当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells.

ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells.

Abstract：

:Natural killer (NK) cells are essential for immunosurveillance against transformed cells. Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel gated by ADP-ribose (ADPR). However, the role of TRPM2-mediated Ca(2+) signaling in the antitumor response of NK cells has not been explored. Here, we show that ADPR-mediated Ca(2+) signaling is important for cytolytic granule polarization and degranulation but not involved in target cell recognition by NK cells. The key steps of this pathway are: 1) the activation of intracellular CD38 by protein kinase A following the interaction of the NK cell with a tumor cell results in the production of ADPR, 2) ADPR targets TRPM2 channels on cytolytic granules, and 3) TRPM2-mediated Ca(2+) signaling induces cytolytic granule polarization and degranulation, resulting in antitumor activity. NK cells treated with 8-Br-ADPR, an ADPR antagonist, as well as NK cells from Cd38(-/-) mice showed reduced tumor-induced granule polarization, degranulation, granzyme B secretion, and cytotoxicity of NK cells. Furthermore, TRPM2-deficient NK cells showed an intrinsic defect in tumoricidal activity. These results highlight CD38, ADPR, and TRPM2 as key players in the specialized Ca(2+) signaling system involved in the antitumor activity of NK cells.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Rah SY,Kwak JY,Chung YJ,Kim UH

doi

10.1038/srep09482

subject

Has Abstract

pub_date

2015-03-25 00:00:00

pages

9482

issn

2045-2322

pii

srep09482

journal_volume

5

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • A new approach to prevent cervical stenosis in postmenopausal women after loop electrosurgical excision procedure: a randomized controlled trial.

    abstract：:To determine whether regular cervical dilatation is effective for preventing cervical stenosis, and to identify the associated risk factors, in postmenopausal women after LEEP. This was a prospective randomized clinical trial in postmenopausal women who underwent LEEP at our hospital between August 2018 and May 2019. ...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/s41598-020-65170-2

    authors： Lin J,Meng Y,Chen Y,Li Z,Xu Y,Wu D

    更新日期：2020-05-22 00:00:00

  • Altered RNA editing in 3' UTR perturbs microRNA-mediated regulation of oncogenes and tumor-suppressors.

    abstract：:RNA editing is a molecular event that alters specific nucleotides in RNA post-transcriptionally. RNA editing has the potential to impact a variety of cellular processes and is implicated in diseases such as cancer. Yet, the precise mechanisms by which RNA editing controls cellular processes are poorly understood. Here...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23226

    authors： Zhang L,Yang CS,Varelas X,Monti S

    更新日期：2016-03-16 00:00:00

  • Evaluating the origin and virulence of a Helicobacter pylori cagA-positive strain isolated from a non-human primate.

    abstract：:Helicobacter pylori cagA-positive strains are critically involved in the development of gastric cancer. Upon delivery into gastric epithelial cells via type IV secretion, the cagA-encoded CagA interacts with and thereby perturbs the pro-oncogenic phosphatase SHP2 and the polarity-regulating kinase PAR1b via the tyrosi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34425-4

    authors： Hashi K,Imai C,Yahara K,Tahmina K,Hayashi T,Azuma T,Miyabe-Nishiwaki T,Sato H,Matsuoka M,Niimi S,Okamoto M,Hatakeyama M

    更新日期：2018-10-29 00:00:00

  • Reduced interfacial recombination in dye-sensitized solar cells assisted with NiO:Eu(3+),Tb(3+) coated TiO2 film.

    abstract：:Eu(3+),Tb(3+) doped and undoped NiO films were deposited on TiO2 by a sol-gel spin-coating method as the photoanodes of dye sensitized solar cells (DSSCs). A comparative study with different structures including TiO2, TiO2/NiO and TiO2/NiO:Eu(3+),Tb(3+) as the photoanodes was carried out to illustrate the photovoltaic...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31123

    authors： Yao N,Huang J,Fu K,Deng X,Ding M,Zhang S,Xu X,Li L

    更新日期：2016-08-10 00:00:00

  • A CRISPR-based method for testing the essentiality of a gene.

    abstract：:The CRISPR/Cas9 system is a powerful method of editing genes by randomly introducing errors into the target sites. Here, we describe a CRISPR-based test for gene essentiality (CRISPR-E test) that allows the identification of essential genes. Specifically, we use sgRNA-mediated CRISPR/Cas9 to target the open reading fr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71690-8

    authors： You Y,Ramachandra SG,Jin T

    更新日期：2020-09-08 00:00:00

  • Optical properties of in-vitro biomineralised silica.

