Abstract：
:Riemerella anatipestifer is a major pathogenic microorganism in poultry causing serositis with significant mortality. Serotype 1 and 2 were most pathogenic, prevalent, and liable over the world. In this study, the intracellular metabolites in R. anatipestifer strains RA-CH-1 (serotype 1) and RA-CH-2 (serotype 2) were identified by gas chromatography-mass spectrometer (GC-MS). The metabolic profiles were performed using hierarchical clustering and partial least squares discriminant analysis (PLS-DA). The results of hierarchical cluster analysis showed that the amounts of the detected metabolites were more abundant in RA-CH-2. RA-CH-1 and RA-CH-2 were separated by the PLS-DA model. 24 potential biomarkers participated in nine metabolisms were contributed predominantly to the separation. Based on the complete genome sequence database and metabolite data, the first large-scale metabolic models of iJL463 (RA-CH-1) and iDZ470 (RA-CH-2) were reconstructed. In addition, we explained the change of purine metabolism combined with the transcriptome and metabolomics data. The study showed that it is possible to detect and differentiate between these two organisms based on their intracellular metabolites using GC-MS. The present research fills a gap in the metabolomics characteristics of R. anatipestifer.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu J,Cheng A,Wang M,Liu M,Zhu D,Yang Q,Wu Y,Jia R,Chen S,Zhao X,Zhang S,Huang J,Ou X,Mao S,Gao Q,Wen X,Zhang L,Liu Y,Yu Y,Tian B,Pan L,Ur Rehman M,Chen Xdoi
10.1038/s41598-020-79733-wsubject
Has Abstractpub_date
2021-01-12 00:00:00pages
616issue
1issn
2045-2322pii
10.1038/s41598-020-79733-wjournal_volume
11pub_type
杂志文章abstract：:Paclitaxel (PTX) has been recognized as a promising drug for intervention of vascular reconstructions. However, it is still difficult to achieve local drug delivery in a spatio-temporally controllable manner under real-time image guidance. Here, we introduce an ultrasound (US) triggered image-guided drug delivery appr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21683
更新日期：2016-02-22 00:00:00
abstract：:The AB0 blood group has been linked to ischaemic heart disease, stroke, and periodontal disease, while the Lewis blood group has been linked to ischaemic heart disease and obesity, all of which have been associated with periodontitis. AB0 or Lewis blood group phenotype may therefore constitute common hereditary compon...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42594-z
更新日期：2019-04-18 00:00:00
abstract：:Maintaining energy balance over a wide range of temperatures is critical for an active pelagic fish species such as the mahi-mahi (Coryphaena hippurus), which can experience rapid changes in temperature during vertical migrations. Due to the profound effect of temperature on mitochondrial function, this study was desi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71741-0
更新日期：2020-09-10 00:00:00
abstract：:Fluorescence is widespread in marine organisms but uncommon in terrestrial tetrapods. We here show that many chameleon species have bony tubercles protruding from the skull that are visible through their scales, and fluoresce under UV light. Tubercles arising from bones of the skull displace all dermal layers other th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-19070-7
更新日期：2018-01-15 00:00:00
abstract：:We present a model on the simulation of the measurement-device independent quantum key distribution (MDI-QKD) with phase randomized general sources. It can be used to predict experimental observations of a MDI-QKD with linear channel loss, simulating corresponding values for the gains, the error rates in different bas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04612
更新日期：2014-04-14 00:00:00
abstract：:Biomass waste treatment and detrimental dye adsorption are two of the crucial environmental issues nowadays. In this study, we investigate to simultaneously resolve the aforementioned issues by synthesizing chitosan sponges as adsorbents toward rose bengal (RB) dye adsorption. Through a temperature-controlled freeze-c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18302-0
更新日期：2017-12-22 00:00:00
abstract：:A new concept in the formulation of hybrid nanostructured materials combining high quality graphene 3D supported by Nickel foam and polyporphyrins for visible light photocatalytic application is here reported. Our innovative approach involves the development of a freestanding device able to: i) offer a high surface ar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23345-y
更新日期：2018-03-22 00:00:00
