Abstract：
:While carbon-based materials have spearheaded numerous breakthroughs in biomedicine, they also have procreated many logical concerns on their overall toxicity. Carbon dots (CDs) as a respectively new member have been extensively explored in nucleus directed delivery and bioimaging due to their intrinsic fluorescence properties coupled with their small size and surface properties. Although various in vitro/in vivo studies have shown that CDs are mostly biocompatible, sufficient information is lacking regarding genotoxicity of them and underlying mechanisms. This study aims to analyze the real-time cytotoxicity of super tiny CDs (2.05 ± 0.22 nm) on human breast cancer cells (MCF7) and human primary dermal fibroblast cell cultures (HDFa) by xCELLigence analysis system for further evaluating their genotoxicity and clastogenicity to evaluate the anti-tumor potential of CDs on breast adenocarcinoma. As combined with flow cytometry studies, comet assay and cytokinesis-block micronucleus assay suggest that the CDs can penetrate to the cell nuclei, interact with the genetic material, and explode DNA damage and G0/G1 phase arrest in cancer cells even at very low concentrations (0.025 ppm) which provide a strong foundation for the design of potentially promising CD-based functional nanomaterials for DNA-damage induced treatment in cancer therapy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Şimşek S,Şüküroğlu AA,Yetkin D,Özbek B,Battal D,Genç Rdoi
10.1038/s41598-020-70796-3subject
Has Abstractpub_date
2020-08-17 00:00:00pages
13880issue
1issn
2045-2322pii
10.1038/s41598-020-70796-3journal_volume
10pub_type
杂志文章abstract：:We present a novel, non-invasive magnetic resonance imaging (MRI) technique to assess real-time dynamic vasomodulation of the microvascular bed. Unlike existing perfusion imaging techniques, our method is sensitive only to blood volume and not flow velocity. Using graded gas challenges and a long-life, blood-pool T 1-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06983-6
更新日期：2017-08-07 00:00:00
abstract：:The distribution of attention between competing processing demands can have dramatic real-world consequences, however little is known about how limited attentional resources are distributed during real-world behaviour. Here we employ mobile EEG to characterise the allocation of attention across multiple sensory-cognit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51996-y
更新日期：2019-11-01 00:00:00
abstract：:The production of tuberous roots is usually reduced by vigorous vegetative growth because of the competition for resource between the vegetative parts and reproductive organs. In this study, we conducted root pruning to examine the vigorous vegetative growth by regulating root growth, subsequently limiting vegetative ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22586-1
更新日期：2018-03-13 00:00:00
abstract：:Parasite death via ion channel activations is the hallmark of anthelmintic and antiparasitic drugs. Glutamate gated chloride channel (GluCl) is a prominent targets for drug selection and design in parasitology. We report several iodine-fluorine based lead activators of GluCl by computational studies and structure-acti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38561-3
更新日期：2019-02-14 00:00:00
abstract：:We recently showed that spinal cord injury (SCI) leads to a decrease in mRNA editing of serotonin receptor 2C (5-HT2CR) contributing to post-SCI spasticity. Here we study post-SCI mRNA editing and global gene expression using massively parallel sequencing. Evidence is presented that the decrease in 5-HT2CR editing is ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12615
更新日期：2015-07-30 00:00:00
abstract：:The ability to process time on the scale of milliseconds and seconds is essential for behaviour. A growing number of studies have started to focus on brain dynamics as a mechanism for temporal encoding. Although there is growing evidence in favour of this view from computational and in vitro studies, there is still a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46053
更新日期：2017-04-10 00:00:00
abstract：:The detection and assessment of leakage in retinal fluorescein angiogram images is important for the management of a wide range of retinal diseases. We have developed a framework that can automatically detect three types of leakage (large focal, punctate focal, and vessel segment leakage) and validated it on images fr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10425
更新日期：2015-06-01 00:00:00
abstract：:Optical polarizing devices exploiting graphene embedded in waveguides have been demonstrated in the literature recently and both the TE- and TM-pass behaviors were reported. The determination of the passing polarization is usually attributed to graphene's Fermi level (and, therefore, doping level), with, however, no d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16949
更新日期：2015-11-19 00:00:00
abstract：:In order to study the molecular differences between type 2 diabetes mellitus (T2DM) and T2DM with depression (DD), we aimed to screen the differential expression of lncRNA, mRNA, and circRNA in the blood of patients with T2DM and DD. Based on the self-rating depression scale (SDS), patient health questionnaire 9 (PHQ9...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47077-9
更新日期：2019-07-24 00:00:00
abstract：:Subduction zones facilitate chemical exchanges between Earth's deep interior and volcanism that affects habitability of the surface environment. Lavas erupted at subduction zones are oxidized and release volatile species. These features may reflect a modification of the oxidation state of the sub-arc mantle by hydrous...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09626-y
更新日期：2017-09-04 00:00:00
abstract：:Thrombocytopenia is common in patients with dengue virus (DENV) infections. With a focus on understanding the possible mechanism of thrombocytopenia in DENV infections we described a direct correlation between activation and depletion of platelets in patients. Our data showed a sharp decrease in platelet counts at day...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41697
更新日期：2017-01-31 00:00:00
abstract：:We present a model on the simulation of the measurement-device independent quantum key distribution (MDI-QKD) with phase randomized general sources. It can be used to predict experimental observations of a MDI-QKD with linear channel loss, simulating corresponding values for the gains, the error rates in different bas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04612
更新日期：2014-04-14 00:00:00
abstract：:A new kind of magnetically-doped antiferromagnetic (AFM) topological insulators (TIs) with stoichiometry Bi1.09Gd0.06Sb0.85Te3 has been studied by angle-resolved photoemission spectroscopy (ARPES), superconducting magnetometry (SQUID) and X-ray magnetic circular dichroism (XMCD) with analysis of its electronic structu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41137-w
更新日期：2019-03-18 00:00:00
