PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2.

Abstract:

:Postsynaptic density-95/Discs large/Zonula occludens-1 (PDZ) domain-mediated protein interactions play pivotal roles in various molecular biological events, including protein localisation, assembly, and signal transduction. Although the vertebrate regulator of planar cell polarity Van Gogh-like 2 (Vangl2) was recently described as a postsynaptic molecule with a PDZ-binding motif, the role of its PDZ interaction at the synapse is unknown. In this report, we demonstrate that the PDZ interaction was dispensable for the normal cluster formation of Vangl2 and not absolutely required for the synapse-associated localisation of Vangl2 in cultured hippocampal neurons. We further showed that the synaptic localisation of Vangl2 was categorised into two types: overlapping co-localisation with postsynaptic density (PSD)-95 or highly correlated but complementary pattern of association with PSD-95. Only the former was significantly sensitive to deletion of the PDZ-binding motif. In addition, the PDZ interaction enhanced the protein interactions between PSD-95 and Prickle2, which is another planar cell polarity factor that is localised at the postsynaptic density. Taken together with our recent report that the density of PSD-95 clusters was reduced in Vangl2-silenced neurons, these results suggest that Vangl2 determines the complex formation and clustering of postsynaptic molecules for synaptogenesis in mammalian brains.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Nagaoka T,Tabuchi K,Kishi M

doi

10.1038/srep12916

subject

Has Abstract

pub_date

2015-08-10 00:00:00

pages

12916

issn

2045-2322

pii

srep12916

journal_volume

5

pub_type

杂志文章
  • A new species of early-diverging Sauropodiformes from the Lower Jurassic Fengjiahe Formation of Yunnan Province, China.

    abstract::Sauropodomorpha were herbivorous saurischian dinosaurs that incorporate Sauropoda and early-diverging sauropodomorphs. The oldest sauropodomorph remains are known from Late Triassic deposits, most of them Gondwanan. The Laurasian record comprises some Triassic forms, but the bulk is Jurassic in age. Among the 14 Juras...

    journal_title:Scientific reports

    pub_type: 历史文章,杂志文章

    doi:10.1038/s41598-020-67754-4

    authors: Peyre de Fabrègues C,Bi S,Li H,Li G,Yang L,Xu X

    更新日期:2020-07-03 00:00:00

  • Male hatchling production in sea turtles from one of the world's largest marine protected areas, the Chagos Archipelago.

    abstract::Sand temperatures at nest depths and implications for hatchling sex ratios of hawksbill turtles (Eretmochelys imbricata) and green turtles (Chelonia mydas) nesting in the Chagos Archipelago, Indian Ocean are reported and compared to similar measurements at rookeries in the Atlantic and Caribbean. During 2012-2014, tem...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20339

    authors: Esteban N,Laloë JO,Mortimer JA,Guzman AN,Hays GC

    更新日期:2016-02-02 00:00:00

  • A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicular germ cell tumor.

    abstract::It was previously demonstrated that microRNA-199a (miR-199a) was down-regulated in testicular germ cell tumor (TGCT) partially caused by hypermethylation of its promoter. miR-199a is encoded by two loci in the human genome, miR-199a-1 on chromosome (Chr) 19 and miR-199a-2 on Chr 1. Both loci encode the same miR-199a. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06413

    authors: Chen BF,Suen YK,Gu S,Li L,Chan WY

    更新日期:2014-09-18 00:00:00

  • Preparation of Zr(Mo,W)2O8 with a larger negative thermal expansion by controlling the thermal decomposition of Zr(Mo,W)2(OH,Cl)2∙2H2O.

    abstract::Solid solutions of Zr(Mo,W)2O7(OH,Cl)2∙2H2O with a preset ratio of components were prepared by a hydrothermal method. The chemical composition of the solutions was determined by energy dispersive X-ray spectroscopy (EDX). For all the samples of ZrMoxW2-xO7(OH,Cl)2∙2H2O (x = 0.0, 0.2, 0.4, 0.6, 0.8, 1.0, 1.2, 1.4, 1.6,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23529-6

    authors: Petrushina MY,Dedova ES,Filatov EY,Plyusnin PE,Korenev SV,Kulkov SN,Derevyannikova EA,Sharafutdinov MR,Gubanov AI

    更新日期:2018-03-28 00:00:00

  • High colloidal stability ZnO nanoparticles independent on solvent polarity and their application in polymer solar cells.

    abstract::Significant aggregation between ZnO nanoparticles (ZnO NPs) dispersed in polar and nonpolar solvents hinders the formation of high quality thin film for the device application and impedes their excellent electron transporting ability. Herein a bifunctional coordination complex, titanium diisopropoxide bis(acetylaceton...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75070-0

    authors: Lee W,Yeop J,Heo J,Yoon YJ,Park SY,Jeong J,Shin YS,Kim JW,An NG,Kim DS,Park J,Kim JY

