Proteomic analysis of knee cartilage reveals potential signaling pathways in pathological mechanism of Kashin-Beck disease compared with osteoarthritis.

abstract：:Short QT syndrome (SQTS) is a rare condition characterized by abnormally 'short' QT intervals on the ECG and increased susceptibility to cardiac arrhythmias and sudden death. This simulation study investigated arrhythmia dynamics in multi-scale human ventricle models associated with the SQT2-related V307L KCNQ1 'gain-...

journal_title：Scientific reports

authors： Adeniran I,Whittaker DG,El Harchi A,Hancox JC,Zhang H

更新日期：2017-08-16 00:00:00

abstract：:Laser radiation pressure is a basis of numerous applications in science and technology such as atom cooling, particle manipulation, material processing, etc. This light force for the case of scalar beams is proportional to the intensity-weighted wavevector known as optical current. The ability to design the optical cu...

journal_title：Scientific reports

authors： Rodrigo JA,Alieva T

更新日期：2016-10-13 00:00:00

abstract：:Technological improvements have resulted in increased discovery of new microRNAs (miRNAs) and refinement and enrichment of existing miRNA families. miRNA families are important because they suggest a common sequence or structure configuration in sets of genes that hint to a shared function. Exploratory tools to enhanc...

journal_title：Scientific reports

authors： Kamanu TK,Radovanovic A,Archer JA,Bajic VB

更新日期：2013-10-15 00:00:00

abstract：:Recent studies suggest that glypican-1 (GPC-1) is a biomarker for prostate cancer, but there are few studies elucidating the role of GPC-1 in prostate cancer progression. We observed high expression of GPC-1 in more aggressive prostate cancer cell lines such as PC-3 and DU-145. While inhibition of GPC-1 expression in ...

journal_title：Scientific reports

authors： Quach ND,Kaur SP,Eggert MW,Ingram L,Ghosh D,Sheth S,Nagy T,Dawson MR,Arnold RD,Cummings BS

更新日期：2019-08-07 00:00:00

abstract：:Thermal management and simulation are becoming increasingly important in many areas of engineering applications. There are three cooling routes for thermal management, namely thermal conduction, thermal convection and thermal radiation, among which the first two approaches have been widely studied and applied, while t...

journal_title：Scientific reports

authors： Zhang HH,Sha WEI,Huang ZX,Shi GM

更新日期：2018-02-08 00:00:00

abstract：:Etoposide (ETO) is a commonly used chemotherapeutic drug that inhibits topoisomerase II activity, thereby leading to genotoxicity and cytotoxicity. However, ETO has limited application due to its side effects on normal organs, especially the kidney. Here, we report the mechanism of ETO-induced cytotoxicity progression...

journal_title：Scientific reports

authors： Shin HJ,Kwon HK,Lee JH,Anwar MA,Choi S

更新日期：2016-09-26 00:00:00

abstract：:CRISPR-Cas9 is a powerful new tool for genome editing, but this technique creates mosaic mutations that affect the efficiency and precision of its ability to edit the genome. Reducing mosaic mutations is particularly important for gene therapy and precision genome editing. Although the mechanisms underlying the CRSIPR...

journal_title：Scientific reports

authors： Tu Z,Yang W,Yan S,Yin A,Gao J,Liu X,Zheng Y,Zheng J,Li Z,Yang S,Li S,Guo X,Li XJ

更新日期：2017-02-03 00:00:00

abstract：:We report the virtually infinite possible carbon feedstocks which support the highly efficient growth of single-wall carbon nanotubes (SWCNTs) using on the water-assisted chemical vapor deposition method. Our results demonstrate that diverse varieties of carbon feedstocks, in the form of hydrocarbons, spanning saturat...

journal_title：Scientific reports

authors： Kimura H,Goto J,Yasuda S,Sakurai S,Yumura M,Futaba DN,Hata K

更新日期：2013-11-26 00:00:00

abstract：:Transition metal dichalcogenides (TMDCs) are promising materials for sensing applications, due to their exceptional high performance in nano-electronics. Inherentely, the chemical and thermal responses of TMDCs are highly stable, hence, they pave way for real time sensor applications. This article proposes inceptively...

journal_title：Scientific reports

authors： Awais M,Khan MU,Hassan A,Bae J,Chattha TE

更新日期：2020-03-26 00:00:00

abstract：:The abundance and sinking of particulate black carbon (PBC) were examined for the first time in the western Arctic and Subarctic Oceans. In the central Arctic Ocean, high PBC concentrations with a mean of 0.021 ± 0.016 μmol L(-1) were observed in the marginal ice zone (MIZ). A number of parameters, including temperatu...

journal_title：Scientific reports

authors： Fang Z,Yang W,Chen M,Zheng M,Hu W

更新日期：2016-07-15 00:00:00

abstract：:A series of alkyl amides was detected and identified in the sedimentary record from an archaeological site at Yuchisi, Mengcheng, Anhui, China. The alkyl amides profiles change abruptly at the depth corresponding to the transition between two prehistoric cultures, which also corresponds to an abrupt change in the fatt...

