Gemini quaternary ammonium compound PMT12-BF4 inhibits Candida albicans via regulating iron homeostasis.


:Quaternary ammonium compounds (QACs) are classified as cationic surfactants, and are known for their biocidal activity. However, their modes of action are thus far not completely understood. In this study, we synthesized a gemini QAC, PMT12-BF4 and found that it exerted unsurpassed broad-spectrum antifungal activity against drug susceptible and resistant Candida albicans, and other pathogenic fungi, with a minimal inhibitory concentration (MIC) at 1 or 2 μg/mL. These results indicated that PMT12-BF4 used a mode of action distinct from current antifungal drugs. In addition, fungal pathogens treated with PMT12-BF4 were not able to grow on fresh YPD agar plates, indicating that the effect of PMT12-BF4 was fungicidal, and the minimal fungicidal concentration (MFC) against C. albicans isolates was 1 or 2 μg/mL. The ability of yeast-to-hyphal transition and biofilm formation of C. albicans was disrupted by PMT12-BF4. To investigate the modes of action of PMT12-BF4 in C. albicans, we used an RNA sequencing approach and screened a C. albicans deletion mutant library to identify potential pathways affected by PMT12-BF4. Combining these two approaches with a spotting assay, we showed that the ability of PMT12-BF4 to inhibit C. albicans is potentially linked to iron ion homeostasis.


Sci Rep


Scientific reports


Hsu LH,Kwaśniewska D,Wang SC,Shen TL,Wieczorek D,Chen YL




Has Abstract


2020-02-19 00:00:00












  • The unique social sense of puerperium: Increased empathy and Schadenfreude in parents of newborns.

    abstract::Pregnancy and puerperium are typified by marked biobehavioral changes. These changes, which are traceable in both mothers and fathers, play an important role in parenthood and may modulate social cognition abilities. However, the latter effects remain notably unexplored in parents of newborns (PNs). To bridge this gap...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Gómez-Carvajal AM,Santamaría-García H,García AM,Valderrama M,Mejia J,Santamaría-García J,Bernal M,Silva J,Ibáñez A,Baez S

    更新日期:2020-04-01 00:00:00

  • Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation.

    abstract::We found a novel spontaneous mouse mutant with depigmentation in the ventral body, which we called White Spotting (WS) mouse. Genetic investigation revealed deletion of a > 1.2-Mb genomic region containing nine genes (Kit, Kdr, Srd5a3, Tmeme165, Clock, Pdcl2, Nmu, Exoc1, and Cep135). We designated this mutant allele K...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Mizuno S,Takami K,Daitoku Y,Tanimoto Y,Dinh TT,Mizuno-Iijima S,Hasegawa Y,Takahashi S,Sugiyama F,Yagami K

    更新日期:2015-09-08 00:00:00

  • Self-instability of finite sized solid-liquid interfaces.

    abstract::In solid-liquid systems, macroscopic solids lose their equilibrium and melt in a manner that results in overall movement of the solid-liquid interface. This phenomenon occurs when they are subjected to temperature gradients or external stress, for example. However, many experiments suggest that the melting of nano- an...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wu LK,Xu B,Li QL,Liu W

    更新日期:2015-12-21 00:00:00

  • Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy.

    abstract::We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification might ameliorate experimental uremic cardiomyopathy i...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Liu J,Tian J,Chaudhry M,Maxwell K,Yan Y,Wang X,Shah PT,Khawaja AA,Martin R,Robinette TJ,El-Hamdani A,Dodrill MW,Sodhi K,Drummond CA,Haller ST,Kennedy DJ,Abraham NG,Xie Z,Shapiro JI

    更新日期:2016-10-04 00:00:00

  • Size dependent microbial oxidation and reduction of magnetite nano- and micro-particles.

    abstract::The ability for magnetite to act as a recyclable electron donor and acceptor for Fe-metabolizing bacteria has recently been shown. However, it remains poorly understood whether microbe-mineral interfacial electron transfer processes are limited by the redox capacity of the magnetite surface or that of whole particles....

