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Interleukin-22 level is negatively correlated with neutrophil recruitment in the lungs in a Pseudomonas aeruginosa pneumonia model.

Abstract：

:Pseudomonas aeruginosa is a major threat for immune-compromised patients. Bacterial pneumonia can induce uncontrolled and massive neutrophil recruitment ultimately leading to acute respiratory distress syndrome and epithelium damage. Interleukin-22 plays a central role in the protection of the epithelium. In this study, we aimed to evaluate the role of interleukin-22 and its soluble receptor IL-22BP in an acute Pseudomonas aeruginosa pneumonia model in mice. In this model, we noted a transient increase of IL-22 during Pseudomonas aeruginosa challenge. Using an antibody-based approach, we demonstrated that IL-22 neutralisation led to increased susceptibility to infection and to lung damage correlated with an increase in neutrophil accumulation in the lungs. On the contrary, rIL-22 administration or IL-22BP neutralisation led to a decrease in mouse susceptibility and lung damage associated with a decrease in neutrophil accumulation. This study demonstrated that the IL-22/IL-22BP system plays a major role during Pseudomonas aeruginosa pneumonia by moderating neutrophil accumulation in the lungs that ultimately leads to epithelium protection.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Broquet A,Jacqueline C,Davieau M,Besbes A,Roquilly A,Martin J,Caillon J,Dumoutier L,Renauld JC,Heslan M,Josien R,Asehnoune K

doi

10.1038/s41598-017-11518-0

subject

Has Abstract

pub_date

2017-09-08 00:00:00

pages

11010

issue

1

issn

2045-2322

pii

10.1038/s41598-017-11518-0

journal_volume

7

pub_type

杂志文章

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