Abstract：
:Advanced maternal age is associated with an increased risk of pregnancy complications. It programmes sex-specific cardiovascular dysfunction in rat offspring, however the intrauterine mechanisms involved remain unknown. This study in the rat assessed the impact of advanced maternal age on placental phenotype in relation to the growth of female and male fetuses. We show that relative to young (3-4 months) dams, advanced maternal age (9.5-10 months) compromises growth of both female and male fetuses but affects the placental phenotype sex-specifically. In placentas from aged versus young dams, the size of the placental transport and endocrine zones were increased and expression of Igf2 (+41%) and placental lactogen (Prl3b1: +59%) genes were upregulated in female, but not male fetuses. Placental abundance of IGF2 protein also decreased in the placenta of males only (-95%). Moreover, in placentas from aged versus young dams, glucocorticoid metabolism (11β-hsd2: +63% and 11β-hsd1: -33%) was higher in females, but lower in males (11β-hsd2: -50% and 11β-hsd1: unaltered). There was however, no change in the placental abundance of 11β-HSD2 protein in aged versus young dams regardless of fetal sex. Levels of oxidative stress in the placenta were increased in female and male fetuses (+57% and +90%, respectively) and apoptosis increased specifically in the placenta of males from aged rat dams (+700%). Thus, advanced maternal age alters placental phenotype in a sex-specific fashion. These sexually-divergent changes may play a role in determining health outcomes of female and male offspring of aged mothers.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Napso T,Hung YP,Davidge ST,Care AS,Sferruzzi-Perri ANdoi
10.1038/s41598-019-53199-xsubject
Has Abstractpub_date
2019-11-28 00:00:00pages
16916issue
1issn
2045-2322pii
10.1038/s41598-019-53199-xjournal_volume
9pub_type
杂志文章abstract：:Abnormalities in actin cytoskeleton have been linked to Friedreich's ataxia (FRDA), an inherited peripheral neuropathy characterised by an early loss of neurons in dorsal root ganglia (DRG) among other clinical symptoms. Despite all efforts to date, we still do not fully understand the molecular events that contribute...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62050-7
更新日期：2020-03-23 00:00:00
abstract：:The Paleozoic Dniepr-Donets Basin in Belarus, Ukraine, and Russia forms a major hydrocarbon province. Although well- and seismic data have established a 20 km thick stratigraphy, field-studies of its sediments are scarce. The inverted Donbas segment (Ukraine) exposes the middle Carboniferous part of the basin's strati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09099
更新日期：2015-03-20 00:00:00
abstract：:Epidemiological investigation have suggested that there is a significantly inverse association between circulating 25-hydroxyvitamin D (25(OH)D) and the risk for developing colorectal cancer (CRC) in humans. However, little is known about the role of vitamin D binding protein (VDBP) in colorectal carcinogenesis. Blood...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07956
更新日期：2015-01-22 00:00:00
abstract：:Biological sulfate-reducing bacteria (SRB) may be effective in removing toxic lead and mercury ions (Pb(II) and Hg(II)) from wet flue gas desulfurization (FGD) wastewater through anaerobic sulfite reduction. To confirm this hypothesis, a sulfite-reducing up-flow anaerobic sludge blanket reactor was set up to treat FGD...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30455
更新日期：2016-07-26 00:00:00
abstract：:MicroRNAs (miRNAs) are noncoding RNAs which control gene expression by the suppression of translation or the degradation of mRNAs. Dre-miR-21 (miR-21) has been reported to impact cardiac valvulogenesis in zebrafish embryos. However, the target genes of miR-21 are still largely unknown. Here a tandem isobaric mass tag ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04166-x
更新日期：2017-06-22 00:00:00
abstract：:The ability to predict the magnitude of an earthquake caused by deep fluid injections is an important factor for assessing the safety of the reservoir storage and the seismic hazard. Here, we propose a new approach to evaluate the seismic energy released during fluid injection by integrating injection parameters, indu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41306-x
更新日期：2019-03-21 00:00:00
abstract：:Enzymatic gold nanoparticles (B-GNPs) have been synthesized using a natural anticancer agent bromelain (a cysteine protease) and these nanoparticles were used to bioconjugate Cisplatin (highly effective against osteosarcoma and lung cancer). Cisplatin bioconjugated bromelain encapsulated gold nanoparticles (B-C-GNPs) ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50215-y
