Abstract：
:The AB0 blood group has been linked to ischaemic heart disease, stroke, and periodontal disease, while the Lewis blood group has been linked to ischaemic heart disease and obesity, all of which have been associated with periodontitis. AB0 or Lewis blood group phenotype may therefore constitute common hereditary components predisposing to these disorders. In this study, we investigated if blood group phenotype associated with periodontitis in a subpopulation consisting of 702 participants from a Danish cross-sectional cohort and, secondarily, attempted to confirm their association with hypertension, ischaemic heart disease, stroke, and obesity. No significant association between blood group phenotype and periodontitis was detected, nor were previously reported associations between blood group phenotype and hypertension, ischaemic heart disease, stroke, and obesity confirmed. This may, at least partly, be attributed to differences in study type, outcome definitions, cohort sizes, and population attributable factors. However, our results suggested a strong association between self-reported stroke and the Lewis (a-b-) phenotype (P = 0.0002, OR: 22.28; CI 95: 4.72-131.63).
journal_name
Sci Repjournal_title
Scientific reportsauthors
Enevold C,Nielsen CH,Molbo D,Lund R,Bendtzen K,Fiehn N-,Holmstrup Pdoi
10.1038/s41598-019-42594-zsubject
Has Abstractpub_date
2019-04-18 00:00:00pages
6283issue
1issn
2045-2322pii
10.1038/s41598-019-42594-zjournal_volume
9pub_type
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