Patterning of regional gene expression in autism: new complexity.

abstract：:The pharmacokinetic compatibility of short-acting CDRI candidate antimalarial trioxane derivative, 99-411, was tested with long-acting prescription antimalarials, lumefantrine and piperaquine. LC-ESI-MS/MS methods were validated for simultaneous bioanalysis of lumefantrine and 99-411 and of piperaquine and 99-411 comb...

journal_title：Scientific reports

authors： Taneja I,Raju KS,Singh SP,Wahajuddin M

更新日期：2015-11-25 00:00:00

abstract：:Combining endurance training with resistance training (RT) may attenuate skeletal muscle hypertrophic adaptation versus RT alone; however, the underlying mechanisms are unclear. We investigated changes in markers of ribosome biogenesis, a process linked with skeletal muscle hypertrophy, following concurrent training v...

journal_title：Scientific reports

authors： Fyfe JJ,Bishop DJ,Bartlett JD,Hanson ED,Anderson MJ,Garnham AP,Stepto NK

更新日期：2018-01-12 00:00:00

abstract：:Precision Medicine in Oncology requires tailoring of therapeutic strategies to individual cancer patients. Due to the limited quantity of tumor samples, this proves to be difficult, especially for early stage cancer patients whose tumors are small. In this study, we exploited a 2.4 × 2.4 centimeters polydimethylsiloxa...

journal_title：Scientific reports

authors： Wong AH,Li H,Jia Y,Mak PI,Martins RPDS,Liu Y,Vong CM,Wong HC,Wong PK,Wang H,Sun H,Deng CX

更新日期：2017-08-22 00:00:00

abstract：:Understanding drought-tolerance mechanisms and identifying genetic dominance are important for crop improvement. Setaria italica, which is extremely drought-tolerant, has been regarded as a model plant for studying stress biology. Moreover, different genotypes of S. italica have evolved various drought-tolerance/avoid...

journal_title：Scientific reports

authors： Tang S,Li L,Wang Y,Chen Q,Zhang W,Jia G,Zhi H,Zhao B,Diao X

更新日期：2017-08-30 00:00:00

abstract：:Bone metastasis of breast cancer cells is a major concern, as it causes increased morbidity and mortality in patients. Bone tissue-derived CXCL12 preferentially recruits breast cancer cells expressing CXCR4 to bone metastatic sites. Thus, understanding how CXCR4 expression is regulated in breast cancer cells could sug...

journal_title：Scientific reports

authors： Masuda T,Endo M,Yamamoto Y,Odagiri H,Kadomatsu T,Nakamura T,Tanoue H,Ito H,Yugami M,Miyata K,Morinaga J,Horiguchi H,Motokawa I,Terada K,Morioka MS,Manabe I,Iwase H,Mizuta H,Oike Y

更新日期：2015-03-16 00:00:00

abstract：:The COVID-19 pandemic caused by the SARS-CoV-2 requires a fast development of antiviral drugs. SARS-CoV-2 viral main protease (Mpro, also called 3C-like protease, 3CLpro) is a potential target for drug design. Crystal and co-crystal structures of the SARS-CoV-2 Mpro have been solved, enabling the rational design of in...

journal_title：Scientific reports

authors： Shitrit A,Zaidman D,Kalid O,Bloch I,Doron D,Yarnizky T,Buch I,Segev I,Ben-Zeev E,Segev E,Kobiler O

更新日期：2020-11-30 00:00:00

abstract：:Genomic selection (GS) by selecting lines prior to field phenotyping using genotyping data has the potential to enhance the rate of genetic gains. Genotype × environment (G × E) interaction inclusion in GS models can improve prediction accuracy hence aid in selection of lines across target environments. Phenotypic dat...

journal_title：Scientific reports

authors： Roorkiwal M,Jarquin D,Singh MK,Gaur PM,Bharadwaj C,Rathore A,Howard R,Srinivasan S,Jain A,Garg V,Kale S,Chitikineni A,Tripathi S,Jones E,Robbins KR,Crossa J,Varshney RK

更新日期：2018-08-03 00:00:00

abstract：:Human African trypanosomiasis (sleeping sickness) is a neglected tropical disease caused by Trypanosoma brucei spp. The parasites are transmitted by tsetse flies and adapt to their different hosts and environments by undergoing a series of developmental changes. During differentiation, the trypanosome alters its prote...

journal_title：Scientific reports

authors： Wenzler T,Schumann Burkard G,Schmidt RS,Mäser P,Bergner A,Roditi I,Brun R

更新日期：2016-03-02 00:00:00

abstract：:Sensory representations are typically endowed with intrinsic noise, leading to variability and inaccuracies in perceptual responses. The Bayesian framework accounts for an optimal strategy to deal with sensory-motor uncertainty, by combining the noisy sensory input with prior information regarding the distribution of ...

