Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer.

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Kim S,Moon M,Kwak M,Lee B,Chang YK

更新日期：2019-06-05 00:00:00

abstract：:Electrostatic gates are of paramount importance for the physics of devices based on high-mobility two-dimensional electron gas (2DEG) since they allow depletion of electrons in selected areas. This field-effect gating enables the fabrication of a wide range of devices such as, for example, quantum point contacts (QPC)...

journal_title：Scientific reports

authors： Bennaceur K,Schmidt BA,Gaucher S,Laroche D,Lilly MP,Reno JL,West KW,Pfeiffer LN,Gervais G

更新日期：2015-09-22 00:00:00

abstract：:Induction of cathelicidin-mediated antimicrobial pathway against intracellular M. tuberculosis by 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active form of vitamin D, has been documented in vitro. However, in in vivo studies related to inflammatory disorders, 1,25(OH)2D3 has been demonstrated to induce an anti-inflam...

journal_title：Scientific reports

authors： Bhatt K,Rafi W,Shah N,Christakos S,Salgame P

更新日期：2016-10-04 00:00:00

abstract：:Mycobacterium spp. are renowned for being the causative agent of diseases like leprosy, Buruli ulcer and tuberculosis in human beings. With more and more mycobacterial genomes being sequenced, any knowledge generated from comparative genomic analysis would provide better insights into the biology, evolution, phylogeny...

journal_title：Scientific reports

authors： Choo SW,Ang MY,Dutta A,Tan SY,Siow CC,Heydari H,Mutha NV,Wee WY,Wong GJ

更新日期：2015-12-15 00:00:00

abstract：:Satellite aerosol optical depth (AOD) is widely used to estimate particulate matter with aerodynamic diameter ≤2.5 µm (PM2.5) mass concentrations. Polar orbiting satellite retrieval 1-2 times each day is frequently affected by cloud, snow cover or misclassification of heavy pollution. Novel methods are therefore requi...

journal_title：Scientific reports

authors： Fu D,Xia X,Wang J,Zhang X,Li X,Liu J

更新日期：2018-07-05 00:00:00

abstract：:Given that the biological processes governing the oncogenesis of pancreatic cancers could present useful therapeutic targets, there is a pressing need to molecularly distinguish between different clinically relevant pancreatic cancer subtypes. To address this challenge, we used targeted proteomics and other molecular ...

journal_title：Scientific reports

authors： Sinkala M,Mulder N,Martin D

更新日期：2020-01-27 00:00:00

abstract：:Marine crabs inhabit shallow coastal/estuarine habitats particularly sensitive to climate change, and yet we know very little about the diversity of their responses to environmental change. We report the effects of a rarely studied, but increasingly prevalent, combination of environmental factors, that of near-future ...

journal_title：Scientific reports

authors： Whiteley NM,Suckling CC,Ciotti BJ,Brown J,McCarthy ID,Gimenez L,Hauton C

更新日期：2018-10-23 00:00:00

abstract：:Extensive studies have been performed on random lasers in which multiple-scattering feedback is used to generate coherent emission. Q-switching and mode-locking are well-known routes for achieving high peak power output in conventional lasers. However, in random lasers, the ubiquitous random cavities that are formed b...

journal_title：Scientific reports

authors： Tang Y,Xu J

更新日期：2015-03-23 00:00:00

abstract：:In this study, we report on a new approach for remote temperature probing that provides accuracy as good as 0.017°C (0.0055% accuracy) by measuring the magnetisation curve of magnetic nanoparticles. We included here the theoretical model construction and the inverse calculation method, and explored the impact caused b...

journal_title：Scientific reports

authors： Zhong J,Liu W,Kong L,Morais PC

更新日期：2014-10-15 00:00:00

abstract：:With the development and application of nanotechnology, large amounts of nanoparticles will be potentially released to the environment and possibly cause many severe health problems. Although the toxicity of nanoparticles has been investigated, prevention and treatment of damages caused by nanoparticles have been rare...

journal_title：Scientific reports

authors： Qi W,Tian L,An W,Wu Q,Liu J,Jiang C,Yang J,Tang B,Zhang Y,Xie K,Wang X,Li Z,Wu W

更新日期：2017-06-06 00:00:00

abstract：:Integrins are α/β heterodimeric transmembrane adhesion receptors. Evidence exists that their transmembrane domain (TMD) separates upon activation. Subunit-specific differences in activation sensitivity of integrins were reported. However, whether sequence variations in the TMD lead to differential TMD association has ...

