6O17 and TiNb2O7 were synthesized using a solid-state method. The techniques were used to assess the electrochemical performance and lithium diffusion kinetics of TiNb6O17 related to the unit cell volume with TiNb2O7. The charge-discharge curves and cyclic voltammetry revealed TiNb6O17 to have a similar redox pote...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16711-9
更新日期：2017-11-30 00:00:00
abstract：:Pleiotrophin (PTN) is a cytokine that is upregulated in different neuroinflammatory disorders. Using mice with transgenic PTN overexpression in the brain (Ptn-Tg), we have found a positive correlation between iNos and Tnfα mRNA and Ptn mRNA levels in the prefrontal cortex (PFC) of LPS-treated mice. PTN is an inhibitor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76415-5
更新日期：2020-11-20 00:00:00
abstract：:When making choices between smaller, sooner rewards and larger, later ones, people tend to discount future outcomes. Individual differences in temporal discounting in older adults have been associated with episodic memory abilities and entorhinal cortical thickness. The cause of this association between better memory ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63373-1
更新日期：2020-04-14 00:00:00
abstract：:Integrins are α/β heterodimeric transmembrane adhesion receptors. Evidence exists that their transmembrane domain (TMD) separates upon activation. Subunit-specific differences in activation sensitivity of integrins were reported. However, whether sequence variations in the TMD lead to differential TMD association has ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23778-5
更新日期：2018-04-10 00:00:00
abstract：:While concerns about human-induced effects on the Earth's climate have mainly concentrated on carbon dioxide (CO2) and methane (CH4), reducing anthropogenic nitrous oxide (N2O) flux, mainly of agricultural origin, also represents an opportunity for substantial mitigation. To develop a solution that induces neither the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56694-3
更新日期：2019-12-27 00:00:00
abstract：:Increasing structural complexity at nanoscale can permit superior control over photophysical properties in the precursor-derived semiconductors. We demonstrate here the synthesis of silicon carbonitride (SiCN)/boron nitride (BN) nanocomposites via a polymer precursor route wherein the cobalt polyamine complexes used a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39866
更新日期：2017-01-13 00:00:00
abstract：:We previously identified Drosophila REPTOR and REPTOR-BP as transcription factors downstream of mTORC1 that play an important role in regulating organismal metabolism. We study here the mammalian ortholog of REPTOR-BP, Crebl2. We find that Crebl2 mediates part of the transcriptional induction caused by mTORC1 inhibiti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56407-w
更新日期：2019-12-27 00:00:00
abstract：:Drying and aging paint dispersions display a wealth of complex phenomena that make their study fascinating yet challenging. To meet the growing demand for sustainable, high-quality paints, it is essential to unravel the microscopic mechanisms underlying these phenomena. Visualising the governing dynamics is, however, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34383
更新日期：2016-09-29 00:00:00
abstract：:The increasing availability of electronic health care records has provided remarkable progress in the field of population health. In particular the identification of disease risk factors has flourished under the surge of available data. Researchers can now access patient data across a broad range of demographics and g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30465
更新日期：2016-07-27 00:00:00
abstract：:Autistic spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social communication and restricted/repetitive behavior patterns or interests. Antagonists targeting histamine H3 receptor (H3R) are considered potential therapeutic agents for the therapeutic management of different brain...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31385-7
更新日期：2018-08-30 00:00:00
abstract：:Alcohol dependence (AD) and aggression-impulsivity are both associated with increased suicide risk. There is a need to evaluate clinical tools in order to improve suicide risk assessment of AD patients. The present study consisted of 95 individuals with a diagnosis of AD, consecutively admitted for addiction treatment...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19373
更新日期：2016-01-19 00:00:00
abstract：:Longitudinal developmental fMRI studies just recently began to focus on within-subject reliability using the intraclass coefficient (ICC). It remains largely unclear which degree of reliability can be achieved in developmental studies and whether this depends on the type of task used. Therefore, we aimed to systematic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02334-7
更新日期：2017-05-23 00:00:00
abstract：:Protein ubiquitination and degradation represent druggable vulnerabilities of cancer cells. We used gene expression and functional annotation analyses to identify genes in the ubiquitin pathway which are differentially expressed between normal breast and basal-like tumors. With this approach we identified 16 ubiquitin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17836-7
更新日期：2017-12-13 00:00:00
abstract：:2-(1-Undecyloxy)-1-ethanol, monochamol, is a male-produced aggregation pheromone of the Monochamus species, which are efficient vectors of the pine wood nematode (PWN), Bursaphelenchus xylophilus, which cause devastating damage to pines worldwide. The nematicidal activity of synthetic monochamol and its homologues (RO...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29300
更新日期：2016-07-11 00:00:00
abstract：:The cation diffusion facilitator (CDF) is a conserved family of divalent d-block metal cation transporters that extrude these cations selectively from the cytoplasm. CDF proteins are composed of two domains: the transmembrane domain, through which the cations are transported, and a regulatory cytoplasmic C-terminal do...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71036-4
更新日期：2020-08-20 00:00:00
abstract：:Surface enhanced Raman scattering (SERS) is generally and widely used to enhance the vibrational fingerprint of molecules located at the vicinity of noble metal nanoparticles. In this work, SERS is originally used to enhance the own vibrational density of states (VDOS) of nude and isolated gold nanoparticles. This off...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39164
更新日期：2016-12-16 00:00:00
