Abstract：
:Airway mucus overproduction is one of the most common symptoms of asthma that causes severe clinical outcomes in patients. Despite the effectiveness of general asthma therapies, specific treatments that prevent mucus overproduction in asthma patients remain lacking. Recent studies have found that activation of GABAA receptors (GABAAR) is important for promoting mucus oversecretion in lung airway epithelia. Here, we report that luteolin, a natural flavonoid compound, suppresses mucus overproduction by functionally inhibiting the GABAergic system. This hypothesis was investigated by testing the effects of luteolin on goblet cell hyperplasia, excessive mucus secretion, and GABAergic transmission using histological and electrophysiological approaches. Our results showed that 10 mg/kg luteolin significantly decreased the number of goblet cells in the lung tissue and inhibited mucus overproduction in an in vivo asthma model induced by ovalbumin (OVA) in mice. Patch-clamp recordings showed that luteolin inhibited GABAAR-mediated currents in A549 cells. Furthermore, the inhibitory effects of luteolin on OVA-induced goblet cell hyperplasia and mucus overproduction were occluded by the GABAAR antagonist picrotoxin. In conclusion, our observations indicate that luteolin effectively attenuates mucus overproduction at least partially by inhibiting GABAARs, suggesting the potential for therapeutic administration of luteolin in the treatment of mucus overproduction in asthma patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Shen ML,Wang CH,Lin CH,Zhou N,Kao ST,Wu DCdoi
10.1038/srep32756subject
Has Abstractpub_date
2016-09-06 00:00:00pages
32756issn
2045-2322pii
srep32756journal_volume
6pub_type
杂志文章abstract：:The recent emergence of highly virulent human adenoviruses (HAdVs) with new tissue tropisms underscores the need to determine their ontogeny. Here we report complete high quality genome sequences and analyses for all the previously unsequenced HAdV serotypes (n = 20) within HAdV species D. Analysis of nucleotide seque...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01812
更新日期：2013-01-01 00:00:00
abstract：:The objective of this study was to investigate the influence of the genes encoding the KIR receptors and their HLA ligands in the susceptibility of ocular toxoplasmosis. A total of 297 patients serologically-diagnosed with toxoplasmosis were selected and stratified according to the presence (n = 148) or absence (n = 1...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep36632
更新日期：2016-11-09 00:00:00
abstract：:Cell penetrating peptides (CPPs) are peptides that can be translocated into cells and used as a carrier platform for the intracellular uptake of cargo molecules. Subject to the source of CPP sequences and their positively charged nature, the cytotoxicity and immunogenicity of conventional CPPs needs to be optimized to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11719
更新日期：2015-06-26 00:00:00
abstract：:When searching for food, foraging fishes expose themselves to hidden predators. The strategies that maximize the survival of foraging fishes are not well understood. Here, we describe a novel type of mobbing behaviour displayed by foraging Scolopsis affinis. The fish direct sharp water jets towards the hidden sessile ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33187
更新日期：2016-09-12 00:00:00
abstract：:Phelan McDermid Syndrome (PMDS) is a genetic disorder characterized by features of Autism spectrum disorders. Similar to reports of Zn deficiency in autistic children, we have previously reported high incidence of Zn deficiency in PMDS. However, the underlying mechanisms are currently not well understood. Here, using ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45190
更新日期：2017-03-27 00:00:00
abstract：:Biomass waste products from green algae have recently been given new life, as these polysaccharides have potential applications in industry, agriculture, and medicine. One such polysaccharide group called ulvans displays many different, potentially useful properties that arise from their structural versatility. Hence,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44115
更新日期：2017-03-22 00:00:00
abstract：:Ruminococcus albus 8 is a specialist plant cell wall degrading ruminal bacterium capable of utilizing hemicellulose and cellulose. Cellulose degradation requires a suite of enzymes including endoglucanases, exoglucanases, and β-glucosidases. The enzymes employed by R. albus 8 in degrading cellulose are yet to be compl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29979
更新日期：2016-07-21 00:00:00
abstract：:Embryonic Stem Cells (ESCs) are expected to show a stable euploid karyotype, but in the last decade (sub)chromosomal aberrations have been systematically described in these cell lines when maintained in vitro. Culture conditions and long-term culture have been traditionally proposed as possible factors involved in the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05324
更新日期：2014-06-17 00:00:00
abstract：:The development of selective visual attention is critical for effectively engaging with an ever-changing world. Its optimal deployment depends upon interactions between neural, motor, and sensory systems across multiple timescales and neurocognitive loci. Previous work illustrates the spatio-temporal dynamics of these...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73187-w
更新日期：2020-10-14 00:00:00
abstract：:Dirt and microorganisms are the major problems in textiles which can generate unpleasant odor during their growth. Here, zinc oxide (ZnO) nanoparticles prepared by sol-gel method were loaded on the cotton fabrics using spin coating technique to enhance their antimicrobial properties and water repellency. The effects o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22324-7
更新日期：2018-03-02 00:00:00
abstract：:Many freshwater and coastal marine ecosystems across the world may have undergone an ecosystem regime change due to a combination of rising anthropogenic disturbances and regional climate change. Such a change in aquatic ecosystems is commonly seen as shifts in algal species. But considerably less detail is known abou...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07265
更新日期：2014-12-01 00:00:00
abstract：:The sustainable use of common pool resources has become a significant global challenge. It is now widely accepted that specific mechanisms such as community-based management strategies, institutional responses such as resource privatization, information availability and emergent social norms can be used to constrain i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02151-y
更新日期：2017-05-23 00:00:00
abstract：:We discuss subwavelength-scale semiconductor metal-optic resonators placed on the metal substrate with various top metal plate sizes. Albeit with large optical losses, addition of metal layers converts a leaky semiconductor nano-block into a highly-confined optical cavity. Optically pumped lasing action is observed wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31793