journal_title：Scientific reports

authors： Pagani G,Gohlke H

更新日期：2018-04-10 00:00:00

abstract：:Macroevolutionary studies of insects at diverse taxonomic scales often reveal dynamic evolutionary patterns, with multiple inferred diversification rate shifts. Responses to major past environmental changes, such as the Cretaceous Terrestrial Revolution, or the development of major key innovations, such as wings or co...

journal_title：Scientific reports

authors： Condamine FL,Clapham ME,Kergoat GJ

更新日期：2016-01-18 00:00:00

abstract：:Marine bacterial strains are of great interest for their ability to produce secondary metabolites with anticancer potentials. Isolation, identification, characterization and anticancer activities of isolated bacteria from El-Hamra Lake, Wadi El-Natrun (Egypt) were the objectives of this study. The isolated bacteria we...

journal_title：Scientific reports

authors： El-Garawani IM,El-Sabbagh SM,Abbas NH,Ahmed HS,Eissa OA,Abo-Atya DM,Khalifa SAM,El-Seedi HR

更新日期：2020-08-21 00:00:00

abstract：:Bose Einstein condensates of spin-1 atoms are known to exist in two different phases, both having spontaneously broken spin-rotation symmetry, a ferromagnetic and a polar condensate. Here we show that in two spatial dimensions it is possible to achieve a quantum phase transition from a polar condensate into a singlet ...

journal_title：Scientific reports

authors： Chudnovskiy AL,Cheianov V

更新日期：2018-08-20 00:00:00

abstract：:Control of nonlinear large-scale dynamical networks, e.g., collective behavior of agents interacting via a scale-free connection topology, is a central problem in many scientific and engineering fields. For the linear version of this problem, the so-called controllability Gramian has played an important role to quanti...

journal_title：Scientific reports

authors： Kashima K

更新日期：2016-06-06 00:00:00

abstract：:COVID-19 caused by the SARS-CoV-2 is a current global challenge and urgent discovery of potential drugs to combat this pandemic is a need of the hour. 3-chymotrypsin-like cysteine protease (3CLpro) enzyme is the vital molecular target against the SARS-CoV-2. Therefore, in the present study, 1528 anti-HIV1compounds wer...

journal_title：Scientific reports

authors： Nand M,Maiti P,Joshi T,Chandra S,Pande V,Kuniyal JC,Ramakrishnan MA

更新日期：2020-11-23 00:00:00

abstract：:We fabricated multi-layered graphene/MoS2 heterostructured devices by positioning mechanically exfoliated bulk graphite and single-crystalline 2H-MoS2 onto Au metal pads on a SiO2/Si substrate via a contamination-free dry transfer technique. We also studied the electrical transport properties of Au/MoS2 junction devic...

journal_title：Scientific reports

authors： Qiu D,Kim EK

更新日期：2015-09-03 00:00:00

abstract：:Human papillomavirus (HPV) is the leading cause of cervical cancer and has been implicated in several other cancer types including vaginal, vulvar, penile, and oropharyngeal cancers. Despite the recent availability of a vaccine, there are still over 310,000 deaths each year worldwide. Current treatments for HPV-mediat...

journal_title：Scientific reports

authors： Padash Barmchi M,Thomas M,Thatte JV,Vats A,Zhang B,Cagan RL,Banks L

更新日期：2021-01-13 00:00:00

abstract：:Based on the electrical characteristic detection technology, the quantitative prediction models of sensory score and physical and chemical quality Index (theaflavins, thearubigins, and theabrownins) were established by using the fermented products of Congou black tea as the research object. The variation law of electr...

journal_title：Scientific reports

authors： Dong C,An T,Zhu H,Wang J,Hu B,Jiang Y,Yang Y,Li J

更新日期：2020-01-31 00:00:00

abstract：:A growing bacterium typically divides into two genetically identical and morphologically similar sister cells and eventually gives rise to a clonal population. Nevertheless, significant phenotypic differentiation among isogenic cells frequently occurs, with the resulting heterogeneity in cellular behavior often ensuri...

journal_title：Scientific reports

authors： Govers SK,Adam A,Blockeel H,Aertsen A

更新日期：2017-08-16 00:00:00

abstract：:Sapphirinid copepods, which are marine zooplankton, exhibit tunable structural colors originating from a layered structure of guanine crystal plates. In the present study, the coloring portion of adult male of a sapphirinid copepod, Sapphirina nigromaculata, under the dorsal body surface was characterized to clarify t...

journal_title：Scientific reports

authors： Kimura T,Takasaki M,Hatai R,Nagai Y,Uematsu K,Oaki Y,Osada M,Tsuda H,Ishigure T,Toyofuku T,Shimode S,Imai H