    abstract：:Silicon is the second most common element on the Earth's crust and its oxide (SiO(2)) the most abundant mineral. Silica and silicates are widely used in medicine and industry as well as in micro- and nano-optics and electronics. However, the fabrication of glass fibres and components requires high temperature and non-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00607

    authors： Polini A,Pagliara S,Camposeo A,Cingolani R,Wang X,Schröder HC,Müller WE,Pisignano D

    更新日期：2012-01-01 00:00:00

  • Identification of helicity-dependent photocurrents from topological surface states in Bi2Se3 gated by ionic liquid.

    abstract：:Dirac-like surface states on surfaces of topological insulators have a chiral spin structure with spin locked to momentum, which is interesting in physics and may also have important applications in spintronics. In this work, by measuring the tunable helicity-dependent photocurrent (HDP), we present an identification ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04889

    authors： Duan J,Tang N,He X,Yan Y,Zhang S,Qin X,Wang X,Yang X,Xu F,Chen Y,Ge W,Shen B

    更新日期：2014-05-08 00:00:00

  • Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice.

    abstract：:Modern society characterized by a 24/7 lifestyle leads to misalignment between environmental cycles and endogenous circadian rhythms. Persisting circadian misalignment leads to deleterious effects on health and healthspan. However, the underlying mechanism remains not fully understood. Here, we subjected adult, wild-t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59541-y

    authors： Inokawa H,Umemura Y,Shimba A,Kawakami E,Koike N,Tsuchiya Y,Ohashi M,Minami Y,Cui G,Asahi T,Ono R,Sasawaki Y,Konishi E,Yoo SH,Chen Z,Teramukai S,Ikuta K,Yagita K

    更新日期：2020-02-13 00:00:00

  • Host genetics determine susceptibility to avian influenza infection and transmission dynamics.

    abstract：:Host-genetic control of influenza virus infection has been the object of little attention. In this study we determined that two inbred lines of chicken differing in their genetic background , Lines 0 and C-B12, were respectively relatively resistant and susceptible to infection with the low pathogenicity influenza vir...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep26787

    authors： Ruiz-Hernandez R,Mwangi W,Peroval M,Sadeyen JR,Ascough S,Balkissoon D,Staines K,Boyd A,McCauley J,Smith A,Butter C

    更新日期：2016-06-09 00:00:00

  • Y-box protein-associated acidic protein (YBAP1/C1QBP) affects the localization and cytoplasmic functions of YB-1.

    abstract：:The Y-box proteins are multifunctional nucleic acid-binding proteins involved in various aspects of gene regulation. The founding member of the Y-box protein family, YB-1, functions as a transcription factor as well as a principal component of messenger ribonucleoprotein particles (mRNPs) in somatic cells. The nuclear...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-24401-3

    authors： Matsumoto K,Kose S,Kuwahara I,Yoshimura M,Imamoto N,Yoshida M

    更新日期：2018-04-18 00:00:00

  • Fragment-based screening identifies inhibitors of ATPase activity and of hexamer formation of Cagα from the Helicobacter pylori type IV secretion system.

    abstract：:Type IV secretion systems are multiprotein complexes that mediate the translocation of macromolecules across the bacterial cell envelope. In Helicobacter pylori a type IV secretion system encoded by the cag pathogenicity island encodes 27 proteins and most are essential for virulence. We here present the identificatio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42876-6

    authors： Arya T,Oudouhou F,Casu B,Bessette B,Sygusch J,Baron C

    更新日期：2019-04-24 00:00:00

  • Breast tumor movements analysis using MRI scans in prone and supine positions.

    abstract：:We quantitatively evaluated breast tumor movement and volume changes between magnetic resonance imaging (MRI) scans in prone and supine positions. Twenty-seven breast tumor patients who received neoadjuvant systemic therapy (NST) for breast-conserving surgery were studied. Before and after NST, MRI scans in prone and ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61802-9

    authors： Wang CB,Lee S,Kim T,Hong D,Kim GB,Yoon GY,Kim HH,Kim N,Ko B

    更新日期：2020-03-17 00:00:00

  • Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts.

    abstract：:Prolonged healing and scar formation are two major challenges in the treatment of soft tissue trauma. Adipose mesenchymal stem cells (ASCs) play an important role in tissue regeneration, and recent studies have suggested that exosomes secreted by stem cells may contribute to paracrine signaling. In this study, we inve...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32993

    authors： Hu L,Wang J,Zhou X,Xiong Z,Zhao J,Yu R,Huang F,Zhang H,Chen L

    更新日期：2016-09-12 00:00:00

  • Crystal orientation and crystal structure of paramagnetic α-Al under a pulsed electromagnetic field.

