1,25 (OH)2D3 treatment alters the granulomatous response in M. tuberculosis infected mice.

abstract：:Translating neuronal activity to measurable behavioral changes has been a long-standing goal of systems neuroscience. Recently, we have developed a model of phase-reversal learning of the vestibulo-ocular reflex, a well-established, cerebellar-dependent task. The model, comprising both the cerebellar cortex and vestib...

journal_title：Scientific reports

authors： Badura A,Clopath C,Schonewille M,De Zeeuw CI

更新日期：2016-11-02 00:00:00

abstract：:Sensitivity to sounds is one frequent symptom of a sport-related concussion, but its assessment rarely goes beyond a single question. Here we examined sensitivity to sounds using psychoacoustic and psychometric outcomes in athletes beyond the acute phase of injury. Fifty-eight college athletes with normal hearing who ...

journal_title：Scientific reports

authors： Assi H,Moore RD,Ellemberg D,Hébert S

更新日期：2018-07-02 00:00:00

abstract：:Pulsatillae radix is a conventional traditional Chinese medicine (TCM) with common name Baitouweng, and has notable effects on inflammation and dysentery. Pulsatilla chinensis (Bge.) Regel is the only source plant of Baitouweng recorded in Chinese Pharmacopoeia, but its adulteration often occurs in the market that pos...

journal_title：Scientific reports

authors： Shi Y,Zhao M,Yao H,Yang P,Xin T,Li B,Sun W,Chen S

更新日期：2017-01-06 00:00:00

abstract：:The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly disrupted due to the inclusion of T. corymbosa on the endangered list of threat...

journal_title：Scientific reports

authors： Smedley CJ,Stanley PA,Qazzaz ME,Prota AE,Olieric N,Collins H,Eastman H,Barrow AS,Lim KH,Kam TS,Smith BJ,Duivenvoorden HM,Parker BS,Bradshaw TD,Steinmetz MO,Moses JE

更新日期：2018-07-13 00:00:00

abstract：:A silica gel coated microsphere resonator is proposed and experimentally demonstrated for measurements of ammonia (NH3) concentration in air with ultra-high sensitivity. The optical properties of the porous silica gel layer change when it is exposed to low (parts per million (ppm)) and even ultra-low (parts per billio...

journal_title：Scientific reports

authors： Mallik AK,Farrell G,Liu D,Kavungal V,Wu Q,Semenova Y

更新日期：2018-01-26 00:00:00

abstract：:Pre-shared non-local entanglement dramatically simplifies and improves the performance of quantum error correction via entanglement-assisted quantum error-correcting codes (EAQECCs). However, even considering the noise in quantum communication only, the non-local sharing of a perfectly entangled pair is technically im...

journal_title：Scientific reports

authors： Wang Z,Yu S,Fan H,Oh CH

更新日期：2014-11-26 00:00:00

abstract：:Fowl cholera is a serious, highly contagious disease caused by the bacterium Pasteurella multocida (P. multocida) in a range of avian species and is characterized by an acute form of septicaemia. The pathogenic mechanism of chicken lung injury caused by the bacterium is unclear. Therefore, P. multocida Q (a reference ...

journal_title：Scientific reports

authors： Li W,Tang Q,Dai N,Feng W,Xie C,Cheng G,Liu X,Zhang W,Hu X,Gu C

更新日期：2020-04-14 00:00:00

abstract：:To explore soil organic carbon (SOC) accumulation mechanisms, the dynamics of C functional groups and macroaggregation were studied synchronously through aggregate fractionation and (13)C NMR spectroscopy in sandy loam soil following an 18-year application of compost and fertilizer in China. Compared with no fertilize...

journal_title：Scientific reports

authors： Yu H,Ding W,Chen Z,Zhang H,Luo J,Bolan N

更新日期：2015-09-11 00:00:00

abstract：:Nanotechnology can improve the performance of dental polymers. The objective of this study was to modify the surfaces of nanoparticles with silanes and proteins, characterize nanoparticles' agglomeration levels and interfaces between nanoparticles and the polymeric matrix. Undoped (n-TiO2), nitrogen-doped (N_TiO2) and...

journal_title：Scientific reports

authors： Esteban Florez FL,Trofimov AA,Ievlev A,Qian S,Rondinone AJ,Khajotia SS

更新日期：2020-06-17 00:00:00

abstract：:Attention and saccadic eye movements are critical components of visual perception. Recent studies proposed the hypothesis of a tight coupling between saccadic adaptation (SA) and attention: SA increases the processing speed of unpredictable stimuli, while increased attentional load boosts SA. Moreover, their cortical ...

journal_title：Scientific reports

authors： Nicolas J,Bidet-Caulet A,Pélisson D

更新日期：2020-08-10 00:00:00

abstract：:A bistable toggle switch is a paradigmatic model in the field of biology. The dynamics of the system induced by Gaussian noise has been intensively investigated, but Gaussian noise cannot incorporate large bursts typically occurring in real experiments. This paper aims to examine effects of variations from one protein...

