Abstract:
:Targeting epigenetic reader proteins by small molecule inhibitors represents a new therapeutic concept in autoimmune diseases such as rheumatoid arthritis (RA). Although inhibitors targeting bromodomain protein 1 (BRD1) are in development, the function of BRD1 has hardly been studied. We investigated the therapeutic potential of BRD1 inhibition in joint-resident cells in RA, synovial fibroblasts (SF) and macrophages. The proliferation of SF was decreased upon BRD1 silencing, accompanied by the downregulation of genes involved in cell cycle regulation. Silencing of BRD1 in SF decreased the basal expression of MMP1 but increased TNF-α- and LPS-induced levels of MMP3, IL6 and IL8. In monocyte-derived macrophages (MDM), silencing of BRD1 decreased the LPS-induced expression of TNF-α, but did not significantly affect basal and the TNF-α- and LPS-induced expression of IL6 and IL8. Our data point to a cell type- and a stimulus-specific function of BRD1. Inhibiting BRD1 could have potential beneficial effects in RA via decreasing the proliferation of SF. Anti-inflammatory effects were limited and only observed in MDM.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Klein K,Kato M,Frank-Bertoncelj M,Kolling C,Ciurea A,Gay S,Ospelt Cdoi
10.1038/s41598-018-29127-wsubject
Has Abstractpub_date
2018-07-24 00:00:00pages
11125issue
1issn
2045-2322pii
10.1038/s41598-018-29127-wjournal_volume
8pub_type
杂志文章abstract::Benign prostatic hyperplasia (BPH) results in a significant public health burden due to the morbidity caused by the disease and many of the available remedies. As much as 70% of men over 70 will develop BPH. Few studies have been conducted to discover the genetic determinants of BPH risk. Understanding the biological ...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究
doi:10.1038/s41598-019-42427-z
更新日期:2019-04-15 00:00:00
abstract::Caenorhabditis elegans presents functioning, biologically relevant phenotypes and is frequently used as a bioindicator of toxicity. However, most C. elegans in vivo effect-assessment methods are laborious and time consuming. Therefore, we developed a novel method to measure the oxygen consumption rate of C. elegans as...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61054-7
更新日期:2020-03-06 00:00:00
abstract::Vitamin D deficiency has been related with metabolic alterations in polycystic ovary syndrome (PCOS). As well, hyperactivation of adrenal axis can be programmed early in life and could be related later with PCOS development. Our aim was to establish the relationship between vitamin D and adrenal parameters with metabo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40653-z
更新日期:2019-03-08 00:00:00
abstract::Therapies targeting somatic bystander genetic events represent a new avenue for cancer treatment. We recently identified a subset of colorectal cancer (CRC) patients who are heterozygous for a wild-type and a low activity allele (NAT2*6) but lack the wild-type allele in their tumors due to loss of heterozygosity (LOH)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80288-z
更新日期:2020-12-31 00:00:00
abstract::Modification of lattice thermal conductivity (κL) of a solid by means of hydrostatic pressure (P) has been a crucially interesting approach that targets a broad range of advanced materials from thermoelectrics and thermal insulators to minerals in mantle. Although it is well documented knowledge that thermal conductiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29801
更新日期:2016-07-19 00:00:00
abstract::In typical numerical simulations, the space-charge force is calculated by slicing a beam into many longitudinal segments and by solving the two-dimensional Poisson equation in each segment. This method neglects longitudinal leakage of the space-charge force to nearby segments owing to its longitudinal spread over 1/γ....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30960-2
更新日期:2018-08-24 00:00:00
abstract::We investigated the metabolic outcome of different coping strategies in 129S6/SvEvTac (129Sv) and C57BL/6Ntac (Bl6) strains. Two different batches of male 129Sv and Bl6 mice were used. One batch was not subjected to any behavioral manipulations (home cage control; HCC), whereas the other batch was treated with saline ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21752-9
更新日期:2018-02-21 00:00:00
abstract::Although numerous reports on nonprecious metal catalysts for replacing expensive Pt-based catalysts have been published, few of these studies have demonstrated their practical application in fuel cells. In this work, we report graphitic carbon nitride and carbon nanofiber hybrid materials synthesized by a facile and g...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08376
