Role of JAK-STAT signaling in maturation of phagosomes containing Staphylococcus aureus.

Abstract:

:Phagocytosis is a required mechanism for the defense against pathogens. Staphylococcus aureus, an important bacterial pathogen, can promptly escape from phagosomes and proliferate within the cytoplasm of host. However, the mechanism of phagocytosis against S. aureus has not been intensively investigated. In this study, the S. aureus was engulfed by macrophages (RAW264.7 cells) but not digested by the cells, suggesting that the phagosomes did not maturate in macrophages. Further investigation revealed that peptidoglycan (PG) induced the phagosome maturation of macrophages, resulting in the eradication of S. aureus. Genome-wide analysis and quantitative real-time PCR indicated that the JAK-STAT pathway was activated by PG during the phagosome maturation of macrophages against S. aureus. This finding presented that the PG-activated JAK-STAT pathway was required for phagosome maturation. Therefore, our study contributed evidence that revealed a novel aspect of PG-triggered JAK-STAT pathway in the phagosome maturation of macrophages.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zhu F,Zhou Y,Jiang C,Zhang X

doi

10.1038/srep14854

subject

Has Abstract

pub_date

2015-10-07 00:00:00

pages

14854

issn

2045-2322

pii

srep14854

journal_volume

5

pub_type

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