journal_title：Scientific reports

authors： Ege R,Opstal AJV,Van Wanrooij MM

更新日期：2018-11-06 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) patients have poor prognosis and poor response to treatment. This is largely due to PDAC being associated with a dense and active stroma and tumor fibrosis (desmoplasia). Desmoplasia is characterized by excessive degradation and formation of the extracellular matrix (ECM) genera...

journal_title：Scientific reports

authors： Willumsen N,Ali SM,Leitzel K,Drabick JJ,Yee N,Polimera HV,Nagabhairu V,Krecko L,Ali A,Maddukuri A,Moku P,Ali A,Poulose J,Menon H,Pancholy N,Costa L,Karsdal MA,Lipton A

更新日期：2019-12-24 00:00:00

abstract：:Solar powered hydrogen evolution reaction (HER) is one of the key reactions in solar-to-chemical energy conversion. It is desirable to develop photocathodic materials that exhibit high activity toward photoelectrochemical (PEC) HER at more positive potentials because a higher potential means a lower overpotential for ...

journal_title：Scientific reports

authors： Yang Y,Xu D,Wu Q,Diao P

更新日期：2016-10-17 00:00:00

abstract：:Graphene and related materials have come to the forefront of research in electrochemical sensors during recent years due to the promising properties of these nanomaterials. Further applications of these nanomaterials have been hampered by insufficient sensitivity offered by these nanohybrids for the type of molecules ...

journal_title：Scientific reports

authors： Sharma P,Bhalla V,Dravid V,Shekhawat G,Jinsong-Wu,Prasad ES,Suri CR

更新日期：2012-01-01 00:00:00

abstract：:We have purified the mammalian synaptophysin/synaptobrevin (SYP/VAMP2) complex to homogeneity in the presence of cholesterol and determined the 3D EM structure by single particle reconstruction. The structure reveals that SYP and VAMP2 assemble into a hexameric ring wherein 6 SYP molecules bind 6 VAMP2 dimers. Using t...

journal_title：Scientific reports

authors： Adams DJ,Arthur CP,Stowell MH

更新日期：2015-09-03 00:00:00

abstract：:Tract tracing with neuronal tracers not only represents a straightforward approach to identify axonal projection connection between regions of the nervous system at distance but also provides compelling evidence for axonal regeneration. An ideal neuronal tracer meets certain criteria including high labeling efficacy, ...

journal_title：Scientific reports

authors： Mi D,Yuan Y,Zhang Y,Niu J,Wang Y,Yan J,Yang Y,Hu W

更新日期：2019-07-09 00:00:00

abstract：:The attenuated Sabin strains contained in the oral poliomyelitis vaccine are genetically unstable, and their circulation in poorly immunized populations can lead to the emergence of pathogenic circulating vaccine-derived polioviruses (cVDPVs). The recombinant nature of most cVDPV genomes and the preferential presence ...

journal_title：Scientific reports

authors： Bessaud M,Joffret ML,Blondel B,Delpeyroux F

更新日期：2016-12-13 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Lai J,Wang G,Fan Z,Chen J,Qin Z,Xiao C,Wang S,Fan X

更新日期：2018-07-11 00:00:00

abstract：:In December 2015, four violent explosive episodes from Mt. Etna's oldest summit crater, the Voragine, produced eruptive columns extending up to 15 km a.s.l. and significant fallout of tephra up to a hundred km from the vent. A combined textural and compositional study was carried out on pyroclasts from three of the fo...

journal_title：Scientific reports

authors： Pompilio M,Bertagnini A,Del Carlo P,Di Roberto A

更新日期：2017-07-06 00:00:00

abstract：:Rice breeding has achieved great productivity improvements by semi-dwarf varieties and hybrid vigour. Due to poor understanding of genetic basis of elite backbone varieties, the continuous increasing in rice yield still faces great challenges. Here, 52 elite rice varieties from three historical representative pedigree...

journal_title：Scientific reports

authors： Zheng X,Li L,Liang F,Tan C,Tang S,Yu S,Diao Y,Li S,Hu Z

更新日期：2017-03-22 00:00:00

abstract：:Ocean warming (OW) and acidification (OA) are key features of global change and are predicted to have negative consequences for marine species and ecosystems. At a smaller scale increasing oil and gas activities at northern high latitudes could lead to greater risk of petroleum pollution, potentially exacerbating the ...

journal_title：Scientific reports

authors： Arnberg M,Calosi P,Spicer JI,Taban IC,Bamber SD,Westerlund S,Vingen S,Baussant T,Bechmann RK,Dupont S

更新日期：2018-11-26 00:00:00

abstract：:The discovery of CRISPR/Cas gene editing has allowed for major advances in many biomedical disciplines and basic research. One arrangement of this biotechnology, a nuclease-based gene drive, can rapidly deliver a genetic element through a given population and studies in fungi and metazoans have demonstrated the succes...

