Publisher Correction: AKT-mTOR signaling modulates the dynamics of IRE1 RNAse activity by regulating ER-mitochondria contacts.

abstract：:Murraya koenigii (MK) leaf being a rich source of bioactive secondary metabolites has received inordinate attention in drug development research. Formation of secondary plant metabolite(s) in medicinal plants depends on several factors and in this study the cause of variation in bioavailability and content of a vital ...

journal_title：Scientific reports

authors： Kandimalla R,Das M,Barge SR,Sarma PP,Koiri DJ,Devi A,Karki AK,Kumar A,Devi R,Pal BC,Talukdar NC,Samanta SK

更新日期：2020-11-18 00:00:00

abstract：:To report the efficacy and safety of large diameter scleral lenses and determine their suitability in Asian subjects with intractable ocular surface diseases. This prospective study enrolled intractable ocular surface diseases subjects with uncorrected visual acuity > counting finger but ≥ 0.3 logMAR and best-correcte...

journal_title：Scientific reports

authors： Moon J,Lee SM,Hyon JY,Kim MK,Oh JY,Choi HJ

更新日期：2021-01-27 00:00:00

abstract：:In cytochrome c oxidase (CytcO) reduction of O2 to water is linked to uptake of eight protons from the negative side of the membrane: four are substrate protons used to form water and four are pumped across the membrane. In bacterial oxidases, the substrate protons are taken up through the K and the D proton pathways,...

journal_title：Scientific reports

authors： Björck ML,Vilhjálmsdóttir J,Hartley AM,Meunier B,Näsvik Öjemyr L,Maréchal A,Brzezinski P

更新日期：2019-12-27 00:00:00

abstract：:Hepatitis E virus is a common hepatotropic virus that causes serious gastrointestinal symptoms. Data of reported HEV cases in Zhejiang Province was collected between 2007 and 2012. Descriptive epidemiological methods and spatial-temporal epidemiological methods were used to investigate the epidemiological trends and i...

journal_title：Scientific reports

authors： Liu K,Cai J,Wang S,Wu Z,Li L,Jiang T,Chen B,Cai G,Jiang Z,Chen Y,Wang Z,Zhu X,Hu L,Gu H,Jiang J

更新日期：2016-05-05 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), a green tea-derived polyphenol, exhibits antitumor activities. An EGCG nanoemulsion (nano-EGCG) was prepared to improve the stability and reduce the side effects of EGCG for treatment of human lung cancer cells, and the antitumor effects were studied. The possible molecular mechanism...

journal_title：Scientific reports

authors： Chen BH,Hsieh CH,Tsai SY,Wang CY,Wang CC

更新日期：2020-03-20 00:00:00

abstract：:Cells spontaneously emit photons in the UV to visible/near-infrared range (ultra-weak photon emission, UPE). Perturbations of the cells' state cause changes in UPE (evoked UPE). The aim of the present study was to analyze the evoked UPE dynamics of cells caused by two types of cell perturbations (stressors): (i) a cel...

journal_title：Scientific reports

authors： Madl P,Verwanger T,Geppert M,Scholkmann F

更新日期：2017-09-12 00:00:00

abstract：:In populations of Drosophila larvae, both, an aggregation and a dispersal behavior can be observed. However, the mechanisms coordinating larval locomotion in respect to other animals, especially in close proximity and during/after physical contacts are currently only little understood. Here we test whether relevant in...

journal_title：Scientific reports

authors： Otto N,Risse B,Berh D,Bittern J,Jiang X,Klämbt C

更新日期：2016-08-11 00:00:00

abstract：:Frataxin is a highly conserved protein encoded by the frataxin (FXN) gene. The full-length 210-amino acid form of protein frataxin (1-210; isoform A) expressed in the cytosol of cells rapidly translocates to the mitochondria, where it is converted to the mature form (81-210) by mitochondrial processing peptidase. Matu...

journal_title：Scientific reports

authors： Guo L,Wang Q,Weng L,Hauser LA,Strawser CJ,Mesaros C,Lynch DR,Blair IA

更新日期：2018-11-19 00:00:00

abstract：:Plant extracts contain many active compounds, which are tremendously fruitful for plant defence against several insect pests. The prime objectives of the present study were to calculate the extraction yield and to evaluate the leaf extracts of Citrullus colocynthis (L.), Cannabis indica (L.) and Artemisia argyi (L.) a...

journal_title：Scientific reports

authors： Ahmed M,Peiwen Q,Gu Z,Liu Y,Sikandar A,Hussain D,Javeed A,Shafi J,Iqbal MF,An R,Guo H,Du Y,Wang W,Zhang Y,Ji M

更新日期：2020-01-16 00:00:00

abstract：:Skeletal muscle represents the largest pool of body zinc, however, little is known about muscle zinc homeostasis or muscle-specific zinc functions. Zip14 (Slc39a14) was the most highly expressed zinc transporter in skeletal muscle of mice in response to LPS-induced inflammation. We compared metabolic parameters of ske...