更新日期：2016-08-23 00:00:00
abstract：:Sphingopyxis granuli strain TFA is an α-proteobacterium that belongs to the sphingomonads, a group of bacteria well-known for its degradative capabilities and oligotrophic metabolism. Strain TFA is the only bacterium in which the mineralisation of the aromatic pollutant tetralin has been completely characterized at bi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65258-9
更新日期：2020-05-26 00:00:00
abstract：:Organic gases undergoing conversion to form secondary organic aerosol (SOA) during atmospheric aging are largely unidentified, particularly in regions influenced by anthropogenic emissions. SOA dominates the atmospheric organic aerosol burden and this knowledge gap contributes to uncertainties in aerosol effects on cl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27881
更新日期：2016-06-17 00:00:00
abstract：:A silica gel coated microsphere resonator is proposed and experimentally demonstrated for measurements of ammonia (NH3) concentration in air with ultra-high sensitivity. The optical properties of the porous silica gel layer change when it is exposed to low (parts per million (ppm)) and even ultra-low (parts per billio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20025-9
更新日期：2018-01-26 00:00:00
abstract：:Campylobacter hyointestinalis is a member of an emerging group of zoonotic Campylobacter spp. that are increasingly identified in both gastric and non-gastric disease in humans. Here, we discovered C. hyointestinalis in three separate classes of New Zealand ruminant livestock; cattle, sheep and deer. To investigate th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20889-x
更新日期：2018-02-05 00:00:00
abstract：:Local polarization of a magnetic layer, a well-known method for storing information, has found its place in numerous applications such as the popular magnetic drawing board toy or the widespread credit cards and computer hard drives. Here we experimentally show that a similar principle can be applied for imprinting th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27159
更新日期：2016-06-06 00:00:00
abstract：:We study the driven translocation of a semi-flexible polymer through a nanopore by means of a modified version of the iso-flux tension propagation theory, and extensive molecular dynamics (MD) simulations. We show that in contrast to fully flexible chains, for semi-flexible polymers with a finite persistence length [F...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07227-3
更新日期：2017-08-07 00:00:00
abstract：:Diatoms are among the most diverse eukaryotic microorganisms on Earth, they are responsible for a large fraction of primary production in the oceans and can be found in different habitats. Pseudo-nitzschia are marine planktonic diatoms responsible for blooms in coastal and oceanic waters. We analyzed the transcriptome...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12329
更新日期：2015-07-20 00:00:00
abstract：:Non-invasive imaging of arthritis activity in rheumatoid arthritis (RA) patients using macrophage PET holds promise for early diagnosis and therapeutic response monitoring. Previously obtained results with macrophage tracer (R)-[11C]PK11195 were encouraging, but the imaging signal could be further improved by reductio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57841-x
更新日期：2020-01-23 00:00:00
abstract：:The cartilaginous and non-neopterygian bony fishes have an electric sense typically comprised of hundreds or thousands of sensory canals distributed in broad clusters over the head. This morphology facilitates neural encoding of local electric field intensity, orientation, and polarity, used for determining the positi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08962
更新日期：2015-03-11 00:00:00
abstract：:Animal models are extensively used to evaluate the in vivo functionality of novel drug delivery systems (DDS). However, many variations likely exist in vivo between the animals and human physiological environment that significantly alter results obtained with animal models relative to human system. To date, it is not ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11631
更新日期：2015-06-26 00:00:00
abstract：:The strategy of using redox additive electrolyte in combination with multiwall carbon nanotubes/metal oxide composites leads to a substantial improvements in the specific energy and power of asymmetric supercapacitors (ASCs). When the pure electrolyte is optimally modified with a redox additive viz., KI, ~105% increas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25793
更新日期：2016-05-17 00:00:00
abstract：:Oral microbiome dysbiosis has been associated with various local and systemic human diseases such as dental caries, periodontal disease, obesity, and cardiovascular disease. Bacterial composition may be affected by age, oral health, diet, and geography, although information about the natural variation found in the gen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59016-0
更新日期：2020-02-07 00:00:00
abstract：:Evidence on behavioural abnormalities in children exposed to secondhand smoke is limited. This study examined the relation between infant/ toddler cotinine concentration, a biomarker of secondhand smoke exposure, and behavioural problems in preschoolers who were unexposed to maternal smoking during gestation. A prospe...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/s41598-018-33829-6
更新日期：2018-10-18 00:00:00
abstract：:Stem cell therapy that can restore function to damaged tissue, avoid host rejection and reduce inflammation throughout body without use of immunosuppressive drugs. The established methods were used to identify and to isolate specific stem cell markers by FACS or by immunomagnetic cell separation. The procedures for di...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09543-0
更新日期：2017-08-29 00:00:00
abstract：:From the viewpoint of networks, a ranking system for players or teams in sports is equivalent to a centrality measure for sports networks, whereby a directed link represents the result of a single game. Previously proposed network-based ranking systems are derived from static networks, i.e., aggregation of the results...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00904
更新日期：2012-01-01 00:00:00
abstract：:Large (>10 kb) palindromic sequences are enriched on mammalian sex chromosomes. In mice, these palindromes harbor gene families (≥2 gene copies) expressed exclusively in post-meiotic testicular germ cells, a time when most single-copy sex-linked genes are transcriptionally repressed. This observation led to the hypoth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27360-x
更新日期：2018-06-12 00:00:00
abstract：:Bt cotton was genetically modified to produce insecticidal proteins targeting Lepidopteran pests and is therefore only minimally affected by caterpillar damage. This could lead to reduced levels of inherent, systemically inducible defensive compounds in Bt cotton which might benefit other important cotton herbivores s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38917-9
更新日期：2019-02-25 00:00:00