    更新日期:2020-10-22 00:00:00

  • Effects of ecological restoration projects on changes in land cover: A case study on the Loess Plateau in China.

    abstract::Changes in land cover have become key components of global environmental change and represent the impact of human activity. To better understand the fundamental processes of land transition characteristics before and after the implementation of ecological programmes, we determined the dominant systematic changes in la...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44496

    authors: Zhao J,Yang Y,Zhao Q,Zhao Z

    更新日期:2017-03-21 00:00:00

  • Myh11+ microvascular mural cells and derived mesenchymal stem cells promote retinal fibrosis.

    abstract::Retinal diseases are frequently characterized by the accumulation of excessive scar tissue found throughout the neural retina. However, the pathophysiology of retinal fibrosis remains poorly understood, and the cell types that contribute to the fibrotic response are incompletely defined. Here, we show that myofibrobla...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72875-x

    authors: Ray HC,Corliss BA,Bruce AC,Kesting S,Dey P,Mansour J,Seaman SA,Smolko CM,Mathews C,Dey BK,Owens GK,Peirce SM,Yates PA

    更新日期:2020-09-25 00:00:00

  • Landscape of the spliced leader trans-splicing mechanism in Schistosoma mansoni.

    abstract::Spliced leader dependent trans-splicing (SLTS) has been described as an important RNA regulatory process that occurs in different organisms, including the trematode Schistosoma mansoni. We identified more than seven thousand putative SLTS sites in the parasite, comprising genes with a wide spectrum of functional class...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-22093-3

    authors: Boroni M,Sammeth M,Gava SG,Jorge NAN,Macedo AM,Machado CR,Mourão MM,Franco GR

    更新日期:2018-03-01 00:00:00

  • Decreased peripheral arterial volume distensibility in patients with branch retinal vein occlusion in comparison with normal subjects.

    abstract::This study aimed to quantify arterial volume distensibility in patients with branch retinal vein occlusion (BRVO) in comparison with normal subjects and to investigate factors associated with their differences. 40 normal subjects and 30 BRVO patients were studied. Brachial-ankle pulse wave velocity (baPWV) was measure...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06685

    authors: Chen Z,Mao L,Liu C,Blake JR,Zheng D

    更新日期:2014-10-20 00:00:00

  • Emergence of double-dome superconductivity in ammoniated metal-doped FeSe.

    abstract::The pressure dependence of the superconducting transition temperature (Tc) and unit cell metrics of tetragonal (NH3)yCs0.4FeSe were investigated in high pressures up to 41 GPa. The Tc decreases with increasing pressure up to 13 GPa, which can be clearly correlated with the pressure dependence of c (or FeSe layer spaci...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09477

    authors: Izumi M,Zheng L,Sakai Y,Goto H,Sakata M,Nakamoto Y,Nguyen HLT,Kagayama T,Shimizu K,Araki S,Kobayashi TC,Kambe T,Gu D,Guo J,Liu J,Li Y,Sun L,Prassides K,Kubozono Y

    更新日期:2015-04-01 00:00:00

  • Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response.

    abstract::Understanding the innate immune response to vaccination is critical in vaccine design. Here, we studied blood innate myeloid cells after first and second immunization of cynomolgus macaques with the modified vaccinia virus Ankara. The inflammation at the injection site was moderate and resolved faster after the boost....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21222-2

    authors: Palgen JL,Tchitchek N,Elhmouzi-Younes J,Delandre S,Namet I,Rosenbaum P,Dereuddre-Bosquet N,Martinon F,Cosma A,Lévy Y,Le Grand R,Beignon AS

    更新日期:2018-02-15 00:00:00

  • Chronic neural activity recorded within breast tumors.

    abstract::Nerve fibers are known to reside within malignant tumors and the greater the neuronal density the worse prognosis for the patient. Recent discoveries using tumor bearing animal models have eluded to the autonomic nervous system having a direct effect on tumor growth and metastasis. We report the first direct and chron...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71670-y

    authors: McCallum GA,Shiralkar J,Suciu D,Covarrubias G,Yu JS,Karathanasis E,Durand DM

    更新日期:2020-09-09 00:00:00

  • Genome-wide transcriptomic analysis uncovers the molecular basis underlying early flowering and apetalous characteristic in Brassica napus L.

    abstract::Floral transition and petal onset, as two main aspects of flower development, are crucial to rapeseed evolutionary success and yield formation. Currently, very little is known regarding the genetic architecture that regulates flowering time and petal morphogenesis in Brassica napus. In the present study, a genome-wide...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30576

    authors: Yu K,Wang X,Chen F,Chen S,Peng Q,Li H,Zhang W,Hu M,Chu P,Zhang J,Guan R

    更新日期:2016-07-27 00:00:00

  • Enterohemorrhagic Escherichia coli pathogenesis: role of Long polar fimbriae in Peyer's patches interactions.