journal_title：Scientific reports

authors： Kim J,Aydemir TB,Jimenez-Rondan FR,Ruggiero CH,Kim MH,Cousins RJ

更新日期：2020-03-04 00:00:00

abstract：:Trastuzumab combined with chemotherapy is standard of care for HER2 positive advanced gastro-esophageal cancers. The reported prevalence of HER2 discordance between primary tumors and corresponding metastases varies, hampering uniform patient selection for HER2 targeted therapy. This meta-analysis explores the influen...

journal_title：Scientific reports

authors： Creemers A,Ter Veer E,de Waal L,Lodder P,Hooijer GKJ,van Grieken NCT,Bijlsma MF,Meijer SL,van Oijen MGH,van Laarhoven HWM

更新日期：2017-06-09 00:00:00

abstract：:Propylea japonica (Thunberg) (Coleoptera: Coccinellidae) is a prevalent pollen consumer in corn fields and is therefore exposed to insecticidal proteins contained in the pollen of insect-resistant transgenic corn cultivars expressing Cry proteins derived from Bacillus thuringiensis (Bt). In the present study, the pote...

journal_title：Scientific reports

authors： Liu Y,Liu Q,Wang Y,Chen X,Song X,Romeis J,Li Y,Peng Y

更新日期：2016-03-23 00:00:00

abstract：:CRISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates. However, CRISPR/Cas9 edited F0 animals too often demonstrate variable phenotypic penetrance due to the mosaic nature of editing outcomes after double strand break (DSB) repair. Even with high efficiency levels of genome editing, phenotyp...

journal_title：Scientific reports

authors： Naert T,Tulkens D,Edwards NA,Carron M,Shaidani NI,Wlizla M,Boel A,Demuynck S,Horb ME,Coucke P,Willaert A,Zorn AM,Vleminckx K

更新日期：2020-09-04 00:00:00

abstract：:Epigenetic mechanisms are known to exert control over gene expression and determine cell fate. Genetic mutations in epigenetic regulators are responsible for several neurologic disorders. Mutations of the chromatin remodeling protein Lsh/HELLS can cause the human Immunodeficiency, Centromere instability and Facial ano...

journal_title：Scientific reports

authors： Han Y,Ren J,Lee E,Xu X,Yu W,Muegge K

更新日期：2017-04-25 00:00:00

abstract：:Contamination by endocrine disrupting compounds (EDCs) concerns the security and sustainability of a drinking water supply system and human exposure via water consumption. This study analyzed the selected EDCs in source (river water, n = 10) and supply (tap water, n = 155) points and the associated risks. A total of 1...

journal_title：Scientific reports

authors： Wee SY,Aris AZ,Yusoff FM,Praveena SM

更新日期：2020-10-20 00:00:00

abstract：:Probing the cellular structure of in vivo biological tissue is a fundamental problem in biomedical imaging and medical science. This work introduces an approach for analyzing diffusion magnetic resonance imaging data acquired by the novel tensor-valued encoding technique for characterizing tissue microstructure. Our a...

journal_title：Scientific reports

authors： Ning L,Szczepankiewicz F,Nilsson M,Rathi Y,Westin CF

更新日期：2021-01-08 00:00:00

abstract：:Chloroquine (CQ) is widely used as an anti-inflammatory therapeutic for rheumatic diseases. Although its modes of action on the innate immune system are well described, there is still insufficient knowledge about its direct effects on the adaptive immune system. Thus, we evaluated the influence of CQ on activation par...

journal_title：Scientific reports

authors： Schmidt RL,Jutz S,Goldhahn K,Witzeneder N,Gerner MC,Trapin D,Greiner G,Hoermann G,Steiner G,Pickl WF,Burgmann H,Steinberger P,Ratzinger F,Schmetterer KG

更新日期：2017-02-07 00:00:00

abstract：:Functional brain connectivity is altered during the pathological processes of Alzheimer's disease (AD), but the specific evolutional rules are insufficiently understood. Resting-state functional magnetic resonance imaging indicates that the functional brain networks of individuals with AD tend to be disrupted in hub-l...

journal_title：Scientific reports

authors： Li W,Wang M,Zhu W,Qin Y,Huang Y,Chen X

更新日期：2016-09-28 00:00:00

abstract：:Cell therapies that invoke pleiotropic mechanisms may facilitate functional recovery in patients with stroke. Based on previous experiments using microglia preconditioned by oxygen-glucose deprivation, we hypothesized that the administration of peripheral blood mononuclear cells (PBMCs) preconditioned by oxygen-glucos...

journal_title：Scientific reports

authors： Hatakeyama M,Kanazawa M,Ninomiya I,Omae K,Kimura Y,Takahashi T,Onodera O,Fukushima M,Shimohata T

更新日期：2019-11-14 00:00:00

abstract：:S-resistin, a non-secretable resistin isoform, acts as an intracrine factor that regulates adipocyte maduration, inflammatory and insulin response in 3T3-L1 cells. However, its intracellular function in vivo is still unknown. In this study, we analyze the central role of s-resistin, decreasing its hypothalamic express...