更新日期：2020-02-10 00:00:00

abstract：:Geometric frustration, in which competing interactions give rise to degenerate ground states, potentially induces various exotic quantum phenomena in magnetic materials. Minimal models comprising triangular units, such as triangular and Kagome lattices, have been investigated for decades to realize novel quantum phase...

journal_title：Scientific reports

authors： Yamaguchi H,Okubo T,Kittaka S,Sakakibara T,Araki K,Iwase K,Amaya N,Ono T,Hosokoshi Y

更新日期：2015-10-15 00:00:00

abstract：:Infestation by the biotrophic pathogen Gymnosporangium asiaticum can be devastating for plant of the family Rosaceae. However, the phytopathology of this process has not been thoroughly elucidated. Using a metabolomics approach, we discovered the intrinsic activities that induce disease symptoms after fungal invasion ...

journal_title：Scientific reports

authors： Lee DK,Ahn S,Cho HY,Yun HY,Park JH,Lim J,Lee J,Kwon SW

更新日期：2016-11-28 00:00:00

abstract：:The human cervical cancer oncogene (HCCR) has been found to be overexpressed in a variety of human cancers. However, the level of expression of HCCR and its biological function in gastric cancer are largely unknown. In this study, we evaluated HCCR expression in several gastric cancer cell lines and in one normal gast...

journal_title：Scientific reports

authors： Zhang JL,Liu XZ,Wang PY,Chen GW,Jiang Y,Qiao SK,Zhu J,Wang X,Pan YS,Liu YC

更新日期：2016-04-07 00:00:00

abstract：:We extend an agent-based multiscale model of vascular tumour growth and angiogenesis to describe transarterial chemoembolisation (TACE) therapies. The model accounts for tumour and normal cells that are both nested in a vascular system that changes its structure according to tumour-related growth factors. Oxygen promo...

journal_title：Scientific reports

authors： Perfahl H,Jain HV,Joshi T,Horger M,Malek N,Bitzer M,Reuss M

更新日期：2020-06-29 00:00:00

abstract：:Reduced near-infrared reflectance observed in September 1973 in Skylab images of the western flank of Mt. Etna has been interpreted as an eruption precursor of the January 1974 eruption. Until now, it has been unclear when this signal started, whether it was sustained and which process(es) could have caused it. By ana...

journal_title：Scientific reports

authors： Seiler R,Houlié N,Cherubini P

更新日期：2017-03-07 00:00:00

abstract：:Nicotinamide riboside (NR) is a newly discovered nicotinamide adenine dinucleotide (NAD+) precursor vitamin. A crystal form of NR chloride termed NIAGEN is generally recognized as safe (GRAS) for use in foods and the subject of two New Dietary Ingredient Notifications for use in dietary supplements. To evaluate the ki...

journal_title：Scientific reports

authors： Conze D,Brenner C,Kruger CL

更新日期：2019-07-05 00:00:00

abstract：:Upper urinary tract urothelial carcinomas are usually managed by radical nephroureterectomy (RNU), often followed by intravesical chemotherapy to minimize recurrence. Open surgery is the gold standard procedure for RNU, but it associates with high morbidity, and it has been increasingly replaced by minimally invasive ...

journal_title：Scientific reports

authors： Oliveira C,Barros AA,Reis RL,Correia-Pinto J,Lima E

更新日期：2019-12-10 00:00:00

abstract：:We measured the interleukin-34 (IL-34) level in sera from patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) using an enzyme-linked immunosorbent assay (ELISA). Blood tests, including assays to determine C-reactive protein (CRP), complement (C) 3, C4, immunoglobulin (Ig) A, IgG, IgM...

journal_title：Scientific reports

authors： Xie HH,Shen H,Zhang L,Cui MY,Xia LP,Lu J

更新日期：2018-02-22 00:00:00

abstract：:Interleukin-27 (IL-27) is an important cytokine in inflammatory diseases, including coronary artery disease (CAD). To explore the precise role of IL-27 in CAD, we investigated the genetic association between IL27 and CAD in the GeneID Chinese Han population. A two-stage case control association analysis was performed ...

journal_title：Scientific reports

authors： Fan Q,Nie S,Li S,Liao Y,Zhang H,Zha L,Wang F,Tang T,Xia N,Xu C,Wang P,Xie T,Xie J,Lu Q,Li Q,Qian J,Li B,Wu G,Wu Y,Yang Y,Wang QK,Tu X,Cheng X

更新日期：2016-05-12 00:00:00