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Byrne JM,van der Laan G,Figueroa AI,Qafoku O,Wang C,Pearce CI,Jackson M,Feinberg J,Rosso KM,Kappler A

    更新日期:2016-08-05 00:00:00

  • Interaction between microRNA expression and classical risk factors in the risk of coronary heart disease.

    abstract::The aim of this study was to identify the synergistic effect of microRNA expression with classical risk factors of coronary heart disease (CHD) and to explore their diagnostic value for coronary stenotic lesions in subjects with CHD. Plasma samples were obtained from 66 subjects with CHD and from 58 control individual...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ding XQ,Ge PC,Liu Z,Jia H,Chen X,An FH,Li LH,Chen ZH,Mao HW,Li ZY,Gu Y,Zhu TB,Li CJ,Wang LS,Ma WZ,Yang ZJ,Jia EZ

    更新日期:2015-10-08 00:00:00

  • Antimicrobial and anti-inflammatory activities of three chensinin-1 peptides containing mutation of glycine and histidine residues.

    abstract::The natural peptide chensinin-1 doesnot exhibit its desired biological properties. In this study, the mutant MC1-1 was designed by replacing Gly in the chensinin-1 sequence with Trp. Mutants MC1-2 and MC1-3 were designed based on the MC1-1 sequence to investigate the specific role of His residues. The mutated peptides...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Dong W,Mao X,Guan Y,Kang Y,Shang D

    更新日期:2017-01-05 00:00:00

  • Manganese oxide electrode with excellent electrochemical performance for sodium ion batteries by pre-intercalation of K and Na ions.

    abstract::Materials with a layered structure have attracted tremendous attention because of their unique properties. The ultrathin nanosheet structure can result in extremely rapid intercalation/de-intercalation of Na ions in the charge-discharge progress. Herein, we report a manganese oxide with pre-intercalated K and Na ions ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Feng M,Du Q,Su L,Zhang G,Wang G,Ma Z,Gao W,Qin X,Shao G

    更新日期:2017-05-22 00:00:00

  • Novel mechanism of harmaline on inducing G2/M cell cycle arrest and apoptosis by up-regulating Fas/FasL in SGC-7901 cells.

    abstract::Harmaline (HAR), a natural occurrence β-carboline alkaloid, was isolated from the seeds of Peganum harmala and exhibited potent antitumor effect. In this study, the anti-gastric tumor effects of HAR were firstly investigated in vitro and in vivo. The results strongly showed that HAR could inhibit tumor cell proliferat...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang Y,Wang C,Jiang C,Zeng H,He X

    更新日期:2015-12-18 00:00:00

  • Solvent-free bulk polymerization of lignin-polycaprolactone (PCL) copolymer and its thermoplastic characteristics.

    abstract::The pristine lignin molecules contain multiple reactive hydroxyl [OH] groups, some of which undergo limited polymerization depending on their configuration (aromatic or aliphatic) or conformation. The key issue in lignin-polymerization is to quantify the number of hydroxyl groups in the pristine molecules for subseque...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Park IK,Sun H,Kim SH,Kim Y,Kim GE,Lee Y,Kim T,Choi HR,Suhr J,Nam JD

    更新日期:2019-05-07 00:00:00

  • Naked Gold Nanoparticles and hot Electrons in Water.

    abstract::The ionizing radiation in aqueous solutions of gold nanoparticles, stabilized by electrostatic non-covalent intermolecular forces and steric interactions, with antimicrobial compounds, are investigated with picosecond pulse radiolysis techniques. Upon pulse radiolysis of an aqueous solution containing very low concent...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ghandi K,Wang F,Landry C,Mostafavi M

    更新日期:2018-05-08 00:00:00

  • Reduced Transition Temperature in Al:ZnO/VO2 Based Multi-Layered Device for low Powered Smart Window Application.

    abstract::The metal-to-insulator transition (MIT) closest to room temperature of 68-70 °C as shown by vanadium oxide (VO2), compared with other transition metal oxides, makes it a potential candidate for smart window coating. We have successfully fabricated a potential smart window device after the optimum design of a multilaye...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Behera MK,Williams LC,Pradhan SK,Bahoura M

    更新日期:2020-02-04 00:00:00

  • Analysis of cell-biomaterial interaction through cellular bridge formation in the interface between hGMSCs and CaP bioceramics.

    abstract::The combination of biomaterials and stem cells for clinical applications constitute a great challenge in bone tissue engineering. Hence, cellular networks derived from cells-biomaterials crosstalk have a profound influence on cell behaviour and communication, preceding proliferation and differentiation. The purpose of...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Benjumeda Wijnhoven I,Vallejos R,Santibanez JF,Millán C,Vivanco JF