journal_title：Scientific reports

authors： Xu Y,Li Y,Zhang H,Li X,Kurths J

更新日期：2016-08-19 00:00:00

abstract：:It is known that patients with chronic obstructive pulmonary disease experience dyspnea during unsupported arm exercise (UAE). We examined the respiratory variables in during a hair-washing motion for healthy young people requiring the UAE to find the effects across gender, motion, and speed. In this study, 33 healthy...

journal_title：Scientific reports

authors： Takahata M,Ishizawa M,Uchiumi T,Yamaki M,Sato T

更新日期：2020-08-04 00:00:00

abstract：:Intravitreal Conbercept (IVC) is the latest applied and effective treatment for the management of retinopathy of prematurity (ROP). However, conbercept escapes from the vitreous into the general circulation and reduce systemic VEGF concentrations. Thus, there are concerns about systemic complications, in these prematu...

journal_title：Scientific reports

authors： Cheng Y,Meng Q,Linghu D,Zhao M,Liang J

更新日期：2018-07-16 00:00:00

abstract：:Threat detection is essential for protecting individuals from adverse situations, in which a network of amygdala, limbic regions and dorsomedial prefrontal cortex (dmPFC) regions are involved in fear processing. Excitability regulation in the dmPFC might be crucial for fear processing, while abnormal patterns could le...

journal_title：Scientific reports

authors： Gonzalez-Escamilla G,Chirumamilla VC,Meyer B,Bonertz T,von Grotthus S,Vogt J,Stroh A,Horstmann JP,Tüscher O,Kalisch R,Muthuraman M,Groppa S

更新日期：2018-09-28 00:00:00

abstract：:Horizontal gene transfer (HGT) was attributed as a major driving force for the innovation and evolution of prokaryotic genomes. Previously, multiple research endeavors were undertaken to decipher HGT in different bacterial lineages. The genus Mycobacterium houses some of the most deadly human pathogens; however, the i...

journal_title：Scientific reports

authors： Panda A,Drancourt M,Tuller T,Pontarotti P

更新日期：2018-10-04 00:00:00

abstract：:Postsynaptic density-95/Discs large/Zonula occludens-1 (PDZ) domain-mediated protein interactions play pivotal roles in various molecular biological events, including protein localisation, assembly, and signal transduction. Although the vertebrate regulator of planar cell polarity Van Gogh-like 2 (Vangl2) was recently...

journal_title：Scientific reports

authors： Nagaoka T,Tabuchi K,Kishi M

更新日期：2015-08-10 00:00:00

abstract：:Zika virus is a teratogenic mosquito-transmitted flavivirus that is associated with birth defects in newborns and Guillain-Barré syndrome in adults. The virus can also be sexually transmitted, but currently, very little is known about the cell types supporting virus replication and persistence in human testes. Using p...

journal_title：Scientific reports

authors： Kumar A,Jovel J,Lopez-Orozco J,Limonta D,Airo AM,Hou S,Stryapunina I,Fibke C,Moore RB,Hobman TC

更新日期：2018-04-03 00:00:00

abstract：:The psychrophilic (cold-loving) fungus Pseudogymnoascus destructans was discovered more than a decade ago to be the pathogen responsible for white-nose syndrome, an emerging disease of North American bats causing unprecedented population declines. The same species of fungus is found in Europe but without associated mo...

journal_title：Scientific reports

authors： Ren P,Rajkumar SS,Zhang T,Sui H,Masters PS,Martinkova N,Kubátová A,Pikula J,Chaturvedi S,Chaturvedi V

更新日期：2020-08-17 00:00:00

abstract：:Although redox reactions are recognized to fractionate iron (Fe) isotopes, the dominant mechanisms controlling the Fe isotope fractionation and notably the role of organic matter (OM) are still debated. Here, we demonstrate how binding to organic ligands governs Fe isotope fractionation beyond that arising from redox ...

journal_title：Scientific reports

authors： Lotfi-Kalahroodi E,Pierson-Wickmann AC,Rouxel O,Marsac R,Bouhnik-Le Coz M,Hanna K,Davranche M

更新日期：2021-01-21 00:00:00

abstract：:Targeting epigenetic reader proteins by small molecule inhibitors represents a new therapeutic concept in autoimmune diseases such as rheumatoid arthritis (RA). Although inhibitors targeting bromodomain protein 1 (BRD1) are in development, the function of BRD1 has hardly been studied. We investigated the therapeutic p...

journal_title：Scientific reports

authors： Klein K,Kato M,Frank-Bertoncelj M,Kolling C,Ciurea A,Gay S,Ospelt C

更新日期：2018-07-24 00:00:00

abstract：:Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three dimensional (3D) architecture and complexity of human tumors. More representative models are required for drug discovery and validation. Here, 2D culture and 3D mono- and stromal co-culture models of increasing complexity have been est...