    abstract::Enterohemorrhagic Escherichia coli (EHEC) are major food-borne pathogens whose survival and virulence in the human digestive tract remain unclear owing to paucity of relevant models. EHEC interact with the follicle-associated epithelium of Peyer's patches of the distal ileum and translocate across the intestinal epith...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44655

    authors: Cordonnier C,Etienne-Mesmin L,Thévenot J,Rougeron A,Rénier S,Chassaing B,Darfeuille-Michaud A,Barnich N,Blanquet-Diot S,Livrelli V

    更新日期:2017-03-20 00:00:00

  • A combination approach to treating fungal infections.

    abstract::Azoles are antifungal drugs used to treat fungal infections such as candidiasis in humans. Their extensive use has led to the emergence of drug resistance, complicating antifungal therapy for yeast infections in critically ill patients. Combination therapy has become popular in clinical practice as a potential strateg...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep17070

    authors: Shrestha SK,Fosso MY,Garneau-Tsodikova S

    更新日期:2015-11-23 00:00:00

  • Control of heart rate through guided high-rate breathing.

    abstract::Understanding the complex dynamics of cardio-respiratory coupling sheds light on the underlying mechanisms governing the communication between these two physiological systems. Previous research has predominantly considered the coupling at respiratory rates slower than the heart rate and shown that respiratory oscillat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-38058-5

    authors: Perry S,Khovanova NA,Khovanov IA

    更新日期:2019-02-07 00:00:00

  • A functional investigation of the suppression of CpG and UpA dinucleotide frequencies in plant RNA virus genomes.

    abstract::Frequencies of CpG and UpA dinucleotides in most plant RNA virus genomes show degrees of suppression comparable to those of vertebrate RNA viruses. While pathways that target CpG and UpAs in HIV-1 and echovirus 7 genomes and restrict their replication have been partly characterised, whether an analogous process drives...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-54853-0

    authors: Ibrahim A,Fros J,Bertran A,Sechan F,Odon V,Torrance L,Kormelink R,Simmonds P

    更新日期:2019-12-04 00:00:00

  • Formants provide honest acoustic cues to body size in American alligators.

    abstract::In many vertebrates, acoustic cues to body size are encoded in resonance frequencies of the vocal tract ("formants"), rather than in the rate of tissue vibration in the sound source ("pitch"). Anatomical constraints on the vocal tract's size render formants honest cues to size in many bird and mammal species, but it i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01948-1

    authors: Reber SA,Janisch J,Torregrosa K,Darlington J,Vliet KA,Fitch WT

    更新日期:2017-05-12 00:00:00

  • Altered regional homogeneity and functional brain networks in Type 2 diabetes with and without mild cognitive impairment.

    abstract::Patients with Type-2 Diabetes Mellitus (T2DM) have a considerably higher risk of developing mild cognitive impairment (MCI) and dementia. The initial symptoms are very insidious at onset. We investigated the alterations in spontaneous brain activity and network connectivity through regional homogeneity (ReHo) and grap...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76495-3

    authors: Xiong Y,Chen X,Zhao X,Fan Y,Zhang Q,Zhu W

    更新日期:2020-12-04 00:00:00

  • Discovery of a new Theileria sp. closely related to Theileria annulata in cattle from Sri Lanka.

    abstract::Theileria annulata is a haemoprotozoan parasite that causes a cancer-like illness known as tropical theileriosis in cattle. In the course of analyzing the genetic diversity of T. annulata in Sri Lanka, we observed that merozoite-piroplasm surface antigen (tams1) and surface protein (tasp)-like gene sequences obtained ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52512-y

    authors: Sivakumar T,Fujita S,Tuvshintulga B,Kothalawala H,Silva SSP,Yokoyama N

    更新日期:2019-11-06 00:00:00

  • Sleep apnea and diabetes mellitus are independently associated with cardiovascular events and hospitalization for heart failure after coronary artery bypass grafting.

    abstract::The relative and combined effects of sleep apnea with diabetes mellitus (DM) on cardiovascular outcomes in patients undergoing coronary artery bypass grafting (CABG) remain unknown. In this secondary analysis of data from the SABOT study, 1007 patients were reclassified into four groups based on their sleep apnea and ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78700-9

    authors: Aung AT,Koo CY,Tam WW,Chen Z,Kristanto W,Sim HW,Kojodjojo P,Kofidis T,Lee CH

    更新日期:2020-12-10 00:00:00

  • Artificial targeting of misfolded cytosolic proteins to endoplasmic reticulum as a mechanism for clearance.