    更新日期:2020-10-05 00:00:00

  • Chronic dysfunction of Stromal interaction molecule by pulsed RNAi induction in fat tissue impairs organismal energy homeostasis in Drosophila.

    abstract::Obesity is a progressive, chronic disease, which can be caused by long-term miscommunication between organs. It remains challenging to understand how chronic dysfunction in a particular tissue remotely impairs other organs to eventually imbalance organismal energy homeostasis. Here we introduce RNAi Pulse Induction (R...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Xu Y,Borcherding AF,Heier C,Tian G,Roeder T,Kühnlein RP

    更新日期:2019-05-06 00:00:00

  • The Fall of Sleep K-Complex in Alzheimer Disease.

    abstract::Although a slowing of electroencephalographic (EEG) activity during wakefulness and -to some extent- sleep of Alzheimer disease (AD) patients (i.e., increased slow-frequency activity) was documented, recent findings in healthy elderly show a decreased 0.6-1 Hz slow wave activity (SWA) during NREM, which was associated...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: De Gennaro L,Gorgoni M,Reda F,Lauri G,Truglia I,Cordone S,Scarpelli S,Mangiaruga A,D'atri A,Lacidogna G,Ferrara M,Marra C,Rossini PM

    更新日期:2017-01-03 00:00:00

  • Axial plane optical microscopy.

    abstract::We present axial plane optical microscopy (APOM) that can, in contrast to conventional microscopy, directly image a sample's cross-section parallel to the optical axis of an objective lens without scanning. APOM combined with conventional microscopy simultaneously provides two orthogonal images of a 3D sample. More im...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Li T,Ota S,Kim J,Wong ZJ,Wang Y,Yin X,Zhang X

    更新日期:2014-12-01 00:00:00

  • Long-tip high-speed atomic force microscopy for nanometer-scale imaging in live cells.

    abstract::Visualization of morphological dynamics of live cells with nanometer resolution under physiological conditions is highly desired, but challenging. It has been demonstrated that high-speed atomic force microscopy is a powerful technique for visualizing dynamics of biomolecules under physiological conditions. However, a...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Shibata M,Uchihashi T,Ando T,Yasuda R

    更新日期:2015-03-04 00:00:00

  • Sfrp1 deficiency makes retinal photoreceptors prone to degeneration.

    abstract::Millions of individuals worldwide suffer from impaired vision, a condition with multiple origins that often impinge upon the light sensing cells of the retina, the photoreceptors, affecting their integrity. The molecular components contributing to this integrity are however not yet fully understood. Here we have asked...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Cisneros E,di Marco F,Rueda-Carrasco J,Lillo C,Pereyra G,Martín-Bermejo MJ,Vargas A,Sanchez R,Sandonís Á,Esteve P,Bovolenta P

    更新日期:2020-03-20 00:00:00

  • Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion.

    abstract::The hippocampus has a significant association with memory, cognition and emotions. The dopaminergic projections from both the ventral tegmental area and substantia nigra are thought to be involved in hippocampal activity. To date, however, few studies have investigated dopaminergic innervation in the hippocampus or th...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Castro-Hernández J,Adlard PA,Finkelstein DI

    更新日期:2017-03-14 00:00:00

  • Epidemiology Investigation of stroke among Mongolian and Han population aged over 45 in Inner Mongolia.

    abstract::To discuss the status of epidemiology of stroke in the Mongolian and Han population aged over 45 years and to understand the treatment and prevention of stroke. Data collected on stroke populations aged over 45 years in the six areas in Inner Mongolia were analyzed by using stratified multi-stage cluster sampling. The...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zhang C,Lan T,Zhe Y,Hu B,Zhang G,He J,Wang Z,Jiang M,Hu R

    更新日期:2017-04-04 00:00:00

  • Genomic diversity and macroecology of the crop wild relatives of domesticated pea.

    abstract::There is growing interest in the conservation and utilization of crop wild relatives (CWR) in international food security policy and research. Legumes play an important role in human health, sustainable food production, global food security, and the resilience of current agricultural systems. Pea belongs to the ancien...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Smýkal P,Hradilová I,Trněný O,Brus J,Rathore A,Bariotakis M,Das RR,Bhattacharyya D,Richards C,Coyne CJ,Pirintsos S

