Abstract:
:Alcohol dependence (AD) and aggression-impulsivity are both associated with increased suicide risk. There is a need to evaluate clinical tools in order to improve suicide risk assessment of AD patients. The present study consisted of 95 individuals with a diagnosis of AD, consecutively admitted for addiction treatment, compared with 95 healthy controls. Suicidal risk was assessed together with exposure of violence and impulsivity. AD patients reported significantly higher rates of exposure to violence in childhood, as measured by the Karolinska Interpersonal Violence Scale (KIVS), compared to HC. Within the AD group, individuals with history of suicidal ideation and suicidal behavior reported higher levels of violence experience compared to AD individuals without such history. AD patients with previous suicidal ideation scored higher on self-reported impulsivity as assessed by the Barratt Impulsivity Scale (BIS). Our main finding was that experience of trauma and expression of violent behavior, coupled with increased impulsivity are associated with an elevated suicide risk in AD patients. Future longitudinal studies assessing these traits are needed to evaluate their potential role in identifying AD patients at risk of future suicide.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Khemiri L,Jokinen J,Runeson B,Jayaram-Lindström Ndoi
10.1038/srep19373subject
Has Abstractpub_date
2016-01-19 00:00:00pages
19373issn
2045-2322pii
srep19373journal_volume
6pub_type
杂志文章abstract::In this work, we utilise a combination of theory, computation and experiments to understand the early events related to the nucleation of Ag filaments on α-Ag2WO4 crystals, which is driven by an accelerated electron beam from an electron microscope under high vacuum. The growth process and the chemical composition and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05391
更新日期:2014-06-23 00:00:00
abstract::Electron ptychography has seen a recent surge of interest for phase sensitive imaging at atomic or near-atomic resolution. However, applications are so far mainly limited to radiation-hard samples, because the required doses are too high for imaging biological samples at high resolution. We propose the use of non-conv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07488-y
更新日期:2017-08-29 00:00:00
abstract::Accumulating evidence across species and memory domains shows that when an existing memory is reactivated, it becomes susceptible to modifications. However, the potential role of reward signals in these mechanisms underlying human memory dynamics is unknown. Leaning on a wealth of findings on the role of reward in rei...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28270
更新日期:2016-06-16 00:00:00
abstract::The rockpool shrimp Palaemon elegans is an ecologically important crustacean species within the European coastline fauna. In the present study, genetic diversity and population structure and connectivity were assessed by examining 21 polymorphic microsatellite loci at 13 sampling sites located along the natural distri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67824-7
更新日期:2020-07-01 00:00:00
abstract::Pulse wave transit time (PWTT) has been widely used as an index in assessing arterial stiffness. Percutaneous coronary intervention (PCI) is usually applied to the treatment of coronary artery disease (CAD). Research on the changes in PWTT caused by PCI is helpful for understanding the impact of the PCI procedure. In ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18520-6
更新日期:2018-01-08 00:00:00
abstract::Myocardial ischemia culminates in ATP production impairment, ionic derangement and cell death. The provision of metabolic substrates during reperfusion significantly increases heart tolerance to ischemia by improving mitochondrial performance. Under normoxia, glutamate contributes to myocardial energy balance as subst...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13478-x
更新日期:2017-10-12 00:00:00
abstract::Currently, diagnostic testing for Lyme disease is done by determination of the serologic responses to Borrelia burgdorferi antigens, with the exception of the early localized phase of disease where diagnosis must be done clinically. Here, we describe the use of microfluidics technology to develop a multiplexed rapid l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35069
更新日期:2016-10-11 00:00:00
abstract::Modulation of photoluminescence of atomically thin transition metal dichalcogenide two-dimensional materials is critical for their integration in optoelectronic and photonic device applications. By coupling with different plasmonic array geometries, we have shown that the photoluminescence intensity can be enhanced an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41175
更新日期:2017-01-30 00:00:00
abstract::We characterised changes in reproductive hormones-LH, FSH, SHBG and AMH-by chronological age and time around the menopause (reproductive age) in mid-life women and explored their associations with lifestyle and reproductive factors. We used data from 1608 women from a UK cohort who had repeat hormone measures and expe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77871-9
更新日期:2020-12-04 00:00:00
abstract::Maternal low-protein (MLP) diet can lead to hepatic steatosis, which only develops with ageing. It is still unclear whether the young offspring show any signs of past exposure to prenatal adverse conditions. We hypothesized that early nutritional insult would first affect the dynamic responsiveness to nutritional chal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10380-4
更新日期:2017-08-29 00:00:00
abstract::Survival analyses for malignancies, including renal cell carcinoma (RCC), have primarily been conducted using the Cox proportional hazards (CPH) model. We compared the random survival forest (RSF) and DeepSurv models with the CPH model to predict recurrence-free survival (RFS) and cancer-specific survival (CSS) in non...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80262-9
更新日期:2021-01-13 00:00:00
abstract::A larger amount of sequence data in private and public databases produced by next-generation sequencing put new challenges due to limitation associated with the alignment-based method for sequence comparison. So, there is a high need for faster sequence analysis algorithms. In this study, we developed an alignment-fre...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40452-6
更新日期:2019-03-06 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide. The use of alpha fetoprotein (AFP) alone was not an accurate biomarker for HCC despite its high specificity. Therefore, we assessed the possible role of serum biomarkers that have been mentioned briefly in previous studie...