更新日期：2019-09-25 00:00:00
abstract：:In insects, the transition from juvenile development to the adult stage is controlled by juvenile hormone (JH) synthesized from the corpora allata (CA) glands. Whereas a JH-free period during the last juvenile instar triggers metamorphosis and the end of the growth period, the reappearance of this hormone after the im...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40234
更新日期：2017-01-11 00:00:00
abstract：:Gastroenterologists are still unable to differentiate between some of the most ordinary disorders of the gut and consequently patients are misdiagnosed. We have developed a swallowable gas sensor capsule for addressing this. The gases of the gut are the by-product of the fermentation processes during digestion, affect...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33387
更新日期：2016-09-16 00:00:00
abstract：:Childbearing women with rheumatoid (RA) and psoriatic arthritis (PsA) have significant peripartum issues. A retrospective anonymous RedCAP survey of peripartum period in females with RA/PsA in the RAPPORT registry was performed. Completed analyses included descriptive statistics, Chi-square and Fisher's exact test. 16...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60451-2
更新日期：2020-02-28 00:00:00
abstract：:Dual terahertz (THz) comb spectroscopy enables high spectral resolution, high spectral accuracy, and broad spectral coverage; however, the requirement for dual stabilized femtosecond lasers hampers its versatility. We here report the first demonstration of dual THz comb spectroscopy using a single free-running fibre l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29403-9
更新日期：2018-07-24 00:00:00
abstract：:Attaching Unique Molecular Identifiers (UMI) to RNA molecules in the first step of sequencing library preparation establishes a distinct identity for each input molecule. This makes it possible to eliminate the effects of PCR amplification bias, which is particularly important where many PCR cycles are required, for e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31064-7
更新日期：2018-09-03 00:00:00
abstract：:This study investigated the variation characteristics of micro-topography during successive erosive stages of water erosion: splash erosion (SpE), sheet erosion (ShE), and rill erosion (RE). Micro-topography was quantified using surface elevation change, soil roughness (SR) and multifractal model. Results showed that ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21852-6
更新日期：2018-02-22 00:00:00
abstract：:This systematic review and meta-analysis was designed to investigate whether maternal psychological stress and recent life events are associated with an increased risk of miscarriage. A literature search was conducted to identify studies reporting miscarriage in women with and without history of exposure to psychologi...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-01792-3
更新日期：2017-05-11 00:00:00
abstract：:It has been reported that in patients with operable stage I non-small cell lung cancer (NSCLC), overall survival (OS) is better in those who undergo hypofractionated stereotactic radiation therapy (HSRT) than in those who undergo surgery. However, the reason that HSRT has a better OS has not been fully explored. Here,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04978-x
更新日期：2017-07-07 00:00:00
abstract：:The Klein tunneling of optical waves near the Dirac points in the metal-dielectric multilayer metamaterials is theoretically investigated and demonstrated through the coupled-mode theory under the tight-binding approximation and the rigorous band structure analysis based on the transfer-matrix method. The optical anal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09899-3
更新日期：2017-08-29 00:00:00
abstract：:Estrogens protect against diet-induced obesity in women and female rodents. For example, a lack of estrogens in postmenopausal women is associated with an increased risk of weight gain, cardiovascular diseases, low-grade inflammation, and cancer. Estrogens act with leptin to regulate energy homeostasis in females. Lep...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56723-1
更新日期：2019-12-27 00:00:00
abstract：:In the present work, an attempt has been made to synthesize the 1,2,3-triazole derivatives resulting from the click reaction, in a mild and green environment using the new copper(II)-coated magnetic core-shell nanoparticles Fe3O4@SiO2 modified by isatoic anhydride. The structure of the catalyst has been determined by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81632-7
更新日期：2021-01-22 00:00:00