abstract：:From the viewpoint of thermodynamics, the formation of DNA loops and the interaction between them, which are all non-equilibrium processes, result in the change of free energy, affecting gene expression and further cell-to-cell variability as observed experimentally. However, how these processes dissipate free energy ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12765-x
更新日期：2017-10-03 00:00:00
abstract：:Living organisms in drying environments build anisotropic structures and exhibit directionality through self-organization of biopolymers. However, the process of macro-scale assembly is still unknown. Here, we introduce a dissipative structure through a non-equilibrium process between hydration and deposition in the d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05883-z
更新日期：2017-07-21 00:00:00
abstract：:Obesity involves alterations in transcriptional programs that can change in response to genetic and environmental signals through chromatin modifications. Since chromatin modifications involve different biochemical, neurological and molecular signaling pathways related to energy homeostasis, we hypothesize that geneti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22231-x
更新日期：2018-03-02 00:00:00
abstract：:We investigated whether maternal metabolic environment affects mesenchymal stromal/stem cells (MSCs) from umbilical cord's Wharton's Jelly (WJ) on a molecular level, and potentially render them unsuitable for clinical use in multiple recipients. In this pilot study on umbilical cords post partum from healthy non-obese...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18034-1
更新日期：2017-12-14 00:00:00
abstract：:Recent advances in next-generation sequencing technologies have paved the path for a considerable amount of sequencing data at a relatively low cost. This has revolutionized the genomics and transcriptomics studies. However, different challenges are now created in handling such data with available bioinformatics platf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75270-8
更新日期：2020-10-26 00:00:00
abstract：:Spatiotemporal tracking of tracer particles or objects of interest can reveal localized behaviors in biological and physical systems. However, existing tracking algorithms are most effective for relatively low numbers of particles that undergo displacements smaller than their typical interparticle separation distance....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23488-y
更新日期：2018-04-03 00:00:00
abstract：:Roselle-Hibiscus sabdariffa L. leaves at different stages of growth, calyces and seeds were analyzed for nutritional and anti-nutritional factors. All the treatments contained a good but varied proportion of carbohydrate in a range of 26.93-54.13%, crude protein from 5.7 to 27.06%, crude fat 1.16-13.09%, crude fibre 1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80433-8
更新日期：2021-01-13 00:00:00
abstract：:MicroRNAs (miRNAs) are noncoding RNAs which control gene expression by the suppression of translation or the degradation of mRNAs. Dre-miR-21 (miR-21) has been reported to impact cardiac valvulogenesis in zebrafish embryos. However, the target genes of miR-21 are still largely unknown. Here a tandem isobaric mass tag ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04166-x
更新日期：2017-06-22 00:00:00
abstract：:We describe the realization and characterization of a compact, autonomous fiber laser system that produces the optical frequencies required for laser cooling, trapping, manipulation, and detection of 87Rb atoms - a typical atomic species for emerging quantum technologies. This device, a customized laser system from th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59971-8
更新日期：2020-02-24 00:00:00
abstract：:Precise temporal coding is necessary for proper acoustic analysis. However, at cortical level, forward suppression appears to limit the ability of neurons to extract temporal information from natural sound sequences. Here we studied how temporal processing can be maintained in the bats' cortex in the presence of suppr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29102
更新日期：2016-06-30 00:00:00
abstract：:Cell mechanics play a key role in several fundamental biological processes, such as migration, proliferation, differentiation and tissue morphogenesis. In addition, many diseased conditions of the cell are correlated with altered cell mechanics, as in the case of cancer progression. For this there is much interest in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08650
更新日期：2015-03-03 00:00:00
abstract：:Psoriatic skin differs distinctly from normal skin by its thickened epidermis. Most gene expression comparisons utilize full-thickness biopsies, with substantial amount of dermis. We assayed the transcriptomes of normal, lesional, and non-lesional psoriatic epidermis, sampled as split-thickness skin grafts, with 5'-en...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22745
更新日期：2016-03-15 00:00:00
abstract：:Advances in lab-on-a-chip (LOC) devices have led to significant improvements in the on-chip manipulation, separation, sorting, and isolation of particles and cells. Among various LOC-based approaches such as inertia-based methods, acoustophoresis, and magnetophoresis, the planar-slanted-electrode dielectrophoresis (DE...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68699-4
更新日期：2020-07-16 00:00:00
abstract：:The lunar cycle is believed to strongly influence the vertical distribution of many oceanic taxa, with implications for the foraging behaviour of nocturnal marine predators. Most studies to date testing lunar effects on foraging have focused on predator activity at-sea, with some birds and marine mammals demonstrating...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01312-3
更新日期：2017-05-03 00:00:00
abstract：:Tuberculosis treatment includes broad-spectrum antibiotics such as rifampicin, streptomycin and fluoroquinolones, which are also used against other pathogenic bacteria. We developed Drug Resistance Associated Genes database (DRAGdb), a manually curated repository of mutational data of drug resistance associated genes ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65766-8
更新日期：2020-06-02 00:00:00
abstract：:Understanding factors associated with tie strength in social networks is essential in a wide variety of settings. With the internet and cellular phones providing additional avenues of communication, measuring and inferring tie strength has become much more complex. We introduce the social bow tie framework, which cons...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27290-8
更新日期：2018-06-19 00:00:00
abstract：:It is recently appreciated that many bacterial chemoreceptors have ligand-binding domains (LBD) of the dCACHE family, a structure with two PAS-like subdomains, one membrane-proximal and the other membrane-distal. Previous studies had implicated only the membrane-distal subdomain in ligand recognition. Here, we report ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14372-2
更新日期：2017-10-26 00:00:00