journal_title：Scientific reports

authors： Yan Y,Finnigan GC

更新日期：2018-11-22 00:00:00

abstract：:Combining strong magnetic anisotropy with strong exchange interaction is a long standing goal in the design of quantum magnets. The lanthanide complexes, while exhibiting a very strong ionic anisotropy, usually display a weak exchange coupling, amounting to only a few wavenumbers. Recently, an isostructural series of ...

journal_title：Scientific reports

authors： Vieru V,Iwahara N,Ungur L,Chibotaru LF

更新日期：2016-04-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Sahani RM,Kumari C,Pandya A,Dixit A

更新日期：2020-02-19 00:00:00

abstract：:Dye-sensitised solar cells (DSCs) are a promising substitute for conventional silicon solar cells. A scattering layer of submicrometer pores or particles has been widely introduced to achieve a high light-harvesting efficiency. However, many such fabrication processes require high temperatures and multiple steps to pr...

journal_title：Scientific reports

authors： Ha SJ,Moon JH

更新日期：2014-07-09 00:00:00

abstract：:The benzodiazepine midazolam is widely used in critical care medicine. Midazolam has a clinically active metabolite, 1-hydroxymidazolam. The contribution of 1-hydroxymidazolam to the effects of midazolam is controversial. The aim of the current study was to compare the actions of midazolam and 1-hydroxymidazolam on ne...

journal_title：Scientific reports

authors： Balk M,Hentschke H,Rudolph U,Antkowiak B,Drexler B

更新日期：2017-06-14 00:00:00

abstract：:Although previous findings identified an association between C-reactive protein (CRP) levels, and impaired cognitive functions in patients with schizophrenia (SZ), little is currently known about the relationship between inflammation, cognition, and sex in SZ. The current study aimed to explore the association between...

journal_title：Scientific reports

authors： Dal Santo F,González-Blanco L,García-Álvarez L,de la Fuente-Tomás L,Velasco Á,Álvarez-Vázquez CM,Martínez-Cao C,Sáiz PA,García-Portilla MP,Bobes J

更新日期：2020-09-29 00:00:00

abstract：:We have explored the mechanical properties, electronic structures and phase transition behaviors of three designed new phases for element boron from ambient condition to high-pressure of 120 GPa including (1) a C2/c symmetric structure (m-B₁₆); (2) a symmetric structure (c-B₅₆) and (3) a Pmna symmetric structure (o-B₂...

journal_title：Scientific reports

authors： Fan C,Li J,Wang L

更新日期：2014-10-27 00:00:00

abstract：:Next generation sequencing (NGS) together with protein expression analysis is back bone of molecularly targeted therapy in precision medicine. Our retrospective study shows our experience with NGS of 324 genes in combination with protein expression in patients with advanced breast cancer (aBC). The primary purpose was...

journal_title：Scientific reports

authors： Hempel D,Ebner F,Garg A,Trepotec Z,Both A,Stein W,Gaumann A,Güttler L,Janni W,DeGregorio A,Hempel L,Milani V

更新日期：2020-06-26 00:00:00

abstract：:Since the 1990s the Mekong River delta has suffered a large decline in sediment supply causing coastal erosion, following catchment disturbance through hydropower dam construction and sand extraction. However, our new geological reconstruction of 2500-years of delta shoreline changes show that serious coastal erosion ...

journal_title：Scientific reports

authors： Tamura T,Nguyen VL,Ta TKO,Bateman MD,Gugliotta M,Anthony EJ,Nakashima R,Saito Y

更新日期：2020-05-15 00:00:00

abstract：:Propionibacterium freudenreichii, a dairy starter, can reach a population of almost 109 propionibacteria per gram in Swiss-type cheese at the time of consumption. Also consumed as a probiotic, it displays strain-dependent anti-inflammatory properties mediated by surface proteins that induce IL-10 in leukocytes. We sel...

journal_title：Scientific reports

authors： Deutsch SM,Mariadassou M,Nicolas P,Parayre S,Le Guellec R,Chuat V,Peton V,Le Maréchal C,Burati J,Loux V,Briard-Bion V,Jardin J,Plé C,Foligné B,Jan G,Falentin H

更新日期：2017-04-13 00:00:00

abstract：:The muscular dystrophy X-linked mouse (mdx) is the most commonly used preclinical model for Duchenne muscular dystrophy. Although disease progression in the mouse does not perfectly model the human disease, it shares many pathological features. Early characterizations of the model reported severe pathology through ear...

journal_title：Scientific reports

authors： Massopust RT,Lee YI,Pritchard AL,Nguyen VM,McCreedy DA,Thompson WJ

更新日期：2020-10-14 00:00:00