journal_title：Scientific reports

authors： Stock K,Estrada MF,Vidic S,Gjerde K,Rudisch A,Santo VE,Barbier M,Blom S,Arundkar SC,Selvam I,Osswald A,Stein Y,Gruenewald S,Brito C,van Weerden W,Rotter V,Boghaert E,Oren M,Sommergruber W,Chong Y,de Hoogt R,Grae

更新日期：2016-07-01 00:00:00

abstract：:Studies have proven that IL-2 and IL-15 showed contrasting roles during CIK cells preparation. By employing microarray, we analyzed miRNA expression profiles of PBMC, CIKIL-2 and CIKIL-15. Advanced bioinformatic analyses were performed to explore the key miRNAs which may regulate cell proliferation and anti-tumor acti...

journal_title：Scientific reports

authors： Wang W,Li R,Meng M,Wei C,Xie Y,Zhang Y,Jiang L,Dong R,Wang C,Zhong Y,Yang F,Tang W,Jin X,Liu B,Hou Z

更新日期：2015-03-31 00:00:00

abstract：:In this study, we analyze the role of different structural variants of proteins in the speciation processes. We separate human and mouse proteomes (taken as a reference) into three previously defined variants of disorder: ordered proteins (ORDPs), structured proteins with intrinsically disordered protein regions (IDPR...

journal_title：Scientific reports

authors： Forcelloni S,Giansanti A

更新日期：2020-03-11 00:00:00

abstract：:Neurodevelopmental changes occur with asymmetric hearing loss, limiting binaural/spatial hearing and putting children at risk for social and educational challenges. These deficits may be mitigated by providing bilateral hearing in children through auditory prostheses. Effects on speech perception and spatial hearing w...

journal_title：Scientific reports

authors： Polonenko MJ,Papsin BC,Gordon KA

更新日期：2018-09-04 00:00:00

abstract：:Here, we characterized the basic properties of repetitive sequences in essential A and supernumerary B chromosomes of Festuca pratensis Huds. This was performed by comparative analysis of low-pass Illumina sequence reads of B chromosome lacking (-B) and B chromosome containing (+B) individuals of F. pratensis. 61% of ...

journal_title：Scientific reports

authors： Ebrahimzadegan R,Houben A,Mirzaghaderi G

更新日期：2019-12-27 00:00:00

abstract：:Wind speed and variability are the most critical climatic factors affecting sand/dust storms, which have not been sufficiently studied in the middle reaches of the Yarlung Tsangpo River (MYR). In this study, wind speed variability was investigated using the moving average over shifting horizon method (MASH), combined ...

journal_title：Scientific reports

authors： Ben Y,Mei Y,Chen Y,Hu T,Zhu D

更新日期：2020-07-29 00:00:00

abstract：:The degree of tumor removal at surgery is a major factor in predicting outcome for ovarian cancer. A single multimodality agent that can be used with magnetic resonance (MR) for staging and pre-surgical planning, and with optical imaging to aid surgical removal of tumors, would present a new paradigm for ovarian cance...

journal_title：Scientific reports

authors： Ravoori MK,Singh S,Bhavane R,Sood AK,Anvari B,Bankson J,Annapragada A,Kundra V

更新日期：2016-12-22 00:00:00

abstract：:Horizontal gene transfer (HGT) is a main mechanism of bacterial evolution endowing bacteria with new genetic traits. The transfer of mobile genetic elements such as plasmids (conjugation) requires the close proximity of cells. HGT between genetically distinct bacteria largely depends on cell movement in water films, w...

journal_title：Scientific reports

authors： Berthold T,Centler F,Hübschmann T,Remer R,Thullner M,Harms H,Wick LY

更新日期：2016-11-04 00:00:00

abstract：:In most species, fertilization induces Ca2+ transients in the egg. In mammals, the Ca2+ rises are triggered by phospholipase Cζ (PLCζ) released from the sperm; IP3 generated by PLCζ induces Ca2+ release from the intracellular Ca2+ store through IP3 receptor, termed IP3-induced Ca2+ release. Here, we developed new fluo...

journal_title：Scientific reports

authors： Matsu-Ura T,Shirakawa H,Suzuki KGN,Miyamoto A,Sugiura K,Michikawa T,Kusumi A,Mikoshiba K

更新日期：2019-03-18 00:00:00

abstract：:Studies on prevalence and significance of alternative polyadenylation (APA) in plants have been so far limited mostly to the model plants. Here, a genome-wide analysis of APA was carried out in different tissue types in the non-model forage legume red clover (Trifolium pratense L). A profile of poly(A) sites in differ...

journal_title：Scientific reports

authors： Chakrabarti M,Dinkins RD,Hunt AG

更新日期：2018-07-27 00:00:00