Abstract：
:Technological improvements have resulted in increased discovery of new microRNAs (miRNAs) and refinement and enrichment of existing miRNA families. miRNA families are important because they suggest a common sequence or structure configuration in sets of genes that hint to a shared function. Exploratory tools to enhance investigation of characteristics of miRNA families and the functions of family-specific miRNA genes are lacking. We have developed, miRNAVISA, a user-friendly web-based tool that allows customized interrogation and comparisons of miRNA families for hypotheses generation, and comparison of per-species chromosomal distribution of miRNA genes in different families. This study illustrates hypothesis generation using miRNAVISA in seven species. Our results unveil a subclass of miRNAs that may be regulated by genomic imprinting, and also suggest that some miRNA families may be species-specific, as well as chromosome- and/or strand-specific.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kamanu TK,Radovanovic A,Archer JA,Bajic VBdoi
10.1038/srep02940subject
Has Abstractpub_date
2013-10-15 00:00:00pages
2940issn
2045-2322pii
srep02940journal_volume
3pub_type
杂志文章abstract：:MicroRNAs play critical role in the development and progression of various diseases. Predicting potential miRNA-disease associations from vast amount of biological data is an important problem in the biomedical research. Considering the limitations in previous methods, we developed Regularized Least Squares for MiRNA-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05501
更新日期：2014-06-30 00:00:00
abstract：:Molecular imaging is a powerful tool for investigating intracellular signalling, but it is difficult to acquire conventional fluorescence imaging from photoreceptive cells. Here we demonstrated that human opsin5 (OPN5) photoreceptor mediates light-induced Ca(2+) response in human embryonic kidney (HEK293) and mouse ne...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05352
更新日期：2014-06-19 00:00:00
abstract：:The thermal field theory is applied to fermionic superfluids by doubling the degrees of freedom of the BCS theory. We construct the two-mode states and the corresponding Bogoliubov transformation to obtain the BCS thermal vacuum. The expectation values with respect to the BCS thermal vacuum produce the statistical ave...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30438-1
更新日期：2018-08-10 00:00:00
abstract：:Alzheimer disease and other dementias have become the 7th cause of death worldwide. Still lacking a cure, an early detection of the disease in order to provide the best intervention is crucial. To develop an assessment system for the general public, speech analysis is the optimal solution since it reflects the speaker...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56020-x
更新日期：2019-12-20 00:00:00
abstract：:We developed a virus-like particle (VLP)-based therapeutic vaccine against angiotensin II receptor type 1, ATR-AP205-001, which could significantly reduce the blood pressure and protect target organs of hypertensive animals. In this study, we focused on the immunological effect and safety of the VLP-based vaccine. By ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12996-y
更新日期：2017-10-03 00:00:00
abstract：:The probability of mitochondrial permeability transition (mPT) pore opening is inversely related to the magnitude of the proton electrochemical gradient. The module conferring sensitivity of the pore to this gradient has not been identified. We investigated mPT's voltage-sensing properties elicited by calcimycin or H2...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26700
更新日期：2016-05-25 00:00:00
abstract：:Viruses use a strategy of high mutational rates to adapt to environmental and therapeutic pressures, circumventing the deleterious effects of random single-point mutations by coevolved compensatory mutations, which restore protein fold, function or interactions damaged by initial ones. This mechanism has been identifi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24957
更新日期：2016-04-22 00:00:00
abstract：:A disposable cyclic voltammetry (CV) tag is printed on a plastic film by integrating wireless power transmitter, polarized triangle wave generator, electrochemical cell and signage through a scalable gravure printing method. By proximity of 13.56 MHz RF reader, the printed CV tag generates 320 mHz of triangular sweep ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08105
更新日期：2015-01-29 00:00:00
abstract：:Drought stress and pathogen infection simultaneously occur in the field. In this study, the interaction of these two stresses with chickpea, their individual and combined effect and the net impact on plant growth and yield traits were systematically assessed under field and confined pot experiments. The field experime...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41463-z
更新日期：2019-04-03 00:00:00
abstract：:Using high resolution powder x-ray and neutron diffraction experiments, we determined the off-centered displacement of the ions within a unit cell and magnetoelectric coupling in nanoscale BiFeO3 (≈20-200 nm). We found that both the off-centered displacement of the ions and magnetoelectric coupling exhibit nonmonotoni...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21803-1
更新日期：2018-02-27 00:00:00
abstract：:This research investigated the association between prolonged disposable diaper (DD) wearing in infancy and primary enuresis (PNE). As a case-control study, we collected data from 376 children with enuresis and 379 healthy children who were sex- and age-matched at three tertiary care institutions in mainland China from...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70195-8
更新日期：2020-09-01 00:00:00
abstract：:We report the development of on-chip fluorescence switching system based on DNA strand displacement and DNA hybridization for the construction of a rewritable and randomly accessible data storage device. In this study, the feasibility and potential effectiveness of our proposed system was evaluated with a series of we...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16535-7
更新日期：2018-01-10 00:00:00
abstract：:Little is known about the feeding behavior of hematophagous insects that require plant sugar to complete their life cycles. We studied plant feeding of Lutzomyia longipalpis sand flies, known vectors of Leishmania infantum/chagasi parasites, in a Brazilian city endemic with visceral leishmaniasis. The DNA barcode tech...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29742
更新日期：2016-07-20 00:00:00
abstract：:This paper presents a study of noise in room-temperature THz radiometers that use THz-to-optical upconversion followed by optical detection of thermal radiation. Despite some undesired upconverted thermal noise, no noise is intrinsically introduced by efficient electro-optic modulation via a sum-frequency-generation p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65987-x