abstract：:Graphite-coated magnetic cobalt nanoparticles (CoNPs) decorated with hindered phenolic antioxidant analogues of 2,6-di-tert-butyl-4-methylphenol (BHT, E321) provided easily removable nanoantioxidants capable of preventing the autoxidation of organic solvents as tetrahydrofuran (THF). ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53531-5
更新日期：2019-11-20 00:00:00
abstract：:Inhibition of DYRK1A kinase, produced by chromosome 21 and consequently overproduced in trisomy 21 subjects, has been suggested as a therapeutic approach to treating the cognitive deficiencies observed in Down syndrome (DS). We now report the synthesis and potent DYRK1A inhibitory activities of fluoro derivatives of 3...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20984-z
更新日期：2018-02-12 00:00:00
abstract：:Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a tinnitus treatment option. Promising results have been obtained by consecutive stimulation of lateral frontal and auditory brain regions. We investigated a combined stimulation paradigm targeting the anterior cingulate cortex (ACC) with double ...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/srep18028
更新日期：2015-12-15 00:00:00
abstract：:The accelerated discovery of disease-related genes emerging from genomic studies has strained the capacity of traditional genetically engineered mouse models (GEMMs) to provide in-vivo validation. Direct, somatic, genetic engineering approaches allow for accelerated and flexible genetic manipulation and represent an a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11061
更新日期：2015-06-05 00:00:00
abstract：:Mutations in the TGFβR2 gene have been associated with a life threatening risk of aortic dissection but no arrhythmic death has been previously reported. Two young females carrying a TGFβR2 mutation, initially diagnosed as Marfan syndrome or Loeys Dietz syndrome, presented sudden death with autopsy ruling out dissecti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31298-5
更新日期：2018-08-29 00:00:00
abstract：:There are more than 2300 genes that are predominantly expressed in mouse testes. The role of hundreds of these genes has been studied in mouse spermatogenesis but still there are many genes whose function is unknown. Gene knockout (KO) strategy in mice is widely used for in vivo study of gene function. The present stu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23176-x
更新日期：2018-03-21 00:00:00
abstract：:Plant cis-elements play important roles in global regulation of gene expression. Based on microarray data from rice flag leaves during early senescence, we identified W-box and G-box cis-elements as positive regulators of senescence in the important rice variety Minghui 63. Both cis-elements were bound by leaf senesce...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20881
更新日期：2016-02-11 00:00:00
abstract：:Given that observational associations may be inaccurate, we used offspring blood pressure (BP) to provide alternative estimates of the associations between own BP and mortality. Observational associations between BP and mortality, estimated as hazard ratios (HRs) from Cox regression, were compared to HRs obtained usin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12399
更新日期：2015-07-22 00:00:00
abstract：:Asymmetric cell divisions are required for cellular diversity and defects can lead to altered daughter cell fates and numbers. In a genetic screen for C. elegans mutants with defects in dopaminergic head neuron specification or differentiation, we isolated a new allele of the transcription factor HAM-1 [HSN (Hermaphro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04375-4
更新日期：2017-06-28 00:00:00
abstract：:Parkinson's Disease can be understood as a disorder of motor habits. A prediction of this theory is that early stage Parkinson's patients will display fewer errors caused by interference from previously over-learned behaviours. We test this prediction in the domain of skilled typing, where actions are easy to record a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39294-z
更新日期：2019-03-04 00:00:00
abstract：:Metallic silver nickel oxide honeycomb nanoarrays were synthesized via a surfactant-assisted hydrothermal route. The crystal structure of the Ag/NiO nanoarrays was confirmed by X-ray diffraction. X-ray photoelectron spectroscopy confirmed the valance state of the nickel, oxygen, and metallic silver. The morphological ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41446-0
更新日期：2019-03-19 00:00:00
abstract：:The IκB kinase (IKK) complex acts as the gatekeeper of canonical NF-κB signaling, thereby regulating immunity, inflammation and cancer. It consists of the catalytic subunits IKKα and IKKβ and the regulatory subunit NEMO/IKKγ. Here, we show that the ubiquitin binding domain (UBAN) in NEMO is essential for IKK/NF-κB act...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18934