更新日期:2015-03-02 00:00:00
abstract::Pseudomonas aeruginosa is a major threat for immune-compromised patients. Bacterial pneumonia can induce uncontrolled and massive neutrophil recruitment ultimately leading to acute respiratory distress syndrome and epithelium damage. Interleukin-22 plays a central role in the protection of the epithelium. In this stud...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11518-0
更新日期:2017-09-08 00:00:00
abstract::Whether the clinical trial treatment effect of urate-lowering therapy (ULT) in patient with chronic kidney disease (CKD) is generalizable to real-word settings is unclear. This study aimed to compare febuxostat with allopurinol for uric acid reduction and renal protection in patients with CKD. Adult CKD patients newly...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67026-1
更新日期:2020-07-01 00:00:00
abstract::Potential distributions of endemic relic shrubs in western Ordos were poorly mapped, which hindered our implementation of proper conservation. Here we investigated the applicability of ecological niche modeling for endangered relic shrubs to detect areas of priority for biodiversity conservation and analyze difference...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26268
更新日期:2016-05-20 00:00:00
abstract::Mitochondria play an essential role in bioenergetics and cellular Ca[Formula: see text] handling. The mitochondrial permeability transition pore (mPTP) is a non-specific channel located in the inner mitochondrial membrane. Long-lasting openings of the pore allow the rapid passage of ions and large molecules, which can...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60177-1
更新日期:2020-03-03 00:00:00
abstract::Post-transcriptional gene regulation by microRNAs (miRNAs) is involved in memory formation. However, the roles of individual miRNAs in these processes remain largely unknown. In this study, we want to clarify the role of miR-181a in hippocampus-dependent memory formation. A transient increase in miR-181a expression wa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09095-3
更新日期:2017-08-16 00:00:00
abstract::Chronic lymphocytic leukaemia (CLL) is characterised by a heterogeneous clinical course. Such heterogeneity is associated with a number of markers, including TP53 gene inactivation. While TP53 gene alterations determine resistance to chemotherapy, it is not clear whether they can influence early disease progression. T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75364-3
更新日期:2020-10-28 00:00:00
abstract::Thrombin-induced and proteinase-activated receptor 1 (PAR1)-mediated signaling increases ROS production, activates ERK, and promotes inflammation and fibroblast proliferation in bleomycin-induced lung injury. Stanniocalcin-1 (STC1) activates anti-oxidant pathways, inhibits inflammation and provides cytoprotection; hen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18117
更新日期:2015-12-07 00:00:00
abstract::We assessed the association between depression status and prevalent and incident type 2 diabetes (T2D) as well as the interaction between depression and a genetic risk score (GS) based on 20 T2D single-nucleotide polymorphisms (SNPs) in a multi-ethnic longitudinal study. We studied 17,375 participants at risk for dysg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01406-y
更新日期:2017-05-09 00:00:00
abstract::The aim was to assess the cognitive dysfunction and physical disability after autologous hematopoietic stem cell transplantation (AHSCT), to explore the potential factors influencing disability regression after AHSCT and to estimate the safety of low-dose immunosuppressive therapy in highly active Multiple Sclerosis (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78160-1
更新日期:2020-12-04 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC) development is a multistage process includes the normal, dysplasia and squamous cell carcinoma (SCC) stages. Recently, increasing evidence has suggested that the tumor microenvironment (TME) is an integral part of malignant transformation. Exploring certain key node genes ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20208
更新日期:2016-02-01 00:00:00
abstract::In this prospective pilot study, we aimed to evaluate the ability of cardiac magnetic resonance imaging (CMR) parameters of right ventricular function and pulmonary artery stiffness to identify pulmonary hypertension (PH), predict major adverse cardiovascular events (MACEs) in patients with secondary PH due to chronic...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-018-32784-6