journal_title：Scientific reports

authors： Wang J,Simoneit BRT,Sheng G,Chen L,Xu L,Wang X,Wang Y,Sun L

更新日期：2017-11-07 00:00:00

abstract：:Biological networks play a key role in determining biological function and therefore, an understanding of their structure and dynamics is of central interest in systems biology. In Boolean models of such networks, the status of each molecule is either "on" or "off" and along with the molecules interact with each other...

journal_title：Scientific reports

authors： Chen H,Wang G,Simha R,Du C,Zeng C

更新日期：2016-01-29 00:00:00

abstract：:Chlorella is a unicellular green microalga that has been used in fields such as bioenergy production and food supplementation. In this study, two promoters of N (nitrogen) deficiency-inducible Chlorella vulgaris N Deficiency Inducible (CvNDI) genes were isolated from Chlorella vulgaris UTEX 395. These promoters were u...

journal_title：Scientific reports

authors： Shin JH,Choi J,Jeon J,Kumar M,Lee J,Jeong WJ,Kim SR

更新日期：2020-07-29 00:00:00

abstract：:We report that misfolded cytosolic proteins can be cleared from mammalian cells by directing them to endoplasmic reticulum (ER). NAT1 R64W and Parkin R42P are naturally occurring misfolded variants of cytosolic enzymes that acetylate arylamines and ubiquitinate proteins, respectively. We demonstrate that proteasome in...

journal_title：Scientific reports

authors： Liu F,Koepp DM,Walters KJ

更新日期：2015-07-14 00:00:00

abstract：:Si and Ge nanocrystals in oxides are of a large interest for photo-effect applications due to the fine-tuning of the optical bandgap by quantum confinement in nanocrystals. In this work, dense Ge nanocrystals suitable for enhanced photoconduction were fabricated from 60% Ge in TiO2 amorphous layers by low temperature ...

journal_title：Scientific reports

authors： Lepadatu AM,Slav A,Palade C,Dascalescu I,Enculescu M,Iftimie S,Lazanu S,Teodorescu VS,Ciurea ML,Stoica T

更新日期：2018-03-20 00:00:00

abstract：:Airway mucus overproduction is one of the most common symptoms of asthma that causes severe clinical outcomes in patients. Despite the effectiveness of general asthma therapies, specific treatments that prevent mucus overproduction in asthma patients remain lacking. Recent studies have found that activation of GABAA r...

journal_title：Scientific reports

authors： Shen ML,Wang CH,Lin CH,Zhou N,Kao ST,Wu DC

更新日期：2016-09-06 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Escobar-Zepeda A,Godoy-Lozano EE,Raggi L,Segovia L,Merino E,Gutiérrez-Rios RM,Juarez K,Licea-Navarro AF,Pardo-Lopez L,Sanchez-Flores A

更新日期：2020-03-03 00:00:00

abstract：:One key ability of human brain is invariant object recognition, which refers to rapid and accurate recognition of objects in the presence of variations such as size, rotation and position. Despite decades of research into the topic, it remains unknown how the brain constructs invariant representations of objects. Prov...

journal_title：Scientific reports

authors： Karimi-Rouzbahani H,Bagheri N,Ebrahimpour R

更新日期：2017-10-31 00:00:00

abstract：:Riemerella anatipestifer is a major pathogenic microorganism in poultry causing serositis with significant mortality. Serotype 1 and 2 were most pathogenic, prevalent, and liable over the world. In this study, the intracellular metabolites in R. anatipestifer strains RA-CH-1 (serotype 1) and RA-CH-2 (serotype 2) were ...

journal_title：Scientific reports

authors： Liu J,Cheng A,Wang M,Liu M,Zhu D,Yang Q,Wu Y,Jia R,Chen S,Zhao X,Zhang S,Huang J,Ou X,Mao S,Gao Q,Wen X,Zhang L,Liu Y,Yu Y,Tian B,Pan L,Ur Rehman M,Chen X

更新日期：2021-01-12 00:00:00

abstract：:A universal technology for the encapsulative protection of unstable anionic species by highly stable layered metal oxide has been developed via the surface modification of a metal oxide nanosheet. The surface anchoring of (3-aminopropyl)triethoxysilane (APTES) on exfoliated titanate nanosheet yields a novel cationic m...

journal_title：Scientific reports

authors： Kim TW,Kim IY,Park DH,Choy JH,Hwang SJ

更新日期：2016-02-24 00:00:00

abstract：:The present work focuses on the dynamical aspects of cross-reactivity between myelin based protein (MBP) self-peptide and two microbial peptides (UL15, PMM) for Hy.1B11 T-cell receptor (TCR). This same TCR was isolated from a patient suffering from multiple sclerosis (MS). The study aims at highlighting the chemical i...

