Abstract：
:Biomarkers are measurable changes associated with the disease. Urine can reflect the changes of the body while blood is under control of the homeostatic mechanisms; thus, urine is considered an important source for early and sensitive disease biomarker discovery. A comprehensive profile of the urinary proteome will provide a basic understanding of urinary proteins. In this paper, we present an in-depth analysis of the urinary proteome based on different separation strategies, including direct one dimensional liquid chromatography-tandem mass spectrometry (LC/MS/MS), two dimensional LC/MS/MS, and gel-eluted liquid fraction entrapment electrophoresis/liquid-phase isoelectric focusing followed by two dimensional LC/MS/MS. A total of 6085 proteins were identified in healthy urine, of which 2001 were not reported in previous studies and the concentrations of 2571 proteins were estimated (spanning a magnitude of 106) with an intensity-based absolute quantification algorithm. The urinary proteins were annotated by their tissue distribution. Detailed information can be accessed at the "Human Urine Proteome Database" (www.urimarker.com/urine).
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhao M,Li M,Yang Y,Guo Z,Sun Y,Shao C,Li M,Sun W,Gao Ydoi
10.1038/s41598-017-03226-6subject
Has Abstractpub_date
2017-06-08 00:00:00pages
3024issue
1issn
2045-2322pii
10.1038/s41598-017-03226-6journal_volume
7pub_type
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