更新日期:2018-09-27 00:00:00
abstract::One way of expediting materials development is to decrease the need for new experiments by making greater use of published literature. Here, we use data mining and automated image analysis to gather new insights on nanoporous gold (NPG) without conducting additional experiments or simulations. NPG is a three-dimension...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25122-3
更新日期:2018-04-30 00:00:00
abstract::Cathelicidins are short cationic host defense peptides and play a central role in host innate immune system. Here we identified two novel cathelicidins, Cl-CATH2 and 3, from Columba livia. Evolutionary analysis of avian cathelicidins via phylogenetic tree and Ka/Ks calculations supported the positive selection that pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11082
更新日期:2015-07-21 00:00:00
abstract::Power induced wave collapse is one of the most fascinating phenomena in optics as it provides extremely high intensities, thus stimulating a range of nonlinear processes. For low power levels, propagation of beams in bulk media is dominated by diffraction, while above a certain threshold self-focusing is steadily enha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46060-8
更新日期:2019-07-02 00:00:00
abstract::Lung cancer (LC) is the leading cause of cancer-related deaths. Downregulation of CDK1, 4 and 6, key regulators of cell cycle progression, correlates with decreased LC cell proliferation. Enforced expression of miRNAs (miRs) is a promising approach to regulate genes. Here, we study the combinatorial treatment of miR-1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28872-2
更新日期:2018-07-12 00:00:00
abstract::Potential formula of an arbitrary resistor network has been an unsolved problem for hundreds of years, which is an interdisciplinary problem that involves many areas of natural science. A new progress has been made in this paper, which discovered the potential formula of a nonregular m × n fan network with two arbitra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24164-x
更新日期:2018-04-11 00:00:00
abstract::MicroRNA-130b (miR-130b) downregulation has been identified in diabetes, but the role and mechanisms for miR-130b in mediating renal tubulointerstitial fibrosis in diabetic nephropathy (DN) remain unknown. We demonstrated that plasma miR-130b downregulation exhibited clinical and biological relevance as it was linked ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20475
更新日期:2016-02-03 00:00:00
abstract::How the human auditory system learns to map complex pinna-induced spectral-shape cues onto veridical estimates of sound-source elevation in the median plane is still unclear. Earlier studies demonstrated considerable sound-localisation plasticity after applying pinna moulds, and to altered vision. Several factors may ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36422-z
更新日期:2018-12-18 00:00:00
abstract::In solid state science, multifunctional materials and especially multiferroics have attracted a great deal of attention, as they open the possibility for next generation spintronic and data storage devices. Interestingly, while many of them host coexisting 3d and 4f elements, the role of the coupling between these two...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15150-w
更新日期:2017-11-06 00:00:00
abstract::Previously, Aznar et al., showed that Daple/CCDC88C enables Wnt receptors to transactivate trimeric G-proteins during non-canonical Wnt signaling via a novel G-protein binding and activating (GBA) motif. By doing so, Daple serves two opposing roles; earlier during oncogenesis it suppresses neoplastic transformation an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48420-w
更新日期:2019-08-20 00:00:00
abstract::The biological function of multiple repetitions of single amino acids, or homo-repeats, is largely unknown, but their occurrence in proteins has been associated with more than 20 hereditary diseases. Analysing 122 bacterial and eukaryotic genomes, we observed that the number of proteins containing homo-repeats is sign...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26941
更新日期:2016-06-03 00:00:00
abstract::Respiratory syncytial virus (RSV) is a significant cause of lower respiratory tract infection in infants and elderly. To understand the evolution of neutralizing epitopes on the RSV glycoprotein (G) and fusion (F) proteins, we conducted a multi-year surveillance program (OUTSMART-RSV) in the US. Analysis of 1,146 RSV ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40387-y
更新日期:2019-03-07 00:00:00