    更新日期:2017-12-12 00:00:00

  • Combination treatment with decitabine and ionizing radiation enhances tumor cells susceptibility of T cells.

    abstract::Decitabine has been found to have anti-metabolic and anti-tumor activities in various tumor cells. Recently, the use of decitabine in combination with other conventional therapies reportedly resulted in improved anti-tumor activity against various tumors. Ionizing radiation (IR) is widely used as a cancer treatment. D...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Son CH,Lee HR,Koh EK,Shin DY,Bae JH,Yang K,Park YS

    更新日期:2016-09-27 00:00:00

  • Pathogenic lineage of Perkinsea associated with mass mortality of frogs across the United States.

    abstract::Emerging infectious diseases such as chytridiomycosis and ranavirus infections are important contributors to the worldwide decline of amphibian populations. We reviewed data on 247 anuran mortality events in 43 States of the United States from 1999-2015. Our findings suggest that a severe infectious disease of tadpole...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Isidoro-Ayza M,Lorch JM,Grear DA,Winzeler M,Calhoun DL,Barichivich WJ

    更新日期:2017-08-31 00:00:00

  • Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice.

    abstract::Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been identified in humans and mice on the basis of their extensive portfoli...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wu Y,Chang YM,Stell AJ,Priestnall SL,Sharma E,Goulart MR,Gribben J,Xia D,Garden OA

    更新日期:2019-09-17 00:00:00

  • Evidence of a Causal Role for mid-Ventrolateral Prefrontal Cortex Based Functional Networks in Retrieving High-Fidelity Memory.

    abstract::Functional neuroimaging studies have implicated regions of both ventrolateral prefrontal cortex (VLPFC) and angular gyrus in processes associated with retrieving goal-relevant information, which increases the fidelity and richness of long-term memory (LTM). To further investigate the roles of these cortical regions as...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wais PE,Montgomery O,Stark CEL,Gazzaley A

    更新日期:2018-10-05 00:00:00

  • Thermoelectric performance of n-type Mg2Ge.

    abstract::Magnesium-based thermoelectric materials (Mg2X, X = Si, Ge, Sn) have received considerable attention due to their availability, low toxicity, and reasonably good thermoelectric performance. The synthesis of these materials with high purity is challenging, however, due to the reactive nature and high vapour pressure of...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Santos R,Nancarrow M,Dou SX,Aminorroaya Yamini S

    更新日期:2017-06-21 00:00:00

  • Inclusion of Population-specific Reference Panel from India to the 1000 Genomes Phase 3 Panel Improves Imputation Accuracy.

    abstract::Imputation is a computational method based on the principle of haplotype sharing allowing enrichment of genome-wide association study datasets. It depends on the haplotype structure of the population and density of the genotype data. The 1000 Genomes Project led to the generation of imputation reference panels which h...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ahmad M,Sinha A,Ghosh S,Kumar V,Davila S,Yajnik CS,Chandak GR

    更新日期:2017-07-27 00:00:00

  • Computationally-driven engineering of sublattice ordering in a hexagonal AlHfScTiZr high entropy alloy.

    abstract::Multi-principle element alloys have enormous potential, but their exploration suffers from the tremendously large range of configurations. In the last decade such alloys have been designed with a focus on random solid solutions. Here we apply an experimentally verified, combined thermodynamic and first-principles desi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Rogal L,Bobrowski P,Körmann F,Divinski S,Stein F,Grabowski B

    更新日期:2017-05-19 00:00:00

  • Design principles governing chemomechanical coupling of kinesin.

    abstract::A systematic chemomechanical network model for the molecular motor kinesin is presented in this report. The network model is based on the nucleotide-dependent binding affinity of the heads to an microtubule (MT) and the asymmetries and similarities between the chemical transitions caused by the intramolecular strain b...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Sumi T

    更新日期:2017-04-25 00:00:00

  • Chemical recognition of fruit ripeness in spider monkeys (Ateles geoffroyi).

    abstract::Primates are now known to possess well-developed olfactory sensitivity and discrimination capacities that can play a substantial role in many aspects of their interaction with conspecifics and the environment. Several studies have demonstrated that olfactory cues may be useful in fruit selection. Here, using a conditi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Nevo O,Orts Garri R,Hernandez Salazar LT,Schulz S,Heymann EW,Ayasse M,Laska M

    更新日期:2015-10-06 00:00:00