journal_title：Scientific reports

authors： Rodríguez M,Pintado C,Moltó E,Gallardo N,Fernández-Martos CM,López V,Andrés A,Arribas C

更新日期：2018-03-02 00:00:00

abstract：:In response to endotoxemia, the organism triggers an inflammatory response, and the visceral adipose tissue represents a major source of proinflammatory cytokines. The regulation of inflammation response in the adipose tissue is thus of crucial importance. We demonstrated that Regulated in development and DNA damage r...

journal_title：Scientific reports

authors： Pastor F,Dumas K,Barthélémy MA,Regazzetti C,Druelle N,Peraldi P,Cormont M,Tanti JF,Giorgetti-Peraldi S

更新日期：2017-08-01 00:00:00

abstract：:Dissolved organic carbon (DOC) concentrations and water colour are increasing in many inland waters across northern Europe and northeastern North America. This inland-water "browning" has profound physical, chemical and biological repercussions for aquatic ecosystems affecting water quality, biological community struc...

journal_title：Scientific reports

authors： Meyer-Jacob C,Michelutti N,Paterson AM,Cumming BF,Keller WB,Smol JP

更新日期：2019-11-13 00:00:00

abstract：:An increasing number of industrial applications need superstrength steels. It is known that refined grains and nanoscale precipitates can increase strength. The hardest martensitic steel reported to date is C0.8 steel, whose nanohardness can reach 11.9 GPa through incremental interstitial solid solution strengthening....

journal_title：Scientific reports

authors： Yu H,Yan M,Lu C,Tieu AK,Li H,Zhu Q,Godbole A,Li J,Su L,Kong C

更新日期：2016-11-28 00:00:00

abstract：:Malaria surveillance data provide opportunity to develop forecasting models. Seasonal variability in environmental factors correlate with malaria transmission, thus the identification of transmission patterns is useful in developing prediction models. However, with changing seasonal transmission patterns, either due t...

journal_title：Scientific reports

authors： Sewe MO,Tozan Y,Ahlm C,Rocklöv J

更新日期：2017-06-01 00:00:00

abstract：:We demonstrate fluorescent Fe embedded magnetic nanodiamonds by ion implantation and two-step annealing. The diamond characteristics with a highly ordered core and a graphite surface layer are maintained after the implantation process. After the two-step annealing process, a bright red fluorescence associated with nit...

journal_title：Scientific reports

authors： Lin BR,Kunuku S,Chen CH,Chen TY,Hsiao TY,Yu HK,Chang YJ,Liao LC,Niu H,Lee CP

更新日期：2019-02-04 00:00:00

abstract：:Serotonin (5-HT) is an important neurotransmitter and neuromodulator that controls a variety of sensory and motor functions through 5-HT receptors (5-HTRs). The 5-HT4R subfamily is linked to Gs proteins, which activate adenylyl cyclases (ACs), and is involved in many responses in peripheral organs. In this study, the ...

journal_title：Scientific reports

authors： Wang T,Yang Z,Zhou N,Sun L,Lv Z,Wu C

更新日期：2017-01-06 00:00:00

abstract：:The influence of the growth conditions of multilayer CdTe/ZnTe quantum dots (QDs) on Si substrate upon their carrier dynamics is studied using intensity integration and broadening photoluminescence. The unusual temperature dependence of the line broadening is explained using a model for interband transitions that invo...

journal_title：Scientific reports

authors： Man MT,Lee HS

更新日期：2015-02-05 00:00:00

abstract：:The frontal lobes are essential for human volition and goal-directed behavior, yet their function remains unclear. While various models have highlighted working memory, reinforcement learning, and cognitive control as key functions, a single framework for interpreting the range of effects observed in prefrontal cortex...

journal_title：Scientific reports

authors： Alexander WH,Brown JW

更新日期：2018-03-01 00:00:00

abstract：:Pharmacotherapy provision based on Nicotine Metabolite Ratio (NMR) status (slow/normal metabolism) may improve smoking cessation rates. However, it is unclear whether NMR status is consistent across patient characteristics and current treatment choice. Data come from 1,826 participants attending Stop Smoking Services ...

journal_title：Scientific reports

authors： Shahab L,Mortimer E,Bauld L,McGowan JA,McNeill A,Tyndale RF

更新日期：2017-12-14 00:00:00

abstract：:Second-harmonic generation (SHG) is the most specific label-free indicator of collagen accumulation in widespread pathologies such as fibrosis, and SHG-based measurements hold important potential for biomedical analyses. However, efficient collagen SHG scoring in histological slides is hampered by the limited depth-of...

journal_title：Scientific reports

authors： Vuillemin N,Mahou P,Débarre D,Gacoin T,Tharaux PL,Schanne-Klein MC,Supatto W,Beaurepaire E

更新日期：2016-07-20 00:00:00