    abstract::We report that misfolded cytosolic proteins can be cleared from mammalian cells by directing them to endoplasmic reticulum (ER). NAT1 R64W and Parkin R42P are naturally occurring misfolded variants of cytosolic enzymes that acetylate arylamines and ubiquitinate proteins, respectively. We demonstrate that proteasome in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12088

    authors: Liu F,Koepp DM,Walters KJ

    更新日期:2015-07-14 00:00:00

  • Urinary profiles of luteinizing hormone, estrogen and progestagen during the estrous and gestational periods in giant pandas (Ailuropda melanoleuca).

    abstract::Luteinizing hormone (LH) is one of the main pituitary hormones that regulate ovulation, however its role has not been studied in giant panda. In this study, we developed an ELISA method for the detection of panda urinary LH. We analyzed urinary hormones of 24 female pandas during 36 breeding periods, we found females ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40749

    authors: Cai K,Yie S,Zhang Z,Wang J,Cai Z,Luo L,Liu Y,Wang H,Huang H,Wang C,Huang X,Lan J,Hou R

    更新日期:2017-01-16 00:00:00

  • Adaptations of Interferon Regulatory Factor 3 with Transition from Terrestrial to Aquatic Life.

    abstract::Interferon regulatory factor 3 (IRF3) and IRF7 are closely related IRF members and the major factors for the induction of interferons, a key component in vertebrate innate immunity. However, there is limited knowledge regarding the evolution and adaptation of those IRFs to the environments. Two unique motifs in IRF3 a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-61365-9

    authors: Angeletti M,Hsu WN,Majo N,Moriyama H,Moriyama EN,Zhang L

    更新日期:2020-03-11 00:00:00

  • A graph-theoretical representation of multiphoton resonance processes in superconducting quantum circuits.

    abstract::We propose a graph-theoretical formalism to study generic circuit quantum electrodynamics systems consisting of a two level qubit coupled with a single-mode resonator in arbitrary coupling strength regimes beyond rotating-wave approximation. We define colored-weighted graphs, and introduce different products between t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37544

    authors: Jooya HZ,Reihani K,Chu SI

    更新日期:2016-11-21 00:00:00

  • Targeting extra-oral bitter taste receptors modulates gastrointestinal motility with effects on satiation.

    abstract::Bitter taste receptors (TAS2Rs) are present in extra-oral tissues, including gut endocrine cells. This study explored the presence and mechanism of action of TAS2R agonists on gut smooth muscle in vitro and investigated functional effects of intra-gastric administration of TAS2R agonists on gastric motility and satiat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15985

    authors: Avau B,Rotondo A,Thijs T,Andrews CN,Janssen P,Tack J,Depoortere I

    更新日期:2015-11-06 00:00:00

  • The effect of posterior tethers on the biomechanics of proximal junctional kyphosis: The whole human finite element model analysis.

    abstract::Little is known about the effects of posterior tethers on the development of proximal junctional kyphosis (PJK). We evaluated the ability of posterior tethers to the proximal motion segment stiffness in long instrumented spinal instrumentation and fusion using a whole body human FE model. A series of finite element (F...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-59179-w

    authors: Yagi M,Nakahira Y,Watanabe K,Nakamura M,Matsumoto M,Iwamoto M

    更新日期:2020-02-26 00:00:00

  • Generation of bioinspired structural colors via two-photon polymerization.

    abstract::Colors of crystals, pigments, metals, salt solutions and bioluminescence occur in nature due to the optical properties of electrons in atoms and molecules. However, colors can also result from interference effects on nanostructures. In contrast to artificial coloration, which are caused by well-defined regular structu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17914-w

    authors: Zyla G,Kovalev A,Grafen M,Gurevich EL,Esen C,Ostendorf A,Gorb S

    更新日期:2017-12-15 00:00:00

  • Imaging local brain activity of multiple freely moving mice sharing the same environment.

    abstract::Electrophysiological field potential dynamics have been widely used to investigate brain functions and related psychiatric disorders. Considering recent demand for its applicability to freely moving subjects, especially for animals in a group and socially interacting with each other, here we propose a new method based...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43897-x

    authors: Inagaki S,Agetsuma M,Ohara S,Iijima T,Yokota H,Wazawa T,Arai Y,Nagai T

    更新日期:2019-05-16 00:00:00

  • Comparative transcriptome analysis of Eogammarus possjeticus at different hydrostatic pressure and temperature exposures.

    abstract::Hydrostatic pressure is an important environmental factor affecting the vertical distribution of marine organisms. Laboratory-based studies have shown that many extant shallow-water marine benthic invertebrates can tolerate hydrostatic pressure outside their known natural distributions. However, only a few studies hav...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39716-y

    authors: Chen J,Liu H,Cai S,Zhang H

    更新日期:2019-03-05 00:00:00