    abstract：:The intermittent electromagnetic fields with a large [Formula: see text] can enhance the properties of ferromagnetic materials and significantly affect paramagnetic materials. In this study, the effect of a pulsed electromagnetic field on the crystal orientation of the primary phase and microstructure evolution of an ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67352-4

    authors： Bai Q,Wang J,Xing S,Ma Y,Bao X

    更新日期：2020-06-30 00:00:00

  • Expression of nicotinamide phosphoribosyltransferase-influenced genes predicts recurrence-free survival in lung and breast cancers.

    abstract：:Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in the salvage pathway of nicotinamide adenine dinucleotide biosynthesis. NAMPT protein is a secreted plasma biomarker in inflammation and in cancer. The NAMPT enzymatic inhibitor, FK866, acts as an inducer of apoptosis and is a cancer therapeuti...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/srep06107

    authors： Zhou T,Wang T,Garcia JG

    更新日期：2014-08-22 00:00:00

  • Genome-wide comparative analysis of papain-like cysteine protease family genes in castor bean and physic nut.

    abstract：:Papain-like cysteine proteases (PLCPs) are a class of proteolytic enzymes involved in many plant processes. Compared with the extensive research in Arabidopsis thaliana, little is known in castor bean (Ricinus communis) and physic nut (Jatropha curcas), two Euphorbiaceous plants without any recent whole-genome duplica...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18760-6

    authors： Zou Z,Huang Q,Xie G,Yang L

    更新日期：2018-01-10 00:00:00

  • Transparent anti-fogging and self-cleaning TiO2/SiO2 thin films on polymer substrates using atmospheric plasma.

    abstract：:Transparent anti-fogging and self-cleaning coatings are of great interest for many applications, including solar panels, windshields and displays or lenses to be used in humid environments. In this paper, we report on the simultaneous synthesis, at atmospheric pressure, of anatase TiO2 nanoparticles and low-temperatur...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-27526-7

    authors： Chemin JB,Bulou S,Baba K,Fontaine C,Sindzingre T,Boscher ND,Choquet P

    更新日期：2018-06-25 00:00:00

  • Estimating the risk of Dengue, Chikungunya and Zika outbreaks in a large European city.

    abstract：:Outbreaks of arbovirus infections vectored by invasive Aedes albopictus have already occurred and are predicted to become increasingly frequent in Southern Europe. We present a probabilistic model to assess risk of arbovirus outbreaks based on incident cases worldwide, on the probability of arrival of infected travele...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34664-5

    authors： Solimini AG,Manica M,Rosà R,Della Torre A,Caputo B

    更新日期：2018-11-06 00:00:00

  • Manipulating size of Li3V2(PO4)3 with reduced graphene oxide: towards high-performance composite cathode for lithium ion batteries.

    abstract：:Lithium vanadium phosphate (Li3V2(PO4)3, LVP)/reduced graphene oxide (rGO) composite is prepared with a rheological method followed by heat treatment. The size and interface of LVP particles, two important merits for a cathode material, can be effectively tuned by the rGO in the composite, which plays as surfactant to...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05768

    authors： Zhu X,Yan Z,Wu W,Zeng W,Du Y,Zhong Y,Zhai H,Ji H,Zhu Y

    更新日期：2014-08-29 00:00:00

  • De novo transcriptome assembly for the spiny mouse (Acomys cahirinus).

    abstract：:Spiny mice of the genus Acomys display several unique physiological traits, including menstruation and scar-free wound healing; characteristics that are exceedingly rare in mammals, and of considerable interest to the scientific community. These unique attributes, and the potential for spiny mice to accurately model h...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09334-7

    authors： Mamrot J,Legaie R,Ellery SJ,Wilson T,Seemann T,Powell DR,Gardner DK,Walker DW,Temple-Smith P,Papenfuss AT,Dickinson H

    更新日期：2017-08-21 00:00:00

  • Steady streaming as a method for drug delivery to the inner ear.

    abstract：:The inner ear, or cochlea, is a fluid-filled organ housing the mechanosensitive hair cells. Sound stimulation is relayed to the hair cells through waves that propagate on the elastic basilar membrane. Sensorineural hearing loss occurs from damage to the hair cells and cannot currently be cured. Although drugs have bee...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79946-z

    authors： Sumner L,Mestel J,Reichenbach T

    更新日期：2021-01-08 00:00:00

  • All-graphene-battery: bridging the gap between supercapacitors and lithium ion batteries.