journal_title：Scientific reports

authors： Kumar A,Delogu F

更新日期：2017-02-14 00:00:00

abstract：:Quaternary ammonium compounds (QACs) are classified as cationic surfactants, and are known for their biocidal activity. However, their modes of action are thus far not completely understood. In this study, we synthesized a gemini QAC, PMT12-BF4 and found that it exerted unsurpassed broad-spectrum antifungal activity a...

journal_title：Scientific reports

authors： Hsu LH,Kwaśniewska D,Wang SC,Shen TL,Wieczorek D,Chen YL

更新日期：2020-02-19 00:00:00

abstract：:The combined effects of cervical electrical stimulation alone or in combination with the monoaminergic agonist buspirone on upper limb motor function were determined in six subjects with motor complete (AIS B) injury at C5 or above and more than one year from time of injury. Voluntary upper limb function was evaluated...

journal_title：Scientific reports

authors： Freyvert Y,Yong NA,Morikawa E,Zdunowski S,Sarino ME,Gerasimenko Y,Edgerton VR,Lu DC

更新日期：2018-10-19 00:00:00

abstract：:Mycobacterium tuberculosis, the etiological agent of the infectious disease tuberculosis, kills approximately 1.5 million people annually, while the spread of multidrug-resistant strains is of great global concern. Thus, continuous efforts to identify new antitubercular drugs as well as novel targets are crucial. Rece...

journal_title：Scientific reports

authors： Chiarelli LR,Mori G,Orena BS,Esposito M,Lane T,de Jesus Lopes Ribeiro AL,Degiacomi G,Zemanová J,Szádocka S,Huszár S,Palčeková Z,Manfredi M,Gosetti F,Lelièvre J,Ballell L,Kazakova E,Makarov V,Marengo E,Mikusova K,Col

更新日期：2018-02-16 00:00:00

abstract：:Quantum walks often provide telling insights about the structure of the system on which they are performed. In [Formula: see text]-symmetric and lossy dimer lattices, the topological properties of the band structure manifest themselves in the quantization of the mean displacement of such a walker. We investigate the f...

journal_title：Scientific reports

authors： Harter AK,Saxena A,Joglekar YN

更新日期：2018-08-13 00:00:00

abstract：:At present, there is a growing interest in the study of the neurotropic activity of polyunsaturated fatty acids ethanolamides (N-acylethanolamines). N-docosahexaenoylethanolamine (DHEA, synaptamide) is an endogenous metabolite and structural analogue of anandamide, a widely studied endocannabinoid derived from arachid...

journal_title：Scientific reports

authors： Ponomarenko AI,Tyrtyshnaia AA,Pislyagin EA,Dyuizen IV,Sultanov RM,Manzhulo IV

更新日期：2021-01-12 00:00:00

abstract：:M. tuberculosis GmhA enzyme catalyzes the isomerization of D-sedoheptulose 7-phosphate into D-glycero-D-α-manno-heptose-7-phosphate in GDP-D-glycero-α-D-manno-heptose biosynthetic pathway. The D-glycero-α-D-manno-heptose is a major constituent of lipopolysaccharide and contributes to virulence and antibiotic resistanc...

journal_title：Scientific reports

authors： Karan S,Pratap B,Yadav SP,Ashish F,Saxena AK

更新日期：2020-11-30 00:00:00

abstract：:In order to study the effect of water-rock interactions on shear strength characteristics, we performed shearing tests under varying hydrochemical environments. Moreover, a custom meso-shear test equipment for coal rock was used for the tests. Through 3D scanning of the shear fractures and scanning electron microscope...

journal_title：Scientific reports

authors： Chen C,Peng S,Wu S,Xu J

更新日期：2019-12-27 00:00:00

abstract：:Ferromagnetism can occur in wide-band gap semiconductors as well as in carbon-based materials when specific defects are introduced. It is thus desirable to establish a direct relation between the defects and the resulting ferromagnetism. Here, we contribute to revealing the origin of defect-induced ferromagnetism usin...

journal_title：Scientific reports

authors： Wang Y,Liu Y,Wang G,Anwand W,Jenkins CA,Arenholz E,Munnik F,Gordan OD,Salvan G,Zahn DR,Chen X,Gemming S,Helm M,Zhou S

更新日期：2015-03-11 00:00:00

abstract：:We report the phonon and magnetic properties of various well-stabilized Co3O4 nanoparticles. The net valence in cobalt (II)/(III) cation can be obtained by subtracting the Co2+ ions in tetrahedral interstices and Co3+ ions in the octahedral interstices, respectively, which will possess spatial inhomogeneity of its mag...

journal_title：Scientific reports

authors： Gawali SR,Gandhi AC,Gaikwad SS,Pant J,Chan TS,Cheng CL,Ma YR,Wu SY

更新日期：2018-01-10 00:00:00