更新日期：2020-06-10 00:00:00
abstract：:A reduction in the particle size is expected to improve the properties and increase the application potential of high-entropy alloys. Therefore, in this study, a novel sol-gel autocombustion technique was first used to synthesize high-entropy alloys. The average grain size of the prepared nanocrystalline CoCrCuNiAl hi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03644-6
更新日期：2017-06-13 00:00:00
abstract：:Culture medium of mesenchymal stromal cells (MSCs) is usually supplemented with either human platelet lysate (HPL) or fetal calf serum (FCS). Many studies have demonstrated that proliferation and cellular morphology are affected by these supplements - it is therefore important to determine if they favor outgrowth of d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05207-1
更新日期：2017-07-11 00:00:00
abstract：:Cell surface expression of alpha-enolase, a glycolytic enzyme displaying moonlighting activities, has been shown to contribute to the motility and invasiveness of cancer cells through the protein non-enzymatic function of binding plasminogen and enhancing plasmin formation. Although a few recent records indicate the i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04185-8
更新日期：2017-06-19 00:00:00
abstract：:Isoliquiritigenin (ISL), a natural flavonoid extracted from licorice, has been demonstrated to exert attenuation of osteoclastogenesis and anti-angiogenesis activity in a wide variety of cells. Here, we first evaluated the effects of ISL on pathogenesis of osteoarthritis in a mouse model of OA. The data showed that IS...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19162-y
更新日期：2018-01-29 00:00:00
abstract：:Magnesium has been shown to effectively prevent vascular calcification associated with chronic kidney disease. Magnesium has been hypothesized to prevent the upregulation of osteoblastic genes that potentially drives calcification. However, extracellular effects of magnesium on hydroxyapatite formation are largely neg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20241-3
更新日期：2018-02-01 00:00:00
abstract：:The replication-incompetent adenovirus (Ad) vector is one of the most promising vectors for gene therapy; however, systemic administration of Ad vectors results in severe hepatotoxicities, partly due to the leaky expression of Ad genes in the liver. Here we show that nuclear factor-kappa B (NF-κB) mediates the leaky e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19922
更新日期：2016-01-27 00:00:00
abstract：:We have observed that one in three patients admitted to the Neurological Rehabilitation Ward for Children and Adolescents due to a syndrome or disease associated with neurodysfunction is short of stature for their age. In order to identify the relationship between growth defects (short stature) and syndromes or diseas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52918-8
更新日期：2019-11-11 00:00:00
abstract：:Ten to twenty percent of the hepatocellular carcinoma (HCC) patients fulfilling the Milan criteria (MC) recurred within three years after orthotopic liver transplantation (OLT). We therefore utilize a training cohort to develop an improved prognostic model for predicting the recurrence in these patients. By univariate...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep44036
更新日期：2017-03-09 00:00:00
abstract：:The potential of Massively Parallel Sequencing (MPS) technology to vastly expand the capabilities of human identification led to the emergence of different MPS platforms that use forensically relevant genetic markers. Two of the MPS platforms that are currently available are the MiSeq® FGx™ Forensic Genomics System (I...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00510-3
更新日期：2017-03-24 00:00:00
abstract：:Phelan-McDermid Syndrome (PMS), which is defined by a deletion within 22q13, demonstrates significant phenotypic variation. Given that six mitochondrial genes are located within 22q13, including complex I and IV genes, we hypothesize that mitochondrial complex activity abnormalities may explain phenotypic variation in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19544
更新日期：2016-01-29 00:00:00
abstract：:Since 2001, hundreds of thousands of hours of underwater acoustic recordings have been made throughout the Southern Ocean south of 60° S. Detailed analysis of the occurrence of marine mammal sounds in these circumpolar recordings could provide novel insights into their ecology, but manual inspection of the entirety of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78995-8
更新日期：2021-01-12 00:00:00
abstract：:The evolution of cooperation is a fundamental problem in biology, especially for non-relatives, where indirect fitness benefits cannot counter within-group inequalities. Multilevel selection models show how cooperation can evolve if it generates a group-level advantage, even when cooperators are disadvantaged within t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29828
更新日期：2016-07-28 00:00:00
abstract：:Previous experimental studies discovered universal growth of chains and nanowires of various chemical elements on a corrugated molecular network of Cu3N on the Cu(110). Herein, performing combined ab initio and quantum Hamiltonian studies we demonstrate that such chains can be used for a fast spin switching and entang...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02972-x
更新日期：2017-06-05 00:00:00
abstract：:The current research on cellular heat stress management focuses on the roles of heat shock proteins (HSPs) and the proteostasis network under severe stress conditions. The mild, fever-type stress and the maintenance of membrane homeostasis are less well understood. Herein, we characterized the acute effect of mild, fe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15821-8
更新日期：2017-11-15 00:00:00
abstract：:The ubiquitin-proteasomal degradation mechanism has gained the attention over the past decade. The E2 ubiquitin conjugating enzymes are the crucial part of ubiquitination mechanism and they are believed to hold imperative association for plant development. It accepts ubiquitin from the E1 enzyme and interacts with the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09121-4
更新日期：2017-08-17 00:00:00
abstract：:The treatment of testicular cancer includes unilateral orchiectomy and chemotherapy and is curative for most patients. However, observational studies revealed an association with depression, anxiety and cognitive impairment. It is unclear whether these side effects are caused by chemotherapy, hemicastration or the dis...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67081-8
更新日期：2020-06-23 00:00:00