    abstract：:Herein, we propose an advanced energy-storage system: all-graphene-battery. It operates based on fast surface-reactions in both electrodes, thus delivering a remarkably high power density of 6,450 W kg(-1)(total electrode) while also retaining a high energy density of 225 Wh kg(-1)(total electrode), which is comparabl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05278

    authors： Kim H,Park KY,Hong J,Kang K

    更新日期：2014-06-13 00:00:00

  • Corrigendum: Engineering the residual side chains of HAP phytases to improve their pepsin resistance and catalytic efficiency.

    abstract：:This corrects the article DOI: 10.1038/srep42133. ...

    journal_title：Scientific reports

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/srep46871

    authors： Niu C,Yang P,Luo H,Huang H,Wang Y,Yao B

    更新日期：2017-06-30 00:00:00

  • Peripheral perfusion, measured by perfusion index, is a novel indicator for renal events in patients with type 2 diabetes mellitus.

    abstract：:Diabetic kidney disease (DKD) is one of the leading causes of end stage renal disease. Despite recent therapies, mortality due to DKD and resources spent on healthcare are important problems. Thus, appropriate markers are needed to predict renal outcomes. Therefore, we investigated the role of peripheral perfusion as ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62926-8

    authors： Okada H,Tanaka M,Yasuda T,Okada Y,Norikae H,Fujita T,Nishi T,Oyamada H,Yamane T,Fukui M

    更新日期：2020-04-08 00:00:00

  • Gamma oryzanol impairs alcohol-induced anxiety-like behavior in mice via upregulation of central monoamines associated with Bdnf and Il-1β signaling.

    abstract：:Adolescent alcohol exposure may increase anxiety-like behaviors by altering central monoaminergic functions and other important neuronal pathways. The present study was designed to investigate the anxiolytic effect of 0.5% γ-oryzanol (GORZ) and its neurochemical and molecular mechanisms under chronic 10% ethanol consu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67689-w

    authors： Akter S,Uddin KR,Sasaki H,Lyu Y,Shibata S

    更新日期：2020-06-30 00:00:00

  • Entanglement dynamics of Nitrogen-vacancy centers spin ensembles coupled to a superconducting resonator.

    abstract：:Exploration of macroscopic quantum entanglement is of great interest in both fundamental science and practical application. We investigate a hybrid quantum system that consists of two nitrogen-vacancy centers ensembles (NVE) coupled to a superconducting coplanar waveguide resonator (CPWR). The collective magnetic coup...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21775

    authors： Liu Y,You J,Hou Q

    更新日期：2016-02-23 00:00:00

  • MEMS Based Broadband Piezoelectric Ultrasonic Energy Harvester (PUEH) for Enabling Self-Powered Implantable Biomedical Devices.

    abstract：:Acoustic energy transfer is a promising energy harvesting technology candidate for implantable biomedical devices. However, it does not show competitive strength for enabling self-powered implantable biomedical devices due to two issues - large size of bulk piezoelectric ultrasound transducers and output power fluctua...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24946

    authors： Shi Q,Wang T,Lee C

    更新日期：2016-04-26 00:00:00

  • Mitochondrial behaviour throughout the lytic cycle of Toxoplasma gondii.

    abstract：:Mitochondria distribution in cells controls cellular physiology in health and disease. Here we describe the mitochondrial morphology and positioning found in the different stages of the lytic cycle of the eukaryotic single-cell parasite Toxoplasma gondii. The lytic cycle, driven by the tachyzoite life stage, is respon...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42746

    authors： Ovciarikova J,Lemgruber L,Stilger KL,Sullivan WJ,Sheiner L

    更新日期：2017-02-16 00:00:00

  • Reversal of drug-resistance by noscapine chemo-sensitization in docetaxel resistant triple negative breast cancer.

    abstract：:Multidrug resistance (MDR) is a major impediment to cancer treatment. Here, for the first time, we investigated the chemo-sensitizing effect of Noscapine (Nos) at low concentrations in conjunction with docetaxel (DTX) to overcome drug resistance of triple negative breast cancer (TNBC). In vitro experiments showed that...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-15531-1

    authors： Doddapaneni R,Patel K,Chowdhury N,Singh M

    更新日期：2017-11-20 00:00:00

  • Effect of high slice energy spread of an electron beam on the generation of isolated, terawatt, attosecond X-ray free-electron laser pulse.

    abstract：:Attosecond (asec) X-ray free-electron laser (XFEL) has attracted considerable interest over the past years. Nowadays typical XFEL application experiments demand 1010-1011 photons per pulse, which corresponds to a peak power of terawatts (TW) in case of asec hard X-ray pulse. To the realization of such TW asec-XFEL pul...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-57905-y

    authors： Shim CH,Parc YW,Kim DE

    更新日期：2020-01-28 00:00:00