更新日期：2016-01-07 00:00:00
abstract：:Cardiovascular risk rapidly increased following exposure to air pollution. Changes in human autonomic regulation have been implicated based on epidemiological associations between exposure estimates and indirect autonomic nervous system measurements. We conducted a mechanistic study to test the hypothesis that, in hea...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-40343-w
更新日期：2019-03-06 00:00:00
abstract：:A high-performance and novel photocatalyst of BiVO4-reduced Graphene Oxide (BiVO4-rGO) nanocomposite was prepared by a facile hydrothermal method. The photocatalyst was characterized by X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electronic microscopy, UV-Vis diffusi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07342-1
更新日期：2017-08-11 00:00:00
abstract：:WO3 is widely used as industrial catalyst. Intrinsic and/or extrinsic defects can tune the electronic properties and extend applications to gas sensors and optoelectonics. However, H doping is a challenge to WO3, the relevant mechanisms being hardly understood. In this context, we investigate intrinsic defects and H d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40882
更新日期：2017-01-18 00:00:00
abstract：:Deubiquitinase MYSM1 has been shown to play a critical role in hematopoietic cell differentiation and hematopoietic stem cell (HSC) maintenance. Mesenchymal stem cells (MSCs) are multipotent stromal cells within the bone marrow. MSCs are progenitors to osteoblasts, chondrocytes, adipocytes, and myocytes. Although, MSC...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22211
更新日期：2016-02-26 00:00:00
abstract：:Splenic immune function was enhanced in diet-induced-obese (DIO) mice caused by Escherichia coli. The changes in spleen function on apoptosis were still unknown. Two hundred mice in groups Lean-E. coli and DIO-E. coli were intranasal instillation of E. coli. And another two hundred mice in groups Lean-PBS and DIO-PBS ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62044-5
更新日期：2020-03-20 00:00:00
abstract：:Thermal management and simulation are becoming increasingly important in many areas of engineering applications. There are three cooling routes for thermal management, namely thermal conduction, thermal convection and thermal radiation, among which the first two approaches have been widely studied and applied, while t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21020-w
更新日期：2018-02-08 00:00:00
abstract：:Scattered and indirect evidence suggests that sea ice occurred as far south as the Iceland Sea during the Early Pliocene, when the global climate was warmer than present. However, conclusive evidence as well as potential mechanisms governing sea ice occurrence outside the Arctic Ocean during a time with elevated green...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37047-y
更新日期：2019-01-30 00:00:00
abstract：:Using 137Cs and 210Pb dating and multi-proxy evidence from a 41-cm sediment core from Bosten Lake in China, the responses of sediment grain size to environmental changes were reconstructed over the past 150 years. After the end of the Little Ice Age, the climate of the Bosten Lake region became warmer and drier, and t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57921-y
更新日期：2020-01-22 00:00:00
abstract：:Using dedicated contrast agents high-quality X-ray imaging of soft tissue structures with isotropic micrometre resolution has become feasible. This technique is frequently titled as virtual histology as it allows production of slices of tissue without destroying the sample. The use of contrast agents is, however, ofte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30385
更新日期：2016-07-27 00:00:00
abstract：:Drought stress and pathogen infection simultaneously occur in the field. In this study, the interaction of these two stresses with chickpea, their individual and combined effect and the net impact on plant growth and yield traits were systematically assessed under field and confined pot experiments. The field experime...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41463-z
更新日期：2019-04-03 00:00:00
abstract：:Membrane type 1 metalloproteinase (MT1-MMP) is an important regulator of cancer invasion, growth and angiogenesis, thus making it an attractive target for cancer imaging and therapy. A non-substrate peptide (MT1-AF7p) that bonded to the "MT-Loop" region of MT1-MMP was identified by using a phage-displayed peptide libr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28493-9
更新日期：2018-07-09 00:00:00