journal_title:Scientific reports
pub_type: 杂志文章,评审
doi:10.1038/s41598-020-62051-6
更新日期:2020-03-20 00:00:00
abstract::Control of genetic regulatory networks is challenging to define and quantify. Previous control centrality metrics, which aim to capture the ability of individual nodes to control the system, have been found to suffer from plausibility and applicability problems. Here we present a new approach to control centrality bas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09746
更新日期:2015-06-11 00:00:00
abstract::Electron-hole exchange interaction in semiconductor quantum dots (QDs) splits the band-edge exciton manifold into optically active ("bright") and passive ("dark") states, leading to a complicated exciton fine structure. In the present work, we resolve by atomistic million-atom many-body pseudopotential calculations th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09812-y
更新日期:2017-08-24 00:00:00
abstract::Allosteric modulation of G protein-coupled receptors represent a promising mechanism of pharmacological intervention. Dramatic developments witnessed in the structural biology of membrane proteins continue to reveal that the binding sites of allosteric modulators are widely distributed, including along protein surface...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42618-8
更新日期:2019-04-16 00:00:00
abstract::Settlement-inducing protein complex (SIPC) is a pheromone that triggers conspecific larval settlement in the barnacle Amphibalanus amphitrite. In the present study, immunostaining and scanning electron microscopy of SIPC revealed signals in the frontal horn pores and the secretions from carapace pores, suggesting that...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29376
更新日期:2016-07-20 00:00:00
abstract::Somatic mutations of many cancer genes tend to co-occur (termed co-mutations) in certain patterns during tumor initiation and progression. However, the genetic and epigenetic mechanisms that contribute to the co-mutations of these cancer genes have yet to be explored. Here, we systematically investigated the associati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35270
更新日期:2016-10-20 00:00:00
abstract::γ-Oryzanol (OZ), which has a lot of beneficial effects, is a mixture of ferulic acid esters of triterpene alcohols (i.e., triterpene alcohol type of OZ (TTA-OZ)) and ferulic acid esters of plant sterols (i.e., plant sterol type of OZ (PS-OZ)). Although it has been reported that OZ is found in several kinds of cereal t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48985-6
更新日期:2019-08-29 00:00:00
abstract::Passive immunotherapy may have particular benefits for the treatment of severe influenza infection in at-risk populations, however little is known of the impact of passive immunotherapy on the formation of memory responses to the virus. Ideally, passive immunotherapy should attenuate the severity of infection while st...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29154
更新日期:2016-07-06 00:00:00
abstract::The obesity-associated inflammation of white adipose tissue (WAT) is one of the factors leading to the development of related diseases such as insulin resistance and liver steatosis. Recently, microRNAs (miRNAs) were identified as important regulators of WAT functions. Herein, we cultured human Simpson-Golabi-Behmel s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38339
更新日期:2016-12-06 00:00:00
abstract::In this paper, we investigate the relationship between the quantum speedup, non-Markovianity and formation of a system-environment bound state. Previous results show a monotonic relation between these three such that providing bound states with more negative energy can lead to a higher degree of non-Markovianity, and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51290-x
更新日期:2019-10-18 00:00:00
abstract::Three-dimensional (3D) image reconstruction of tumors based on serial histological sectioning is one of the most powerful methods for accurate high-resolution visualization of tumor structures. However, 3D histological reconstruction of whole tumor has not yet been achieved. We established a high-resolution 3D model o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76081-7
更新日期:2020-11-03 00:00:00
abstract::Five-component icosahedral quasicrystals with compositions in the range Al68-73Fe11-16Cu10-12Cr1-4Ni1-2 were recently recovered after shocking metallic CuAl5 and (Mg0.75Fe0.25)2SiO4 olivine in a stainless steel 304 chamber, intended to replicate a natural shock that affected the Khatyrka meteorite. The iron in those q...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15771-1
更新日期:2017-11-15 00:00:00
abstract::IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored. We investigated a combinatorial approach for the analysis of IgAN-relevant -omics data, aiming...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09393-w
更新日期:2017-08-22 00:00:00
abstract::Prognosis of patients with advanced sarcoma after progression from FDA approved therapies remains grim. In this study, clinical outcomes of 100 patients with advanced sarcoma who received treatment on novel targeted therapy trials were evaluated. Outcomes of interest included best response, clinical benefit rate, prog...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35448
更新日期:2016-10-17 00:00:00
abstract::The physical properties of polycrystalline materials depend on their microstructure, which is the nano- to centimeter scale arrangement of phases and defects in their interior. Such microstructure depends on the shape, crystallographic phase and orientation, and interfacing of the grains constituting the material. Thi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09717-w
更新日期:2017-08-25 00:00:00
abstract::Without any root contact with the soil, epiphytic bryophytes must experience and explore poor, patchy, and heterogeneous habitats; while, the nitrogen (N) uptake and use strategies of these organisms remain uncharacterized, which obscures their roles in the N cycle. To investigate the N sources, N preferences, and res...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30408
更新日期:2016-07-27 00:00:00
abstract::Familial history of hypertension is associated with autonomic dysfunction and increase in blood pressure (BP). However, an active lifestyle has been found to improve a number of health outcomes and reduce all-cause mortality. The aim of the present study was to investigate the effects of an active lifestyle on hemodyn...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69104-w
更新日期:2020-07-24 00:00:00
abstract::A central goal of electronics based on correlated materials or 'Mottronics' is the ability to switch between distinct collective states with a control voltage. Small changes in structure and charge density near a transition can tip the balance between competing phases, leading to dramatic changes in electronic and mag...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01876
更新日期:2013-01-01 00:00:00