abstract：:Ubiquitin C-terminal Hydrolase-1 (UCHL1) is a deubiquitinating enzyme, which plays a key role in Parkinson's disease (PD). It is one of the most important proteins, which constitute Lewy body in PD patient. However, how this well folded highly soluble protein presents in this proteinaceous aggregate is still unclear. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44558
更新日期：2017-03-16 00:00:00
abstract：:For people suffering from severe paralysis, communication can be difficult or nearly impossible. Technology systems called brain-computer interfaces (BCIs) are being developed to assist these people with communication by using their brain activity to control a computer without any muscle activity. To benefit the devel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50834-5
更新日期：2019-10-02 00:00:00
abstract：:Deforestation and forest degradation around the world endanger the functioning of ecosystems, climate stability, and conservation of biodiversity. We assessed the spatial and temporal dynamics of forest cover in Myanmar's Hkakabo Razi Landscape (HRL) to determine its integrity based on forest change and fragmentation ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70917-y
更新日期：2020-08-19 00:00:00
abstract：:Acquisition of nutrients during intra-vacuolar growth of L. pneumophila within macrophages or amoebae is poorly understood. Since many genes of L. pneumophila are acquired by inter-kingdom horizontal gene transfer from eukaryotic hosts, we examined the presence of human solute carrier (SLC)-like transporters in the L....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26782-x
更新日期：2018-05-29 00:00:00
abstract：:Immunoglobulin A is the dominant antibody isotype found in mucosal secretions and enforces host-microbiota symbiosis in mice, yet selective IgA-deficiency (sIgAd) in humans is often described as asymptomatic. Here, we determined the effects of IgA deficiency on human gut microbiota composition and evaluated the possib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49923-2
更新日期：2019-09-19 00:00:00
abstract：:Atmospheric nitrogen (N) dry deposition is an important component in total N deposition. However, uncertainty exists in the assessment of global dry deposition. Here, we develop empirical models for estimating ground N concentrations using NO2 satellite measurements from the Ozone Monitoring Instrument (OMI) and groun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19810
更新日期：2016-01-27 00:00:00
abstract：:The present study investigated when emotion modulates working memory from the perspective of neural activation. Using fMRI, we measured brain activity during the encoding and retrieval phases of a reading span test (RST) that used emotional contexts. The emotional RST required participants to read sentences that elici...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01375
更新日期：2013-01-01 00:00:00
abstract：:This paper reports a facile and green method for conversion of graphene oxide (GO) into graphene by low-temperature heating (80 °C) in the presence of a glass wafer. Compared to conventional GO chemical reduction methods, the presented approach is easy-scalable, operationally simple, and based on the use of a non-toxi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32488-x
更新日期：2018-09-20 00:00:00
abstract：:One mechanism of action for the anticaries effect of topical fluoridation is through precipitation of CaF2. In this in vitro study energy-dispersive x-ray spectroscopy (EDX) is used as a semiquantitative method to detect enamel fluoride-precipitation under the influence of acidic and neutral pH-value and absence or pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49742-5
更新日期：2019-09-17 00:00:00
abstract：:Apparently mundane, amorphous nanostructures of carbon have optical properties which are as exotic as their crystalline counterparts. In this work we demonstrate a simple and inexpensive mechano-chemical method to prepare bulk quantities of self-passivated, amorphous carbon dots. Like the graphene quantum dots, the wa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28021-9
更新日期：2018-06-27 00:00:00
abstract：:At ambient pressure, the hydrogen bond in materials such as ice, hydrates, and hydrous minerals that compose the Earth and icy planets generally takes an asymmetric O-H···O configuration. Pressure significantly affects this configuration, and it is predicted to become symmetric, such that the hydrogen is centered betw...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33598-2
更新日期：2018-10-19 00:00:00
abstract：:CeTe3 is a unique platform to investigate the itinerant magnetism in a van der Waals (vdW) coupled metal. Despite chemical pressure being a promising route to boost quantum fluctuation in this system, a systematic study on the chemical pressure effect on Ce3+(4f1) states is absent. Here, we report on the successful gr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72300-3
更新日期：2020-09-17 00:00:00
